DC ablation in mice: promises, pitfalls, and challenges

Trends in Immunology

Volumn 28, Issue 12, 2007, Pages 525-531

  Bennett, Clare L ^a   Clausen, Björn E ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN RECEPTOR; COLONY STIMULATING FACTOR 1; GANCICLOVIR; GELATINASE B; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; PLACENTAL GROWTH FACTOR; STROMAL CELL DERIVED FACTOR 1; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; CD207 PROTEIN, MOUSE; GLYCOPROTEIN P 15095; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; HEPARIN-BINDING EGF-LIKE GROWTH FACTOR; LECTIN; MANNOSE BINDING LECTIN; MEMBRANE ANTIGEN; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

ANGIOGENESIS; BONE MARROW CELL; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; DRUG TARGETING; GENE DELIVERY SYSTEM; HUMAN; MONOCYTE; NONHUMAN; PROTEIN EXPRESSION; REVIEW; SOLID TUMOR; STEM CELL; TUMOR ASSOCIATED LEUKOCYTE; ANIMAL; DENDRITIC CELL; GENETICS; IMMUNITY; IMMUNOLOGY; MOUSE; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD11C; ANTIGENS, SURFACE; DENDRITIC CELLS; HUMANS; IMMUNITY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LECTINS, C-TYPE; MANNOSE-BINDING LECTINS; MICE; MICE, TRANSGENIC; TRANSGENES;

EID: 85058248273     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2007.08.011     Document Type: Review

References (61)

