Innate immunity, coagulation and surgery

Frontiers in Bioscience

Volumn 14, Issue 8, 2009, Pages 2970-2982

  Koch, Alexander ^a   Zacharowski, Paula ^a   Boehm, Olaf ^b   Zacharowski, Kai ^a  

^a UNIVERSITY HOSPITALS BRISTOL NHS FOUNDATION TRUST   (United Kingdom)

^b UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

Coagulation; Fibrin fragments; Inflammation; Innate immunity; Review; Surgery; Toll like receptors

Indexed keywords

CYTOKINE;

BLOOD CLOTTING; GENETIC POLYMORPHISM; HUMAN; INFLAMMATION; INNATE IMMUNITY; PHYSIOLOGY; REVIEW; SURGERY;

BLOOD COAGULATION; CYTOKINES; HUMANS; IMMUNITY, INNATE; INFLAMMATION; POLYMORPHISM, GENETIC; SURGICAL PROCEDURES, OPERATIVE;

EID: 63849319598     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2735/3427     Document Type: Article

References (134)

1. N. Garrett and E. M. Martini: The boomers are coming: a total cost of care model of the impact of population aging on the cost of chronic conditions in the United States. Dis.Manag. 10, 51-60 (2007). (Pubitemid 46709328)
2. D. C. Angus, W. T. Linde-Zwirble, J. Lidicker, G. Clermont, J. Carcillo and M. R. Pinsky: Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 29, 1303-1310 (2001). (Pubitemid 32641789)
3. J. Cohen: The immunopathogenesis of sepsis. Nature 420, 885-891 (2002). (Pubitemid 36019643)
4. P. Libby: Inflammation in atherosclerosis. Nature 420, 868-874 (2002). (Pubitemid 36019640)
5. M. A. Gonzalez and A. P. Selwyn: Endothelial function, inflammation, and prognosis in cardiovascular disease. Am.J.Med. 115 Suppl 8A, 99S-106S (2003).
6. M. Levi, E. de Jonge and P. T. van der: New treatment strategies for disseminated intravascular coagulation based on current understanding of the pathophysiology. Ann.Med. 36, 41-49 (2004). (Pubitemid 38230698)
7. R. Paoletti, A. M. Gotto Jr. and D. P. Hajjar: Inflammation in atherosclerosis and implications for therapy. Circulation 109, III20-III26 (2004). (Pubitemid 38786439)
8. Y. Kumagai, O. Takeuchi and S. Akira: Pathogen recognition by innate receptors. J.Infect.Chemother. 14, 86- 92 (2008). (Pubitemid 351624472)
9. S. Akira, S. Uematsu and O. Takeuchi: Pathogen recognition and innate immunity. Cell 124, 783-801 (2006). (Pubitemid 43261452)
10. T. Kawai and S. Akira: Signaling to NF-kappaB by Toll-like receptors. Trends Mol.Med 13, 460-469 (2007).
11. A. Aderem and R. J. Ulevitch: Toll-like receptors in the induction of the innate immune response. Nature 406, 782- 787 (2000).
12. A. Iwasaki and R. Medzhitov: Toll-like receptor control of the adaptive immune responses. Nat.Immunol. 5, 987- 995 (2004). (Pubitemid 41057715)
13. R. Schwandner, R. Dziarski, H. Wesche, M. Rothe and C. J. Kirschning: Peptidoglycan- and lipoteichoic acidinduced cell activation is mediated by toll-like receptor 2. J.Biol.Chem. 274, 17406-17409 (1999).
14. K. Hoshino, O. Takeuchi, T. Kawai, H. Sanjo, T. Ogawa, Y. Takeda, K. Takeda and S. Akira: Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J.Immunol. 162, 3749-3752 (1999). (Pubitemid 29314747)
15. S. Yokota, T. Ohnishi, M. Muroi, K. Tanamoto, N. Fujii and K. Amano: Highly-purified Helicobacter pylori LPS preparations induce weak inflammatory reactions and utilize Toll-like receptor 2 complex but not Toll-like receptor 4 complex. FEMS Immunol.Med Microbiol. 51, 140-148 (2007). (Pubitemid 47387489)
16. S. Thakran, H. Li, C. L. Lavine, M. A. Miller, J. E. Bina, X. R. Bina and F. Re: Identification of Francisella tularensis lipoproteins that stimulate the toll-like receptor (TLR) 2/TLR1 heterodimer. J.Biol.Chem. 283, 3751-3760 (2008).
