Distinct transcriptional profiles of adrenocortical tumors uncovered by DNA microarray analysis

American Journal of Pathology

Volumn 162, Issue 2, 2003, Pages 521-531

  Giordano, Thomas J ^a,b   Thomas, Dafydd G ^a   Kuick, Rork ^a   Lizyness, Michelle ^a   Misek, David E ^a   Smith, Angela L ^a   Sanders, Donita ^a   Aljundi, Rima T ^a   Gauger, Paul G ^a   Thompson, Norman W ^a   Taylor, Jeremy M G ^a   Hanash, Samir M ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b UNIVERSITY OF MICHIGAN HOSPITALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GENE PRODUCT; KI 67 ANTIGEN; OSTEOPONTIN; PROTEIN SERINE THREONINE KINASE; PROTEIN TOP2A; SOMATOMEDIN B; UNCLASSIFIED DRUG;

ADRENAL CORTEX CARCINOMA; ADRENAL CORTEX TUMOR; ARTICLE; CLUSTER ANALYSIS; CONTROLLED STUDY; DISEASE CLASSIFICATION; DISEASE MARKER; DNA DETERMINATION; DNA FINGERPRINTING; DNA MICROARRAY; DNA STRUCTURE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IGF2 GENE; IMMUNOHISTOCHEMISTRY; KI67 GENE; PRIORITY JOURNAL; QUANTITATIVE ASSAY; REGULATOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPP GENE; STK15 GENE; STRUCTURE ANALYSIS; TOP2A GENE; TRANSCRIPTION REGULATION; VALIDATION PROCESS;

EID: 0037331277     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63846-1     Document Type: Article

References (66)

