NMR experiments for lead generation in drug discovery

Progress in Nuclear Magnetic Resonance Spectroscopy

Volumn 44, Issue 3-4, 2004, Pages 225-256

  Peng, Jeffrey W ^a,b   Moore, Jonathan ^a   Abdul Manan, Norzehan ^a  

^a VERTEX PHARMACEUTICALS   (United States)

^b UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

Atomic resolution; Drug discovery; NMR screening; Protein ligand interactions; Structure activity

Indexed keywords

ABSORPTION; DRUG DOSAGE; ENZYMES; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OPTIMIZATION; SOLUBILITY; TOXICITY;

ATOMIC RESOLUTION; DRUG DISCOVERY; LEAD GENERATION; LEAD OPTIMIZATION; NMR SCREENING; PROTEIN-LIGAND INTERACTIONS; STRUCTURE-ACTIVITY;

LEAD COMPOUNDS;

EID: 2942550654     PISSN: 00796565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnmrs.2004.03.001     Document Type: Review

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