17. E. T. Rietschel, T. Kirikae, F. U. Schade, U. Mamat, G. Schmidt, H. Loppnow, A. J. Ulmer, U. Zahringer, U. Seydel, F. Di Padova and et al.: Bacterial endotoxin: molecular relationships of structure to activity and function. Faseb J 8, 217-225 (1994). (Pubitemid 24067145)
18. J. Schletter, H. Heine, A. J. Ulmer and E. T. Rietschel: Molecular mechanisms of endotoxin activity. Arch Microbiol 164, 383-389 (1995). (Pubitemid 26018509)
19. M. Guha and N. Mackman: LPS induction of gene expression in human monocytes. Cell Signal. 13, 85-94 (2001). (Pubitemid 32222977)
20. G. Wakabayashi, J. A. Gelfand, W. K. Jung, R. J. Connolly, J. F. Burke and C. A. Dinarello: Staphylococcus epidermidis induces complement activation, tumor necrosis factor and interleukin-1, a shock-like state and tissue injury in rabbits without endotoxemia. Comparison to Escherichia coli. J Clin Invest 87, 1925-1935 (1991).
21. W. Fischer: Physiology of lipoteichoic acids in bacteria. Adv Microb Physiol 29, 233-302 (1988).
22. K. M. Kengatharan, S. De Kimpe, C. Robson, S. J. Foster and C. Thiemermann: Mechanism of gram-positive shock: identification of peptidoglycan and lipoteichoic acid moieties essential in the induction of nitric oxide synthase, shock, and multiple organ failure. J.Exp.Med. 188, 305-315 (1998). (Pubitemid 28357759)
23. S. Immenschuh, J. Stritzke, S. Iwahara and G. Ramadori: Up-regulation of heme-binding protein 23 (HBP23) gene expression by lipopolysaccharide is mediated via a nitric oxide-dependent signaling pathway in rat Kupffer cells. Hepatology 30, 118-127 (1999). (Pubitemid 29300577)
24. S. Kurata, M. Matsumoto and U. Yamashita: Concomitant transcriptional activation of nitric oxide synthase and heme oxygenase genes during nitric oxidemediated macrophage cytostasis. J.Biochem. (Tokyo) 120, 49-52 (1996). (Pubitemid 26258247)
25. A. M. Vicente, M. I. Guillen and M. J. Alcaraz: Modulation of haem oxygenase-1 expression by nitric oxide and leukotrienes in zymosan-activated macrophages. Br.J.Pharmacol. 133, 920-926 (2001). (Pubitemid 32751802)
26. A. M. Choi and J. Alam: Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury. Am.J.Respir.Cell Mol.Biol. 15, 9-19 (1996). (Pubitemid 126439851)
27. M. D. Maines: Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. FASEB J. 2, 2557-2568 (1988).
28. S. Moncada, R. M. Palmer and E. A. Higgs: Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43, 109-142 (1991).
29. C. Nathan: Nitric oxide as a secretory product of mammalian cells. FASEB J. 6, 3051-3064 (1992).
30. K. Tanjoh, A. Shima, M. Aida, R. Tomita and Y. Kurosu: Nitric oxide and active oxygen species in severe sepsis and surgically stressed patients. Surg.Today 25, 774- 777 (1995).
31. C. Szabo: The pathophysiological role of peroxynitrite in shock, inflammation, and ischemia-reperfusion injury. Shock 6, 79-88 (1996). (Pubitemid 126727744)
32. H. Fahmi, D. Charon, M. Mondange and R. Chaby: Endotoxin-induced desensitization of mouse macrophages is mediated in part by nitric oxide production. Infect.Immun. 63, 1863-1869 (1995).
33. D. Soszynski: Inhibition of nitric oxide synthase delays the development of tolerance to LPS in rats. Physiol Behav. 76, 159-169 (2002). (Pubitemid 34521821)
34. K. Srisook and Y. N. Cha: Biphasic induction of heme oxygenase-1 expression in macrophages stimulated with lipopolysaccharide. Biochem.Pharmacol. 68, 1709-1720 (2004). (Pubitemid 39278493)
35. A. Koch, O. Boehm, P. A. Zacharowski, S. A. Loer, J. Weimann, H. Rensing, S. J. Foster, R. Schmidt, R. Berkels, S. Reingruber and K. Zacharowski: Inducible nitric oxide synthase and heme oxygenase-1 in the lung during lipopolysaccharide tolerance and cross tolerance. Crit Care Med. (2007).
36. G. P. Chrousos: The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N.Engl.J.Med. 332, 1351-1362 (1995).
37. I. A. MacPhee, F. A. Antoni and D. W. Mason: Spontaneous recovery of rats from experimental allergic encephalomyelitis is dependent on regulation of the immune system by endogenous adrenal corticosteroids. J.Exp.Med. 169, 431-445 (1989). (Pubitemid 19050641)
38. R. Abe, T. Shimosegawa, K. Kimura, T. Abe, J. Kashimura, M. Koizumi and T. Toyota: The role of endogenous glucocorticoids in rat experimental models of acute pancreatitis. Gastroenterology 109, 933-943 (1995).
