메뉴 건너뛰기




Volumn 46, Issue 1, 2009, Pages 10-24

Review paper: Current strategies in the development of Anti-obesity drugs and their safety concerns

Author keywords

Antiobesity drugs; Pulmonary arterial hypertension; Safety issues; Valvulopathy

Indexed keywords

ANIMALIA;

EID: 63249123940     PISSN: 03009858     EISSN: 15442217     Source Type: Journal    
DOI: 10.1354/vp.46-1-10     Document Type: Article
Times cited : (57)

References (137)
  • 3
    • 0037066585 scopus 로고    scopus 로고
    • Orlistat: Its current status as an anti-obesity drug
    • Ballinger A, Peikin SR.: Orlistat: Its current status as an anti-obesity drug. Eur J Pharmacol 440:109- 117, 2002
    • (2002) Eur J Pharmacol , vol.440 , pp. 109-117
    • Ballinger, A.1    Peikin, S.R.2
  • 6
    • 15444362306 scopus 로고    scopus 로고
    • Rimonabant: A selective CB1 antagonist
    • Boyd TS, Fremming BA: Rimonabant: a selective CB1 antagonist. Ann Pharmacother 39:684-690, 2005
    • (2005) Ann Pharmacother , vol.39 , pp. 684-690
    • Boyd, T.S.1    Fremming, B.A.2
  • 7
    • 0032943658 scopus 로고    scopus 로고
    • Effects of prenatal co-administration of phentermine and dexfenfluramine in rats
    • Bratter J, Gessner IH, Rowland NE: Effects of prenatal co-administration of phentermine and dexfenfluramine in rats. Eur J Pharmacol 369:R1- R3, 1999
    • (1999) Eur J Pharmacol , vol.369
    • Bratter, J.1    Gessner, I.H.2    Rowland, N.E.3
  • 8
    • 2942657650 scopus 로고    scopus 로고
    • Medical consequences of obesity
    • Bray GA: Medical consequences of obesity. J Clin Endocrinol Metab 89:2583-2589, 2004
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2583-2589
    • Bray, G.A.1
  • 10
    • 23944497107 scopus 로고    scopus 로고
    • Rimonabant: The first therapeutically relevant cannabinoid antagonist
    • Carai MA, Colombo G, Gessa GL: Rimonabant: the first therapeutically relevant cannabinoid antagonist. Life Sci 77:2339-2350, 2005
    • (2005) Life Sci , vol.77 , pp. 2339-2350
    • Carai, M.A.1    Colombo, G.2    Gessa, G.L.3
  • 11
    • 37549068962 scopus 로고    scopus 로고
    • Pathogenic mechanisms of pulmonary arterial hypertension
    • Chan SY, Loscalzo J: Pathogenic mechanisms of pulmonary arterial hypertension. J Mol Cell Cardiol 44:14-30, 2008
    • (2008) J Mol Cell Cardiol , vol.44 , pp. 14-30
    • Chan, S.Y.1    Loscalzo, J.2
  • 12
    • 33846034925 scopus 로고    scopus 로고
    • Currently available drugs for the treatment of obesity: Sibutra- mine and orlistat
    • Chaput JP, St-Pierre S, Tremblay A: Currently available drugs for the treatment of obesity: sibutra- mine and orlistat. Mini Rev Med Chem 7:3-10, 2007
    • (2007) Mini Rev Med Chem , vol.7 , pp. 3-10
    • Chaput, J.P.1    St-Pierre, S.2    Tremblay, A.3
  • 14
    • 33750510903 scopus 로고    scopus 로고
    • The obesity pipeline: Current strategies in the development of anti-obesity drugs
    • Cooke D, Bloom S: The obesity pipeline: current strategies in the development of anti-obesity drugs. Nat Rev Drug Discov 5:919-931, 2006
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 919-931
    • Cooke, D.1    Bloom, S.2
  • 16
    • 31744452243 scopus 로고    scopus 로고
    • Obesity: America's epidemic
    • Daniels J: Obesity: America's epidemic. Am J Nurs 106:40-49, 2006
    • (2006) Am J Nurs , vol.106 , pp. 40-49
    • Daniels, J.1
  • 17
    • 1842611887 scopus 로고    scopus 로고
    • The endocannabinoid system: A general view and latest additions
    • De Petrocellis L, Cascio MG, Di Marzo D: The endocannabinoid system: a general view and latest additions. Br J Pharmacol 141:765-774, 2004
    • (2004) Br J Pharmacol , vol.141 , pp. 765-774
    • De Petrocellis, L.1    Cascio, M.G.2    Di Marzo, D.3
  • 18
    • 27844463517 scopus 로고    scopus 로고
    • Rimonabant in Obesity-Lipids Study Group. Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia
    • Despres JP, Golay A, Sjostrom L: Rimonabant in Obesity-Lipids Study Group. Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N Engl J Med 353:2121-2134, 2005
    • (2005) N Engl J Med , vol.353 , pp. 2121-2134
    • Despres, J.P.1    Golay, A.2    Sjostrom, L.3
  • 19
  • 20
    • 17844388556 scopus 로고    scopus 로고
    • Endocannabinoid control of food intake and energy balance
    • Di Marzo D, Matias I: Endocannabinoid control of food intake and energy balance. Nat Neurosci 8:585-589, 2005
    • (2005) Nat Neurosci , vol.8 , pp. 585-589
    • Di Marzo, D.1    Matias, I.2
  • 22
    • 0035082469 scopus 로고    scopus 로고
    • Eddahibi S, Adnot S, Frisdal E, Levame M, Hamon M, Raffestin B: Dexfenfluramine-associat- ed changes in 5-hydroxytryptamine transporter expression and development of hypoxic pulmonary hypertension in rats. J Pharmacol Exp Ther 297:148-154, 2001
    • Eddahibi S, Adnot S, Frisdal E, Levame M, Hamon M, Raffestin B: Dexfenfluramine-associat- ed changes in 5-hydroxytryptamine transporter expression and development of hypoxic pulmonary hypertension in rats. J Pharmacol Exp Ther 297:148-154, 2001
  • 23
    • 0036014810 scopus 로고    scopus 로고
    • Is the serotonin transporter involved in the pathogenesis of pulmonary hypertension?
