RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity

Molecular Biology of the Cell

Volumn 12, Issue 9, 2001, Pages 2711-2720

  Arthur, W T ^a   Burridge, K ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRONECTIN; GROWTH ASSOCIATED PROTEIN; GUANOSINE TRIPHOSPHATASE; RHO FACTOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SCLEROPROTEIN;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL MEMBRANE; CELL MIGRATION; CELL MOTILITY; CELL POLARITY; CELL SPREADING; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; FIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

EID: 0035158377     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.12.9.2711     Document Type: Article

References (51)

1. Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism
2. A novel regulator of p21-activated kinases
3. Requirement for Rho in integrin signaling
4. Fibronectin regulates assembly of actin filaments and focal contacts in cultured cells via the heparin-binding site in repeat III13
5. The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development
6. c-Src regulates the simultaneous rearrangement of actin cytoskeleton, p190RhoGAP, and p120RasGAP following epidermal growth factor stimulation
7. Rho-stimulated contractility drives the formation of stress fibers and focal adhesions
8. Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the Rho family of GTPases
9. Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases
10. Multiple roles for Cdc42 in cell regulation
11. Mechanism of centrosome positioning during the wound response in BSC-1 cells
12. Regulation of p190 Rho-GAP by v-Src is linked to cytoskeletal disruption during transformation
13. Rho GTPases and the actin cytoskeleton
14. The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases
15. Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells
16. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
17. The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts
18. Role of p120 Ras-GAP in directed cell movement
19. Polarization of the Golgi apparatus and the microtubule-organizing center in cultured fibroblasts at the edge of an experimental wound
20. Cell migration: A physically integrated molecular process
21. Regulation of the RhoA pathway in human endothelial cell spreading on type IV collagen: Role of calcium influx
22. The polarization of the motile cell
23. Activation of beta1 integrin signaling stimulates tyrosine phosphorylation of p190RhoGAP and membrane-protrusive activities at invadopodia
24. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
25. Rho GTPases control polarity, protrusion, and adhesion during cell movement
26. Rho guanine dissociation inhibitors: Pivotal molecules in cellular signaling
27. Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover
28. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton
29. Involvement of the small GTPase rho in integrin-mediated activation of mitogen-activated protein kinase
30. Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells
31. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
32. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
33. Phosphotyrosine (p-Tyr)-dependent and -independent mechanisms of p190 RhoGAP-p120 RasGAP interaction: Tyr 1105 of p190, a substrate for c-Src, is the sole p-Tyr mediator of complex formation
34. Interplay between Rac and Rho in the control of substrate contact dynamics
35. Syndecan-4 signals cooperatively with integrins in a Rho-dependent manner in the assembly of focal adhesions and actin stress fibers
36. Focal adhesions: A nexus for intracellular signaling and cytoskeletal dynamics
37. Association between GTPase activators for Rho and Ras families
38. Rapid recruitment of p120RasGAP and its associated protein, p190RhoGAP, to the cytoskeleton during integrin mediated cell-substrate interaction
39. Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration
40. Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration
41. Small GTP-binding proteins
42. Involvement of Rho p21 small GTP-binding protein and its regulator in the HGF-induced cell motility
43. The function of the p190 Rho GTPase-activating protein is controlled by its N-terminal GTP binding domain
44. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
45. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
46. Rho GTPases and signaling networks
47. Aberrant Ras regulation and reduced p190 tyrosine phosphorylation in cells lacking p120-Gap
48. Cooperation between mDia1 and ROCK in Rho-induced actin reorganization
49. Expression cloning of lsc, a novel oncogene with structural similarities to the Dbl family of guanine nucleotide exchange factors
50. Protein kinase C involvement in focal adhesion formation
51. RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion