Dendritic cells - Why can they help and hurt us

Experimental Dermatology

Volumn 18, Issue 3, 2009, Pages 264-273

  Sckäkel, Knut ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Allergy; Cancer; Dendritic cell; Immune regulation; Immunology; Lupus; Poriasis; SlanDC; T cell

Indexed keywords

ALPHA INTERFERON; AUTOANTIGEN; INTERLEUKIN 23; LECTIN RECEPTOR; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PATTERN RECOGNITION RECEPTOR; RETINOIC ACID INDUCIBLE PROTEIN I; STAT3 PROTEIN; TOLL LIKE RECEPTOR;

ADAPTIVE IMMUNITY; ANTIGEN PRESENTATION; AUTOIMMUNITY; CANCER IMMUNOTHERAPY; CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; CELL SELECTION; CELLULAR DISTRIBUTION; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG TARGETING; HUMAN; HYPERSENSITIVITY; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; LUPUS ERYTHEMATOSUS; NEOPLASM; NONHUMAN; PATHOPHYSIOLOGY; PATTERN RECOGNITION; PROTEIN EXPRESSION; PSORIASIS; RECEPTOR UPREGULATION; REGULATORY T LYMPHOCYTE; REVIEW; SENSITIZATION; TH1 CELL; TH17 CELL; TISSUE DISTRIBUTION;

ANIMALS; AUTOIMMUNITY; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; HUMANS; HYPERSENSITIVITY; IMMUNE SYSTEM; INFECTION; MICE; MICE, TRANSGENIC; NEOPLASMS;

EID: 64549116854     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2008.00823.x     Document Type: Review

References (121)