39. H. O. Besedovsky and A. del Rey: Immune-neuroendocrine interactions: facts and hypotheses. Endocr.Rev. 17, 64-102 (1996).
40. T. Wilckens and R. De Rijk: Glucocorticoids and immune function: unknown dimensions and new frontiers. Immunol.Today 18, 418-424 (1997). (Pubitemid 27381982)
41. D. T. Boumpas, G. P. Chrousos, R. L. Wilder, T. R. Cupps and J. E. Balow: Glucocorticoid therapy for immune-mediated diseases: basic and clinical correlates. Ann.Intern.Med. 119, 1198-1208 (1993). (Pubitemid 23361450)
42. S. R. Bornstein and G. P. Chrousos: Clinical review 104: Adrenocorticotropin (ACTH)- and non-ACTHmediated regulation of the adrenal cortex: neural and immune inputs. J.Clin.Endocrinol.Metab 84, 1729-1736 (1999). (Pubitemid 30644284)
43. J. I. Webster and E. M. Sternberg: Role of the hypothalamic-pituitary- adrenal axis, glucocorticoids and glucocorticoid receptors in toxic sequelae of exposure to bacterial and viral products. J.Endocrinol. 181, 207-221 (2004). (Pubitemid 38744671)
44. D. M. Agnese, J. E. Calvano, S. J. Hahm, S. M. Coyle, S. A. Corbett, S. E. Calvano and S. F. Lowry: Human tolllike receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections. J.Infect.Dis. 186, 1522-1525 (2002). (Pubitemid 35286126)
45. S. Kiechl, E. Lorenz, M. Reindl, C. J. Wiedermann, F. Oberhollenzer, E. Bonora, J. Willeit and D. A. Schwartz: Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med 347, 185-192 (2002). (Pubitemid 34764822)
46. E. Lorenz, J. P. Mira, K. L. Cornish, N. C. Arbour and D. A. Schwartz: A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection. Infect.Immun. 68, 6398-6401 (2000).
47. S. R. Bornstein, P. Zacharowski, R. R. Schumann, A. Barthel, N. Tran, C. Papewalis, V. Rettori, S. M. McCann, K. Schulze-Osthoff, W. A. Scherbaum, J. Tarnow and K. Zacharowski: Impaired adrenal stress response in Toll-like receptor 2-deficient mice. Proc.Natl.Acad.Sci.U.S.A 101, 16695-16700 (2004). (Pubitemid 39557775)
48. K. Zacharowski, P. A. Zacharowski, A. Koch, A. Baban, N. Tran, R. Berkels, C. Papewalis, K. Schulze-Osthoff, P. Knuefermann, U. Zahringer, R. R. Schumann, V. Rettori, S. M. McCann and S. R. Bornstein: Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome. Proc.Natl.Acad.Sci.U.S.A 103, 6392-6397 (2006).
49. S. R. Bornstein, R. R. Schumann, V. Rettori, S. M. McCann and K. Zacharowski: Toll-like receptor 2 and Toll-like receptor 4 expression in human adrenals. Horm.Metab Res. 36, 470-473 (2004). (Pubitemid 39119251)
50. D. Annane, V. Sebille, C. Charpentier, P. E. Bollaert, B. Francois, J. M. Korach, G. Capellier, Y. Cohen, E. Azoulay, G. Troche, P. Chaumet-Riffaut and E. Bellissant: Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 288, 862-871 (2002).
51. S. R. Bornstein and J. Briegel: A new role for glucocorticoids in septic shock: balancing the immune response. Am.J.Respir.Crit Care Med. 167, 485-486 (2003).
52. M. S. Cooper and P. M. Stewart: Corticosteroid insufficiency in acutely ill patients. N.Engl.J.Med. 348, 727-734 (2003). (Pubitemid 36237043)
53. C. L. Sprung, D. Annane, D. Keh, R. Moreno, M. Singer, K. Freivogel, Y. G. Weiss, J. Benbenishty, A. Kalenka, H. Forst, P. F. Laterre, K. Reinhart, B. H. Cuthbertson, D. Payen and J. Briegel: Hydrocortisone therapy for patients with septic shock. N.Engl.J.Med 358, 111-124 (2008).
54. J. Bruce, Z. H. Krukowski, G. Al Khairy, E. M. Russell and K. G. Park: Systematic review of the definition and measurement of anastomotic leak after gastrointestinal surgery. Br.J.Surg 88, 1157-1168 (2001). (Pubitemid 34015597)
55. Y. Parc, P. Frileux, G. Schmitt, N. Dehni, J. M. Ollivier and R. Parc: Management of postoperative peritonitis after anterior resection: experience from a referral intensive care unit. Dis.Colon Rectum 43, 579- 587 (2000).
