Extramembrane Central Pore of Multidrug Exporter AcrB in Escherichia coli Plays an Important Role in Drug Transport

Journal of Biological Chemistry

Volumn 279, Issue 5, 2004, Pages 3743-3748

  Murakami, Satoshi ^a,b   Tamura, Norihisa ^a   Saito, Asami ^a   Hirata, Takahiro ^a,b   Yamaguchi, Akihito ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; CROSSLINKING; CRYSTAL STRUCTURE; DIMERS; ESCHERICHIA COLI; MONOMERS;

PERMEABILITY BARRIERS;

BIOCHEMISTRY;

2 (DIMETHYLAMINOSTYRYL) 1 ETHYLPYRIDINIUM; 2-(DIMETHYLAMINOSTYRYL)-1-ETHYLPYRIDINIUM; ACRE PROTEIN, E COLI; CARRIER PROTEIN; CROSS LINKING REAGENT; CYSTEINE; ESCHERICHIA COLI PROTEIN; GLYCOPROTEIN P; MEMBRANE PROTEIN; N ETHYLMALEIMIDE; PROTEIN; PROTEIN ACRB; PYRIDINIUM DERIVATIVE; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; CROSS LINKING; CRYSTAL STRUCTURE; DIMERIZATION; DRUG TRANSPORT; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; GENE MUTATION; MEMBRANE TRANSPORT; METABOLISM; MOLECULAR GENETICS; MULTIDRUG RESISTANCE; MUTATION; NONHUMAN; OUTER MEMBRANE; PLASMID; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; TIME; WESTERN BLOTTING;

AMINO ACID SEQUENCE; BLOTTING, WESTERN; CARRIER PROTEINS; CROSS-LINKING REAGENTS; CYSTEINE; DIMERIZATION; DRUG RESISTANCE, MICROBIAL; DRUG RESISTANCE, MULTIPLE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; ETHYLMALEIMIDE; MEMBRANE PROTEINS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PLASMIDS; PROTEIN BINDING; PROTEIN CONFORMATION; PYRIDINIUM COMPOUNDS; SEQUENCE HOMOLOGY, AMINO ACID; TIME FACTORS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0942298094     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M308893200     Document Type: Article

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