MyD88 regulation of fusarium keratitis is dependent on tlr4 and il-1r1 but not TLR2

Journal of Immunology

Volumn 181, Issue 1, 2008, Pages 593-600

  Tarabishy, Ahmad B ^a   Aldabagh, Bishr ^a   Sun, Yan ^a   Imamura, Yoshifumi ^a   Mukherjee, Pranab K ^a   Lass, Jonathan H ^a   Ghannoum, Mahmoud A ^a,b   Pearlman, Eric ^a,c  

^a Department of Ophthalmology and Visual Sciences ^*  (United States)

^b UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CXCL1 CHEMOKINE; INTERLEUKIN 1ALPHA; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; INTERLEUKIN 1 RECEPTOR TYPE I; MYD88 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CONTROLLED STUDY; FUNGUS GROWTH; FUSARIUM SOLANI; IMMUNOREGULATION; INFECTION RESISTANCE; KERATOMYCOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; FUSARIUM; GENETICS; IMMUNOLOGY; IMMUNOTHERAPY; KERATITIS; METABOLISM; MOUSE MUTANT; NEUTROPHIL CHEMOTAXIS; PATHOLOGY; PHYSIOLOGY;

ANIMALS; CHEMOKINE CXCL1; FUSARIUM; IMMUNOTHERAPY; KERATITIS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; NEUTROPHIL INFILTRATION; RECEPTORS, INTERLEUKIN-1 TYPE I; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 47949085611     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.1.593     Document Type: Article

References (49)