56. D. L. Williams, T. Ha, C. Li, J. H. Kalbfleisch, J. Schweitzer, W. Vogt and I. W. Browder: Modulation of tissue Toll-like receptor 2 and 4 during the early phases of polymicrobial sepsis correlates with mortality. Crit Care Med. 31, 1808-1818 (2003). (Pubitemid 36714241)
57. C. F. Benjamim, S. K. Lundy, N. W. Lukacs, C. M. Hogaboam and S. L. Kunkel: Reversal of long-term sepsisinduced immunosuppression by dendritic cells. Blood 105, 3588-3595 (2005). (Pubitemid 40628205)
58. P. C. Sedman, J. MacFie, P. Sagar, C. J. Mitchell, J. May, B. Mancey-Jones and D. Johnstone: The prevalence of gut translocation in humans. Gastroenterology 107, 643- 649 (1994). (Pubitemid 24265509)
59. J. MacFie: Current status of bacterial translocation as a cause of surgical sepsis. Br.Med Bull. 71, 1-11 (2004).
60. E. Bolke, P. M. Jehle, K. Orth, G. Steinbach, A. Hannekum and M. Storck: Changes of gut barrier function during anesthesia and cardiac surgery. Angiology 52, 477- 482 (2001). (Pubitemid 32660791)
61. J. MacFie: Current status of bacterial translocation as a cause of surgical sepsis. Br.Med.Bull. 71, 1-11 (2004).
62. H. Tsujimoto, S. Ono, T. Majima, P. A. Efron, M. Kinoshita, H. Hiraide, L. L. Moldawer and H. Mochizuki: Differential toll-like receptor expression after ex vivo lipopolysaccharide exposure in patients with sepsis and following surgical stress. Clin.Immunol. 119, 180-187 (2006).
63. L. Harter, L. Mica, R. Stocker, O. Trentz and M. Keel: Increased expression of toll-like receptor-2 and -4 on leukocytes from patients with sepsis. Shock 22, 403- 409 (2004). (Pubitemid 39472563)
64. J. S. Hadley, J. E. Wang, L. C. Michaels, C. M. Dempsey, S. J. Foster, C. Thiemermann and C. J. Hinds: Alterations in inflammatory capacity and TLR expression on monocytes and neutrophils after cardiopulmonary bypass. Shock 27, 466-473 (2007). (Pubitemid 46626072)
65. M. K. Brunialti, P. S. Martins, C. H. Barbosa de, F. R. Machado, L. M. Barbosa and R. Salomao: TLR2, TLR4, CD14, CD11B, and CD11C expressions on monocytes surface and cytokine production in patients with sepsis, severe sepsis, and septic shock. Shock 25, 351-357 (2006).
66. D. Bastian, H. Shegarfi, B. Rolstad, C. Naper, S. P. Lyngstadaas and O. Reikeras: Investigation of lipopolysaccharide receptor expression on human monocytes after major orthopaedic surgery. Eur.Surg.Res. 40, 239-245 (2008). (Pubitemid 351252934)
67. B. Dybdahl, A. Wahba, E. Lien, T. H. Flo, A. Waage, N. Qureshi, O. F. Sellevold, T. Espevik and A. Sundan: Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4. Circulation 105, 685-690 (2002). (Pubitemid 34157370)
68. H. Ikushima, T. Nishida, K. Takeda, T. Ito, T. Yasuda, M. Yano, S. Akira and H. Matsuda: Expression of Toll-like receptors 2 and 4 is downregulated after operation. Surgery 135, 376-385 (2004). (Pubitemid 38453492)
69. J. E. Calvano, D. M. Agnese, J. Y. Um, M. Goshima, R. Singhal, S. M. Coyle, M. T. Reddell, A. Kumar, S. E. Calvano and S. F. Lowry: Modulation of the lipopolysaccharide receptor complex (CD14, TLR4, MD-2) and toll-like receptor 2 in systemic inflammatory response syndrome-positive patients with and without infection: relationship to tolerance. Shock 20, 415-419 (2003).