    • Eddahibi S, Raffestin B, Hamon M, Adnot S: Is the serotonin transporter involved in the pathogenesis of pulmonary hypertension? J Lab Clin Med 139:194-201, 2002
    • (2002) J Lab Clin Med , vol.139 , pp. 194-201
    • Eddahibi, S.1    Raffestin, B.2    Hamon, M.3    Adnot, S.4
  • 25
    • 0036628968 scopus 로고    scopus 로고
    • Endocardial myxomatous change in Harlan Sprague Dawley rats (Hsd:S-D) and CD-I mice: Its microscopic resemblance to drug-induced valvulopathy in humans
    • Elangbam CS, Colman KA, Lightfoot RM, Tyler RD, Wall HG: Endocardial myxomatous change in Harlan Sprague Dawley rats (Hsd:S-D) and CD-I mice: its microscopic resemblance to drug-induced valvulopathy in humans. Toxicol Pathol 30:483- 491, 2002
    • (2002) Toxicol Pathol , vol.30 , pp. 483-491
    • Elangbam, C.S.1    Colman, K.A.2    Lightfoot, R.M.3    Tyler, R.D.4    Wall, H.G.5
  • 26
    • 46649092122 scopus 로고    scopus 로고
    • 5-Hydroxytryp- tamine (5HT)-induced valvulopathy: Compositional valvular alterations are associated with 5HT2B receptor and 5HT transporter transcript changes in Sprague-Dawley rats
    • Elangbam CS, Job LE, Zadrozny LM, Barton JC, Yoon LW, Gates LD, Slocum N: 5-Hydroxytryp- tamine (5HT)-induced valvulopathy: compositional valvular alterations are associated with 5HT2B receptor and 5HT transporter transcript changes in Sprague-Dawley rats. Exp Toxicol Pathol 60:253- 262, 2008
    • (2008) Exp Toxicol Pathol , vol.60 , pp. 253-262
    • Elangbam, C.S.1    Job, L.E.2    Zadrozny, L.M.3    Barton, J.C.4    Yoon, L.W.5    Gates, L.D.6    Slocum, N.7
  • 28
    • 33750379825 scopus 로고    scopus 로고
    • Evaluation of glycosaminoglycans content and 5-hydroxytryptamine 2B receptor in rat heart valves with spontaneous mitral valvulopathy: A possible exacerbation by dl, amphetamine sulfate in Fischer rats
    • Elangbam CS, Wehe JG, Barton JC, Krull DL, Nyska A, Crabbs TA, Kissling G: Evaluation of glycosaminoglycans content and 5-hydroxytryptamine 2B receptor in rat heart valves with spontaneous mitral valvulopathy: a possible exacerbation by dl, amphetamine sulfate in Fischer rats. Exp Toxicol Pathol 58:89-99, 2006
    • (2006) Exp Toxicol Pathol , vol.58 , pp. 89-99
    • Elangbam, C.S.1    Wehe, J.G.2    Barton, J.C.3    Krull, D.L.4    Nyska, A.5    Crabbs, T.A.6    Kissling, G.7
  • 29
    • 0030954150 scopus 로고    scopus 로고
    • A new role for an old molecule: Serotonin as a mitogen
    • Fanburg BL, Lee SL: A new role for an old molecule: serotonin as a mitogen. Am J Physiol 272:L795-L806, 1997
    • (1997) Am J Physiol , vol.272
    • Fanburg, B.L.1    Lee, S.L.2
  • 31
    • 0034095342 scopus 로고    scopus 로고
    • One-year treatment of obesity: A randomized, double-blind, placebo-controlled, multicentre study of orlistat, a gastrointestinal lipase inhibitor
    • Finer N, James WP, Kopelman PG, Lean ME, Williams G: One-year treatment of obesity: a randomized, double-blind, placebo-controlled, multicentre study of orlistat, a gastrointestinal lipase inhibitor. Int J Obes Relat Metab Disord 24:306-313, 2000
    • (2000) Int J Obes Relat Metab Disord , vol.24 , pp. 306-313
    • Finer, N.1    James, W.P.2    Kopelman, P.G.3    Lean, M.E.4    Williams, G.5
  • 32
    • 0033547771 scopus 로고    scopus 로고
    • Aminorex to fen/phen: An epidemic foretold
    • Fishman AP: Aminorex to fen/phen: an epidemic foretold. Circulation 99:156-161, 1999
    • (1999) Circulation , vol.99 , pp. 156-161
    • Fishman, A.P.1
  • 34
    • 26844444244 scopus 로고    scopus 로고
    • Early mortality among Medicare beneficiaries undergoing bariatric surgical procedures
    • Flum DR, Salem I, Elrod JA, Dellinger EP, Cheadle A, Chan I: Early mortality among Medicare beneficiaries undergoing bariatric surgical procedures. J Am Med Assoc 294:1903-1908, 2005
    • (2005) J Am Med Assoc , vol.294 , pp. 1903-1908
    • Flum, D.R.1    Salem, I.2    Elrod, J.A.3    Dellinger, E.P.4    Cheadle, A.5    Chan, I.6
  • 35
    • 0037661996 scopus 로고    scopus 로고
    • Role of endogenous cannabinoids in synaptic signaling
    • Freund TF, Katona I, Piomelli D: Role of endogenous cannabinoids in synaptic signaling. Physiol Rev 83:1017-1066, 2003
    • (2003) Physiol Rev , vol.83 , pp. 1017-1066
    • Freund, T.F.1    Katona, I.2    Piomelli, D.3
  • 36
    • 0017686699 scopus 로고
    • Release of platelet 5-hydroxytryptamine by some anorexic and other sympathomimetics and their acetyl derivatives
    • Fristrom S, Airaksinen MM, Halmekoski J: Release of platelet 5-hydroxytryptamine by some anorexic and other sympathomimetics and their acetyl derivatives. Acta Pharmacol Toxicol (Co- penh) 41:218-224, 1977
    • (1977) Acta Pharmacol Toxicol (Co- penh) , vol.41 , pp. 218-224
    • Fristrom, S.1    Airaksinen, M.M.2    Halmekoski, J.3
  • 37
    • 31044456243 scopus 로고    scopus 로고
    • The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits cell proliferation and increases markers of adipocyte maturation in cultured mouse 3T3 F442A preadipocytes