1. Steinman R M, Cohn Z A. Identification of a novel cell type in peripheral lymphoid organs of mice: I. Morphology, quantification, tissue distribution. J Exp Med 1973: 137: 1142-1162.
2. Steinman R M, Cohn Z A. Identification of a novel cell type in peripheral lymphoid organs of mice: II. Functional properties in vitro. J Exp Med 1974: 139: 380-397.
3. Cooper M D, Alder M N. The evolution of adaptive immune systems. Cell 2006: 124: 815-822.
4. Steinman R M, Banchereau J. Taking dendritic cells into medicine. Nature 2007: 449: 419-426.
5. Macpherson A J, Uhr T. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 2004: 303: 1662-1665.
6. Akbari O, DeKruyff R H, Umetsu D T. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immunol 2001: 2: 725-731.
7. Schiller M, Metze D, Luger T A, Grabbe S, Gunzer M. Immune response modifiers - mode of action. Exp Dermatol 2006: 15: 331-341.
8. Dhodapkar K M, Kaufman J L, Ehlers M et al. Selective blockade of inhibitory Fcgamma receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells. Proc Natl Acad Sci USA 2005: 102: 2910-2915.
9. Bergtold A, Desai D D, Gavhane A, Clynes R. Cell surface recycling of internalized antigen permits dendritic cell priming of B Cells. Immunity 2005: 23: 503-514.
10. Adams S, O'Neill D W, Bhardwaj N. Recent advances in dendritic cell biology. J Clin Immunol 2005: 25: 177-188.
11. Trombetta E S, Mellman I. Cell biology of antigen processing in vitro and in vivo. Annu Rev Immunol 2005: 23: 975-1028.
12. Porcelli S A, Modlin R L. The CD1 system: Antigen-presenting molecules for T cell recognition of lipids and glycolipids. Annu Rev Immunol 1999: 17: 297-329.
13. Itano A A, McSorley S J, Reinhardt R L et al. Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. Immunity 2003: 19: 47-57.
14. Kapsenberg M L. Dendritic-cell control of pathogen-driven T-cell polarization. Nat Rev Immunol 2003: 3: 984-993.
15. Suvas S, Rouse B T. Treg control of antimicrobial T cell responses. Curr Opin Immunol 2006: 18: 344-348.
16. Sakaguchi S. Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004: 22: 531-562.
17. Mahnke K, Johnson T S, Ring S, Enk A H. Tolerogenic dendritic cells and regulatory T cells: A two-way relationship. J Dermatol Sci 2007: 46: 159-167.
18. Bopp T, Becker C, Klein M et al. Cyclic adenosine monophosphate is a key component of regulatory T cell mediated suppression. J Exp Med 2007: 204: 1303-1310.
19. Hawiger D, Inaba K, Dorsett Y et al. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med 2001: 194: 769-779.
20. Mahnke K, Qian Y, Knop J, Enk A H. Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells. Blood 2003: 101: 4862-4869.
21. Kretschmer K, Apostolou I, Hawiger D, Khazaie K, Nussenzweig M C, von B H. Inducing and expanding regulatory T cell populations by foreign antigen. Nat Immunol 2005: 6: 1219-1227.
22. Wenzel J, Tuting T. Identification of type I interferon-associated inflammation in the pathogenesis of cutaneous lupus erythematosus opens up options for novel therapeutic approaches. Exp Dermatol 2007: 16: 454-463.
23. Bruder D, Westendorf A M, Hansen W et al. On the edge of autoimmunity: Tcell stimulation by steady-state dendritic cells prevents autoimmune diabetes. Diabetes 2005: 54: 3395-3401.
24. Steinbrink K, Graulich E, Kubsch S, Knop J, Enk A H. CD4+ and CD8+ anergic T cells induced by interleukin-10-treated human dendritic cells display antigenspecific suppressor activity. Blood 2002: 99: 2468-2476.
25. Griffin M D, Lutz W, Phan V A, Bachman L A, McKean D J, Kumar R. Dendritic cell modulation by 1 + 1,25 dihydroxyvitamin D3 and its analogs: A vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo. Proc Natl Acad Sci USA 2001: 98: 6800-6805.
26. Smits H H, Engering A, van der K D et al. Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin. J Allergy Clin Immunol 2005: 115: 1260-1267.
27. Reis e Sousa C. Dendritic cells in a mature age. Nat Rev Immunol 2006: 6: 476-483.
28. Gately M K, Renzetti L M, Magram J et al. The interleukin-12/ interleukin-12-receptor system: Role in normal and pathologic immune responses. Annu Rev Immunol 1998: 16: 495-521.
29. Mosmann T R, Coffman R L. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989: 7: 145-173.
30. Kadowaki N, Ho S, Antonenko S et al. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med 2001: 194: 863-869.
31. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 2003: 3: 133-146.
32. Kiss A, Montes M, Susarla S et al. A new mechanism regulating the initiation of allergic airway inflammation. J Allergy Clin Immunol 2007: 120: 334-342.
