Recognition of tumor glycans by antigen-presenting cells

Current Opinion in Immunology

Volumn 18, Issue 1, 2006, Pages 105-111

  Aarnoudse, Corlien A ^a   Vallejo, Juan J García ^a   Saeland, Eiríkur ^a   Van Kooyk, Yvette ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; GLYCAN; GLYCOPROTEIN; LECTIN RECEPTOR; MUCIN 1;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; CANCER IMMUNOTHERAPY; GLYCOSYLATION; HUMAN; IN VIVO STUDY; NONHUMAN; PROTEIN PROTEIN INTERACTION; REVIEW; TUMOR IMMUNITY; TUMOR IMMUNOLOGY; VACCINATION;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, NEOPLASM; CARCINOEMBRYONIC ANTIGEN; GLYCOSYLATION; HUMANS; IMMUNOTHERAPY; LECTINS, C-TYPE; MICE; NEOPLASMS; POLYSACCHARIDES; RECEPTORS, CELL SURFACE;

EID: 30044448460     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2005.11.001     Document Type: Review

References (54)

1. E.P. McGreal, J.L. Miller, and S. Gordon Ligand recognition by antigen-presenting cell C-type lectin receptors Curr Opin Immunol 17 2005 18 24
2. T.B. Geijtenbeek, S.J. van Vliet, A. Engering, B.A. 't Hart, and Y. van Kooyk Self- and nonself-recognition by C-type lectins on dendritic cells Annu Rev Immunol 22 2004 33 54
3. X/Y.
4. M.A. Hollingsworth, and B.J. Swanson Mucins in cancer: protection and control of the cell surface Nat Rev Cancer 4 2004 45 60
5. M. Garcia, C. Seigner, C. Bastid, R. Choux, M.J. Payan, and H. Reggio Carcinoembryonic antigen has a different molecular weight in normal colon and in cancer cells due to N-glycosylation differences Cancer Res 51 1991 5679 5686
6. X/a in cancer. This study demonstrates that the 'Warburg effect' (metabolic shift from oxidative to elevated anaerobic glycolysis to cope with hypoxic environments) results in the upregulation of a set of glycosylation-related genes via the enhanced expression of hypoxia inducible factors.
7. R. Kannagi Molecular mechanism for cancer-associated induction of sialyl Lewis X and sialyl Lewis A expression-The Warburg effect revisited Glycoconj J 20 2004 353 364
8. A. Lopez-Ferrer, and C. de Bolos The expression of human FUT1 in HT-29/M3 colon cancer cells instructs the glycosylation of MUC1 and MUC5AC apomucins Glycoconj J 19 2002 13 21
9. M.M. Halloran, W.W. Carley, P.J. Polverini, C.J. Haskell, S. Phan, B.J. Anderson, J.M. Woods, P.L. Campbell, M.V. Volin, A.E. Backer, and A.E. Koch Ley/H: an endothelial-selective, cytokine-inducible, angiogenic mediator J Immunol 164 2000 4868 4877
10. S. Hakomori Traveling for the glycosphingolipid path Glycoconj J 17 2000 627 647
11. M. Dalziel, C. Whitehouse, I. McFarlane, I. Brockhausen, S. Gschmeissner, T. Schwientek, H. Clausen, J.M. Burchell, and J. Taylor-Papadimitriou The relative activities of the C2GnT1 and ST3Gal-I glycosyltransferases determine O-glycan structure and expression of a tumor-associated epitope on MUC1 J Biol Chem 276 2001 11007 11015
12. K. Kumamoto, Y. Goto, K. Sekikawa, S. Takenoshita, N. Ishida, M. Kawakita, and R. Kannagi Increased expression of UDP-galactose transporter messenger RNA in human colon cancer tissues and its implication in synthesis of Thomsen-Friedenreich antigen and sialyl Lewis A/X determinants Cancer Res 61 2001 4620 4627
13. N.T. Marcos, S. Pinho, C. Grandela, A. Cruz, B. Samyn-Petit, A. Harduin-Lepers, R. Almeida, F. Silva, V. Morais, and J. Costa Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen Cancer Res 64 2004 7050 7057