    • Gary-Bobo M, Elachouri G, Scatton B, Le Fur G, Oury-Donat F, Bensaid M: The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits cell proliferation and increases markers of adipocyte maturation in cultured mouse 3T3 F442A preadipocytes. Mol Pharmacol 69:471178, 2006
    • (2006) Mol Pharmacol , vol.69 , pp. 471178
    • Gary-Bobo, M.1    Elachouri, G.2    Scatton, B.3    Le Fur, G.4    Oury-Donat, F.5    Bensaid, M.6
  • 41
    • 0021986849 scopus 로고
    • Aminorex and pulmonary hypertension
    • Gurtner HP: Aminorex and pulmonary hypertension. Cor Vasa 27:160-171, 1985
    • (1985) Cor Vasa , vol.27 , pp. 160-171
    • Gurtner, H.P.1
  • 43
    • 33645782262 scopus 로고    scopus 로고
    • Obesity drugs in clinical development
    • Halford JCG: Obesity drugs in clinical development. Curr Opin Invest Drugs 7:312-318, 2006
    • (2006) Curr Opin Invest Drugs , vol.7 , pp. 312-318
    • Halford, J.C.G.1
  • 44
    • 0037298936 scopus 로고    scopus 로고
    • Treatment of obesity: An update on antiobesity medications
    • Halpern A, Mancini MC: Treatment of obesity: an update on antiobesity medications. Obes Rev 4:25-42, 2002
    • (2002) Obes Rev , vol.4 , pp. 25-42
    • Halpern, A.1    Mancini, M.C.2
  • 47
  • 48
    • 0034048643 scopus 로고    scopus 로고
    • Orlistat, a new lipase inhibitor for the management of obesity
    • Heck AM, Yanovski JA, Calis KA: Orlistat, a new lipase inhibitor for the management of obesity. Pharmacotherapy 20:270-279, 2000
    • (2000) Pharmacotherapy , vol.20 , pp. 270-279
    • Heck, A.M.1    Yanovski, J.A.2    Calis, K.A.3
  • 49
    • 0037074929 scopus 로고    scopus 로고
    • Coexpression of the cannabinoid receptor type 1 with dopamine and serotonin receptors in distinct neuronal sub- populations of the adult mouse forebrain
    • Hermann H, Marsicano G, Lutz B: Coexpression of the cannabinoid receptor type 1 with dopamine and serotonin receptors in distinct neuronal sub- populations of the adult mouse forebrain. Neuro- science 109:451-460, 2002
    • (2002) Neuro- science , vol.109 , pp. 451-460
    • Hermann, H.1    Marsicano, G.2    Lutz, B.3
  • 50
    • 0034607330 scopus 로고    scopus 로고
    • Heart valve disorders and appetite- suppressant drugs
    • Hershel J: Heart valve disorders and appetite- suppressant drugs. JAMA 283:1738-1740, 2000
    • (2000) JAMA , vol.283 , pp. 1738-1740
    • Hershel, J.1
  • 54
    • 0037484189 scopus 로고    scopus 로고
    • Orlistat in the treatment of obesity
    • Hollander P: Orlistat in the treatment of obesity. Primary Care 30:427-440, 2003
    • (2003) Primary Care , vol.30 , pp. 427-440
    • Hollander, P.1
  • 55
    • 85047691827 scopus 로고    scopus 로고
    • Endocannabinoids and the regulation of body fat: The smoke is clearing
    • Horvath T: Endocannabinoids and the regulation of body fat: the smoke is clearing. J Clin Invest 112:323-326, 2003
    • (2003) J Clin Invest , vol.112 , pp. 323-326
    • Horvath, T.1
  • 56
    • 4644331847 scopus 로고    scopus 로고
    • Howlett AC, Breivogel CS, Childers SR, Dead- wyler SA, Hampson RE, Porrino LJ: Cannabinoid physiology and pharmacology: 30 years of progress. Neuropharmacology 47:345-358, 2004
    • Howlett AC, Breivogel CS, Childers SR, Dead- wyler SA, Hampson RE, Porrino LJ: Cannabinoid physiology and pharmacology: 30 years of progress. Neuropharmacology 47:345-358, 2004
  • 59
    • 33645468559 scopus 로고    scopus 로고
    • Safety of drug therapies used for weight loss and treatment of obesity
    • Ioannides-Demos LL, Proietto J, Tonkin AM, McNeil JJ: Safety of drug therapies used for weight loss and treatment of obesity. Drug Saf 29:277-302, 2006
    • (2006) Drug Saf , vol.29 , pp. 277-302
    • Ioannides-Demos, L.L.1    Proietto, J.2    Tonkin, A.M.3    McNeil, J.J.4
  • 60
    • 36849068505 scopus 로고    scopus 로고
    • Overweight/obesity and cancer genesis: More than a biological link
    • Irigaray P, Newby JA, Lacomme S, Belpomme D: Overweight/obesity and cancer genesis: more than a biological link. Biomed Pharmacother 61:665-678, 2007
    • (2007) Biomed Pharmacother , vol.61 , pp. 665-678
    • Irigaray, P.1    Newby, J.A.2    Lacomme, S.3    Belpomme, D.4
  • 61
    • 18144416218 scopus 로고    scopus 로고
    • Agonism at 5HT2B receptors is not a class effect of the ergolines
    • Jahnichen S, Horowski R, Pertz HH: Agonism at 5HT2B receptors is not a class effect of the ergolines. Eur J Pharmacol 513:225-228, 2005
    • (2005) Eur J Pharmacol , vol.513 , pp. 225-228
    • Jahnichen, S.1    Horowski, R.2    Pertz, H.H.3
  • 62
    • 0034516930 scopus 로고    scopus 로고
    • Effect of sibutramine on weight maintenance after weight loss: A randomised trial. STORM Study Group. Sibutramine Trial of Obesity Reduction and Maintenance
    • James WP, Astrup A, Finer N, Hilsted J, Kopel- man P, Rossner S, Saris WH, Van Gaal LF: Effect of sibutramine on weight maintenance after weight loss: a randomised trial. STORM Study Group. Sibutramine Trial of Obesity Reduction and Maintenance. Lancet 356:2119-2125, 2000
    • (2000) Lancet , vol.356 , pp. 2119-2125
