On the inhibition of HIV-1 protease by hydrazino-ureas displaying the N→C{double bond, long}O interaction

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 10, 2009, Pages 3671-3679

  Waibel, Michael ^a   Pitrat, Delphine ^a   Hasserodt, Jens ^a  

^a UNIVERSITÉ DE LYON   (France)

Author keywords

Cyclic urea; HIV 1 protease inhibitors; N C double bond, long O interaction; Preorganization; Transition state isostere

Indexed keywords

1 [1 BENZYL 3 (1 BENZYL 2 OXOETHYL)UREIDO]PYRROLIDINE 2 CARBOXYLIC ACID [1 (1 TERT BUTYLCARBAMOYL 2 METHYLPROPYLCARBAMOYL) 2 METHYL BUTYL]AMIDE; 1 [1 BENZYL 3 (1 BENZYL 2 OXOETHYL)UREIDO]PYRROLIDINE 2 CARBOXYLIC ACID TERT BUTYLAMIDE; 1 BENZYL 3 (1 BENZYL 2 OXOETHYL) 1 PIPERIDIN 1 YLUREA; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; HYDRAZINE DERIVATIVE; MOZENAVIR; PROTEINASE; PROTEINASE INHIBITOR; TIPRANAVIR; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; IN VITRO STUDY; MOLECULAR INTERACTION; MOLECULAR WEIGHT; NONHUMAN; PROTEINASE INHIBITION; PROTON NUCLEAR MAGNETIC RESONANCE; VIRUS INHIBITION;

HIV PROTEASE; HIV PROTEASE INHIBITORS; HUMANS; HYDRAZINES; HYDROGEN BONDING; KINETICS; UREA;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 65349106612     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.03.059     Document Type: Article

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