Requirement of TLR2-mediated signaling for the induction of IL-15 gene expression in human monocytic cells by HSV-1

Blood

Volumn 112, Issue 6, 2008, Pages 2360-2368

  Ahmad, Rasheed ^a   El Bassam, Souad ^a   Cordeiro, Paulo ^a   Menezes, José ^a,b  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITY OF MONTREAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 15; MONOCLONAL ANTIBODY; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN TIRAP; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR SP1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; IRAK1 PROTEIN, HUMAN; MEMBRANE PROTEIN; TIRAP PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE ACTIVATION; GENE ACTIVITY; GENE CONTROL; GENE EXPRESSION; GENE INDUCTION; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; MONOCYTE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSACTIVATION; UPREGULATION; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; PROTEIN TRANSPORT; VIROLOGY;

GENE EXPRESSION REGULATION; HERPESVIRUS 1, HUMAN; HUMANS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; INTERLEUKIN-15; MEMBRANE GLYCOPROTEINS; MONOCYTES; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; PROTEIN TRANSPORT; RECEPTORS, INTERLEUKIN-1; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 6; TOLL-LIKE RECEPTOR 2;

EID: 55249113979     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-02-137711     Document Type: Article

References (60)

1. Biron CA, Nguyen KB, Pien GC, Cousens LP, Salazar-MatherTP. Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu Rev Immunol. 1999;17:189-220.
2. Biron CA, Byron KS, Sullivan JL. Severe herpesvirus infections in an adolescent without natural killer cells. N Engl J Med. 1989:320:1731-1735.
3. Ahmad A, Sharif-Askari E. Fawaz L. Menezes J. Innate immune response of the human host to exposure with herpes simplex virus type 1: in vitro control of the virus infection by enhanced natural killer activity via interleukin-15 induction. J Virol. 2000;74:7196-7203.
4. Biron CA. Turgiss LR, Welsh RM. Increase in NK cell number and turnover rate during acute viral infection. J Immunol. 1983;131:1539-1545.
5. Carson WE, Ross ME, Baiocchi RA, et al. Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro. J Clin Invest. 1995;96:2578-2582.
6. Mrozek E, Anderson P, Caligiuri MA. Role of interleukin-15 in the development of human CD56+ natural killer cells from CD34+ hematopoietic progenitor cells. Blood. 1996;87:2632-2640.
7. Kennedy MK, Glaccum M, Brown SN, etal. Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J Exp Med. 2000:191:771-780.
8. Lodolce JP, Boone DL, Chai S, et al. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity. 1998;9:669-676.
9. DiSanto JP, MullerW, Guy-Grand D, Fischer A, Rajewsky K. Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. Proc Natl Acad Sci U S A. 1995: 92:377-381.
10. Suzuki H, Duncan GS, Takimoto H, Mak TW. Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain. J Exp Med. 1997:185:499-505.
11. NosakaT, van Deursen JM, Tripp RA, et al. Defective lymphoid development in mice lacking Jak3. Science. 1995:270:800-802.
12. ParkSY, Saijo K, TakahashiT, et al. Developmental defects of lymphoid cells in Jak3 kinasedeficient mice. Immunity. 1995:3:771-782.
13. Mclnnes IB, Gracie JA. lnterleukin-15: a new cytokine target for the treatment of inflammatory diseases. CurrOpin Pharmacol. 2004:4:392-397.
14. Ahmad A, Ahmad R, TomaE, Morisset R, Menezes J. Impaired induction of IL-15 in response to herpes simplex virus type 1 infection in peripheral blood mononuclear cells of H IV-infected patients. AIDS. 2000; 14:744-746.