1. Chang, D. C, G. B. Grant, K. O'Donnell, K. A. Wannemuehler, J. Noble-Wang, C. Y. Rao, L. M. Jacobson, C. S. Crowell, R. S. Sneed, F. M. Lewis, et al. 2006. Multistate outbreak of Fusarium keratitis associated with use of a contact lens solution. J. Am. Med. Assoc. 296: 953-963.
2. Imamura, Y., J. Chandra, P. K. Mukherjee, A. A. Lattif, L. B. Szczotka-Flynn, E. Pearlman, J. II. Lass, K. O'Donnell, and M. A. Ghannoum. 2008. Fusarium and Candida albicans biofilms on soft contact lenses: model development, influence of lens type, and susceptibility to lens care solutions. Antimicrob. Agents Chemother. 52: 171-182.
3. Rosa, R. H., Jr., D. Miller, and E. C. Alfonso. 1994. The changing spectrum of fungal keratitis in south Florida. Ophthalmology 101: 1005-1013.
4. Bharathi, M. J., R. Ramakrishnan, R. Meenakshi, S. Padmavathy, C. Shivakumar, and M. Srinivasan. 2007. Microbial keratitis in South India: influence of risk factors, climate, and geographical variation. Ophthalmic Epidemiol. 14: 61-69.
5. Thomas, P. A., and P. Geraldine. 2007. Infectious keratitis. Curr. Opin. Infect. Dis. 20: 129-141.
6. Xie, L., W. Zhong, W. Shi, and S. Sun. 2006. Spectrum of fungal keratitis in north China. Ophthalmology 113: 1943-1948.
7. Zhang, N., K. O'Donnell, D. A. Sutton, F. A. Nalim, R. C. Summerbell, A. A. Padhye, and D. M. Geiser. 2006. Members of the Fusarium solani species complex that cause infections in both humans and plants are common in the environment. J. Clin. Microbiol. 44: 2186-2190.
8. Madhavan, M., C. Ratnakar, A. J. Veliath, R. Kanungo, S. R. Smile, and S. Bhat. 1992. Primary disseminated fusarial infection. Postgrad. Med. J. 68: 143-144.
9. Mayayo, E., J. Guarro, and I. Pujol. 1998. Endogenous endophthalmitis by Fusarium solani: an animal experimental model. Med. Mycol. 36: 249-253.
10. Mayayo, E., I. Pujol, and J. Guarro. 1999. Experimental pathogenicity of four opportunist Fusarium species in a murine model. J. Med. Microbiol. 48: 363-366.
11. Raad, I.I., R. Y. Hachem, R. Herbrecht, J. R. Graybill, R. Hare, G. Corcoran, and D. P. Kontoyiannis. 2006. Posaconazole as salvage treatment for invasive fusa-riosis in patients with underlying hematologic malignancy and other conditions. Clin. Infect. Dis. 42: 1398-1403.
12. Thomas, P. A. 2003. Fungal infections of the comea. Eye 17: 852-862.
13. Leck, A. K., P. A. Thomas, M. Hagan, J. Kaliamurthy, E. Ackuaku, M. John, M. J. Newman, F. S. Codjoe, J. A. Opintan, C. M. Kalavathy, et al. 2002. Aetiology of suppurative comeal ulcers in-Ghana and south India, and epidemiology of fungal keratitis. Br. J. Ophthalmol. 86: 1211-1215.
14. Zhong, W. X., S. Y. Sun, J. Zhao, W. Y. Shi, and L. X. Xie. 2007. Retrospective study of suppurative keratitis in 1054 patients. Zhonghua yan ke za zhi 43: 245-250.
15. Forster, R. K., and G. Rcbell. 1975. Animal model of Fusarium solani keratitis. Am. J. Ophthalmol. 79: 510-515.
16. Ishibashi, Y., H. E. Kaufman, and S. Kagawa. 1986. Comparison of the patho-genicities of Fusarium solani and Candida albicans in the rabbit comea. J. Med. Vet Mycol. 24: 369-376.
17. Kiryu, H., S. Yoshida, Y. Suenaga, and M. Asahi. 1991. Invasion and survival of Fusarium solani in the dexamethasone-treated comea of rabbits. J. Med. Vet Mycol. 29: 395-406.
18. O'Day, D. M., W. A. Ray, W. S. Head, R. D. Robinson, and T. E. Williams. 1991. Influence of corticosteroid on experimentally induced keratomycosis. Arch. Ophthalmol. 109: 1601-1604.
19. Wu, T. G., V. V. Keasler, B. M. Mitchell, and K. R. Wilhelmus. 2004. Immu-nosuppression affects the severity of experimental Fusarium solani keratitis. J. Infect. Dis. 190: 192-198.
20. Hazlett, L. D. 2002. Pathogenic mechanisms of P. aeruginosa keratitis: a review of the role of T cells, Laneerhans cells, PMN, and cytokines. DNA Cell Biol. 21: 383-390.
21. Pearlman, E., J. H. Lass, D. S. Bardenstein, M. Kopf, F. E. Hazlett, Jr., E. Diaconu, and J. W. Kazura. 1995. Interleukin 4 and T helper type 2 cells are required for development of experimental onchocercal keratitis (river blindness). J. Exp. Med. 182: 931-940.
22. Johnson, A. C, F. P. Heinzel, E. Diaconu, Y. Sun, A. G. Hise, D. Golenbock, J. H. Lass, and E. Pearlman. 2005. Activation of Toll-like receptor (TLR)2, TLR4, and TLR9 in the mammalian comea induces MyD88-dependent comeal inflammation. Invest. Ophthal. Vis. Sci. 46: 589-595.
23. Johnson, A. C, X. Li, and E. Pearlman. 2008. MyD88 functions as a negative regulator of TLR3/TRIF-induced comeal inflammation by inhibiting activation of c-Jun N-terminal kinase. J. Biol. Chem. 283: 3988-3996.
24. + T cell priming during respiratory fungal infection. Immunity 25: 665-675.
25. Biondo, C, A. Midiri, L. Messina, F. Tomasello, G. Garufi, M. R. Catania, M. Bombaci, C. Beninati, G. Teti, and G. Mancuso. 2005. MyD88 and TLR2, but not TLR4, are required for host defense against Cryptococcus neoformans. Eur. J. Immunol. 35: 870-878.
26. Villamon, E., D. Gozalbo, P. Roig, C. Murciano, J. E. O'Connor, D. Fradelizi, and M. L. Gil. 2004. Myeloid differentiation factor 88 (MyD88) is required for murine resistance to Candida albicans and is critically involved in Candida-induced production of cytokines. Eur. Cytokine. Network 15: 263-271.
