Indole-3-carbinol Inhibits CDK6 Expression in Human MCF-7 Breast Cancer Cells by Disrupting Sp1 Transcription Factor Interactions with a Composite Element in the CDK6 Gene Promoter

Journal of Biological Chemistry

Volumn 276, Issue 25, 2001, Pages 22332-22340

  Cram, Erin J ^a   Liu, Betty D ^a   Bjeldanes, Leonard F ^a   Firestone, Gary L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CELLS; COMPLEXATION; DNA; ELECTROPHORESIS; PROTEINS; TUMORS;

BREAST CANCER CELLS;

BIOCHEMISTRY;

3 INDOLEMETHANOL; CYCLIN DEPENDENT KINASE 6; MESSENGER RNA; TRANSCRIPTION FACTOR SP1; CDK6 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE; INDOLE DERIVATIVE; INDOLE-3-CARBINOL; NUCLEAR PROTEIN; PRIMER DNA; PROTEIN SERINE THREONINE KINASE;

ARTICLE; BINDING SITE; CANCER INHIBITION; CDK6 GENE; CELL STRAIN MCF 7; GENE; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; BREAST TUMOR; CELL CULTURE; CELL CYCLE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR CLONING; MUTAGENESIS; PATHOLOGY;

BRASSICA; MINK CELL FOCUS-FORMING VIRUS;

BASE SEQUENCE; BREAST NEOPLASMS; CELL CYCLE; CLONING, MOLECULAR; CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASES; DNA PRIMERS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INDOLES; MUTAGENESIS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SP1 TRANSCRIPTION FACTOR; TUMOR CELLS, CULTURED;

EID: 0035933895     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M010539200     Document Type: Article

References (70)