15. AshkarAA, Rosenthal KL. lnterleukin-15 and natural killer and NKT cells play a critical role in innate protection against genital herpes simplex virus type 2 infection. J Virol. 2003:77:10168-10171.
16. Gosselin J. TomoluA, Gallo RC, Flamand L. lnterleukin-15 as an activator of natural killer cellmediated antiviral response. Blood. 1999;94: 4210-4219.
17. Tsunobuchi H, Nishimura H. Goshima F, et al. A protective role of interleukin-15 in a mouse model for systemic infection with herpes simplex virus. Virology. 2000:275:57-66.
18. Sharif-Askari E, FawazLM, Tran P, AhmadA, Menezes J. Interleukin 15-mediated induction of cytotoxic effector cells capable of eliminating Epstein-Barr virus-transformed/immortalized lymphocytes in culture. J Natl Cancer Inst. 2001;93: 1724-1732.
19. Fawaz LM, Sharif-Askari E, Menezes J. Upregulation of NK cytotoxic activity via IL-15 induction by different viruses: a comparative study. J Immunol. 1999:163:4473-4480.
20. Tran P, Ahmad R, Xu J, Ahmad A, Menezes J. Host's innate immune response to fungal and bacterial agents in vitro: up-regulation of interleukin-15 gene expression resulting in enhanced natural killer cell activity. Immunology. 2003:109:263-270.
21. Flamand L. Stefanescu I. Menezes J. Human herpesvirus-6 enhances natural killer cell cytotoxicityvia IL-15. J Clin Invest. 1996;97:1373-1381.
22. Kawai T. Akira S. Innate immune recognition of viral infection. Nat Immunol. 2006;7:131-137.
23. Aravalli RN, Hu S. RowenTN. PalmquistJM. Lokensgard JR. Cutting edge: TLR2-mediated proinflammatory cytokine and chemokine production by microglial cells in response to herpes simplex virus. J Immunol. 2005;175:4189-4193.
24. Kurt-Jones EA. Chan M. Zhou S, et al. Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. Proc Natl Acad Sci U S A. 2004:101:1315-1320.
25. Lund J. Sato A, Akira S, Medzhitov R, Iwasaki A. Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med. 2003;198:513-520.
26. Kawai T, Akira S. TLR signaling. Cell Death Differ. 2006:13:816-825.
27. Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol. 2004;4:499-511.
28. Takeda K. KaishoT, Akira S. Toll-like receptors. Annu Rev Immunol. 200321:335-376.
29. Barton GM, Medzhitov R. Toll-like receptor signaling pathways. Science. 2003:300:1524-1525.
30. Cao Z. Xiong J, Takeuchi M, Kurama T. Goeddel DV. TRAF6 is a signal transducer for interleukin-1. Nature. 1996;383:443-446.
31. Cao Z. Henzel WJ. Gao X. IRAK: a kinase associated with the interleukin-1 receptor. Science. 1996:271:1128-1131.
32. Gohda J. MatsumuraT, Inoue J. Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling. J Immunol. 2004:173:2913-2917.
33. Hayden MS. West AP, Ghosh S. NF-kappaB and the immune response. Oncogene. 2006;25:6758-6780.
34. Gosselin J, Flamand L, D'Addario M, Hiscott J, Menezes J. Infection of peripheral blood mononuclear cells by herpes simplex and Epstein-Barr viruses: differential induction of interleukin 6 and tumor necrosis factor-alpha. J Clin Invest. 1992: 89:1849-1856.
35. Ahmad R. Ennaciri J, Cordeiro P. El Bassam S, Menezes J. Herpes simplex virus-1 up-regulates IL-15 gene expression in monocytic cells through the activation of protein tyrosine kinase and PKC zeta/lambda signaling pathways. J Mol Biol. 2007:367:25-35.
36. Musso T. Calosso L, Zucca M, et al. Human monocytes constitutively express membranebound, biologically active, and interferon-gammaupregulated interleukin-15. Blood. 1999;93:3531-3539.
37. Kurt-Jones EA. Belko J, Yu C, et al. The role of toll-like receptors in herpes simplex infection in neonates. J Infect Dis. 2005;191:746-748.