27. Kawai, T., and S. Akira. 2007. TLR signaling. Semin. Immunol. 19: 24-32.
28. Bellocchio, S., S. Moretti, K. Perruccio, F. Fallarino, S. Bozza, C. Montagnoli, P. Mosci, G. B. Lipford, L. Pitzurra, and L. Romani. 2004. TLRs govern neu-trophil activity in aspergillosis. J. Immunol. 173: 7406-7415.
29. Braedel, S., M. Radsak, H. Einsele, J. P. Latge, A. Michan, J. Loeffler, Z. Haddad, U. Grigoleit, H. Schild, and H. Hebart. 2004. Aspergillus fumigalus antigens activate innate immune cells via Toll-like receptors 2 and 4. Br. J. Haematol. 125: 392-399.
30. Netea, M. G., A. Warns, J. W. Van der Meer, M. J. Fenton, T. J. Verver-Janssen, L. E. Jacobs, T. Andresen, P. E. Verweij, and B. J. Kullberg. 2003. Aspergillus fumigatus evades immune recognition during germination through loss of Toll-like receptor-4-mediated signal transduction. J. Infect. Dis. 188: 320-326.
31. Meier, A., C. J. Kirschning, T. Nikolaus, H. Wagner, J. Heesemann, and F. Ebel. 2003. Toll-like receptor (TLR) 2 and TLR4 are essential for Aspergillus-induced activation of murine macrophages. Cell. Microbiol. 5: 561-570.
32. Blasi, E., A. Mucci, R. Neglia, F. Pezzini, B. Colombari, D. Radzioch, A. Cossarizza, E. Lugli, G. Volpini, G. Del Giudice, and S. Peppoloni. 2005. Biological importance of the two Toll-like receptors, TLR2 and TLR4, in mac-rophage response to infection with Candida albicans. FEMS Immunol. Med. Microbiol. 44: 69-79.
33. Netea, M. G., C. A. Van Der Graaf, A. G. Vonk, I. Verschueren, J. W. Van Der Meer, and B. J. Kullberg. 2002. The role of Toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis. J. Infect. Dis. 185: 1483-1489.
34. van der Graaf, C. A., M. G. Netea, I. Verschueren, J. W. van der Meer, and B. J. Kullberg. 2005. Differential cytokine production and Toll-like receptor signaling pathways by Candida albicans blastoconidia and hyphae. Infect. Immun. 73: 7458-7464.
35. Lin, M., E. Carlson, E. Diaconu, and E. Pearlman. 2007. CXCL1/KC and CXCL5/LIX are selectively produced by corneal fibroblasts and mediate neutro-phil infiltration to the comeal stroma in LPS keratitis. J. Leukocyte Biol. 81: 786-792.
36. Nakamura, K., K. Miyagi, Y. Koguchi, Y. Kinjo, K. Uezu, T. Kinjo, M. Akamine, J. Fujita, I. Kawamura, M. Mitsuyama, et al. 2006. Limited contribution of Toll-like receptor 2 and 4 to the host response to a fungal infectious pathogen, Cryptococcus neoformans. FEMS Immunol. Med. Microbiol 47: 148-154.
37. Aratani, Y., H. Koyama, S. Nyui, K. Suzuki, F. Kura, and N. Maeda. 1999. Severe impairment in early host defense against Candida albicans in mice deficient in myeloperoxidase. Infect. Immun. 67: 1828-1836.
38. Lavigne, L. M., J. E. Albina, and J. S. Reichner. 2006. β-Glucan is a fungal determinant for adhesion-dependent human neutrophil functions. J. Immunol. 177: 8667-8675.
39. Rudner, X. L., K. A. Kemacki, R. P. Barrett, and L. D. Hazlett. 2000. Prolonged elevation of IL-1 in Pseudotnonas aeruginosa ocular infection regulates mac-rophage-inflammatory protein-2 production, polymorphonuclear neutrophil persistence, and cornea] perforation. J. Immunol. 164: 6576-6582.
40. Netea, M. G., G. D. Brown, B. J. Kullberg, and N. A. Gow. 2008. An integrated model of the recognition of Candida albicans by the innate immune system. Nat. Rev. 6: 67-78.
41. Herre, J., J. A. Willment, S. Gordon, and G. D. Brown. 2004. The role of Dectin-l in antifungal immunity. Crit. Rev. Immunol. 24: 193-203.
42. Reid, D. M., M. Montoya, P. R. Taylor, P. Borrow, S. Gordon, G. D. Brown, and S. Y. Wong. 2004. Expression of the β-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions. J. Leukocyte Biol. 76: 86-94.
43. Willment, J. A., A. S. Marshall, D. M. Reid, D. L. Williams, S. Y. Wong, S. Gordon, and G. D. Brown. 2005. The human β-glucan receptor is widely expressed and functionally equivalent to murine Dectin-1 on primary cells. Eur. J. Immunol. 35: 1539-1547.
44. Viriyakosol, S., J. Fierer, G. D. Brown, and T. N. Kirkland. 2005. Innate immunity to the pathogenic fungus Coccidioides posadasii is dependent on Toll-like receptor 2 and Dectin-1. Infect. Immun. 73: 1553-1560.
45. Netea, M. G., N. A. Gow, C. A. Munro, S. Bates, C. Collins, G. Fenverda, R. P. Hobson, G. Bertram, H. B. Hughes, T. Jansen, et al. 2006. Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors. J. Clin. Invest. 116: 1642-1650.
46. Brissette-Storkus, C. S., S. M. Reynolds, A. J. Lepisto, and R. L. Hendricks. 2002. Identification of a novel macrophage population in the normal mouse corneal stroma. Invest. Ophthalmol. Vis. Sci. 43: 2264-2271.
47. + cells in the mouse cornea. J. Immunol. 180: 5779-5783.
48. Chinnery, II. R., M. J. Ruitenberg, G. W. Plant, E. Pearlman, S. Jung, and P. G. McMenamin. 2007. The chemokine receptor CX3CR1 mediates homing of MHC class H-positive cells to the normal mouse comeal epithelium. Invest. Ophthalmol. Vis. Sci. 48: 1568-1574.
49. Hamrah, P., Y. Liu, Q. Zhang, and M. R. Dana. 2003. The corneal stroma is endowed with a significant number of resident dendritic cells. Invest. Ophthalmol. Vis. Sci. 44: 581-589.