The bile acid tauroursodeoxycholic acid modulates phosphorylation and translocation of Bad via phosphatidylinositol 3-kinase in glutamate-induced apoptosis of rat cortical neurons

Journal of Pharmacology and Experimental Therapeutics

Volumn 311, Issue 2, 2004, Pages 845-852

  Castro, Rui E ^a   Solá, Susana ^a   Ramalho, Rita M ^a   Steer, Clifford J ^b   Rodrigues, Cecília M P ^a,c  

^a UNIVERSITY OF LISBON   (Portugal)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c NONE   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; CASPASE; CYTOCHROME C; GLUTAMIC ACID; INHIBITOR OF APOPTOSIS PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAD; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; TAURODEOXYCHOLIC ACID;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL; CELL STRUCTURE; CONTROLLED STUDY; CYTOSOL; DEGENERATIVE DISEASE; DEPHOSPHORYLATION; DOWN REGULATION; DRUG PROTEIN BINDING; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; FETUS; GLUTAMATE RELEASE; MITOCHONDRION; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NEUROTRANSMITTER RELEASE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; BILE ACIDS AND SALTS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CEREBRAL CORTEX; DOWN-REGULATION; GLUTAMATES; GLUTAMIC ACID; NEURONS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR; TAUROCHENODEOXYCHOLIC ACID;

EID: 6344279913     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.070532     Document Type: Article

References (40)

1. Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA, and Nicotera P (1995) Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15:961-973.
2. Ayata C, Ayata G, Kara H, Matthews RT, Beal MF, Ferrante RJ, Endres M, Kim A, Christie RH, Waeber C, et al. (1997) Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice. J Neurosci 17:6908-6917.
3. Behl C, Hovey L 3rd, Krajewski S, Schubert D, and Reed JC (1993) BCL-2 prevents killing of neuronal cells by glutamate but not by amyloid beta protein. Biochem Biophys Res Commun 197:949-956.
4. Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, and Lipton SA (1995) Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci USA 92:7162-7166.
5. Brewer GJ, Torricelli JR, Evege EK, and Price PJ (1993) Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination. J Neurosci Res 35:567-576.
6. Cheung NS, Pascoe CJ, Giardina SF, John CA, and Beart PM (1998) Micromolar L-glutamate induces extensive apoptosis in an apoptotic-necrotic continuum of insult-dependent, excitotoxic injury in cultured cortical neurones. Neuropharmacology 37:1419-1429.
7. Dargusch R, Piasecki D, Tan S, Liu Y, and Schubert D (2001) The role of Bax in glutamate-induced nerve cell death. J Neurochem 76:295-301.
8. Datta SR, Brunet A, and Greenberg ME (1999) Cellular survival: a play in three Akts. Genes Dev 13:2905-2927.
9. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, and Greenberg ME (1997) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-241.
10. del Peso L, Gonzalez-Garcia M, Page C, Herrera R, and Nunez G (1997) Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science (Wash DC) 278:687-689.
11. Dirnagl U, Iadecola C, and Moskowitz MA (1999) Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 22:391-397.
12. Du Y, Bales KR, Dodel RC, Hamilton-Byrd E, Horn JW, Czilli DL, Simmons LK, Ni B, and Paul SM (1997) Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons. Proc Natl Acad Sci USA 94:11657-11662.
13. Harada H, Becknell B, Wilm M, Mann M, Huang LJ, Taylor SS, Scott JD, and Korsmeyer SJ (1999) Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A. Mol Cell 3:413-422.
14. Hawkins PT, Eguinoa A, Qiu RG, Stokoe D, Cooke FT, Walters R, Wennstrom S, Claesson-Welsh L, Evans T, Symons M, et al. (1995) PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase. Curr Biol 5:393-403.
15. Hinton HJ and Welham MJ (1999) Cytokine-induced protein kinase B activation and Bad phosphorylation do not correlate with cell survival of hemopoietic cells. J Immunol 162:7002-7009.
16. Howard S, Bottino C, Brooke S, Cheng E, Giffard RG, and Sapolsky R (2002) Neuroprotective effects of bcl-2 overexpression in hippocampal cultures: interactions with pathways of oxidative damage. J Neurochem 83:914-923.
17. Keene CD, Rodrigues CMP, Eich T, Chhabra MS, Steer CJ, and Low WC (2002) Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease. Proc Natl Acad Sci USA 99:10671-10676.
18. Kroemer G and Reed JC (2000) Mitochondrial control of cell death. Nat Med 6:513-519.
19. Larm JA, Cheung NS, and Beart PM (1997) Apoptosis induced via AMPA-selective glutamate receptors in cultured murine cortical neurons. J Neurochem 69:617-622.
20. Lawrence MS, Ho DY, Sun GH, Steinberg GK, and Sapolsky RM (1996) Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo. J Neurosci 16:486-496.
21. Lazaridis KN, Gores GJ, and Lindor KD (2001) Ursodeoxycholic acid "mechanisms of action and clinical use in hepatobiliary disorders." J Hepatol 35:134-146.
22. Mattson MP (1997) Neuroprotective signal transduction: relevance to stroke. Neurosci Biobehav Rev 21:193-206.
23. Misra S, Ujhazy P, Gatmaitan Z, Varticovski L, and Arias IM (1998) The role of phosphoinositide 3-kinase in taurocholate-induced trafficking of ATP-dependent canalicular transporters in rat liver. J Biol Chem. 273:26638-26644.
24. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63.
25. Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, and Donner DB (1999) NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature (Lond) 401:82-85.
26. Petersen A, Mani K, and Brundin P (1999) Recent advances on the pathogenesis of Huntington's disease. Exp Neurol 157:1-18.
27. Qiao L, Yacoub A, Studer E, Gupta S, Pei XY, Grant S, Hylemon PB, and Dent P (2002) Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes. Hepatology 35:779-789.
28. Ramalho RM, Ribeiro PS, Solá S, Castro RE, Steer CJ, and Rodrigues CMP (2004) Inhibition of the E2F-1/p53/Bax pathway by tauroursodeoxycholic acid in amyloid β-peptide-induced apoptosis of PC12 cells. J Neurochem 90:567-575.
29. Rodrigues CMP, Solá S, Nan Z, Castro RE, Ribeiro PS, Low WC, and Steer CJ (2003) Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats. Proc Natl Acad Sci USA 100:6087-6092.
30. Rodrigues CMP, Spellman SR, Solá S, Grande AW, Linehan-Stieers C, Low WC, and Steer CJ (2002) Neuroprotection by a bile acid in an acute stroke model in the rat. J Cereb Blood Flow Metab 22:463-471.
31. Rodrigues CMP, Stieers CL, Keene CD, Ma X, Kren BT, Low WC, and Steer CJ (2000) Tauroursodeoxycholic acid partially prevents apoptosis induced by 3-nitropropionic acid: evidence for a mitochondrial pathway independent of the permeability transition. J Neurochem 75:2368-2379.
32. Rodrigues CMP, Castro RE, and Steer CJ (2004) The role of bile acids in the modulation of apoptosis, in Principles of Medical Biology (Bittar EE ed) vol 15, pp 119-146, Elsevier Science, Amsterdam, The Netherlands.
33. Rust C, Karnitz LM, Paya CV, Moscat J, Simari RD, and Gores GJ (2000) The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade. J Biol Chem 275:20210-20216.
34. Sastry PS and Rao KS (2000) Apoptosis and the nervous system. J Neurochem 74:1-20.
35. Schubert D and Piasecki D (2001) Oxidative glutamate toxicity can be a component of the excitotoxicity cascade. J Neurosci 21:7455-7462.
36. Solá S, Castro RE, Laires PA, Steer CJ, and Rodrigues CMP (2003) Tauroursodeoxycholic acid prevents amyloid β-peptide-induced neuronal death through a phosphatidylinositol 3-kinase-dependent signaling pathway. Mol Med 9:226-234.
37. Wang HG, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, McKeon F, Bobo T, Franke TF, and Reed JC (1999) Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science (Wash DC) 284:339-343.
38. Wang HG, Rapp UR, and Reed JC (1996) Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell 87:629-638.
39. Wolf D, Witte V, Laffert B, Blume K, Stromer E, Trapp S, d'Aloja P, Schurmann A, and Baur AS (2001) HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals. Nat Med 7:1217-1224.
40. Yang E, Zha J, Jockel J, Boise LH, Thompson CB, and Korsmeyer SJ (1995) Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80:285-291.