33. Rogers P R, Croft M. CD28, Ox-40, LFA-1, and CD4 modulation of Th1/Th2 differentiation is directly dependent on the dose of antigen. J Immunol 2000: 164: 2955-2963.
34. Lanzavecchia A, Sallusto F. Progressive differentiation and selection of the fittest in the immune response. Nat Rev Immunol 2002: 2: 982-987.
35. Napolitani G, Rinaldi A, Bertoni F, Sallusto F, Lanzavecchia A. Selected toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat Immunol 2005: 6: 769-776.
36. Weaver C T, Harrington L E, Mangan P R, Gavrieli M, Murphy K M. Th17: An effector CD4 T cell lineage with regulatory T Cell ties. Immunity 2006: 24: 677-688.
37. Steinman L. A rush to judgment on Th17. J Exp Med 2008: 205: 1517-1522.
38. Cua D J, Sherlock J, Chen Y et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003: 421: 744-748.
39. Sabat R, Philipp S, Hoflich C et al. Immunopathogenesis of psoriasis. Exp Dermatol 2007: 16: 779-798.
40. Nakae S, Nambu A, Sudo K, Iwakura Y. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J Immunol 2003: 171: 6173-6177.
41. Fujino S, Andoh A, Bamba S et al. Increased expression of interleukin 17 in inflammatory bowel disease. Gut 2003: 52: 65-70.
42. Luger D, Silver P B, Tang J et al. Either a Th17 or a Th1 effector response can drive autoimmunity: Conditions of disease induction affect dominant effector category. J Exp Med 2008: 205: 799-810.
43. Kroenke M A, Carlson T J, Andjelkovic A V, Segal B M. IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition. J Exp Med 2008: 205: 1535-1541.
44. Moldovan I R, Rudick R A, Cotleur A C et al. Interferon gamma responses to myelin peptides in multiple sclerosis correlate with a new clinical measure of disease progression. J Neuroimmunol 2003: 141: 132-140.
45. Huang W, Na L, Fidel P L, Schwarzenberger P. Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J Infect Dis 2004: 190: 624-631.
46. Rudner X L, Happel K I, Young E A, Shellito J E. Interleukin-23 (IL-23)-IL-17 cytokine axis in murine pneumocystis carinii infection. Infect Immun 2007: 75: 3055-3061.
47. Zelante T, De L A, Bonifazi P et al. IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Eur J Immunol 2007: 37: 2695-2706.
48. Caruso R, Pallone F, Monteleone G. Emerging role of IL-23/IL-17 axis in H pylori-associated pathology. World J Gastroenterol 2007: 13: 5547-5551.
49. Ivanov II, McKenzie B S, Zhou L et al. The orphan nuclear receptor ROR[gamma]t directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 2006: 126: 1121-1133.
50. McGeachy M J, Cua D J. Th17 cell differentiation: The long and winding road. Immunity 2008: 28: 445-453.
51. Kalinski P, Moser M. Consensual immunity: Success-driven development of T-helper-1 and T-helper-2 responses. Nat Rev Immunol 2005: 5: 251-260.
52. Granucci F, Vizzardelli C, Virzi E, Rescigno M, Ricciardi-Castagnoli P. Transcriptional reprogramming of dendritic cells by differentiation stimuli. Eur J Immunol 2001: 31: 2539-2546.
53. Albert M L, Sauter B, Bhardwaj N. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 1998: 392: 86-89.
54. Bennett C L, Clausen Br E. DC ablation in mice: Promises, pitfalls, and challenges. Trends Immunol 2007: 28: 519-525.
55. Filippi C, Hugues S, Cazareth J, Julia V, Glaichenhaus N, Ugolini S. CD4+ T cell polarization in mice is modulated by strain-specific major histocompatibility complex-independent differences within dendritic cells. J Exp Med 2003: 198: 201-209.
56. Lemos M P, Esquivel F, Scott P, Laufer T M. MHC class II expression restricted to CD8alpha+ and CD11b+ dendritic cells is sufficient for control of Leishmania major. J Exp Med 2004: 199: 725-730.
57. Allan R S, Smith C M, Belz G T et al. Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells. Science 2003: 301: 1925-1928.
58. Zhao X, Deak E, Soderberg K et al. Vaginal submucosal dendritic cells, but not langerhans cells, induce protective Th1 responses to herpes simplex virus-2. J Exp Med 2003: 197: 153-162.
59. Pooley J L, Heath W R, Shortman K. Cutting edge: Intravenous soluble antigen is presented to CD4 T cells by CD8) dendritic cells, but cross-presented to CD8 T cells by CD8+ dendritic cells. J Immunol 2001: 166: 5327-5330.
60. McIlroy D, Troadec C, Grassi F et al. Investigation of human spleen dendritic cell phenotype and distribution reveals evidence of in vivo activation in a subset of organ donors. Blood 2001: 97: 3470-3477.
61. Shortman K, Naik S H. Steady-state and inflammatory dendritic-cell development. Nat Rev Immunol 2007: 7: 19-30.
62. Cella M, Jarrossay D, Facchetti F et al. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat Med 1999: 5: 919-923.