    • James, W.P.1    Astrup, A.2    Finer, N.3    Hilsted, J.4    Kopel- man, P.5    Rossner, S.6    Saris, W.H.7    Van Gaal, L.F.8
  • 63
    • 0034686036 scopus 로고    scopus 로고
    • Specific uptake of 5-hydroxytryptamine is reduced in lungs from hypoxic pulmonary hypertensive rats
    • Jeffery TK, Bryan-Lluka LJ, Wanstall JC: Specific uptake of 5-hydroxytryptamine is reduced in lungs from hypoxic pulmonary hypertensive rats. Eur J Pharmacol 396:137-140, 2000
    • (2000) Eur J Pharmacol , vol.396 , pp. 137-140
    • Jeffery, T.K.1    Bryan-Lluka, L.J.2    Wanstall, J.C.3
  • 64
    • 0034595380 scopus 로고    scopus 로고
    • Fenfluramine and phentermine and cardiovascular findings: Effect of treatment duration on prevalence of valve abnormalities
    • Jollis JG, Landolfo CK, Kisslo J, Constantine GD, Davis KD, Ryan T: Fenfluramine and phentermine and cardiovascular findings: effect of treatment duration on prevalence of valve abnormalities. Circulation 101:2071-2077, 2000
    • (2000) Circulation , vol.101 , pp. 2071-2077
    • Jollis, J.G.1    Landolfo, C.K.2    Kisslo, J.3    Constantine, G.D.4    Davis, K.D.5    Ryan, T.6
  • 65
    • 85047675987 scopus 로고
    • Role of 5- hydroxytryptamine in the progression of monocro- taline induced pulmonary hypertension in rats
    • Kanai Y, Hori S, Tanaka T, Yasuoka M, Watanabe K, Aikawa N, Hosoda Y: Role of 5- hydroxytryptamine in the progression of monocro- taline induced pulmonary hypertension in rats. Cardiovasc Res 27:1619-1623, 1993
    • (1993) Cardiovasc Res , vol.27 , pp. 1619-1623
    • Kanai, Y.1    Hori, S.2    Tanaka, T.3    Yasuoka, M.4    Watanabe, K.5    Aikawa, N.6    Hosoda, Y.7
  • 66
    • 33746335649 scopus 로고    scopus 로고
    • 5-Hydroxytryptamine receptors in the human cardiovascular system
    • Kaumann AJ, Levy FO: 5-Hydroxytryptamine receptors in the human cardiovascular system. Pharmacol Ther 111:674-706, 2006
    • (2006) Pharmacol Ther , vol.111 , pp. 674-706
    • Kaumann, A.J.1    Levy, F.O.2
  • 68
    • 0035824915 scopus 로고    scopus 로고
    • Contribution of the 5-HT1B receptor to hypoxia- induced pulmonary hypertension. Converging evidence using 5-HTlB-receptor knockout mice and the 5-HT1B/1D antagonist GR127935
    • Keegan A, Morecroft I, Hicks MN, MacLean MR: Contribution of the 5-HT1B receptor to hypoxia- induced pulmonary hypertension. Converging evidence using 5-HTlB-receptor knockout mice and the 5-HT1B/1D antagonist GR127935. Circ Res 89:1231-1239, 2001
    • (2001) Circ Res , vol.89 , pp. 1231-1239
    • Keegan, A.1    Morecroft, I.2    Hicks, M.N.3    MacLean, M.R.4
  • 70
    • 0034611791 scopus 로고    scopus 로고
    • Obesity as a medical problem
    • Kopelman PG: Obesity as a medical problem. Nature 404:635-643, 2000
    • (2000) Nature , vol.404 , pp. 635-643
    • Kopelman, P.G.1
  • 71
    • 2942655401 scopus 로고    scopus 로고
    • Pharmacological approaches to weight reduction: Therapeutic targets
    • Korner J, Aronne LJ: Pharmacological approaches to weight reduction: therapeutic targets. J Clin Endocrinol Metab 89:2616-2621, 2004
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2616-2621
    • Korner, J.1    Aronne, L.J.2
  • 72
    • 23444432920 scopus 로고    scopus 로고
    • The endocannabinoid system: Drug targets, lead compounds and potential therapeutic applications
    • Lambert DM, Fowler CJ: The endocannabinoid system: drug targets, lead compounds and potential therapeutic applications. J Med Chem 48:5059- 5087, 2005
    • (2005) J Med Chem , vol.48 , pp. 5059-5087
    • Lambert, D.M.1    Fowler, C.J.2
  • 75
    • 0037279371 scopus 로고    scopus 로고
    • Weight management and current options in pharmacotherapy: Orlistat and sibutramine
    • Leung WY, Thomas GN, Chan JC, Tomlinson B: Weight management and current options in pharmacotherapy: orlistat and sibutramine. Clin Ther 25:58-80, 2003
    • (2003) Clin Ther , vol.25 , pp. 58-80
    • Leung, W.Y.1    Thomas, G.N.2    Chan, J.C.3    Tomlinson, B.4
  • 76
    • 13244249625 scopus 로고    scopus 로고
    • Effects of the cannabinoid CB1 receptor antagonist SR141716 on oxygen consumption and soleus muscle glucose uptake in Lep(ob)/Lep(ob) mice
    • Liu YL, Connoley IP, Wilson CA, Stock MJ: Effects of the cannabinoid CB1 receptor antagonist SR141716 on oxygen consumption and soleus muscle glucose uptake in Lep(ob)/Lep(ob) mice. Int J Obes 29:183-187, 2005
    • (2005) Int J Obes , vol.29 , pp. 183-187
    • Liu, Y.L.1    Connoley, I.P.2    Wilson, C.A.3    Stock, M.J.4
  • 78
  • 79
    • 32544458797 scopus 로고    scopus 로고
    • Machado RD, Aldred MA, James V, Harrison RE, Patel B, Schwalbe EC, Gruenig E, Janssen B, Koehler R, Seeger W, Eickelberg O, Olschewski H, Elliott CG, Glissmeyer E, Carlquist J, Kim M, Torbicki A, Fijalkowska A, Szewczyk G, Parma J, Abramowicz MJ, Galie N, Morisaki H, Kyotani S, Nakanishi N, Morisaki T, Humbert M, Simonneau G, Sitbon O, Soubrier F, Coulet F, Morrell NW, Trembath RC: Mutations of the TGF-beta type II receptor BMPR2 in pulmonary arterial hypertension. Hum Mutat 27:121-132, 2006
