Caspase-8 mediates mitochondrial release of pro-apoptotic proteins in a manner independent of its proteolytic activity apoptosis induced by the protein synthesis inhibitor acetoxycycloheximide in human leukemia Jurkat cells

Journal of Biological Chemistry

Volumn 284, Issue 9, 2009, Pages 5478-5487

  Kadohara, Kimiko ^a   Nagumo, Michiko ^a   Asami, Shun ^a   Tsukumo, Yoshinori ^a   Sugimoto, Hikaru ^a   Igarashi, Masayuki ^b   Nagai, Kazuo ^a,c   Kataoka, Takao ^a,d  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b INSTITUTE OF MICROBIAL CHEMISTRY   (Japan)

^c CHUBU UNIVERSITY   (Japan)

^d KYOTO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL DEATH; CHEMICAL ACTIVATION; DISEASES; MITOCHONDRIA; PROTEINS;

APOPTOSIS INDUCTION; APOPTOTIC PROTEINS; CASPASE ACTIVATION; CASPASE INHIBITORS; CONFORMATIONAL CHANGE; MITOCHONDRIAL PATHWAYS; MOLECULAR MECHANISM; PROTEOLYTIC ACTIVITIES;

BIOSYNTHESIS;

ACETOXYCYCLOHEXIMIDE; ALLOGRAFT INFLAMMATORY FACTOR 1; CASPASE 3; CASPASE 6; CASPASE 7; CASPASE 8; CASPASE 9; CYTOCHROME C; FAS LIGAND; PROTEIN BAK; PROTEIN BCL XL; PROTEIN SYNTHESIS INHIBITOR; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; BAX PROTEIN, HUMAN; CASPASE; CYCLOHEXIMIDE; DRUG DERIVATIVE; PROTEIN BAX; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; CELL FRACTIONATION; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; PHYSIOLOGY; WESTERN BLOTTING;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CASPASE 8; CASPASES; CYCLOHEXIMIDE; CYTOCHROMES C; CYTOSOL; ENZYME ACTIVATION; HUMANS; JURKAT CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PROTEIN CONFORMATION; PROTEIN SYNTHESIS INHIBITORS; RNA, SMALL INTERFERING; SUBCELLULAR FRACTIONS; TRANSFECTION;

EID: 65549108364     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M808523200     Document Type: Article

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