1. Sharma, S., Stutzman, J. D., Kelloff, G. J., and Steele, V. E. (1994) Cancer Res. 54, 5848-5855
2. Grubbs, C. J., Steele, V. E., Casebolt, T., Juliana, M. M., Eto, I., Whitaker, L. M., Dragnev, K. H., Kelloff, G. J., and Lubet, R. L. (1995) Anticancer Res. 15, 709-716
3. Bradlow, H. L., Sepkovic, D. W., Telang, N. T., and Osborne, M. P. (1995) Ann. N. Y. Acad. Sci. 768, 180-200
4. Broadbent, T. A., and Broadbent, H. S. (1998) Curr. Med. Chem. 5, 469-491
5. Broadbent, T. A., and Broadbent, H. S. (1998) Curr. Med. Chem. 5, 337-352
6. Bjeldanes, L. F., Kim, J. Y., Grose, K. R., Bartholomew, J. C., and Bradfield, C. A. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 9543-9547
7. Bradlow, H. L., Michnovicz, J. J., Halper, M., Miller, D. G., Wong, G. Y., and Osborne, M. P. (1994) Cancer Epidemiol. Biomarkers Prev. 3, 591-595
8. Chen, I., McDougal, A., Wang, F., and Safe, S. (1998) Carcinogenesis 19, 1631-1639
9. Srivastava, B., and Shukla, Y. (1998) Cancer Lett. 134, 91-95
10. Cover, C. M., Hsieh, S. J., Tran, S. H., Hallden, G., Kim, G. S., Bjeldanes, L. F., and Firestone, G. L. (1998) J. Biol. Chem. 273, 3838-3847
11. Hamel, P. A., and Hanley, H. J. (1997) Cancer Invest. 15, 143-152
12. Sherr, C. J. (2000) Cancer Res. 60, 3689-3695
13. Weinberg, R. A. (1995) Cell 81, 323-330
14. van den Heuvel, S., and Harlow, E. (1993) Science 262, 2050-2054
15. Morgan, D. O. (1995) Nature 374, 131-134
16. King, R. W., Jackson, P. K., and Kirschner, M. W. (1994) Cell 79, 563-571
17. Sherr, C. J. (1996) Science 274, 1672-1677
18. Stillman, B. (1996) Science 274, 1659-1664
19. Harbour, J. W., and Dean, D. C. (2000) Nat. Cell Biol. 2, E65-E67
20. Taya, Y. (1997) Trends Biochem. Sci. 22, 14-17
21. Helin, K., Lees, J. A., Vidal, M., Dyson, N., Harlow, E., and Fattaey, A. (1992) Cell 70, 337-350
22. Slansky, J. E., and Farnham, P. J. (1996) Curr. Top Microbiol. Immunol. 208, 1-30
23. Takahashi, Y., Rayman, J. B., and Dynlacht, B. D. (2000) Genes Dev. 14, 804-816
24. Buckley, M. F., Sweeney, K. J., Hamilton, J. A., Sini, R. L., Manning, D. L., Nicholson, R. I., deFazio, A., Watts, C. K., Musgrove, E. A., and Sutherland, R. L. (1993) Oncogene 8, 2127-2133
25. Zhu, X. L., Hartwick, W., Rohan, T., and Kandel, R. (1998) Mod. Pathol. 11, 1082-1088
26. Oyama, T., Kashiwabara, K., Yoshimoto, K., Arnold, A., and Koerner, F. (1998) Cancer Res. 58, 2876-2880
27. Tanner, M. M., Karhu, R. A., Nupponen, N. N., Borg, A., Baldetorp, B., Pejovic, T., Ferno, M., Killander, D., and Isola, J. J. (1998) Am. J. Pathol. 153, 191-199
28. Cover, C. M., Hsieh, S. J., Cram, E. J., Hong, C., Riby, J. E., Bjeldanes, L. F., and Firestone, G. L. (1999) Cancer Res. 59, 1244-1251
29. Kwon, T. K., Nagel, J. E., Buchholz, M. A., and Nordin, A. A. (1996) Gene (Amst.) 180, 113-120
30. Akagi, T., Ono, H., and Shimotohno, K. (1996) Oncogene 13, 399-405
31. Ishida, T., Kobayashi, N., Tojo, T., Ishida, S., Yamamoto, T., and Inoue, J. (1995) J. Immunol. 155, 5527-5535
32. Horiguchi-Yamada, J., Yamada, H., Nakada, S., Ochi, K., and Nemoto, T. (1994) Mol. Cell. Biochem. 132, 31-37
33. Tanguay, D. A., and Chiles, T. C. (1994) Mol. Immunol. 31, 643-649
34. Shiffman, D., Brooks, E. E., Brooks, A. R., Chan, C. S., and Milner, P. G. (1996) J. Biol. Chem. 271, 12199-12204
35. Badie, C., Itzhaki, J. E., Sullivan, M. J., Carpenter, A. J., and Porter, A. C. (2000) Mol. Cell. Biol. 20, 2358-2366