70. D. Ducloux, M. Deschamps, M. Yannaraki, C. Ferrand, J. Bamoulid, P. Saas, A. Kazory, J. M. Chalopin and P. Tiberghien: Relevance of Toll-like receptor-4 polymorphisms in renal transplantation. Kidney Int. 67, 2454-2461 (2005). (Pubitemid 41623410)
71. N. W. Schroder and R. R. Schumann: Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease. Lancet Infect.Dis. 5, 156-164 (2005). (Pubitemid 40568671)
72. K. Tomokiyo, Y. Kamikubo, T. Hanada, T. Araki, Y. Nakatomi, Y. Ogata, S. M. Jung, T. Nakagaki and M. Moroi: Von Willebrand factor accelerates platelet adhesion and thrombus formation on a collagen surface in plateletreduced blood under flow conditions. Blood 105, 1078- 1084 (2005). (Pubitemid 40170878)
73. B. Savage, M. Cattaneo and Z. M. Ruggeri: Mechanisms of platelet aggregation. Curr.Opin.Hematol. 8, 270-276 (2001). (Pubitemid 32826497)
74. K. G. Mann, C. van't Veer, K. Cawthern and S. Butenas: The role of the tissue factor pathway in initiation of coagulation. Blood Coagul.Fibrinolysis 9 Suppl 1, S3-S7 (1998). (Pubitemid 28511559)
75. F. J. Castellino and V. A. Ploplis: Structure and function of the plasminogen/plasmin system. Thromb.Haemost. 93, 647-654 (2005). (Pubitemid 40485399)
76. K. Karkouti, D. N. Wijeysundera, T. M. Yau, W. S. Beattie, E. Abdelnaem, S. A. McCluskey, M. Ghannam, E. Yeo, G. Djaiani and J. Karski: The independent association of massive blood loss with mortality in cardiac surgery. Transfusion 44, 1453-1462 (2004). (Pubitemid 39318980)
77. N. Tabuchi, I. Tigchelaar and W. van Oeveren: Shearinduced pathway of platelet function in cardiac surgery. Semin.Thromb.Hemost. 21 Suppl 2, 66-70 (1995).
78. M. J. Ray, N. A. Marsh and G. A. Hawson: Relationship of fibrinolysis and platelet function to bleeding after cardiopulmonary bypass. Blood Coagul.Fibrinolysis 5, 679-685 (1994). (Pubitemid 24366359)
79. S. Dial, E. Delabays, M. Albert, A. Gonzalez, J. Camarda, A. Law and D. Menzies: Hemodilution and surgical hemostasis contribute significantly to transfusion requirements in patients undergoing coronary artery bypass. J.Thorac.Cardiovasc.Surg. 130, 654-661 (2005).
80. R. L. Heimark, K. Kurachi, K. Fujikawa and E. W. Davie: Surface activation of blood coagulation, fibrinolysis and kinin formation. Nature 286, 456-460 (1980). (Pubitemid 10017679)
81. M. D. Boisclair, D. A. Lane, H. Philippou, M. P. Esnouf, S. Sheikh, B. Hunt and K. J. Smith: Mechanisms of thrombin generation during surgery and cardiopulmonary bypass. Blood 82, 3350-3357 (1993). (Pubitemid 23356706)
82. H. J. Hertfelder, M. Bos, D. Weber, K. Winkler, P. Hanfland and C. J. Preusse: Perioperative monitoring of primary and secondary hemostasis in coronary artery bypass grafting. Semin.Thromb.Hemost. 31, 426-440 (2005). (Pubitemid 41362349)
83. M. D. Boisclair, H. Ireland and D. A. Lane: Assessment of hypercoagulable states by measurement of activation fragments and peptides. Blood Rev. 4, 25-40 (1990). (Pubitemid 20163926)
84. P. Li, J. Sanders, E. Hawe, D. Brull, H. Montgomery and S. Humphries: Inflammatory response to coronary artery bypass surgery: does the heme-oxygenase-1 gene microsatellite polymorphism play a role? Chin Med.J. (Engl.) 118, 1285-1290 (2005). (Pubitemid 41150353)
85. P. J. Hess Jr.: Systemic inflammatory response to coronary artery bypass graft surgery. Am.J.Health Syst.Pharm. 62, S6-S9 (2005). (Pubitemid 41324180)
86. G. Kalweit, J. Bach, H. Huwer, J. Winning and P. Hellstern: The impact of cardiac ischemia and reperfusion on markers of activated haemostasis and fibrinolysis during cardiopulmonary bypass: comparison of plasma levels in arterial and coronary venous blood. Thromb.Res. 116, 33- 39 (2005). (Pubitemid 40546323)
87. R. Grossmann, J. Babin-Ebell, M. Misoph, S. Schwender, K. Neukam, T. Hickethier, O. Elert and F. Keller: Changes in coagulation and fibrinolytic parameters caused by extracorporeal circulation. Heart Vessels 11, 310-317 (1996). (Pubitemid 27298206)
88. A. J. Chu: Tissue factor upregulation drives a thrombosis-inflammation circuit in relation to cardiovascular complications. Cell Biochem.Funct. (2004).
