Application of NMR screening techniques for observing ligand binding with a protein receptor

Magnetic Resonance in Chemistry

Volumn 43, Issue 1, 2005, Pages 69-72

  Shimotakahara, Sakurako ^a   Furihata, Kazuo ^b   Tashiro, Mitsuru ^c  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c TOKYO METROPOLITAN UNIVERSITY   (Japan)

Author keywords

1H NMR; NMR; NMR screening; NOE pumping; Protein ligand interactions; Saturation transfer difference; WaterLOGSY

Indexed keywords

MOLECULES; PROTEINS;

1H NMR; LIGAND BINDING; NMR SCREENING; NOE PUMPING; PROTEIN RECEPTORS; PROTEIN-LIGAND INTERACTIONS; SATURATION-TRANSFER DIFFERENCES; SCREENING TECHNIQUES; WATER LIGAND OBSERVED VIA GRADIENT SPECTROSCOPY; WATER LIGANDS;

LIGANDS;

ENZYME INHIBITOR; LIGAND; RECEPTOR SUBUNIT; PROTEIN;

ANALYTIC METHOD; ARTICLE; COMPLEX FORMATION; LIGAND BINDING; MOLECULAR INTERACTION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RECEPTOR BINDING; BINDING SITE; CHEMISTRY; METHODOLOGY; PROTEIN CONFORMATION;

BINDING SITES; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION; PROTEINS;

EID: 16644383315     PISSN: 07491581     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrc.1492     Document Type: Article

References (31)

1. Chen Y, Reizer J, Saier MH, Fairbrother WJ, Wright PE. Biochemistry 1993; 32: 32.
2. Emerson SD, Madison VS, Palermo RE, Waugh DS, Scheffler JE, Tsao KL, Kiefer SE, Liu SP, Fry DC. Biochemistry 1995; 34: 6911.
3. Gronenborn AM, Clore GM. J. Mol. Biol. 1993; 233: 331.
4. Grzesiek S, Bax A, Clore GM, Gronenborn AM, Hu JS, Kaufman J, Palmer I, Stahl SJ, Wingfield PT. Nat. Struct. Biol. 1996; 3: 340.
5. Farmer BT, Constantine KL, Goldfarb V, Friedrichs MS, Wittekind M, Yanchunas J, Robertson JG, Mueller L. Nat. Struct. Biol. 1996; 3: 995.
6. Garrett DS, Seok YJ, Peterkofsky P, Clore GM, Gronenborn AM. Biochemistry 1997; 26: 4393.
7. Ross A, Salzmann M, Senn H. J. Biomol. NMR 1997; 10: 389.
8. Shuker SB, Hajduk PJ, Meadows RP, Fesik SW. Science 1996; 274: 1531.
9. van Nuland NAJ, Boelens R, Scheek RM, Robillard GT. J. Mol. Biol. 1995; 246: 180.
10. Clore GM, Gronenborn AM. J. Magn. Reson. 1982; 48: 402.
11. Clore GM, Gronenborn AM. J. Magn. Reson. 1983; 53: 423.
12. Meyer B, Weimar T, Peters T. Eur. J. Biochem. 1997; 246: 705.
13. Shimizu H, Field RA, Homans SW, Donohue-Rolfe A. Biochemistry 1998; 37: 11 078.
14. Lin M, Shapiro MJ, Wareing JR. J. Am. Chem. Soc. 1997; 119: 5249.
15. Lin M, Shapiro MJ, Wareing JR. J. Org. Chem. 1997; 62: 8930.
16. Hajduk PJ, Olejniczak ET, Fesik SW. J. Am. Chem. Soc. 1997; 119: 12257.
17. Chen A, Shapiro MJ. J. Am. Chem. Soc. 1998; 120: 10 258.
18. Mayer M, Meyer B. J. Am. Chem. Soc. 2001; 123: 6108.
19. Dalvit C, Pevarello P, Tatò M, Veronesi M, Vulpetti A, Sundström M. J. Biomol. NMR 2000; 18: 65.
20. Dalvit C, Fogliatto GP, Stewart A, Veronesi M, Stockman BJ. J. Biomol. NMR 2001; 21: 349.
21. Chen A, Shapiro MJ. J. Am. Chem. Soc. 2000; 122: 414.
22. Furihata K, Shimotakahara S, Tashiro M. Magn. Reson. Chem. 2003; 41: 955.
23. Stott K, Stonehouse J, Keeler J, Hwang TL, Shaka AJ. J. Am. Chem. Soc. 1995; 117: 4199.
24. Stott K, Keeler J, Van QN, Shaka AJ. J. Magn. Reson. 1997; 125: 302.
25. Mackin G, Shaka AJ. J. Magn. Reson. A 1996; 118: 247.
26. Mori S, Abeygunawardana C, Johnson MO, Zijl PCMV. J. Magn. Reson. B 1995; 108: 94.
27. Sklenar V, Piotto M, Leppik R, Saudek V. J. Magn. Reson. A 1993; 102: 241.
28. Ding J, Koellner G, Grunert HP, Saenger W. J. Biol. Chem. 1991; 266: 15128.
29. Martinez-Oyanedel J, Choe HW, Heinemann U, Saenger W. J. Mol. Biol. 1991; 222: 335.
30. Jung DM, Ropp JSD, Ebeler SE. J. Agric. Food Chem. 2002; 50: 4262.
31. Silver MS, Joseph RI, Hoult DI. J. Magn. Reson. 1984; 59: 347.