63. Siegal F P, Kadowaki N, Shodell M et al. The nature of the principal type 1 interferon-producing cells in human blood. Science 1999: 284: 1835-1837.
64. Farkas L, Beiske K, Lund-Johansen F, Brandtzaeg P, Jahnsen F L. Plasmacytoid dendritic cells (natural interferon-{{alpha}}/ {beta}-producing cells) accumulate in cutaneous lupus erythematosus lesions. Am J Pathol 2001: 159: 237-243.
65. Passlick B, Flieger D, Ziegler-Heitbrock H W. Identification and characterization of a novel monocyte subpopulation in human peripheral blood. Blood 1989: 74: 2527-2534.
66. Schakel K, Poppe C, Mayer E, Federle C, Riethmuller G, Rieber E P. M-DC8+ leukocytes - a novel human dendritic cell population. Pathobiology 1999: 67: 287-290.
67. Schakel K, Kannagi R, Kniep B et al. 6-Sulfo LacNAc, a novel carbohydrate modification of PSGL-1, defines an inflammatory type of human dendritic cells. Immunity 2002: 17: 289-301.
68. Schmitz M, Zhao S, Schakel K, Bornhauser M, Ockert D, Rieber E P. Native human blood dendritic cells as potent effectors in antibody-dependent cellular cytotoxicity. Blood 2002: 100: 1502-1504.
69. Schmitz M, Zhao S, Deuse Y et al. Tumoricidal potential of native blood dendritic cells: Direct tumor cell killing and activation of NK cell-mediated cytotoxicity. J Immunol 2005: 174: 4127-4134.
70. Schakel K, von K M, Hansel A et al. Human 6-sulfo LacNAc-expressing dendritic cells are principal producers of early interleukin-12 and are controlled by erythrocytes. Immunity 2006: 24: 767-777.
71. de Baey A, Mende I, Baretton G et al. A subset of human dendritic cells in the T cell area of mucosa-associated lymphoid tissue with a high potential to produce TNF-{alpha}. J Immunol 2003: 170: 5089-5094.
72. Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 1994: 179: 1109-1118.
73. Inaba K, Inaba M, Romani N et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 1992: 176: 1693-1702.
74. Leon B, Lopez-Bravo M, Ardavin C. Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania. Immunity 2007: 26: 519-531.
75. Krutzik S R, Tan B, Li H et al. TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells. Nat Med 2005: 11: 653-660.
76. Dhodapkar M V, Steinman R M, Sapp M et al. Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells. J Clin Invest 1999: 104: 173-180.
77. Dhodapkar M V, Krasovsky J, Steinman R M, Bhardwaj N. Mature dendritic cells boost functionally superior CD8(+) T-cell in humans without foreign helper epitopes. J Clin Invest 2000: 105: R9-R14.
78. O'Neill D W, Adams S, Bhardwaj N. Manipulating dendritic cell biology for the active immunotherapy of cancer. Blood 2004: 104: 2235-2246.
79. Tacken P J, de V I, Torensma R, Figdor C G. Dendritic-cell immunotherapy: From ex vivo loading to in vivo targeting. Nat Rev Immunol 2007: 7: 790-802.
80. Mahnke K, Guo M, Lee S et al. The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments. J Cell Biol 2000: 151: 673-684.
81. Bonifaz L, Bonnyay D, Mahnke K, Rivera M, Nussenzweig M C, Steinman R M. Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J Exp Med 2002: 196: 1627-1638.
82. Kanzler H, Barrat F J, Hessel E M, Coffman R L. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat Med 2007: 13: 552-559.
83. Dittel B N, Visintin I, Merchant R M, Janeway C A Jr. Presentation of the self antigen myelin basic protein by dendritic cells leads to experimental autoimmune encephalomyelitis. J Immunol 1999: 163: 32-39.
84. Ludewig B, Odermatt B, Landmann S, Hengartner H, Zinkernagel R M. Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissue. J Exp Med 1998: 188: 1493-1501.
85. Hooks J J, Moutsopoulos H M, Geis S A, Stahl N I, Decker J L, Notkins A L. Immune interferon in the circulation of patients with autoimmune disease. N Engl J Med 1979: 301: 5-8.
86. Dall'era M C, Cardarelli P M, Preston B T, Witte A, Davis J C Jr. Type I interferon correlates with serological and clinical manifestations of SLE. Ann Rheum Dis 2005: 64: 1692-1697.
87. Baechler E C, Batliwalla F M, Karypis G et al. Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc Natl Acad Sci USA 2003: 100: 2610-2615.
88. Graham R R, Kozyrev S V, Baechler E C et al. A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus. Nat Genet 2006: 38: 550-555.
89. Braun D, Geraldes P, Demengeot J. Type I Interferon controls the onset and severity of autoimmune manifestations in lpr mice. J Autoimmun 2003: 20: 15-25.
90. Santiago-Raber M L, Baccala R, Haraldsson K M et al. Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice. J Exp Med 2003: 197: 777-788.
91. Mathian A, Weinberg A, Gallegos M, Banchereau J, Koutouzov S. IFN-{alpha} induces early lethal lupus in preautoimmune (New Zealand Black × New Zealand White)F1 but not in BALB/c mice. J Immunol 2005: 174: 2499-2506.