89. M. E. Lissauer, S. B. Johnson, G. Siuzdak, G. Bochicchio, C. Whiteford, B. Nussbaumer, R. Moore and T. M. Scalea: Coagulation and complement protein differences between septic and uninfected systemic inflammatory response syndrome patients. J.Trauma 62, 1082-1092 (2007). (Pubitemid 46742955)
90. G. Lissalde-Lavigne, C. Combescure, L. Muller, C. Bengler, A. Raillard, J. Y. Lefrant and J. C. Gris: Simple coagulation tests improve survival prediction in patients with septic shock. J.Thromb.Haemost. 6, 645-653 (2008). (Pubitemid 351404932)
91. S. Gando, S. Nanzaki, S. Sasaki and O. Kemmotsu: Significant correlations between tissue factor and thrombin markers in trauma and septic patients with disseminated intravascular coagulation. Thromb.Haemost. 79, 1111-1115 (1998). (Pubitemid 28297156)
92. S. Gando, S. Nanzaki and O. Kemmotsu: Disseminated intravascular coagulation and sustained systemic inflammatory response syndrome predict organ dysfunctions after trauma: application of clinical decision analysis. Ann.Surg. 229, 121-127 (1999). (Pubitemid 30190389)
93. B. Dixon, J. Santamaria and D. Campbell: Coagulation activation and organ dysfunction following cardiac surgery. Chest 128, 229-236 (2005). (Pubitemid 40994478)
94. M. Schouten, W. J. Wiersinga, M. Levi and P. T. van der: Inflammation, endothelium, and coagulation in sepsis. J.Leukoc.Biol. 83, 536-545 (2008). (Pubitemid 351966862)
95. M. Riewald, V. V. Kravchenko, R. J. Petrovan, P. J. O'Brien, L. F. Brass, R. J. Ulevitch and W. Ruf: Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1. Blood 97, 3109- 3116 (2001).
96. G. Busch, I. Seitz, B. Steppich, S. Hess, R. Eckl, A. Schomig and I. Ott: Coagulation factor Xa stimulates interleukin-8 release in endothelial cells and mononuclear leukocytes: implications in acute myocardial infarction. Arterioscler.Thromb.Vasc.Biol. 25, 461-466 (2005). (Pubitemid 40189174)
97. A. Rahman, A. L. True, K. N. Anwar, R. D. Ye, T. A. Voyno-Yasenetskaya and A. B. Malik: Galpha (q) and Gbetagamma regulate PAR-1 signaling of thrombin-induced NF-kappaB activation and ICAM-1 transcription in endothelial cells. Circ.Res. 91, 398-405 (2002). (Pubitemid 35034207)
98. M. E. Lee, K. J. Rhee and S. U. Nham: Fragment E derived from both fibrin and fibrinogen stimulates interleukin-6 production in rat peritoneal macrophages. Mol.Cells 9, 7-13 (1999). (Pubitemid 129620070)
99. L. R. Languino, A. Duperray, K. J. Joganic, M. Fornaro, G. B. Thornton and D. C. Altieri: Regulation of leukocyteendothelium interaction and leukocyte transendothelial migration by intercellular adhesion molecule 1-fibrinogen recognition. Proc.Natl.Acad.Sci U.S.A 92, 1505-1509 (1995).
100. D. C. Altieri, J. Plescia and E. F. Plow: The structural motif glycine 190-valine 202 of the fibrinogen gamma chain interacts with CD11b/CD18 integrin (alpha M beta 2, Mac-1) and promotes leukocyte adhesion. J Biol.Chem. 268, 1847- 1853 (1993). (Pubitemid 23033584)
101. D. C. Altieri, A. Duperray, J. Plescia, G. B. Thornton and L. R. Languino: Structural recognition of a novel fibrinogen gamma chain sequence (117-133) by intercellular adhesion molecule-1 mediates leukocyte-endothelium interaction. J Biol.Chem. 270, 696-699 (1995).
102. F. M. Szaba and S. T. Smiley: Roles for thrombin and fibrin (ogen) in cytokine/chemokine production and macrophage adhesion in vivo. Blood 99, 1053-1059 (2002). (Pubitemid 34525570)
103. P. Petzelbauer, P. A. Zacharowski, Y. Miyazaki, P. Friedl, G. Wickenhauser, F. J. Castellino, M. Groger, K. Wolff and K. Zacharowski: The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemiareperfusion injury. Nat.Med. 11, 298-304 (2005). (Pubitemid 40460558)
104. A. Holmberg, D. Bergqvist, B. Westman and A. Siegbahn: Cytokine and fibrinogen response in patients undergoing open abdominal aortic aneurysm surgery. Eur.J.Vasc.Endovasc.Surg. 17, 294-300 (1999). (Pubitemid 29141372)
105. O. Reikeraas, J. Sun, C. D. Krohn, J. E. Wang and A. O. Aasen: Reduced capacity of whole blood leucocytes to express tumour necrosis factor-alpha and interleukin-10 following major orthopaedic surgery. Eur.Surg Res. 37, 210-215 (2005). (Pubitemid 41547087)
106. K. Schumacher, S. Korr, J. F. Vazquez-Jimenez, G. von Bernuth, J. Duchateau and M. C. Seghaye: Does cardiac surgery in newborn infants compromise blood cell reactivity to endotoxin? Crit Care 9, R549-R555 (2005).
