Trichothecene mycotoxins trigger a ribotoxic stress response that activates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase and induces apoptosis

Journal of Biological Chemistry

Volumn 274, Issue 20, 1999, Pages 13985-13992

  Shifrin, Victor I ^a,b   Anderson, Paul ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b Scriptgen Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANISOMYCIN; HARRINGTONINE; MITOGEN ACTIVATED PROTEIN KINASE; MYCOTOXIN; STRESS ACTIVATED PROTEIN KINASE; TRICHOTHECENE;

APOPTOSIS; ARTICLE; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION;

ANISOMYCIN; APOPTOSIS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CASPASE 3; CASPASES; DNA FRAGMENTATION; EMETINE; ENZYME ACTIVATION; HARRINGTONINES; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; JURKAT CELLS; KINETICS; MITOGEN-ACTIVATED PROTEIN KINASES; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN SYNTHESIS INHIBITORS; RIBOSOMES; T-2 TOXIN; TRICHOTHECENES;

EID: 0033553563     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.20.13985     Document Type: Article

References (57)

1. Bukowski, R., Vaughn, C., Bottomley, R., and Chen, T. (1982) Cancer Treat. Rep. 66, 381-383
2. Adler, S., Lowenbraun, S., Birch, B., Jarrell, R., and Garrard, J. (1984) Cancer Treat. Rep. 68, 423-425
3. DeSimone, P., Greco, F., Lessner, H., and Bartolucci, A. (1986) Am. J. Clin. Oncol. 9, 187-188
4. Goodwin, W., Stephens, R., McCracken, J., and Groppe, C. (1983) Cancer Treat. Rep. 67, 285-286
5. Thigpen, J., Vaughn, C., and Stuckey, W. (1981) Cancer Treat. Rep. 65, 881-882
6. Jimenez, A., and Vazquez, D. (1975) Eur. J. Biochem. 54, 483-492
7. Jimenez, A., Sanchez, L., and Vazquez, D. (1975) Biochim. Biophys. Acta 383, 427-434
8. Carter, C., Cannon, M., and Smith, K. (1976) Biochem. J. 154, 171-178
9. Cannon, M., Jimenez, A., and Vazquez, D. (1976) Biochem. J. 160, 137-145
10. Middlebrook, J., and Leatherman, D. (1989) Biochem. Pharmacol. 38, 3103-3110
11. Iordanov, M., Pribnow, D., Magun, J., Dinh, T., Pearson, J., Chen, S., and Magun, B. (1997) Mol. Cell. Biol. 17, 3373-3381
12. Cano, E., Hazzalin, C., and Mahadevan, L. (1994) Mol. Cell. Biol. 14, 7352-7362
13. Cano, E., Doza, Y., Ben-Levy, R., Cohen, P., and Mahadevan, L. (1996) Oncogene 12, 805-812
14. Derijard, B., Hibl, M., Wu, I.-H., Barrett, T., Su, B., Deng, T., Karin, M., and Davis, R. (1994) Cell 76, 1025-1037
15. Kyriakis, J., Baneijee, P., Nikolakaki, E., Dai, T., Rubie, E., Ahmad, M., Avruch, J., and Woodgett, J. (1994) Nature 369, 156-160
16. Han, J., Lee, J., Bibbs, L., and Ulevitch, R. (1994) Science 265, 808-811
17. Rouse, J., Cohen, P., Trigon, S., Morange, M., Alonso-Llamazares, A., Zamanillo, D., Hunt, T., and Nebreda, A. (1994) Cell 78, 1027-1037
18. Polverino, A., and Patterson, S. (1997) J. Biol. Chem. 272, 7013-7021
19. Kochi, S., and Collier, R. (1993) Exp. Cell Res. 208, 296-302
20. Sugita, M., Morita, T., and Yonesaki, T. (1995) Zool. Sci. 12, 419-425
21. Xia, Z., Dickens, M., Raingeaud, J., Davis, R., and Greenberg, M. (1995) Science 270, 1326-1331
22. Chen, Y., Wang, W., Kong, A., and Tan, T. (1998) J. Biol. Chem. 273, 1769-1775
23. Gajate, C., Santos-Beneit, A., Modolell, M., and Mollinedo, F. (1998) Mol. Pharmacol. 53, 602-612
24. Yu, W., Simmons-Menchaca, M., You, H., Brown, P., Birrer, M., Sanders, B., and K, K. (1998) Mol. Carcinogen. 22, 247-257
25. Goillot, E., Raingeaud, J., Ranger, A., Tepper, R., Davis, R., Harlow, E., and Sanchez, I. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 3302-3307