    • Machado RD, Aldred MA, James V, Harrison RE, Patel B, Schwalbe EC, Gruenig E, Janssen B, Koehler R, Seeger W, Eickelberg O, Olschewski H, Elliott CG, Glissmeyer E, Carlquist J, Kim M, Torbicki A, Fijalkowska A, Szewczyk G, Parma J, Abramowicz MJ, Galie N, Morisaki H, Kyotani S, Nakanishi N, Morisaki T, Humbert M, Simonneau G, Sitbon O, Soubrier F, Coulet F, Morrell NW, Trembath RC: Mutations of the TGF-beta type II receptor BMPR2 in pulmonary arterial hypertension. Hum Mutat 27:121-132, 2006
  • 80
    • 33144480327 scopus 로고    scopus 로고
    • Cannabinoid receptors as therapeutic targets
    • Mackie K: Cannabinoid receptors as therapeutic targets. Annu Rev Pharmacol Toxicol 46:101-122, 2006
    • (2006) Annu Rev Pharmacol Toxicol , vol.46 , pp. 101-122
    • Mackie, K.1
  • 81
    • 0033404424 scopus 로고    scopus 로고
    • Pulmonary hypertension, anorexi- gens and 5-HT-pharmacological synergism in action?
    • MacLean MR: Pulmonary hypertension, anorexi- gens and 5-HT-pharmacological synergism in action? Trends Pharmacol Sci 20:490-495, 1999
    • (1999) Trends Pharmacol Sci , vol.20 , pp. 490-495
    • MacLean, M.R.1
  • 83
    • 0029911551 scopus 로고    scopus 로고
    • 5-Hydroxytrypta- mine receptors mediating vasoconstriction in pulmonary arteries from control and pulmonary hypertensive rats
    • MacLean MR, Sweeney G, Baird M, McCulloch KM, Houslay M, Morecroft I: 5-Hydroxytrypta- mine receptors mediating vasoconstriction in pulmonary arteries from control and pulmonary hypertensive rats. Br J Pharmacol 119:917-930,1996
    • (1996) Br J Pharmacol , vol.119 , pp. 917-930
    • MacLean, M.R.1    Sweeney, G.2    Baird, M.3    McCulloch, K.M.4    Houslay, M.5    Morecroft, I.6
  • 86
    • 0026733190 scopus 로고
    • Simultaneous effects of p- chloroamphetamine, d-fenfluramine, and reserpine on free and stored 5-hydroxytryptamine in brain and blood
    • Martin F, Artigas F: Simultaneous effects of p- chloroamphetamine, d-fenfluramine, and reserpine on free and stored 5-hydroxytryptamine in brain and blood. J Neurochem 59:1138-1144, 1992
    • (1992) J Neurochem , vol.59 , pp. 1138-1144
    • Martin, F.1    Artigas, F.2
  • 89
    • 34247198299 scopus 로고    scopus 로고
    • Overexpression of human bone morphogenetic protein receptor 2 does not ameliorate monocrotaline pulmonary arterial hypertension
    • McMurtry M, Moudgil R, Hashimoto K, Bonnet S, Michelakis E, Archer S: Overexpression of human bone morphogenetic protein receptor 2 does not ameliorate monocrotaline pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol 292:L872-L878, 2007
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.292
    • McMurtry, M.1    Moudgil, R.2    Hashimoto, K.3    Bonnet, S.4    Michelakis, E.5    Archer, S.6
  • 91
    • 0029784311 scopus 로고    scopus 로고
    • The effect of orlistat, an inhibitor of dietary fat absorption on the absorption of vitamins A and E in healthy volunteers
    • Melia AT, Koss-Twardy SG, Zhi J: The effect of orlistat, an inhibitor of dietary fat absorption on the absorption of vitamins A and E in healthy volunteers. J Clin Pharmacol 36:647-653, 1996
    • (1996) J Clin Pharmacol , vol.36 , pp. 647-653
    • Melia, A.T.1    Koss-Twardy, S.G.2    Zhi, J.3
  • 92
    • 0035057728 scopus 로고    scopus 로고
    • Anorectic drugs and pulmonary hypertension from the bedside to the bench
    • Michelakis ED, Weir EK: Anorectic drugs and pulmonary hypertension from the bedside to the bench. Am J Med Sci 321:292-299, 2001
    • (2001) Am J Med Sci , vol.321 , pp. 292-299
    • Michelakis, E.D.1    Weir, E.K.2
  • 93
    • 0036827811 scopus 로고    scopus 로고
    • Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes
    • Millan MJ, Maiofiss L, Cussac D, Audinot V, Boutin JA, Newman-Tancredi A: Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J Pharmcol Exp Ther 303:791-804, 2002
    • (2002) J Pharmcol Exp Ther , vol.303 , pp. 791-804
    • Millan, M.J.1    Maiofiss, L.2    Cussac, D.3    Audinot, V.4    Boutin, J.A.5    Newman-Tancredi, A.6
  • 94
    • 0344550444 scopus 로고    scopus 로고
    • Cannabinoid CB1 receptor and serotonin 3 receptor subunit A (5-HT3A) are co-expressed in GABA neurons in the rat telencephalon
    • Morales M, Wang SD, Diaz-Ruiz O, Jho DH: Cannabinoid CB1 receptor and serotonin 3 receptor subunit A (5-HT3A) are co-expressed in GABA neurons in the rat telencephalon. J Comp Neurol 468:205-216, 2004
    • (2004) J Comp Neurol , vol.468 , pp. 205-216
    • Morales, M.1    Wang, S.D.2    Diaz-Ruiz, O.3    Jho, D.H.4
  • 95
    • 0004316772 scopus 로고    scopus 로고
    • Lung, and Blood Institute, in cooperation with the National Institute of Diabetes and Digestive and Kidney Diseases: Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults
    • National Institutes of Health, National Heart, NIH Publication No. 981083. US Government Press, Washington, DC
