Indole-3-carbinol inhibits MDA-MB-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity

International Journal of Cancer

Volumn 124, Issue 10, 2009, Pages 2294-2302

  Brew, Christine T ^a   Aronchik, Ida ^a   Kosco, Karena ^b   McCammon, Jasmine ^a   Bjeldanes, Leonard F ^a   Firestone, Gary L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BURNHAM INSTITUTE   (United States)

Author keywords

Breast cancer; Focal adhesions; Indole 3 carbinol; Migration; Rho kinase; RhoA

Indexed keywords

3 INDOLEMETHANOL; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ACTIN; COFILIN; FOCAL ADHESION KINASE; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; VINCULIN; INDOLE DERIVATIVE; INDOLE-3-CARBINOL;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CANCER INVASION; CELL LOSS; CELL MIGRATION; CELL MOTILITY; CELLULAR DISTRIBUTION; CHEMOTAXIS; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVITY; FOCAL ADHESION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRESS FIBER; CELL ADHESION; CELL MOTION; DRUG EFFECT; ENZYME ACTIVATION; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; TUMOR CELL LINE;

CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; ENZYME ACTIVATION; FLUORESCENT ANTIBODY TECHNIQUE; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; INDOLES; RHOA GTP-BINDING PROTEIN;

EID: 64249172315     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.24210     Document Type: Article

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