26. Lenczowski, J., Dominguez, L., Eder, A., King, L., Zacharchuk, C., and Ashwell, J. (1997) Mol. Cell. Biol. 17, 170-181
27. Cahill, M., Peter, M., Kischkel, F., Chinnaiyan, A., Dixit, V., Krammer, P., and Nordheim, A. (1996) Oncogene 13, 2087-2096
28. Deak, J., Cross, J., Lewis, M., Qian, Y., Parrott, L., Distelhorst, C., and Templeton, D. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 5595-5600
29. Crow, T., and Forrester, J. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 4490-4494
30. Eskin, A., Yeung, S., and Klass, M. (1984) Proc. Natl. Acad. Sci. U. S. A. 81, 7637-7641
31. Tian, Q., Streuli, M., Saito, H., Schlossman, S., and Anderson, P. (1991) Cell 67, 629-639
32. Nicholson, D., Ali, A., Thornberry, N., Vaillancourt, J., Ding, C., Gallant, M., Gareau, Y., Griffin, P., Labelle, M., and Lazebnik, Y., Munday, N. A., Raju, S. M., Smulson, M. E., Yamin, T.-T., Yu, V. L., and Miller, D. K. (1995) Nature 376, 37-43
33. Budihardjo, I., Poirier, G., and Kaufmann, S. (1998) Mol. Cell. Biochem. 178, 245-249
34. Shifrin, V., Davis, R., and Neel, B. (1997) J. Biol. Chem. 272, 2957-2962
35. Harlow, E., and Lane, D. (1988) Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
36. Gabai, V., Meriin, A., Mosser, D., Caron, A., Rits, S., Shifrin, V., and Sherman, M. (1997) J. Biol. Chem. 272, 18033-18037
37. Ausbel, F., Brent, R., Kingston, R., Moore, D., Seidman, J., Smith, J., and Struhl, K. (1995) Current Protocols in Molecular Biology, John Wiley & Sons, Inc., New York
38. Juo, P., Kuo, C., Reynolds, S., Konz, R., Raingeaud, J., Davis, R., Biemann, H., and Blenis, J. (1997) Mol. Cell. Biol. 17, 24-35
39. Rudel, T., Zenke, F., Chuang, T., and Bokoch, G. (1998) J. Immunol. 160, 7-11
40. Rudel, T., and Bokoch, G. (1997) Science 276, 1571-1574
41. Middlebrook, J., and Leatherman, D. (1989) J. Pharmacol. Exp. Ther. 250, 860-866
42. Anderson, P. (1997) Microbiol Mol. Biol. Rev. 61, 33-46
43. Leist, M., Gantner, F., Bohlinger, I., Germann, P., Tiegs, G., and Wendel, A. (1994) J. Immunol. 153, 1778-1788, and references therein
44. Nagata, S. (1997) Cell 88, 355-365
45. Fresno, M., Jimenez, A., and Vazquez, D. (1977) Eur. J. Biochem. 72, 323-330
46. Hobden, A., and Cundliffe, E. (1980) Biochem. J. 190, 765-770
47. Li, L., Xia, L., Jiang, C., and Han, R. (1994) Yao Hsueh Hsueh Pao 29, 667-672
48. Cashel, M., and Rudd, K. (1987) in Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology (Neidhardt, F., Ingraham, J., Low, K., Magasanik, B., Schaechter, M., and Umbarger, H., eds) Vol. 2, pp. 1410-1438, American Society for Microbiology, Washington, DC
49. Ballestra, J. (1991) in Translation in Eukaryotes (Trachsel, H., ed), CRC Press, Boca Raton, FL
50. Iordanov, M., Pribnow, D., Magun, J., Dinh, T., Pearson, J., and Magun, B. (1998) J. Biol. Chem. 273, 15794-15803
51. Iordanov, M., and Magun, B. (1998) J. Biol. Chem. 273, 3528-3534
52. Leatherman, D., and Middlebrook, J. (1993) J Pharmacol. Exp. Ther. 266, 741-748
53. Leatherman, D., and Middlebrook, J. (1993) J Pharmacol. Exp. Ther. 266, 732-740
54. Synetos, D., Amils, R., and Ballesta, J. (1986) Biochim. Biophys. Acta 868, 249-253
55. Tejedor, F., Amils, R., and Ballesta, J. (1985) Biochemistry 24, 3667-3672
56. Kaufmann, S., Desnoyers, S., Ottaviano, Y., Davidson, N., and Poirier, G. (1993) Cancer Res. 53, 3976-3985
57. Lazebnik, Y., Kaufmann, S., Desnoyers, S., Poirier, G., and Earnshaw, W. (1994) Nature 371, 346-347