Mechanisms of platelet aggregation

Current Opinion in Hematology

Volumn 8, Issue 5, 2001, Pages 270-276

  Savage, Brian ^a   Cattaneo, Marco ^a,b   Ruggeri, Zaverio M ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENYLATE CYCLASE; AMINO ACID; CLOPIDOGREL; COLLAGEN; DIACYLGLYCEROL; FILAMIN; GLYCOPROTEIN; INOSITOL 1,4,5 TRISPHOSPHATE; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE A2; PHOSPHOLIPASE C; PHOSPHOLIPID; PROTEIN; PROTEIN KINASE C; PROTEINASE ACTIVATED RECEPTOR 1; PURINE P2 RECEPTOR; RISTOCETIN; THROMBIN; THROMBIN RECEPTOR; THROMBOCYTE RECEPTOR; THROMBOXANE A2; TICLOPIDINE; UNINDEXED DRUG; VON WILLEBRAND FACTOR;

CLINICAL TRIAL; GENE MUTATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; THROMBOCYTE; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBOGENESIS; THROMBOSIS;

ANIMALS; INTEGRINS; MODELS, BIOLOGICAL; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; RECEPTORS, COLLAGEN; RECEPTORS, PURINERGIC P2; RECEPTORS, THROMBIN; SIGNAL TRANSDUCTION; THROMBIN;

EID: 0034837561     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/00062752-200109000-00002     Document Type: Review

References (100)