1. Brennan MF: Adrenocortical carcinoma. CA Cancer J Clin 1987, 37:348-365
2. Weiss LM: Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors. Am J Surg Pathol 1984, 8:163-169
3. Weiss LM, Medeiros LJ, Vickery Jr AL: Pathologic features of prognostic significance in adrenocortical carcinoma. Am J Surg Pathol 1989, 13:202-206
4. Munro LM, Kennedy A, McNicol AM: The expression of inhibin/activin subunits in the human adrenal cortex and its tumours. J Endocrinol 1999, 161:341-347
5. McCluggage WG, Burton J, Maxwell P, Sloan JM: Immunohistochemical staining of normal, hyperplastic, and neoplastic adrenal cortex with a monoclonal antibody against alpha inhibin. J Clin Pathol 1998, 51:114-116
6. Arola J, Liu J, Heikkila P, Voutilainen R, Kahri A: Expression of inhibin alpha in the human adrenal gland and adrenocortical tumors. Endocr Res 1998, 24:865-867
7. Pelkey TJ, Frierson Jr HF, Mills SE, Stoler MH: The alpha subunit of inhibin in adrenal cortical neoplasia. Mod Pathol 1998, 11:516-524
8. Cho EY, Ahn GH: Immunoexpression of inhibin alpha-subunit in adrenal neoplasms. Appl Immunohistochem Mol Morphol 2001, 9:222-228
9. Renshaw AA, Granter SR: A comparison of A103 and inhibin reactivity in adrenal cortical tumors: distinction from hepatocellular carcinoma and renal tumors. Mod Pathol 1998, 11:1160-1164
10. Goldblum JR, Shannon R, Kaldjian EP, Thiny M, Davenport R, Thompson N, Lloyd RV: Immunohistochemical assessment of proliferative activity in adrenocortical neoplasms. Mod Pathol 1993, 6:663-668
11. Iino K, Sasano H, Yabuki N, Oki Y, Kikuchi A, Yoshimi T, Nagura H: DNA topoisomerase II alpha and Ki-67 in human adrenocortical neoplasms: a possible marker of differentiation between adenomas and carcinomas. Mod Pathol 1997, 10:901-907
12. Nakazumi H, Sasano H, Iino K, Ohashi Y, Orikasa S: Expression of cell cycle inhibitor p27 and Ki-67 in human adrenocortical neoplasms. Mod Pathol 1998, 11:1165-1170
13. Terzolo M, Boccuzzi A, Bovio S, Cappia S, De Giuli P, Ali A, Paccotti P, Porpiglia F, Fontana D, Angeli A: Immunohistochemical assessment of Ki-67 in the differential diagnosis of adrenocortical tumors. Urology 2001, 57:176-182
14. Wachenfeld C, Beuschlein F, Zwermann O, Mora P, Fassnacht M, Allolio B, Reincke M: Discerning malignancy in adrenocortical tumors: are molecular markers useful? Eur J Endocrinol 2001, 145:335-341
15. Gupta D, Shidham V, Holden J, Layfield L: Value of topoisomerase II alpha, MIB-1, p53, E-cadherin, retinoblastoma gene protein product, and HER-2/neu immunohistochemical expression for the prediction of biologic behavior in adrenocortical neoplasms. Appl Immunohistochem Mol Morphol 2001, 9:215-221
16. Arola J, Salmenkivi K, Liu J, Kahri AI, Heikkila P: p53 and Ki67 in adrenocortical tumors. Endocr Res 2000, 26:861-865
17. Li FP, Fraumeni Jr JF: Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome? Ann Intern Med 1969, 71:747-752
18. Ohgaki H, Kleihues P, Heitz PU: p53 mutations in sporadic adrenocortical tumors. Int J Cancer 1993, 54:408-410
19. Lin SR, Lee YJ, Tsai JH: Mutations of the p53 gene in human functional adrenal neoplasms. J Clin Endocrinol Metab 1994, 78:483-491
20. Reincke M, Wachenfeld C, Mora P, Thumser A, Jaursch-Hancke C, Abdelhamic S, Chrousos GP, Allolio B: p53 mutations in adrenal tumors: Caucasian patients do not show the exon 4 "hot spot" found in Taiwan. J Clin Endocrinol Metab 1996, 81:3636-3638
21. Li M, Squire JA, Weksberg R: Molecular genetics of Wiedemann-Beckwith syndrome. Am J Med Genet 1998, 79:253-259
22. Ilvesmaki V, Kahri AI, Miettinen PJ, Voutilainen R: Insulin-like growth factors (IGFs) and their receptors in adrenal tumors: high IGF-II expression in functional adrenocortical carcinomas. J Clin Endocrinol Metab 1993, 77:852-858
23. Gicquel C, Bertagna X, Schneid H, Francillard-Leblond M, Luton JP, Girard F, Le Bouc Y: Rearrangements at the 11p15 locus and overexpression of insulin-like growth factor-II gene in sporadic adrenocortical tumors. J Clin Endocrinol Metab 1994, 78:1444-1453
24. Logie A, Boulle N, Gaston V, Perin L, Boudou P, Le Bouc Y, Gicquel C: Autocrine role of IGF-II in proliferation of human adrenocortical carcinoma NCI H295R cell line. J Mol Endocrinol 1999, 23:23-32