    • National Institutes of Health, National Heart, Lung, and Blood Institute, in cooperation with the National Institute of Diabetes and Digestive and Kidney Diseases: Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults: The Evidence Report. NIH Publication No. 981083. US Government Press, Washington, DC, 1998
    • (1998) The Evidence Report
  • 96
    • 0344874623 scopus 로고    scopus 로고
    • A benefit-risk assessment of sibutramine in the management of obesity
    • Nisoli E, Carruba MO: A benefit-risk assessment of sibutramine in the management of obesity. Drug Saf 26:1027-1048, 2003
    • (2003) Drug Saf , vol.26 , pp. 1027-1048
    • Nisoli, E.1    Carruba, M.O.2
  • 99
    • 0346250180 scopus 로고    scopus 로고
    • Long-term pharmacotherapy for overweight and obesity: A systematic review and meta-analysis of randomized controlled trials
    • Padwal R, Li SK, Lau DC: Long-term pharmacotherapy for overweight and obesity: a systematic review and meta-analysis of randomized controlled trials. Int J Obes Relat Metab Disord 27:1437- 1446, 2003
    • (2003) Int J Obes Relat Metab Disord , vol.27 , pp. 1437-1446
    • Padwal, R.1    Li, S.K.2    Lau, D.C.3
  • 100
    • 33845874637 scopus 로고    scopus 로고
    • Drug treatments for obesity: Orlistat, sibutramine, and rimonabant
    • Padwal RS, Majumdar SR: Drug treatments for obesity: orlistat, sibutramine, and rimonabant. Lancet 369:71-77, 2007
    • (2007) Lancet , vol.369 , pp. 71-77
    • Padwal, R.S.1    Majumdar, S.R.2
  • 101
    • 21344453761 scopus 로고    scopus 로고
    • The endocannabinoid system and the treatment of obesity
    • Pagotto U, Vicennati V, Pasquali R: The endocannabinoid system and the treatment of obesity. Ann Med 37:270-275, 2005
    • (2005) Ann Med , vol.37 , pp. 270-275
    • Pagotto, U.1    Vicennati, V.2    Pasquali, R.3
  • 103
    • 32644441249 scopus 로고    scopus 로고
    • RIO-North America Study Group. Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial
    • Pi-Sunyer FX, Aronne LJ, Heshmati HM, Devin J, Rosenstock J: RIO-North America Study Group. Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. JAMA 295:761- 775, 2006
    • (2006) JAMA , vol.295 , pp. 761-775
    • Pi-Sunyer, F.X.1    Aronne, L.J.2    Heshmati, H.M.3    Devin, J.4    Rosenstock, J.5
  • 107
    • 0034118327 scopus 로고    scopus 로고
    • Anorexigens and pulmonary hypertension in the United States: Results from the surveillance of North American pulmonary hypertension
    • Rich S, Rubin L, Walker AM, Schneeweiss S, Abenhaim L: Anorexigens and pulmonary hypertension in the United States: results from the surveillance of North American pulmonary hypertension. Chest 117:870-874, 2000
    • (2000) Chest , vol.117 , pp. 870-874
    • Rich, S.1    Rubin, L.2    Walker, A.M.3    Schneeweiss, S.4    Abenhaim, L.5
  • 108
    • 0242404681 scopus 로고    scopus 로고
    • Comparison of survival in patients with pulmonary hypertension associated with fenfluramine to patients with primary pulmonary hypertension
    • Rich S, Shillington A, McLaughlin V: Comparison of survival in patients with pulmonary hypertension associated with fenfluramine to patients with primary pulmonary hypertension. Am J Cardiol 92:1366-1368, 2003
    • (2003) Am J Cardiol , vol.92 , pp. 1366-1368
    • Rich, S.1    Shillington, A.2    McLaughlin, V.3
  • 109
    • 4243066291 scopus 로고    scopus 로고
    • SR147778 [5-(4-bromophenyl)-l-(2,4-dichlorophe- nyl)-4-ethyl-N-(l-piperidinyl)-lH- pyrazole-3-carbox- amide], a new potent and selective antagonist of the CB1 cannabinoid receptor: Biochemical and pharmacological characterization
    • Rinaldi-Carmona M, Barth F, Congy C, Martinez S, Oustric D, Perio A, Poncelet M, Maruani J, Arnone M, Finance O, Soubrie P, Le Fur G: SR147778 [5-(4-bromophenyl)-l-(2,4-dichlorophe- nyl)-4-ethyl-N-(l-piperidinyl)-lH- pyrazole-3-carbox- amide], a new potent and selective antagonist of the CB1 cannabinoid receptor: biochemical and pharmacological characterization. J Pharmacol Exp Ther 310:905-914, 2004
    • (2004) J Pharmacol Exp Ther , vol.310 , pp. 905-914
    • Rinaldi-Carmona, M.1    Barth, F.2    Congy, C.3    Martinez, S.4    Oustric, D.5    Perio, A.6    Poncelet, M.7    Maruani, J.8    Arnone, M.9    Finance, O.10    Soubrie, P.11    Le Fur, G.12
  • 110
    • 33846017361 scopus 로고    scopus 로고
    • Drugs and valvular heart disease
    • Roth BL: Drugs and valvular heart disease. N Engl J Med 356:6-9, 2007
    • (2007) N Engl J Med , vol.356 , pp. 6-9
    • Roth, B.L.1
  • 111
    • 0034610435 scopus 로고    scopus 로고
    • Evidence for possible involvement of 5HT2B receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications
    • Rothman RB, Michael H, Baumann MH, Savage JE, Rauser L, McBride A, Hufeisen SJ, Roth BL: Evidence for possible involvement of 5HT2B receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation 101:2836-2841, 2000
    • (2000) Circulation , vol.101 , pp. 2836-2841
    • Rothman, R.B.1    Michael, H.2    Baumann, M.H.3    Savage, J.E.4    Rauser, L.5    McBride, A.6    Hufeisen, S.J.7    Roth, B.L.8
  • 112
    • 0031031440 scopus 로고    scopus 로고