1. Steinman R.M., and Cohn Z.A. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J. Exp. Med. 137 (1973) 1142-1162
2. Banchereau J., and Steinman R.M. Dendritic cells and the control of immunity. Nature 392 (1998) 245-252
3. Steinman R.M., and Nussenzweig M.C. Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 351-358
4. Steinman R.M., et al. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21 (2003) 685-711
5. Villadangos J.A., and Heath W.R. Life cycle, migration and antigen presenting functions of spleen and lymph node dendritic cells: limitations of the Langerhans cells paradigm. Semin. Immunol. 17 (2005) 262-272
6. Shortman K., and Naik S.H. Steady-state and inflammatory dendritic-cell development. Nat. Rev. Immunol. 7 (2007) 19-30
7. Kuwajima S., et al. Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation. Nat. Immunol. 7 (2006) 740-746
8. Ochando J.C., et al. Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts. Nat. Immunol. 7 (2006) 652-662
9. Dudziak D., et al. Differential antigen processing by dendritic cell subsets in vivo. Science 315 (2007) 107-111
10. Cheong C., et al. Production of monoclonal antibodies that recognize the extracellular domain of mouse Langerin/CD207. J. Immunol. Methods 324 (2007) 48-62
11. Kreitman R.J. Toxin-labeled monoclonal antibodies. Curr. Pharm. Biotechnol. 2 (2001) 313-325
12. Van Rooijen N., and Sanders A. Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications. J. Immunol. Methods 174 (1994) 83-93
13. Zhang Y., et al. APCs in the liver and spleen recruit activated allogeneic CD8+ T cells to elicit hepatic graft-versus-host disease. J. Immunol. 169 (2002) 7111-7118
14. Grabbe S., et al. Removal of the majority of epidermal Langerhans cells by topical or systemic steroid application enhances the effector phase of murine contact hypersensitivity. J. Immunol. 155 (1995) 4207-4217
15. Allan R.S., et al. Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming. Immunity 25 (2006) 153-162
16. Merad M., et al. Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease. Nat. Med. 10 (2004) 510-517
17. Holzmann S., et al. A model system using tape stripping for characterization of Langerhans cell-precursors in vivo. J. Invest. Dermatol. 122 (2004) 1165-1174
18. Merad M., et al. Langerhans cells renew in the skin throughout life under steady-state conditions. Nat. Immunol. 3 (2002) 1135-1141
19. Naglich J.G., et al. Expression cloning of a diphtheria toxin receptor: identity with a heparin-binding EGF-like growth factor precursor. Cell 69 (1992) 1051-1061
20. Mitamura T., et al. Structure-function analysis of the diphtheria toxin receptor toxin binding site by site-directed mutagenesis. J. Biol. Chem. 272 (1997) 27084-27090
21. Saito M., et al. Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice. Nat. Biotechnol. 19 (2001) 746-750
22. Pappenheimer Jr. A.M., et al. Diphtheria toxin and related proteins: effect of route of injection on toxicity and the determination of cytotoxicity for various cultured cells. J. Infect. Dis. 145 (1982) 94-102
23. Thorburn J., et al. Apoptosis by leukemia cell-targeted diphtheria toxin occurs via receptor-independent activation of Fas-associated death domain protein. Clin. Cancer Res. 9 (2003) 861-865
24. Miyake Y., et al. Protective role of macrophages in noninflammatory lung injury caused by selective ablation of alveolar epithelial type II cells. J. Immunol. 178 (2007) 5001-5009
25. Bennett C.L., et al. Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity. J. Cell Biol. 169 (2005) 569-576
26. Buch T., et al. A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration. Nat. Methods 2 (2005) 419-426
27. Jung S., et al. In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens. Immunity 17 (2002) 211-220
28. Brocker T., et al. Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo. J. Exp. Med. 185 (1997) 541-550
29. Neuenhahn M., et al. CD8α+ dendritic cells are required for efficient entry of Listeria monocytogenes into the spleen. Immunity 25 (2006) 619-630
30. Zammit D.J., et al. Dendritic cells maximize the memory CD8 T cell response to infection. Immunity 22 (2005) 561-570
31. Varol C., et al. Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J. Exp. Med. 204 (2007) 171-180
32. Naik S.H., et al. Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes. Nat. Immunol. 7 (2006) 663-671
33. Zaft T., et al. CD11chigh dendritic cell ablation impairs lymphopenia-driven proliferation of naive and memory CD8+ T cells. J. Immunol. 175 (2005) 6428-6435
34. Probst H.C., et al. Histological analysis of CD11c-DTR/GFP mice after in vivo depletion of dendritic cells. Clin. Exp. Immunol. 141 (2005) 398-404
35. van Rijt L.S., et al. In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. J. Exp. Med. 201 (2005) 981-991
36. Hebel K., et al. Plasma cell differentiation in T-independent type 2 immune responses is independent of CD11c(high) dendritic cells. Eur. J. Immunol. 36 (2006) 2912-2919
37. Laouar Y., et al. Transforming growth factor-β controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma. Nat. Immunol. 6 (2005) 600-607
38. Sapoznikov A., et al. Organ-dependent in vivo priming of naïve CD4+, but not CD8+, T cells by plasmacytoid dendritic cells. J. Exp. Med. 204 (2007) 1923-1933
39. Kissenpfennig A., et al. Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 22 (2005) 643-654
40. Valladeau J., et al. Identification of mouse langerin/CD207 in Langerhans cells and some dendritic cells of lymphoid tissues. J. Immunol. 168 (2002) 782-792
41. Douillard P., et al. Mouse lymphoid tissue contains distinct subsets of langerin/CD207 dendritic cells, only one of which represents epidermal-derived Langerhans cells. J. Invest. Dermatol. 125 (2005) 983-994
42. Takahara K., et al. Identification and expression of mouse Langerin (CD207) in dendritic cells. Int. Immunol. 14 (2002) 433-444
43. Stoecklinger A., et al. Epidermal langerhans cells are dispensable for humoral and cell-mediated immunity elicited by gene gun immunization. J. Immunol. 179 (2007) 886-893
44. Bennett, C.L. et al. Langerhans cells are required for efficient presentation of topically applied hapten to T cells. J. Immunol. (in press)
45. Kissenpfennig A., and Malissen B. Langerhans cells-revisiting the paradigm using genetically engineered mice. Trends Immunol. 27 (2006) 132-139
46. Kaplan D.H., et al. Epidermal Langerhans cell-deficient mice develop enhanced contact hypersensitivity. Immunity 23 (2005) 611-620
47. Borkowski T.A., et al. A role for endogenous transforming growth factor β 1 in Langerhans cell biology: the skin of transforming growth factor β 1 null mice is devoid of epidermal Langerhans cells. J. Exp. Med. 184 (1996) 2417-2422
48. Prlic M., et al. Duration of the initial TCR stimulus controls the magnitude but not functionality of the CD8+ T cell response. J. Exp. Med. 203 (2006) 2135-2143
49. Nichols L.A., et al. Deletional self-tolerance to a melanocyte/melanoma antigen derived from tyrosinase is mediated by a radio-resistant cell in peripheral and mesenteric lymph nodes. J. Immunol. 179 (2007) 993-1003
50. Cailhier J.F., et al. Conditional macrophage ablation demonstrates that resident macrophages initiate acute peritoneal inflammation. J. Immunol. 174 (2005) 2336-2342
51. Lahl K., et al. Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J. Exp. Med. 204 (2007) 57-63
52. Kim J.M., et al. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat. Immunol. 8 (2007) 191-197
53. Walzer T., et al. Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 3384-3389
54. Probst H.C., and van den Broek M. Priming of CTLs by Lymphocytic Choriomeningitis virus depends on dendritic cells. J. Immunol. 174 (2005) 3920-3924
55. Kassim S.H., et al. In vivo ablation of CD11c-positive dendritic cells increases susceptibility to herpes simplex virus type 1 infection and diminishes NK and T-cell responses. J. Virol. 80 (2006) 3985-3993
56. Tian T., et al. In vivo depletion of CD11c+ cells delays the CD4+ T cell response to Mycobacterium tuberculosis and exacerbates the outcome of infection. J. Immunol. 175 (2005) 3268-3272
57. Liu C.H., et al. Cutting edge: dendritic cells are essential for in vivo IL-12 production and development of resistance against Toxoplasma gondii infection in mice. J. Immunol. 177 (2006) 31-35
58. Ciavarra R.P., et al. Evaluation of immunological paradigms in a virus model: are dendritic cells critical for antiviral immunity and viral clearance?. J. Immunol. 177 (2006) 492-500
59. Lucas M., et al. Dendritic cells prime natural killer cells by trans-presenting interleukin 15. Immunity 26 (2007) 503-517
60. Schmieg J., et al. Glycolipid presentation to natural killer T cells differs in an organ-dependent fashion. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 1127-1132
61. Bezbradica J.S., et al. Distinct roles of dendritic cells and B cells in Va14Ja18 natural T cell activation in vivo. J. Immunol. 174 (2005) 4696-4705