Indole-3-carbinol (I3C) inhibits cyclin-dependent kinase-2 function in human breast cancer cells by regulating the size distribution, associated cyclin E forms, and subcellular localization of the CDK2 protein complex

Journal of Biological Chemistry

Volumn 280, Issue 10, 2005, Pages 8756-8764

  Garcia, Hanh H ^a   Brar, Gloria A ^a   Nguyen, David H H ^a   Bjeldanes, Leonard F ^a   Firestone, Gary L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; COMPOSITION; DIMERIZATION; ENZYMES; HORMONES; IMMUNOLOGY; PRECIPITATION (CHEMICAL); TUMORS;

CELL CYCLE; CONTROL CELLS; INDOLE-3-CARBINOL (I3C); SUBCELLULAR LOCALIZATION;

BIOCHEMISTRY;

3 INDOLEMETHANOL; CYCLIN DEPENDENT KINASE 2; CYCLIN E; PROTEIN P21; PROTEIN P27; TAMOXIFEN;

ARTICLE; BREAST CANCER; CANCER CELL; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIMERIZATION; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN FUNCTION;

BREAST NEOPLASMS; CDC2-CDC28 KINASES; CELL LINE, TUMOR; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; FEMALE; HUMANS; INDOLES; PROTEIN ISOFORMS; SUBCELLULAR FRACTIONS;

MINK CELL FOCUS-FORMING VIRUS;

EID: 15744375609     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M407957200     Document Type: Article

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