14. T. Iwai, T. Kudo, R. Kawamoto, T. Kubota, A. Togayachi, T. Hiruma, T. Okada, T. Kawamoto, K. Morozumi, and H. Narimatsu Core 3 synthase is down-regulated in colon carcinoma and profoundly suppresses the metastatic potential of carcinoma cells Proc Natl Acad Sci USA 102 2005 4572 4577
15. B.J. Appelmelk, I. Van Die, S.J. van Vliet, C.M. Vandenbroucke-Grauls, T.B. Geijtenbeek, and Y. van Kooyk Cutting Edge: Carbohydrate Profiling Identifies New Pathogens That Interact with Dendritic Cell-Specific ICAM-3-Grabbing Nonintegrin on Dendritic Cells J Immunol 170 2003 1635 1639
16. S.J. van Vliet, E. van Liempt, E. Saeland, C.A. Aarnoudse, B. Appelmelk, T. Irimura, T.B. Geijtenbeek, O. Blixt, R. Alvarez, I. van Die, and Y. van Kooyk Carbohydrate profiling reveals a distinctive role for the C-type lectin MGL in the recognition of helminth parasites and tumor antigens by dendritic cells Int Immunol 17 2005 661 669
17. K. Denda-Nagai, N. Kubota, M. Tsuiji, M. Kamata, and T. Irimura Macrophage C-type lectin on bone marrow-derived immature dendritic cells is involved in the internalization of glycosylated antigens Glycobiology 12 2002 443 450
18. E.M. Hiltbold, A.M. Vlad, P. Ciborowski, S.C. Watkins, and O.J. Finn The mechanism of unresponsiveness to circulating tumor antigen MUC1 is a block in intracellular sorting and processing by dendritic cells J Immunol 165 2000 3730 3741
19. C.A. Carlos, H.F. Dong, O.M. Howard, J.J. Oppenheim, F.G. Hanisch, and O.J. Finn Human Tumor Antigen MUC1 Is Chemotactic for Immature Dendritic Cells and Elicits Maturation but Does Not Promote Th1 Type Immunity J Immunol 175 2005 1628 1635 Different glycoforms of MUC1 result in different effects on chemotaxis and maturation of immature DCs, indicating roles for different CLRs.
20. P.R. Crocker Siglecs in innate immunity Curr Opin Pharmacol 5 2005 431 437
21. A. Engering, T.B. Geijtenbeek, S.J. van Vliet, M. Wijers, E. van Liempt, N. Demaurex, A. Lanzavecchia, J. Fransen, C.G. Figdor, V. Piguet, and Y. van Kooyk The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells J Immunol 168 2002 2118 2126
22. K.W. Schjetne, K.M. Thompson, T. Aarvak, B. Fleckenstein, L.M. Sollid, and B. Bogen A mouse C kappa-specific T cell clone indicates that DC-SIGN is an efficient target for antibody-mediated delivery of T cell epitopes for MHC class II presentation Int Immunol 14 2002 1423 1430
23. A. Moris, C. Nobile, F. Buseyne, F. Porrot, J.P. Abastado, and O. Schwartz DC-SIGN promotes exogenous MHC-I-restricted HIV-1 antigen presentation Blood 103 2004 2648 2654
24. J.F. Arrighi, M. Pion, E. Garcia, J.M. Escola, Y. van Kooyk, T.B. Geijtenbeek, and V. Piguet DC-SIGN-mediated infectious synapse formation enhances X4 HIV-1 transmission from dendritic cells to T cells J Exp Med 200 2004 1279 1288
25. T.B. Geijtenbeek, S.J. van Vliet, E.A. Koppel, M. Sanchez-Hernandez, C.M. Vandenbroucke-Grauls, B. Appelmelk, and Y. van Kooyk Mycobacteria target DC-SIGN to suppress dendritic cell function J Exp Med 197 2003 7 17
26. H.H. Smits, A. Engering, D. van der Kleij, E.C. de Jong, K. Schipper, T.M. van Capel, B.A. Zaat, M. Yazdanbakhsh, E.A. Wierenga, Y. van Kooyk, and M.L. Kapsenberg Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin J Allergy Clin Immunol 115 2005 1260 1267
27. + bacteria have a Th2-like cytokine profile.
28. Steeghs L, van Vliet SJ, Uronen-Hansson H, van Mourik A, Engering A, Sanchez-Hernandez M, Klein N, Callard R, van Putten JPM, van der Ley P et al.: Neisseria meningitidis expressing lgtB lipopolysaccharide targets DC-SIGN and modulates dendritic cell function. Cell Microbiol 2005, in press. Lipopolysaccharide from an oligosaccharide mutant Neisseria meningitidis expressing truncated outer core glycans exhibited strong adhesion and internalization to DCs via DC-SIGN. In this case, the activation of DC-SIGN skewed T cell responses driven by DCs towards T helper 1 activity, whereas the wild-type form induced a Th2-like cytokine profile.
29. A. Cambi, F. de Lange, N.M. van Maarseveen, M. Nijhuis, B. Joosten, E.M. van Dijk, B.I. de Bakker, J.A. Fransen, P.H. Bovee-Geurts, and F.N. van Leeuwen Microdomains of the C-type lectin DC-SIGN are portals for virus entry into dendritic cells J Cell Biol 164 2004 145 155
30. A.J. Engering, M. Cella, D.M. Fluitsma, E.C. Hoefsmit, A. Lanzavecchia, and J. Pieters Mannose receptor mediated antigen uptake and presentation in human dendritic cells Adv Exp Med Biol 417 1997 183 187
31. M.C. Tan, A.M. Mommaas, J.W. Drijfhout, R. Jordens, J.J. Onderwater, D. Verwoerd, A.A. Mulder, A.N. van der Heiden, D. Scheidegger, and L.C. Oomen Mannose receptor-mediated uptake of antigens strongly enhances HLA class II-restricted antigen presentation by cultured dendritic cells Eur J Immunol 27 1997 2426 2435
32. S.J. Lee, S. Evers, D. Roeder, A.F. Parlow, J. Risteli, L. Risteli, Y.C. Lee, T. Feizi, H. Langen, and M.C. Nussenzweig Mannose receptor-mediated regulation of serum glycoprotein homeostasis Science 295 2002 1898 1901
33. A. Rughetti, I. Pellicciotta, M. Biffoni, M. Backstrom, T. Link, E.P. Bennet, H. Clausen, T. Noll, G.C. Hansson, and J.M. Burchell Recombinant tumor-associated MUC1 glycoprotein impairs the differentiation and function of dendritic cells J Immunol 174 2005 7764 7772
34. A.M. Vlad, S. Muller, M. Cudic, H. Paulsen, L. Otvos Jr., F.G. Hanisch, and O.J. Finn Complex carbohydrates are not removed during processing of glycoproteins by dendritic cells: processing of tumor antigen MUC1 glycopeptides for presentation to major histocompatibility complex class II-restricted T cells J Exp Med 196 2002 1435 1446
35. D. Hawiger, K. Inaba, Y. Dorsett, M. Guo, K. Mahnke, M. Rivera, J.V. Ravetch, R.M. Steinman, and M.C. Nussenzweig Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo J Exp Med 194 2001 769 779
36. L. Bonifaz, D. Bonnyay, K. Mahnke, M. Rivera, M.C. Nussenzweig, and R.M. Steinman Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance J Exp Med 196 2002 1627 1638
37. D.H. Dube, and C.R. Bertozzi Glycans in cancer and inflammation-potential for therapeutics and diagnostics Nat Rev Drug Discov 4 2005 477 488 An excellent review on altered glycosylation in tumors and inflammation and consequences for immunotherapy.
38. K. Mahnke, Y. Qian, J. Knop, and A.H. Enk Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells Blood 101 2003 4862 4869
39. K. Mahnke, Y. Qian, S. Fondel, J. Brueck, C. Becker, and A.H. Enk Targeting of antigens to activated dendritic cells in vivo cures metastatic melanoma in mice Cancer Res 65 2005 7007 7012 A recent paper that shows the potency of targeting melanoma antigens to DC-specific CLRs in an in vivo melanoma model.
