Acetoxycycloheximide (E-73) rapidly induces apoptosis mediated by the release of cytochrome c via activation of c-Jun N-terminal kinase

Biochemical Pharmacology

Volumn 69, Issue 4, 2005, Pages 551-560

  Kadohara, Kimiko ^a   Tsukumo, Yoshinori ^a   Sugimoto, Hikaru ^a   Igarashi, Masayuki ^b   Nagai, Kazuo ^a   Kataoka, Takao ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b INSTITUTE OF MICROBIAL CHEMISTRY   (Japan)

Author keywords

Acetoxycycloheximide; Apoptosis; c Jun N terminal kinase; Cycloheximide; Cytochrome c; E 73

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETOXYCYCLOHEXIMIDE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; CYTOCHROME C; FLICE INHIBITORY PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROCASPASE 3; PROTEIN BCL 2; PROTEIN BCL XL; PUROMYCIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME RELEASE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MITOCHONDRION; PRIORITY JOURNAL;

APOPTOSIS; BCL-X PROTEIN; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASES; CELL NUCLEUS; CYCLOHEXIMIDE; CYCLOPHOSPHAMIDE; CYTOCHROMES C; DNA FRAGMENTATION; ENZYME ACTIVATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; JURKAT CELLS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 12744256754     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.11.009     Document Type: Article

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