92. von Landenberg P, Bauer S. Nucleic acid recognizing Toll-like receptors and autoimmunity. Curr Opin Immunol 2007: 19: 606-610.
93. Lenert P. Inhibitory oligodeoxynucleotides - therapeutic promise for systemic autoimmune diseases? Clin Exp Immunol 2005: 140: 1-10.
94. Rutz M, Metzger J, Gellert T et al. Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner. Eur J Immunol 2004: 34: 2541-2550.
95. Tezak Z, Hoffman E P, Lutz J L et al. Gene expression profiling in DQA1*0501+ children with untreated dermatomyositis: A novel model of pathogenesis. J Immunol 2002: 168: 4154-4163.
96. Gottenberg J E, Cagnard N, Lucchesi C et al. Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjogren's syndrome. Proc Natl Acad Sci USA 2006: 103: 2770-2775.
97. Guillot B, Portales P, Thanh A D et al. The expression of cytotoxic mediators is altered in mononuclear cells of patients with melanoma and increased by interferon-alpha treatment. Br J Dermatol 2005: 152: 690-696.
98. Papewalis C, Jacobs B, Wuttke M et al. IFN-{alpha} skews monocytes into CD56+-expressing dendritic cells with potent functional activities in vitro and in vivo. J Immunol 2008: 180: 1462-1470.
99. Nickoloff B J. Cracking the cytokine code in psoriasis. Nat Med 2007: 13: 242-244.
100. Lowes M A, Bowcock A M, Krueger J G. Pathogenesis and therapy of psoriasis. Nature 2007: 445: 866-873.
101. Lowes M A, Chamian F, Abello M V et al. Increase in TNF-{alpha} and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a). Proc Natl Acad Sci USA 2005: 102: 19057-19062.
102. Nestle F O, Conrad C, Tun-Kyi A et al. Plasmacytoid predendritic cells initiate psoriasis through interferon-{alpha} production. J Exp Med 2005: 202: 135-143.
103. Wolfer L U, Goerdt S, Schroder K, Zouboulis C C, Orfanos C E. [Interferonalpha-induced psoriasis vulgaris]. Hautarzt 1996: 47: 124-128.
104. Lande R, Gregorio J, Facchinetti V et al. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 2007: 449: 564-569.
105. Akbari O, Freeman G J, Meyer E H et al. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat Med 2002: 8: 1024-1032.
106. Kikuchi Y, Takai T, Kuhara T et al. Crucial commitment of proteolytic activity of a purified recombinant major house dust mite allergen Der p1 to sensitization toward IgE and IgG responses. J Immunol 2006: 177: 1609-1617.
107. Traidl-Hoffmann C, Mariani V, Hochrein H et al. Pollen-associated phytoprostanes inhibit dendritic cell interleukin-12 production and augment T helper type 2 cell polarization. J Exp Med 2005: 201: 627-636.
108. Krishnamoorthy N, Oriss T B, Paglia M et al. Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma. Nat Med 2008: 14: 565-573.
109. Soumelis V, Reche P A, Kanzler H et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol 2002: 3: 673-680.
110. Yoo J, Omori M, Gyarmati D et al. Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin. J Exp Med 2005: 202: 541-549.
111. Zhou B, Comeau M R, De S T et al. Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nat Immunol 2005: 6: 1047-1053.
112. Rabinovich G A, Gabrilovich D, Sotomayor E M. Immunosuppressive strategies that are mediated by tumor cells. Annu Rev Immunol 2007: 25: 267-296.
113. Bromberg J F, Wrzeszczynska M H, Devgan G et al. Stat3 as an Oncogene. Cell 1999: 98: 295-303.
114. Kortylewski M, Jove R, Yu H. Targeting STAT3 affects melanoma on multiple fronts. Cancer Metastasis Rev 2005: 24: 315-327.
115. Enk A H, Jonuleit H, Saloga J, Knop J. Dendritic cells as mediators of tumor-induced tolerance in metastatic melanoma. Int J Cancer 1997: 73: 309-316.
116. Steinbrink K, Jonuleit H, Muller G, Schuler G, Knop J, Enk A H. Interleukin-10-treated human dendritic cells induce a melanoma-antigen-specific anergy in CD8(+) T cells resulting in a failure to lyse tumor cells. Blood 1999: 93: 1634-1642.
117. Chomarat P, Banchereau J, Davoust J, Palucka A K. IL-6 switches the differentiation of monocytes from dendritic cells to macrophages. Nat Immunol 2000: 1: 510-514.
118. Aarnoudse C A, Garcia Vallejo J J, Saeland E, van K Y. Recognition of tumor glycans by antigen-presenting cells. Curr Opin Immunol 2006: 18: 105-111.
119. Finn O J, Jerome K R, Henderson R A et al. MUC-1 epithelial tumor mucinbased immunity and cancer vaccines. Immunol Rev 1995: 145: 61-89.
120. Aspord C, Pedroza-Gonzalez A, Gallegos M et al. Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor development. J Exp Med 2007: 204: 1037-1047.
121. Bursch L S, Wang L, Igyarto B et al. Identification of a novel population of Langerin + dendritic cells. J Exp Med 2007: 204: 3147-3156.