    • Primary pulmonary hypertension
    • Rubin LJ: Primary pulmonary hypertension. N Engl J Med 336:111-117, 1997
    • (1997) N Engl J Med , vol.336 , pp. 111-117
    • Rubin, L.J.1
  • 113
    • 0036911037 scopus 로고    scopus 로고
    • Effect of fenfluramine- derivative diet pills on cardiac valves: A meta-analysis of observational studies
    • Sachdev M, Miller WC, Ryan T, Jollis JG: Effect of fenfluramine- derivative diet pills on cardiac valves: a meta-analysis of observational studies. Am Heart J 144:1065-1073, 2002
    • (2002) Am Heart J , vol.144 , pp. 1065-1073
    • Sachdev, M.1    Miller, W.C.2    Ryan, T.3    Jollis, J.G.4
  • 115
    • 33845889549 scopus 로고    scopus 로고
    • RIO-Diabetes Study Group, Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes
    • Scheen AJ, Finer N, Hollander P, Jensen MD, Van Gaal LF, RIO-Diabetes Study Group, Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes. Lancet 368:1160 - 1172, 2006
    • (2006) Lancet , vol.368 , pp. 1160-1172
    • Scheen, A.J.1    Finer, N.2    Hollander, P.3    Jensen, M.D.4    Van Gaal, L.F.5
  • 116
    • 0038779278 scopus 로고    scopus 로고
    • 3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions of human cardiac valvular interstitial cells in vitro
    • Setola V, Hufeisen SJ, GrandeAllen KJ, Vesely I, Glennon RA, Blough B, Rothman RB, Roth BL: 3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions of human cardiac valvular interstitial cells in vitro. Mol Pharmacol 63:1223-1229, 2003
    • (2003) Mol Pharmacol , vol.63 , pp. 1223-1229
    • Setola, V.1    Hufeisen, S.J.2    GrandeAllen, K.J.3    Vesely, I.4    Glennon, R.A.5    Blough, B.6    Rothman, R.B.7    Roth, B.L.8
  • 117
    • 33644784540 scopus 로고    scopus 로고
    • Screening the receptorme reveals molecular targets responsible for drug- induced side effects: Focus on 'fen-phen
    • Setola V, Roth BL: Screening the receptorme reveals molecular targets responsible for drug- induced side effects: focus on 'fen-phen.' Expert Opin Drug Metab Toxicol 1:377-387, 2005
    • (2005) Expert Opin Drug Metab Toxicol , vol.1 , pp. 377-387
    • Setola, V.1    Roth, B.L.2
  • 118
    • 0035885179 scopus 로고    scopus 로고
    • Effective decision making: Progressing compounds through clinical development
    • Shillingford CA, Vose CW: Effective decision making: progressing compounds through clinical development. Drug Discov Today 6:941-946, 2001
    • (2001) Drug Discov Today , vol.6 , pp. 941-946
    • Shillingford, C.A.1    Vose, C.W.2
  • 119
    • 0031718736 scopus 로고    scopus 로고
    • Primary pulmonary hypertension associated with the use of fenfluramine derivatives
    • Simonneau G, Fartoukh M, Sitbon O, Humbert M, Jagot JL, Herve P: Primary pulmonary hypertension associated with the use of fenfluramine derivatives. Chest 114:195S-199S, 1998
    • (1998) Chest , vol.114
    • Simonneau, G.1    Fartoukh, M.2    Sitbon, O.3    Humbert, M.4    Jagot, J.L.5    Herve, P.6
  • 120
    • 0033592829 scopus 로고    scopus 로고
    • Diet drug maker agrees to $3.75 billion settlement
    • SoRelle R: Diet drug maker agrees to $3.75 billion settlement. Circulation 100:133-134, 1999
    • (1999) Circulation , vol.100 , pp. 133-134
    • SoRelle, R.1
  • 122
    • 34247211701 scopus 로고    scopus 로고
    • Challenges in the discovery and development of new agents for the treatment of obesity
    • Staten MA: Challenges in the discovery and development of new agents for the treatment of obesity. Clin Pharmacol Ther 81:753-755, 2007
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 753-755
    • Staten, M.A.1
  • 124
    • 33644849222 scopus 로고    scopus 로고
    • Thorn T, Haase N, Rosamond W, Howard VJ, Rumsfeld J, Manolio T, Zheng ZJ, Flegal K, O'Donnell C, Kittner S, Lloyd-Jones D, Goff DC Jr, Hong Y, Adams R, Friday G, Furie K, Gorelick P, Kissela B, Marler J, Meigs J, Roger V, Sidney S, Sorlie P, Steinberger J, Wasserthiel-Smoller S, Wilson M, Wolf P: American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 113:e85-el51, 2006
    • Thorn T, Haase N, Rosamond W, Howard VJ, Rumsfeld J, Manolio T, Zheng ZJ, Flegal K, O'Donnell C, Kittner S, Lloyd-Jones D, Goff DC Jr, Hong Y, Adams R, Friday G, Furie K, Gorelick P, Kissela B, Marler J, Meigs J, Roger V, Sidney S, Sorlie P, Steinberger J, Wasserthiel-Smoller S, Wilson M, Wolf P: American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 113:e85-el51, 2006
  • 125
    • 27744444882 scopus 로고    scopus 로고
    • X-PERT: Weight reduction with orlistat in obese subjects receiving a mildly or moderately reduced-energy diet: early response to treatment predicts weight maintenance
    • Toplak H, Ziegler O, Keller U, Hamann A, Godin C, Wittert G, Zanella MT, Zuniga-Guajardo S, Van Gaal L: X-PERT: weight reduction with orlistat in obese subjects receiving a mildly or moderately reduced-energy diet: early response to treatment predicts weight maintenance. Diabetes Obes Metab 7:699-708, 2005
    • (2005) Diabetes Obes Metab , vol.7 , pp. 699-708