40. D. Hawiger, R.F. Masilamani, E. Bettelli, V.K. Kuchroo, and M.C. Nussenzweig Immunological unresponsiveness characterized by increased expression of CD5 on peripheral T cells induced by dendritic cells in vivo Immunity 20 2004 695 705
41. M.E. Luca, J.M. Kel, W. van Rijs, J.W. Drijfhout, F. Koning, and L. Nagelkerken Mannosylated PLP(139-151) induces peptide-specific tolerance to experimental autoimmune encephalomyelitis J Neuroimmunol 160 2005 178 187
42. R.K. Gieseler, G. Marquitan, M.J. Hahn, L.A. Perdon, W.H. Driessen, S.M. Sullivan, and M.J. Scolaro DC-SIGN-specific liposomal targeting and selective intracellular compound delivery to human myeloid dendritic cells: implications for HIV disease Scand J Immunol 59 2004 415 424
43. N. Korokhov, T.D. de Gruijl, W.A. Aldrich, P.L. Triozzi, P.T. Banerjee, S.D. Gillies, T.J. Curiel, J.T. Douglas, R.J. Scheper, and D.T. Curiel High Efficiency Transduction of Dendritic Cells by Adenoviral Vectors Targeted To DC-SIGN Cancer Biol Ther 4 2005 289 294
44. P.J. Tacken, I.J. de Vries, K. Gijzen, B. Joosten, D. Wu, R.P. Rother, S.J. Faas, C.J. Punt, R. Torensma, G.J. Adema, and C.G. Figdor Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DC-SIGN antibody Blood 106 2005 1278 1285 Antibody-mediated DC-SIGN targeting of antigen KLH; in vitro experiments show enhanced antigen presentation to T cells from KLH-vaccinated patients.
45. E. van Liempt, A. Imberty, C.M. Bank, S.J. van Vliet, Y. van Kooyk, T.B. Geijtenbeek, and I. Van Die Molecular basis of the differences in binding properties of the highly related C-type lectins DC-SIGN and L-SIGN to Lewis X trisaccharide and Schistosoma mansoni egg antigens J Biol Chem 279 2004 33161 33167
46. Y. Guo, H. Feinberg, E. Conroy, D.A. Mitchell, R. Alvarez, O. Blixt, M.E. Taylor, W.I. Weis, and K. Drickamer Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR Nat Struct Mol Biol 11 2004 591 598
47. A.K. Chakraborty, and J.M. Pawelek GnT-V, macrophage and cancer metastasis: a common link Clin Exp Metastasis 20 2003 365 373
48. T. Saito, E. Miyoshi, K. Sasai, N. Nakano, H. Eguchi, K. Honke, and N. Taniguchi A secreted type of beta 1,6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation: a novel function of GnT-V distinct from the original glycosyltransferase activity J Biol Chem 277 2002 17002 17008
49. S. Gretschel, W. Haensch, P.M. Schlag, and W. Kemmner Clinical relevance of sialyltransferases ST6GAL-I and ST3GAL-III in gastric cancer Oncology 65 2003 139 145
50. R. Seidenfaden, A. Krauter, F. Schertzinger, R. Gerardy-Schahn, and H. Hildebrandt Polysialic acid directs tumor cell growth by controlling heterophilic neural cell adhesion molecule interactions Mol Cell Biol 23 2003 5908 5918
51. M. Suzuki, M. Suzuki, J. Nakayama, A. Suzuki, K. Angata, S. Chen, K. Sakai, K. Hagihara, Y. Yamaguchi, and M. Fukuda Polysialic acid facilitates tumor invasion by glioma cells Glycobiology 15 2005 887 894
52. A. Takada, K. Ohmori, T. Yoneda, K. Tsuyuoka, A. Hasegawa, M. Kiso, and R. Kannagi Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endothelium Cancer Res 53 1993 354 361
53. K. Tei, N. Kawakami-Kimura, O. Taguchi, K. Kumamoto, S. Higashiyama, N. Taniguchi, K. Toda, R. Kawata, Y. Hisa, and R. Kannagi Roles of cell adhesion molecules in tumor angiogenesis induced by cotransplantation of cancer and endothelial cells to nude rats Cancer Res 62 2002 6289 6296
54. S. Julien, C. Lagadec, M.A. Krzewinski-Recchi, G. Courtand, X. Le Bourhis, and P. Delannoy Stable expression of sialyl-Tn antigen in T47-D cells induces a decrease of cell adhesion and an increase of cell migration Breast Cancer Res Treat 90 2005 77 84