25. Giordano TJ, Shedden KA, Schwartz DR, Kuick R, Taylor JM, Lee N, Misek DE. Greenson JK, Kardia SL, Beer DG, Rennert G, Cho KR, Gruber SB, Fearon ER, Hanash S: Organ-specific molecular classification of primary lung, colon, and ovarian adenocarcinomas using gene expression profiles. Am J Pathol 2001, 159:1231-1238
26. Beer DG, Kardia SL, Huang C-C, Giordano TJ, Levin AL, Misek DE, Lin L, Chen G, Gharib TG, Thomas DG, Lizyness ML, Kuick R, Hayasaka S, Taylor JMG, Iannettoni MD, Orringer MB, Hanash S: Gene expression profiles predict survival of patients lung adenocarcinoma. Nat Med 2002, 62:4722-4729
27. Schwatrz DR, Kardia SL, Shedden KA, Kuick R, Michailidis G, Taylor JMG, Misek DE, Wu R, Zhai Y, Darrah DM, Reed H, Ellenson LH, Giordano TJ, Hanash SM, Cho KR: Gene expression in ovarian cancer reflects both morphology and biological behavior, distinguishing clear cell from other poor-prognosis ovarian carcinomas. Cancer Res 2002, 8:816-824
28. Young AN, Amin MB, Moreno CS, Lim SD, Cohen C, Petros JA, Marshall FF, Neish AS: Expression profiling of renal epithelial neoplasms: a method for tumor classification and discovery of diagnostic molecular markers. Am J Pathol 2001, 158:1639-1651
29. Kihara C, Tsunoda T, Tanaka T, Yamana H, Furukawa Y, Ono K, Kitahara O, Zembutsu H, Yanagawa R, Hirata K, Takagi T, Nakamura Y: Prediction of sensitivity of esophageal tumors to adjuvant chemotherapy by cDNA microarray analysis of gene-expression profiles. Cancer Res 2001, 61:6474-6479
30. Huang Y, Prasad M, Lemon WJ, Hampel H, Wright FA, Kornacker K, LiVolsi V, Frankel W, Kloos RT, Eng C, Pellegata NS, de la Chapelle A: Gene expression in papillary thyroid carcinoma reveals highly consistent profiles. Proc Natl Acad Sci USA 2001, 98:15044-15049
31. Xu XR, Huang J, Xu ZG, Qian BZ, Zhu ZD, Yan Q, Cai T, Zhang X, Xiao HS, Qu J, Liu F, Huang QH, Cheng ZH, Li NG, Du JJ, Hu W, Shen KT, Lu G, Fu G, Zhong M, Xu SH, Gu WY, Huang W, Zhao XT, Hu GX, Gu JR, Chen Z, Han ZG: Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. Proc Natl Acad Sci USA 2001, 98:15089-15094
32. Bertucci F, Houlgatte R, Nguyen C, Viens P, Jordan BR, Birnbaum D: Gene expression profiling of cancer by use of DNA arrays: how far from the clinic? Lancet Oncol 2001, 2:674-682
33. Rickman DS, Bobek MP, Misek DE, Kuick R, Blaivas M, Kurnit DM, Taylor J, Hanash SM: Distinctive molecular profiles of high-grade and low-grade gliomas based on oligonucleotide microarray analysis. Cancer Res 2001, 61:6885-6891
34. Kononen J, Bubendorf L, Kallioniemi A, Barlund M, Schraml P, Leighton S, Torhorst J, Mihatsch MJ, Sauter G, Kallioniemi OP: Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med 1998, 4:844-847
35. Sheibani K, Tubbs RR: Enzyme immunohistochemistry: technical aspects Semin Diagn Pathol 1984, 1:235-250
36. Held CA, Stevens J, Livak KJ, Williams PM: Real time quantitative PCR. Genome Res 1996, 6:986-994
37. Collins C, Rommens JM, Kowbel D, Godfrey T, Tanner M, Hwang SI, Polikoff D, Nonet G, Cochran J, Myambo K, Jay KE, Froula J, Cloutier T, Kuo WL, Yaswen P, Dairkee S, Giovanola J, Hutchinson JB, Isola J, Kallioniemi OP, Palazzolo M, Martin C, Ericsson C, Pinkel D, Albertson DL, Li WB, Gray JW: Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma. Proc Natl Acad Sci USA 1998, 95:8703-8708
38. Brown FM, Gaffey TA, Wold LE, Lloyd RV: Myxoid neoplasms of the adrenal cortex: a rare histologic variant. Am J Surg Pathol 2000, 24:396-401
39. Golub TR, Slonim DK, Tamayo P, Huard C, Gaasenbeek M, Mesirov JP, Coller H, Loh ML, Downing JR, Caligiuri MA, Bloomfield CD, Lander ES: Molecular classification of cancer: class discovery and class prediction by gene expression monitoring Science 1999, 286:531-537
40. Lakhani SR, Ashworth A: Microarray and histopathological analysis of tumours: the future and the past? Nature Rev Cancer 2001, 1:151-157
41. Liotta L, Petricoin E: Molecular profiling of human cancer. Nat Rev Genet 2000, 1:48-56
42. Yeang CH, Ramaswamy S, Tamayo P, Mukherjee S, Rifkin RM, Angelo M, Reich M, Lander E, Mesirov J, Golub T: Molecular classification of multiple tumor types. Bioinformatics 2001, 17:S316-S322
43. Su AI, Welsh JB, Sapinoso LM, Kern SG, Dimitrov P, Lapp H, Schultz PG, Powell SM, Moskaluk CA, Frierson Jr HF, Hampton GM: Molecular classification of human carcinomas by use of gene expression signatures. Cancer Res 2001, 61:7388-7393
44. Ricci MS, el-Deiry WS: Novel strategies for therapeutic design in molecular oncology using gene expression profiles. Curr Opin Mol Ther 2000, 2:682-690