107. J. Borgermann, I. Friedrich, S. Flohe, J. Spillner, M. Majetschak, O. Kuss, A. Sablotzki, T. Feldt, J. C. Reidemeister and F. U. Schade: Tumor necrosis factoralpha production in whole blood after cardiopulmonary bypass: downregulation caused by circulating cytokineinhibitory activities. J.Thorac.Cardiovasc.Surg 124, 608- 617 (2002).
108. R. Prondzinsky, A. Knupfer, H. Loppnow, F. Redling, D. W. Lehmann, I. Stabenow, R. Witthaut, S. Unverzagt, J. Radke, H. R. Zerkowski and K. Werdan: Surgical trauma affects the proinflammatory status after cardiac surgery to a higher degree than cardiopulmonary bypass. J.Thorac.Cardiovasc.Surg. 129, 760-766 (2005). (Pubitemid 40487875)
109. A. Franke, W. Lante, V. Fackeldey, H. P. Becker, E. Kurig, L. G. Zoller, C. Weinhold and A. Markewitz: Proinflammatory cytokines after different kinds of cardiothoracic surgical procedures: is what we see what we know? Eur.J.Cardiothorac.Surg. 28, 569-575 (2005). (Pubitemid 41345246)
110. V. Tomic, S. Russwurm, E. Moller, R. A. Claus, M. Blaess, F. Brunkhorst, M. Bruegel, K. Bode, F. Bloos, J. Wippermann, T. Wahlers, H. P. Deigner, J. Thiery, K. Reinhart and M. Bauer: Transcriptomic and proteomic patterns of systemic inflammation in on-pump and offpump coronary artery bypass grafting. Circulation 112, 2912-2920 (2005). (Pubitemid 41612292)
111. R. Sarbinowski, S. Arvidsson, M. Tylman, T. Oresland and A. Bengtsson: Plasma concentration of procalcitonin and systemic inflammatory response syndrome after colorectal surgery. Acta Anaesthesiol.Scand. 49, 191-196 (2005). (Pubitemid 40313231)
112. R. R. Hutchins, M. P. Gunning, D. N. Lucas, T. G. Allen-Mersh and N. C. Soni: Relaparotomy for suspected intraperitoneal sepsis after abdominal surgery. World J.Surg. 28, 137-141 (2004). (Pubitemid 38299016)
113. M. M. Wurfel, A. C. Gordon, T. D. Holden, F. Radella, J. Strout, O. Kajikawa, J. T. Ruzinski, G. Rona, R. A. Black, S. Stratton, G. P. Jarvik, A. M. Hajjar, D. A. Nickerson, M. Rieder, J. Sevransky, J. P. Maloney, M. Moss, K. C. Barnes, J. A. Russel and T. R. Martin: Tolllike Receptor 1 Polymorphisms Affect Innate Immune Responses and Outcomes in Sepsis. Am.J.Respir.Crit Care Med (2008).
114. E. Lorenz, J. P. Mira, K. L. Frees and D. A. Schwartz: Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock. Arch.Intern.Med. 162, 1028-1032 (2002). (Pubitemid 34492532)
115. N. J. Child, I. A. Yang, M. C. Pulletz, K. Courcy-Golder, A. L. Andrews, V. J. Pappachan and J. W. Holloway: Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome. Biochem.Soc.Trans. 31, 652-653 (2003). (Pubitemid 36750749)
116. R. F. De Jongh, K. C. Vissers, L. H. Booij, K. L. De Jongh, P. Vincken and T. F. Meert: Interleukin-6 and perioperative thermoregulation and HPA-axis activation. Cytokine 21, 248-256 (2003). (Pubitemid 36765417)
117. N. Ameziane, T. Beillat, P. Verpillat, S. Chollet-Martin, M. C. Aumont, P. Seknadji, M. Lamotte, D. Lebret, V. Ollivier and D. de Prost: Association of the Toll-like receptor 4 gene Asp299Gly polymorphism with acute coronary events. Arterioscler.Thromb.Vasc.Biol. 23, e61- e64 (2003).
118. C. L. Holmes, J. A. Russell and K. R. Walley: Genetic polymorphisms in sepsis and septic shock: role in prognosis and potential for therapy. Chest 124, 1103-1115 (2003). (Pubitemid 37123334)
119. N. Cheng, R. He, J. Tian, P. P. Ye and R. D. Ye: Cutting edge: TLR2 is a functional receptor for acute-phase serum amyloid A. J.Immunol. 181, 22-26 (2008).