36. Chirgwin, J. M., Przybyla, A. E., MacDonald, R. J., and Rutter, W. J. (1979) Biochemistry 18, 5294-5299
37. Dignam, J. D., Lebovitz, R. M., and Roeder, R. G. (1983) Nucleic Acids Res. 11, 1475-1489
38. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
39. Meyerson, M., Enders, G. H., Wu, C. L., Su, L. K., Gorka, C., Nelson, C., Harlow, E., and Tsai, L. H. (1992) EMBO J. 11, 2909-2917
40. Russo, A. A., Tong, L., Lee, J. O., Jeffrey, P. D., and Pavletich, N. P. (1998) Nature 395, 237-243
41. Thomas, J. W., Lee-Lin, S. Q., and Green, E. D. (1999) Mamm. Genome 10, 764-767
42. Quandt, K., Frech, K., Karas, H., Wingender, E., and Werner, T. (1995)Nucleic Acids Res. 23, 4878-4884
43. Dalton, S. (1992) EMBO J. 11, 1797-1804
44. Muller, C., Yang, R., Beck-von-Peccoz, L., Idos, G., Verbeek, W., and Koeffler, H. P. (1999) J. Biol. Chem. 274, 11220-11228
45. Azizkhan, J. C., Jensen, D. E., Pierce, A. J., and Wade, M. (1993) Crit. Rev. Eukaryotic Gene Expr. 3, 229-254
46. Briggs, M. R., Kadonaga, J. T., Bell, S. P., and Tjian, R. (1986) Science 234, 47-52
47. Brandeis, M., Frank, D., Keshet, I., Siegfried, Z., Mendelsohn, M., Nemes, A., Temper, V., Razin, A., and Cedar, H. (1994) Nature 371, 435-438
48. Meng, Q., Qi, M., Chen, D. Z., Yuan, R., Goldberg, I., D., Rosen, E. M., Auborn, K., and Fan, S. (2000) J. Mol. Med. 78, 155-165
49. Lania, L., Majello, B., and De Luca, P. (1997) Int. J. Biochem. Cell Biol. 29, 1313-1323
50. Margana, R. K., and Boggaram, V. (1997) J. Biol. Chem. 272, 3083-3090
51. Fry, C. J., and Farnham, P. J. (1999) J. Biol. Chem. 274, 29583-29586
52. Kobayashi, A., Sogawa, K., and Fujii-Kuriyama, Y. (1996) J. Biol. Chem. 271, 12310-12316
53. Wang, F., Hoivik, D., Pollenz, R., and Safe, S. (1998) Nucleic Acids Res. 26, 3044-3052
54. Wang, W., Dong, L., Saville, B., and Safe, S. (1999) Mol. Endocrinol. 13, 1373-1387
55. Qin, X. Q., Livingston, D. M., Ewen, M., Sellers, W. R., Arany, Z., and Kaelin, W. J. (1995) Mol. Cell. Biol. 15, 742-755
56. Xie, W., Duan, R., and Safe, S. (1999) Endocrinology 140, 219-227
57. Duan, R., Porter, W., and Safe, S. (1998) Endocrinology 139, 1981-1990
58. Saville, B., Wormke, M., Wang, F., Nguyen, T., Enmark, E., Kuiper, G., Gustafsson, J. A., and Safe, S. (2000) J. Biol. Chem. 275, 5379-5387
59. Lu, S., Jenster, G., and Epner, D. E. (2000) Mol. Endocrinol. 14, 753-760
60. Wasylyk, B., Hagman, J., and Gutierrez-Hartmann, A. (1998) Trends Biochem. Sci. 23, 213-216
61. Sharrocks, A. D., Brown, A. L., Ling, Y., and Yates, P. R. (1997) Int. J. Biochem. Cell Biol. 29, 1371-1387
62. Graves, B. J., and Petersen, J. M. (1998) Adv. Cancer Res. 75, 1-55
63. Dean, G., Young, D. A., Edwards, D. R., and Clark, I. M. (2000) J. Biol. Chem. 275, 32664-32671
64. Rosmarin, A. G., Luo, M., Caprio, D. G., Shang, J., and Simkevich, C. P. (1998) J. Biol. Chem. 273, 13097-13103
65. Krehan, A., Ansuini, H., Bocher, O., Grein, S., Wirkner, U., and Pyerin, W. (2000) J. Biol. Chem. 275, 18327-18336
66. Torchia, J., Glass, C., and Rosenfeld, M. G. (1998) Curr. Opin. Cell Biol. 10, 373-383
67. Davie, J. R., and Chadee, D. N. (1998) J. Cell. Biochem. 31, (suppl.) 203-213
68. Ryu, S., Zhou, S., Ladurner, A. G., and Tjian, R. (1999) Nature 397, 446-450
69. Freedman, L. P. (1999) Cell 97, 5-8
70. Brown, C. E., Lechner, T., Howe, L., and Workman, J. L. (2000) Trends Biochem. Sci. 25, 15-19