45. Meltzer PS: Spotting the target: microarrays for disease gene discovery. Curr Opin Genet Dev 2001, 11:258-263
46. Green CD, Simons JF, Taillon BE, Lewin DA: Open systems: panoramic views of gene expression. J Immunol Methods 2001, 250:67-79
47. Madden SL, Wang CJ, Landes G: Serial analysis of gene expression: from gene discovery to target identification. Drug Discov Today 2000, 5:415-425
48. Erickson LA, Jin L, Sebo TJ, Lohse C, Pankratz VS, Kendrick ML, van Heerden JA, Thompson GB, Grant CS, Lloyd RV: Pathologic features and expression of insulin-like growth factor-2 in adrenocortical neoplasms. Endocr Pathol 2001, 12:429-435
49. Gicquel C, Le Bouc Y: Insulin-like growth factor II (IGF II) and adrenocortical tumorigenesis. Annu Endocrinol 1995, 56:617-618
50. Gicquel C, Raffin-Sanson ML, Gaston V, Bertagna X, Plouin PF, Schlumberger M, Louvel A, Luton JP, Le Bouc Y: Structural and functional abnormalities at 11p15 are associated with the malignant phenotype in sporadic adrenocortical tumors: study on a series of 82 tumors. J Clin Endocrinol Metab 1997, 82:2559-2565
51. Wilkin F, Gagne N, Paquette J, Oligny LL, Deal C: Pediatric adrenocortical tumors: molecular events leading to insulin-like growth factor II gene overexpression. J Clin Endocrinol Metab 2000, 85:2048-2056
52. Gicquel C, Bertagna X, Gaston V, Coste J, Louvel A, Baudin E, Bertherat J, Chapuis Y, Duclos JM, Schlumberger M, Plouin PF, Luton JP, Le Bouc Y: Molecular markers and long-term recurrences in a large cohort of patients with sporadic adrenocortical tumors. Cancer Res 2001, 61:6762-6767
53. Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, Ford JM, Lydon NB, Kantarjian H, Capdeville R, Ohno-Jones S, Sawyers CL: Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001, 344:1031-1037
54. Joensuu H, Roberts PJ. Sarlomo-Rikala M, Andersson LC, Tervahartiala P, Tuveson D, Silberman S, Capdeville R, Dimitrijevic S, Druker B, Demetri GD: Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. N Engl J Med 2001, 344:1052-1056
55. Favelyukis S, Till JH, Hubbard SR, Miller WT: Structure and autoregulation of the insulin-like growth factor 1 receptor kinase. Nat Struct Biol 2001, 8:1058-1063
56. Zhou H, Kuang J, Zhong L, Kuo WL, Gray JW, Sahin A, Brinkley BR, Sen S: Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat Genet 1998, 20:189-193
57. Mertens F, Kullendorff CM, Moell C, Alumets J, Mandahl N: Complex karyotype in a childhood adrenocortical carcinoma. Cancer Genet Cytogenet 1998, 105:190-192
58. Limon J, Dal Cin P, Kakati S, Huben RP, Sandberg AA: Cytogenetic findings in a primary adrenocortical carcinoma. Cancer Genet Cytogenet 1987, 26:271-277
59. Visconti RP, Richardson CD, Sato TN: Orchestration of angiogenesis and arteriovenous contribution by angiopoietins and vascular endothelial growth factor (VEGF). Proc Natl Acad Sci USA 2002, 99:8219-8224
60. Aristarkhov A, Eytan E, Moghe A, Admon A, Hershko A, Ruderman JV: E2-C, a cyclin-selective ubiquitin carrier protein required for the destruction of mitotic cyclins. Proc Natl Acad Sci USA 1996, 93:4294-4299
61. Townsley FM, Aristarkhov A, Beck S, Hershko A, Ruderman JV: Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase. Proc Natl Acad Sci USA 1997, 94:2362-2367
62. Fujita M, Furukawa Y, Tsunoda T, Tanaka T, Ogawa M, Nakamura Y: Up-regulation of the ectodermal-neural cortex 1 (ENC1) gene, a downstream target of the beta-catenin/T-cell factor complex, in colorectal carcinomas. Cancer Res 2001, 61:7722-7726
63. Fedele M, Battista S, Manfioletti G, Croce CM, Giancotti V, Fusco A: Role of the high mobility group A proteins in human lipomas. Carcinogenesis 2001, 22:1583-1591
64. Finelli P, Pierantoni GM, Giardino D, Losa M, Rodeschini O, Fedele M, Valtorta E, Mortini P, Croce CM, Larizza L, Fusco A: The high mobility group A2 gene is amplified and overexpressed in human protactinomas. Cancer Res 2002, 62:2398-2405
65. Zhao J, Roth J, Bode-Lesniewska B, Pfaltz M, Heitz PU, Komminoth P: Combined comparative genomic hybridization and genomic microarray for detection of gene amplifications in pulmonary artery intimal sarcomas and adrenocortical tumors. Genes Chromosom Cancer 2002, 34:48-57
66. Eisen MB, Spellman PT, Brown PO, Botstein D: Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA 1998, 95:14863-14868