    • Toplak, H.1    Ziegler, O.2    Keller, U.3    Hamann, A.4    Godin, C.5    Wittert, G.6    Zanella, M.T.7    Zuniga-Guajardo, S.8    Van Gaal, L.9
  • 126
    • 34447574994 scopus 로고    scopus 로고
    • Panel advises against Rimonabant approval
    • Traynor K: Panel advises against Rimonabant approval. Am J Health Syst Pharm 64:1460-1461, 2007
    • (2007) Am J Health Syst Pharm , vol.64 , pp. 1460-1461
    • Traynor, K.1
  • 127
    • 0003761221 scopus 로고    scopus 로고
    • US Department of Health and Human Services, Public Health Service:, Office of the Surgeon General, Rockville, MD
    • US Department of Health and Human Services, Public Health Service: The Surgeon General's Call to Action to Prevent and Decrease Overweight and Obesity, Office of the Surgeon General, Rockville, MD, 2001
    • (2001) The Surgeon General's Call to Action to Prevent and Decrease Overweight and Obesity
  • 128
    • 17144382751 scopus 로고    scopus 로고
    • Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study
    • and for the RIO-Europe Study Group
    • Van Gaal LF, Rissanen AM, Scheen AJ, Ziegler O, Rossner S and for the RIO-Europe Study Group: Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Lancet 365:1389-1397, 2005
    • (2005) Lancet , vol.365 , pp. 1389-1397
    • Van Gaal, L.F.1    Rissanen, A.M.2    Scheen, A.J.3    Ziegler, O.4    Rossner, S.5
  • 129
    • 0035218345 scopus 로고    scopus 로고
    • Aortic and mitral fenfluramine-phentermine valvulopathy in 64 patients treated with anorectic agents
    • Volmar KE, Hutchins GM: Aortic and mitral fenfluramine-phentermine valvulopathy in 64 patients treated with anorectic agents. Arch Pathol Lab Med 125:1555-1561, 2001
    • (2001) Arch Pathol Lab Med , vol.125 , pp. 1555-1561
    • Volmar, K.E.1    Hutchins, G.M.2
  • 130
    • 34547227547 scopus 로고    scopus 로고
    • The obesity epidemic in the United States-gender, age, socioeconomic, racial/ ethnic, and geographic characteristics: A systematic review and meta-regression analysis
    • Wang Y, Beydoun MA: The obesity epidemic in the United States-gender, age, socioeconomic, racial/ ethnic, and geographic characteristics: a systematic review and meta-regression analysis. Epidemiol Rev 29:6-28, 2007
    • (2007) Epidemiol Rev , vol.29 , pp. 6-28
    • Wang, Y.1    Beydoun, M.A.2
  • 131
    • 0023626926 scopus 로고
    • Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini, I: Producing organism, fermentation, isolation and biological activity
    • Weibel EK, Hadvary P, Hochuli E, Kupfer E, Lengsfeld H: Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini, I: producing organism, fermentation, isolation and biological activity. J Antibiot 40:1081-1085, 1987
    • (1987) J Antibiot , vol.40 , pp. 1081-1085
    • Weibel, E.K.1    Hadvary, P.2    Hochuli, E.3    Kupfer, E.4    Lengsfeld, H.5
  • 132
    • 26844441917 scopus 로고    scopus 로고
    • Weighing in on bariatric surgery: Procedure use, readmission rates, and mortality
    • Wolfe BM, Morton JM: Weighing in on bariatric surgery: procedure use, readmission rates, and mortality. JAMA 294:1960-1963, 2005
    • (2005) JAMA , vol.294 , pp. 1960-1963
    • Wolfe, B.M.1    Morton, J.M.2
  • 133
    • 0036098099 scopus 로고    scopus 로고
    • Obesity drug sibutramine (Meridia): Hypertension and cardiac arrhythmias
    • Wooltorton E: Obesity drug sibutramine (Meridia): hypertension and cardiac arrhythmias. CMAJ 166:1307-1308, 2002
    • (2002) CMAJ , vol.166 , pp. 1307-1308
    • Wooltorton, E.1
  • 135
    • 0031023380 scopus 로고    scopus 로고
    • The effects of aminorex and related compounds on brain monoamines and metabolites in CBA mice
    • Zheng Y, Russell B, Schmierer D, Laverty R: The effects of aminorex and related compounds on brain monoamines and metabolites in CBA mice. J Pharm Pharmacol 49:89-96, 1997
    • (1997) J Pharm Pharmacol , vol.49 , pp. 89-96
    • Zheng, Y.1    Russell, B.2    Schmierer, D.3    Laverty, R.4
  • 136
    • 0141988881 scopus 로고    scopus 로고
    • The effect of short-term (21-day) orlistat treatment on the physiologic balance of six selected macrominerals and micro- minerals in obese adolescents
    • Zhi J, Moore R, Kanitra L: The effect of short-term (21-day) orlistat treatment on the physiologic balance of six selected macrominerals and micro- minerals in obese adolescents. J Am Coll Nutr 22:357-362, 2003
    • (2003) J Am Coll Nutr , vol.22 , pp. 357-362
    • Zhi, J.1    Moore, R.2    Kanitra, L.3
  • 137
    • 0036708028 scopus 로고    scopus 로고
    • Pharmacokinetic evaluation of the possible interaction between selected concomitant medications and orlistat at steady state in health subjects
    • Zhi J, Moore R, Kanitra L, Mulligan TE: Pharmacokinetic evaluation of the possible interaction between selected concomitant medications and orlistat at steady state in health subjects. J Clin Pharmacol 42:1011-1019, 2002
    • (2002) J Clin Pharmacol , vol.42 , pp. 1011-1019
    • Zhi, J.1    Moore, R.2    Kanitra, L.3    Mulligan, T.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.