Induction of apoptosis in MCF-7 cells by indole-3-carbinol is independent of p53 and bax

Anticancer Research

Volumn 19, Issue 4 B, 1999, Pages 3199-3203

  Ge, Xiaokang ^a   Fares, Fuad A ^b   Yannai, Shmuel ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b Carmel Lady Davis Medical Center   (Israel)

Author keywords

Apoptosis; Breast cancer cells; Indole 3 carbinol

Indexed keywords

3 INDOLEMETHANOL; 3,3' DIINDOLYLMETHANE; ANTINEOPLASTIC AGENT; PROTEIN BAX; PROTEIN P53; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CONTROLLED STUDY; CULTURE MEDIUM; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NORTHERN BLOTTING; PRIORITY JOURNAL;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL CYCLE; CULTURE MEDIA; HUMANS; INDOLES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0033452650     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Boone CW, Kelloff OJ and Malone WE: Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials: a review. Cancer Res 50: 2-9, 1990.
2. Scholar EM, Wolterman K, Birt DF and Bresnick E: Effect of dietary fat on metastasis of Lewis Lung Carcinoma and the BALB/c Mammary Carcinoma. Nutr Cancer 12: 109-119, 1989.
3. McDanell R, McLean AE, Hanley AB, Heaney RK, Fenwick GR: Chemical and biological properties of indole glucosinolates (glucobrassicins): a review. Food Chem Toxicol 26: 59-70, 1988.
4. Bradlow HL, Michnovicz JJ, Telang T, Osborne M: Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumours in mice. Carcinogenesis 12: 1571-1574, 1991.
5. Morse MA, LaGreca SD, Amin SG, Chung FL: Effect of indole-3-carbinol on lung tumorigenesis and DNA methylation increased by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and on the metabolism and disposition of NNK in A/J mice. Cancer Res 50: 2613-2617, 1990.
6. Fong AT, Swanson HT, Dashwood RH, Williams DE, Hendricks JD, Bailey GS: Mechanisms of anti-carcinogenesis by indole-3-carbinol: studies of enzyme induction, electrophile-scavenging, and inhibition of aflatoxin B1 activiation. Biochem Pharmacol 39: 19-26, 1990.
7. Stresser DM, Bailey GS, Williams DE: Indole-3-carbinol and ß-naphthoflavoen induction of aflatoxin B1 metabolism and cytochrome P-450 associated with bioactivation and detoxication of aflatoxin B1 in the rat. Drug Metab Dispos 22: 383-391, 1994
8. Suto A, Bradlow HL, Kubota T, Kitajima M, Wong GY, Osborne MF, Telang NT: Alteration in proliferate and endocrine responsiveness of human mammary carcinoma cells by prototypic tumor-suppressing agents. Steroids 58: 215-219, 1993.
9. Dashwood RH, Arbogast DN, Fong AT, Hendricks JD, Bailey DS: Mechanisms of anti-carcinogenesis by indole-3-carbinol: detailed in vivo DNA binding dose-responce studies after dietary administration with aflatoxin B1 (AFB1). Carcinogenesis 9: 427-432, 1988.
10. Shertzer HG, Berger ML, and Tabor MW: Intervention in free radical mediated hepatotoxicity and lipid peroxidation by indole-3-carbinol. Biochem Pharmacol 37: 333-338, 1988.
11. Liu H, Wormke M, Safe SH, Bjeldanes LF: Indole[3,2-b]carbazole: a diet-derived factor that exhibits both antiestrogenic and estrogenic activity. J Natl Cancer Inst 86: 1758-1765, 1994.
12. Christensen JG and LeBlanc GA: Reversal of multidrug resistance in vivo by dietary administration of the phytochemical indole-3-carbinol. Cancer Res 56: 574-581, 1996.
13. Tiwari RK, Guo L, Bradlow HL, Telang NT, Osborne MP: Selective responsiveness of human breast cancer cells to indole-3-carbinol, a chemopreventive agent. J Natl Cancer Inst 86: 126-131, 1994.
14. Cover CM, Hsieh SJ, Tran SH, Hallden G, Kim GS, Bjeldanes LF and Firestone GL: Indole-carbinol inhibits the expression of cyclin-dependent kinase-6 and induces a G1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling. J Biol Chem 273: 3838-3847, 1998.
15. Ge X, Yannai S, Rennert G, Gruener N and Fares FA: 3,3′-Diindolylmethane induces apoptosis in human cancer cells. Biochem Biophys Res Commun 228: 153-158, 1996.
16. Leete E and Marion L: The dehydrogenolysis of 3-hydroxymethylindole and other indole derivatives with lithium aluminum hydride. Can J Chem 31: 775-784, 1953.
17. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
18. Chomczynski P and Sacchi N: Single-step method of RNA isolation by acid guanidinum thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
19. Bradfield CA and Bjeldanes LF: Structure-activity relationships of dietary indoles: a proposed mechanism of action as modifiers of xenobiotic metabolism. J Toxic Environ Health 21: 311-323, 1987.
20. Brooks SC, Locke ER and Soule HD: Estrogen receptor in human cell line (MCF-7) from breast carcinoma. J Biol Chem 248: 6251-6253, 1973.
21. Eastman A: Survival factors, intracellular signal transduction, and the activation of endonucleases in apoptosis. Seminar in Cancer Biol 6: 45-52, 1995.
22. Yonish-Rouch E, Resnitzky D, Lotem J, Sachs L, Kimchi A and Oren M: Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin 6. Nature 352: 345-347, 1991.
23. Oltiva ZN, Milliman CL, Korsmeyer SJ: bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell 74: 609-619, 1993.
24. Miyashita T, Krajewski S, Krajewski M, Wang HG, Lin HK, Liebermann DA, Hoffman B and Reed JC: Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9: 1799-1805, 1994.
25. Hoeppner DJ, Hengartner MD, Fisher DE: Programmed cell death: from development to disease. Biochem Biophys Acta 1242: 217-220, 1996.
26. Dashwood RH, Fong AT, Arbogast, DN, Bjeldanes JD, Hendricks JD, Bailey GS: Anticarcinogenic activity of indole-3-carbinol acid products: Ultrasensitive bioassay by trout embryo microinjection. Cancer Res 54: 3617-3619, 1994.
27. Baldwin WS and LeBlanc GA: The anti-carcinogenic plant compound indole-3-carbinol differentially modulates P-450 mediated steroid hydroxylase activites in mice. Chem Biol Interact 83: 155-169, 1992.
28. Niwa T, Swaneck G and Bradlow HL: Alterations in estradiol metabolism in MCF-7 cells induced by treatment with indole-3-carbinol and related compounds. Steroids 59: 523-527, 1994.