Identification of individual protein-ligand NOEs in the limit of intermediate exchange

Journal of Biomolecular NMR

Volumn 36, Issue 1, 2006, Pages 1-11

  Reibarkh, Mikhail ^a   Malia, Thomas J ^a,b   Hopkins, Brian T ^c   Wagner, Gerhard ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c Infinity Pharmaceuticals Inc   (United States)

Author keywords

First generation compound; High throughput screening; Intermediate exchange; Nuclear Overhauser Effect

Indexed keywords

PROTEIN BCL XL;

ARTICLE; DRUG DESIGN; HIGH THROUGHPUT SCREENING; MATHEMATICAL ANALYSIS; MOLECULAR SIZE; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN NUCLEIC ACID INTERACTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTON TRANSPORT; SAMPLING; SOLUBILITY; STOICHIOMETRY;

AMINO ACIDS, AROMATIC; BCL-X PROTEIN; BINDING SITES; CARBON ISOTOPES; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; PROTEINS; PROTONS;

EID: 33749179209     PISSN: 09252738     EISSN: 15735001     Source Type: Journal    
DOI: 10.1007/s10858-006-9028-7     Document Type: Article

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