120. S. Thakran, H. Li, C. L. Lavine, M. A. Miller, J. E. Bina, X. R. Bina and F. Re: Identification of Francisella tularensis lipoproteins that stimulate the toll-like receptor (TLR) 2/TLR1 heterodimer. J.Biol.Chem. 283, 3751-3760 (2008).
121. N. Funderburg, M. M. Lederman, Z. Feng, M. G. Drage, J. Jadlowsky, C. V. Harding, A. Weinberg and S. F. Sieg: Human -defensin-3 activates professional antigenpresenting cells via Toll-like receptors 1 and 2. Proc.Natl.Acad.Sci.U.S. A 104, 18631-18635 (2007). (Pubitemid 350210748)
122. S. Chang, A. Dolganiuc and G. Szabo: Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins. J.Leukoc.Biol. 82, 479-487 (2007). (Pubitemid 47367138)
123. K. W. Boehme, M. Guerrero and T. Compton: Human cytomegalovirus envelope glycoproteins B and H are necessary for TLR2 activation in permissive cells. J.Immunol. 177, 7094-7102 (2006). (Pubitemid 44715077)
124. S. Gariboldi, M. Palazzo, L. Zanobbio, S. Selleri, M. Sommariva, L. Sfondrini, S. Cavicchini, A. Balsari and C. Rumio: Low molecular weight hyaluronic acid increases the self-defense of skin epithelium by induction of betaInnate defensin 2 via TLR2 and TLR4. J.Immunol. 181, 2103- 2110 (2008).
125. S. Gillet-Hladky, K. Duperrier, S. Picandet, V. Mathias, M. C. de Carvalho, J. Bernaud, D. Masseau, J. Bienvenu and D. Rigal: Induction of high expression of CCR7 and high production of IL-12 in human monocytederived dendritic cells by a new bacterial component: LCOS 1013. Int.Immunopharmacol. 8, 1151-1163 (2008).
126. R. Ahmad, B. S. El, P. Cordeiro and J. Menezes: Requirement of TLR2-mediated signalling for the induction of IL-15 gene expression in human monocytic cells by HSV-1. Blood (2008).
127. A. B. Tarabishy, B. Aldabagh, Y. Sun, Y. Imamura, P. K. Mukherjee, J. H. Lass, M. A. Ghannoum and E. Pearlman: MyD88 regulation of Fusarium keratitis is dependent on TLR4 and IL-1R1 but not TLR2. J.Immunol. 181, 593-600 (2008).
128. K. L. Richard, M. Filali, P. Prefontaine and S. Rivest: Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease. J.Neurosci. 28, 5784-5793 (2008).
129. N. J. Nilsen, S. Deininger, U. Nonstad, F. Skjeldal, H. Husebye, D. Rodionov, A. S. von, T. Hartung, E. Lien, O. Bakke and T. Espevik: Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling; role of CD14 and CD36. J.Leukoc.Biol. 84, 280-291 (2008). (Pubitemid 351960303)
130. N. J. Nilsen, S. Deininger, U. Nonstad, F. Skjeldal, H. Husebye, D. Rodionov, A. S. von, T. Hartung, E. Lien, O. Bakke and T. Espevik: Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling; role of CD14 and CD36. J.Leukoc.Biol. 84, 280-291 (2008). (Pubitemid 351960303)
131. K. Page, K. M. Lierl, V. S. Hughes, P. Zhou, J. R. Ledford and M. Wills-Karp: TLR2-mediated activation of neutrophils in response to German cockroach frass. J.Immunol. 180, 6317-6324 (2008).
132. P. S. Coelho, A. Klein, A. Talvani, S. F. Coutinho, O. Takeuchi, S. Akira, J. S. Silva, H. Canizzaro, R. T. Gazzinelli and M. M. Teixeira: Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes induce in vivo leukocyte recruitment dependent on MCP-1 production by IFN-gamma-primedmacrophages. J.Leukoc.Biol. 71, 837-844 (2002).
133. J. Fischer, C. Suire and H. Hale-Donze: TLR2 recognition of the microsporidia Encephalitozoon spp. induces nuclear translocation of NF-{kappa}B and subsequent inflammatory responses. Infect.Immun. (2008).
134. K. Bieback, E. Lien, I. M. Klagge, E. Avota, J. Schneider-Schaulies, W. P. Duprex, H. Wagner, C. J. Kirschning, M. Ter, V and S. Schneider-Schaulies: Hemagglutinin protein of wild-type measles virus activates toll-like receptor 2 signaling. J.Virol. 76, 8729-8736 (2002). (Pubitemid 34864068)