1. Asialo von Willebrand factor interactions with platelets. Interdependence of glycoproteins Ib and IIb/IIIa for binding and aggregation
2. Interaction of asialo von Willebrand factor with glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and mediates platelet aggregation
3. Fibrinogen-independent platelet adhesion and thrombus formation on subendothelium mediated by glycoprotein IIb-IIIa complex at high shear rate
4. Integrin signaling: The platelet paradigm
5. Platelet receptors for collagen
6. Flow cytometric analysis of platelet activation by different collagen types present in the vessel wall
7. Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow
8. Platelet-collagen interactions: Membrane receptors and intracellular signaling pathways
9. Platelet receptors for collagen
10. Platelet-collagen interactions
11. Platelet adhesion to collagen: An update
12. Collagen receptor signaling in platelets: Extending the role of the ITAM
13. The collagen-platelet interaction
14. Update on collagen receptor interactions in platelets: Is the two-model still valid?
15. Cloning and expression of the platelet-specific collagen receptor glycoprotein VI
16. The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcαR and the natural killer receptors
17. A synthetic nonapeptide derived from the sequence of a platelet type I collagen receptor inhibits type I collagen-mediated platelet aggregation
18. Role of the recombinant non-integrin platelet collagen receptor P65 on platelet activation induced by convulxin
19. Asialo von Willebrand factor interactions with platelets. Interdependence of glycoproteins Ib and IIb/IIIa for binding and aggregation
20. Interaction of asialo von Willebrand factor with glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and mediates platelet aggregation
21. Fibrinogen-independent platelet adhesion and thrombus formation on subendothelium mediated by glycoprotein IIb-IIIa complex at high shear rate
22. Involvement of large plasma von Willebrand factor (vWF) multimers and unusually large vWF forms derived from endothelial cells in shear stress-induced platelet aggregation
23. Shear-induced platelet aggregation requires von Willebrand factor and platelet membrane glycoproteins Ib and IIb-IIIa
24. The role of von Willebrand Factor and fibrinogen in platelet aggregation under varying shear stress
25. Transmembrane calcium influx associated with von Willebrand factor binding to GP Ib in the initiation of shear-induced platelet aggregation
26. Platelets and shear stress
27. Distinct mechanisms of platelet aggregation as a consequence of different shearing flow conditions
28. Characterization of the unique mechanism mediating the shear-dependent binding of soluble von Willebrand factor to platelets
29. Von Willebrand factor-dependent shear-induced platelet aggregation: Basic mechanisms and clinical implications
30. Modeling and functional analysis of the interaction between von Willebrand factor A1 domain and glycoprotein Ibα
31. Identification of aspartic acid 514 through glutamic acid 542 as a glycoprotein Ib-IX complex receptor recognition sequence in von Willebrand factor. Mechanisms of modulation of von Willebrand factor by ristocetin and botrocetin
32. Ristocetin and botrocetin involve two distinct domains of von Willebrand factor for binding to platelet membrane glycoprotein Ib
33. A role for von Willebrand factor proline residues 702-704 in ristocetin-mediated binding to platelet glycoprotein Ib
34. Structure and function of the von Willebrand factor A1 domain: Analysis with monoclonal antibodies reveals distinct binding sites involved in recognition of the platelet membrane glycoprotein Ib-IX-V complex and ristocetin-dependent activation
35. Identification of discontinuous von Willebrand factor sequences involved in complex formation with botrocetin: A model for the regulation of von Willebrand factor binding to platelet glycoprotein Ib
36. Ristocetin-dependent, but not botrocetin-dependent, binding of von Willebrand factor to the platelet glycoprotein Ib-IX-V complex correlates with shear-dependent interactions
37. Ristocetin-mediated interaction of human von Willebrand factor with platelet glycoprotein lb evokes a transient calcium signal: Observations with Fura-PE3
38. Cytoskeletal regulation of the platelet glycoprotein lb/V/IX-von Willebrand factor interaction
39. Regulation of vWF binding to the platelet glycoprotein lb-IX by a membrane skeleton-dependent inside-out signal
40. Platelet plasma membrane glycoproteins: Identification of a proteolytic substrate for thrombin
41. Increased thrombin responsiveness in platelets from mice lacking glycoprotein V
42. A thrombin receptor function for platelet glycoprotein lb-IX unmasked by cleavage of glycoprotein V
43. Thrombin signaling and protease-activated receptors
44. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
45. Domains specifying thrombin-receptor interaction
46. Thrombin receptor activation: Confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode
47. Cloned piatelet thrombin receptor is necessary for thrombin-induced piatelet activation
48. Structure and function of the human platelet thrombin receptor
49. A dual thrombin receptor system for piatelet activation
50. Protease-activated receptor 3 is a second thrombin receptor in humans
51. Cloning and characterization of human protease-activated receptor 4
52. Molecular cloning of a potential proteinase activated receptor
53. Role of the thrombin receptor in development and evidence for a second receptor
54. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin
55. Cathepsin G activates protease-activated receptor-4 in human platelets
56. PAR3 is a cofactor for PAR4 activation by thrombin
57. Thrombin-induced GPIb-IX centralization on the platelet surface requires actin assembly and myosin II activation
58. Two thrombin-activated Ca2+ channels in human platelets
59. Phosphatidylinositol 3,4,5-trisphosphate triggers platelet aggregation by activating Ca2+ influx
60. Biphasic kinetics of activation and signaling for PAR1 and PAR4 thrombin receptors in platelets
61. ADP receptors and clinical bleeding disorders
62. Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation
63. Receptors for purines and pyrimidines
64. Families of ion channels with two hydrophobic segments
65. New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor
66. A new class of ligand-gated ion channels defined by P2X receptor for extracellular ATP
67. 1receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells
68. Identification of the platelet ADP receptor targeted by antithrombotic drugs
69. ADP is the cognate ligand for the orphan G-protein coupled receptor SP1999
70. 1purinoceptors in human platelets and megakaryobiastic cell lines
71. 1purinoceptor in human platelets: Molecular cloning and functional characterization after heterologous expression
72. 1receptor, an adenosine triphosphate-gated cation channel is expressed in human platelets but not in human blood leukocytes
73. 1purinoceptor expressed on human gplatelets
74. Activation of G 12/G 13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets
75. Dichotomous regulation of myosin phosphorylation and shape change by Rho-kinase and calcium in intact human platelets
76. Molecular basis for ADP-induced platelet activation, Ih the P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets
77. 1receptor is necessary for adenosine 5′-diphosphate-induced platelet aggregation
78. Role of P2Y1 purinoceptor in ADP-induced platelet activation
79. Molecular basis for ADP-induced platelet activation, I: Evidence for three distinct ADP receptors on human platelets
80. 1-receptors in human platelets which are pharmacologically distinct from P2Y(ADP)-receptors
81. Evidence for two distinct G-protein-coupled ADP receptors mediating platelet activation
82. 21 receptors
83. Ligand specificity and ticlopidine effects distinguish three human platelet ADP receptors
84. 1-deficient mice
85. 1 receptor-null mice
86. Identification of a new congenital defect of platelet function characterized by severe impairment of platelet responses to adenosine diphosphate
87. An inherited bleeding disorder linked to a defective interaction between ADP and its receptor on platelets
88. 2 production and normal granule stores
89. 1 receptor is normal in a patient presenting a severe deficiency of ADP-induced platelet aggregation: Further evidence for a distinct P2 receptor responsible for adenylyl cyclase inhibition
90. 33p]2MeS-ADP binding sites on platelets with secretion defect, normal granule stores and normal thromboxane A2 production: Evidence that ADP potentiates platelet secretion independently of the formation of large platelet aggregates and thromboxane A2 production
91. A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1 -activating peptide through the late activation of phosphoinositide 3-kinase
92. Released adenosine diphosphate stabilizes thrombin-induced human platelet aggregates
93. Pharmacology of ticlopidine and clopidogrel
94. Pharmacology of AR-C69931MX and related compounds: From pharmacological tools to clinical trials
95. 1 not P2T purinoceptors in human platelets
96. 1 receptors: Evidence for separate receptors stimulated by ATP and ADP on human platelets
97. No requirement of P2X1 purinoceptors for platelet aggregation
98. Platelet shape change evoked by selective activation of P2X1 purinoceptors with αβ.methylene ATP
99. A natural dominant negative P2Xl receptor due to deletion of a single amino acid residue
100. 1 receptors