38. Sato A. Linehan MM, Iwasaki A. Dual recognition of herpes simplex viruses byTLR2 and TLR9 in dendritic cells. Proc Natl Acad Sci USA. 2006; 103:17343-17348.
39. Haehnel V. Schwarzfischer L. Fenton MJ. Rehli M. Transcriptional regulation of the human tolllike receptor 2 gene in monocytes and macrophages. J Immunol. 2002:168:5629-5637.
40. Blume SW. Snyder RC. Ray R, et al. Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo. J Clin Invest. 1991;88: 1613-1621.
41. Martin B, Vaquero A, Priebe W, Portugal J. Bisanthracycline WP631 inhibits basal and Sp1-activated transcription initiation in vitro. Nucleic Acids Res. 1999;27:3402-3409.
42. Horng T, Barton GM, Flavell RA, Medzhitov R. The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature. 2002; 420:329-333.
43. Yamamoto M, Sato S, Hemmi H, et al. Essential role forTIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature. 2002; 420:324-329.
44. Kawai T Akira S. Antiviral signaling through pattern recognition receptors. J Biochem. 2007:141: 137-145.
45. Krug A. Luker GD. Barchet W. et al. Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9. Blood. 2004:103:1433-1437.
46. Adachi O. Kawai T, Takeda K. et al. Targeted disruption of the MyD88 gene results in loss of IL-1 - and IL-18-mediated function. Immunity. 1998:9: 143-150.
47. Mansur DS, Kroon EG, Nogueira ML, et al. Lethal encephalitis in myeloid differentiation factor 88-deficient mice infected with herpes simplex virus 1. Am J Pathol. 2005:166:1419-1426.
48. Tengvall S, Harandi AM. Importance of myeloid differentiation factor 88 in innate and acquired immune protection against genital herpes infection in mice. J Reprod Immunol. 2008:78:49-57.
49. Zhou S, Kurt-Jones EA, Mandell L, et al. MyD88 is critical for the development of innate and adaptive immunity during acute lymphocytic choriomeningitis virus infection. Eur J Immunol. 2005; 35:822-830.
50. Zhou S, Kurt-Jones EA, Fitzgerald KA, et al. Role of MyD88 in route-dependent susceptibility to vesicular stomatitis virus infection. J Immunol. 2007; 178:5173-5181.
51. Bieback K, Lien E, Klagge IM, et al. Hemagglutinin protein of wild-type measles virus activates toll-like receptor 2 signaling. J Virol. 2002;76: 8729-8736.
52. DolganiucA, Oak S, Kodys K, et al. Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation. Gastroenterology. 2004;127:1513-1524.
53. Duesberg U, von dem Bussche A, Kirschning C, Miyake K, Sauerbruch T, Spengler U. Cell activation by synthetic lipopeptides of the hepatitis C virus (HCV)-core protein is mediated by toll like receptors (TLRs) 2 and 4. Immunol Lett. 2002;84: 89-95.
54. Riordan SM, Skinner NA. KurtovicJ, et al. Tolllike receptor expression in chronic hepatitis C: correlation with pro-inflammatory cytokine levels and liver injury. Inflamm Res. 2006:55:279-285.
55. Yakushijin T, KantoT, Inoue M, et al. Reduced expression and functional impairment of Toll-like receptor 2 on dendritic cells in chronic hepatitis C virus infection. Hepatol Res. 2006;34:156-162.
56. SheedyFJ, O'Neill LA. The Troll in Toll: Mai and Tram as bridges for TLR2 and TLR4 signaling. J Leukoc Biol. 2007;82:196-203.
57. O'Neill LA. The role of MyD88-like adapters in Toll-like receptor signal transduction. Biochem SocTrans. 2003;31:643-647.
58. Fitzgerald KA, Palsson-McDermott EM, Bowie AG, et al. Mai (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature. 2001:413:78-83.
59. Horng T Barton GM, Medzhitov R. TIRAP: an adapter molecule in the Toll signaling pathway. Nat Immunol. 2001;2:835-841.
60. O'Neill LA. How Toll-like receptors signal: what we know and what we don't know. Curr Opin Immunol. 2006;18:3-9.