5-Hydroxytryptamine receptors mediating vasoconstriction in pulmonary arteries from control and pulmonary hypertensive rats

British Journal of Pharmacology

Volumn 119, Issue 5, 1996, Pages 917-930

  MacLean, M R ^a   Sweeney, G ^a   Baird, M ^a   McCulloch, K M ^a   Houslay, M ^a   Morecroft, I ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

5 HT receptors; Chronic hypoxia; Cyclic nucleotides; Pulmonary artery; Pulmonary hypertension; Sumatriptan; Vascular tone; Vasoconstriction

Indexed keywords

5 CARBAMOYLTRYPTAMINE; CYCLIC AMP; CYCLIC GMP; KETANSERIN; METITEPINE; SEROTONIN; SEROTONIN 1 AGONIST; SEROTONIN 1B RECEPTOR; SEROTONIN 1D ANTAGONIST; SEROTONIN 2A RECEPTOR; SEROTONIN RECEPTOR; SUMATRIPTAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY TONE; ARTICLE; CONTROLLED STUDY; HYPOXIC LUNG VASOCONSTRICTION; MALE; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; RESISTANCE BLOOD VESSEL; VASOCONSTRICTION;

EID: 0029911551     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15760.x     Document Type: Article

References (48)

1. 1Dβ receptor. Mol. Pharmacol., 41, 1-7.
2. ASHMORE, R.C., RODMAN, D.M., SATO, K., OBRIEN, R.F., MCMURTRY, I.F. & STELZNER, T.J. (1991). Paradoxical constriction to platelets by arteries from rats with pulmonary hypertension. Am. J. Physiol., 260, H1929-H1934.
3. ID-like receptor. J. Recept. Res., 13, 479-502.
4. BRINK, C., CERRINA, C., LABAT, C., VERLEY, J. & BENVENISTE, J. (1988). The effect of contractile agonists on isolated pulmonary arterial and venous muscle preparations derived from patients with primary pulmonary hypertension. Am. Rev. Resp. Dis.., 137, A106.
5. BROWN, B.L., EKINS, R.P. & ALBANO, J.D.M. (1972). Saturation assay for cyclic AMP using endogenous binding protein. Adv. Cyclic Nucleotide Res., 2, 25-29.
6. 1D binding sites in rat brain. Naunyn Schmiedeberg's Arch. Pharmacol., 347, 569-582.
7. 1D receptor subtypes mediating cerebral vasoconstriction. Cephalalgia, 15, (suppl 14), 99.
8. 1B receptors mediate potent contractile responses to 5-HT in rat caudal artery. Br. J. Pharmacol., 109, 609-611.
9. FISHMAN, A.P. (1976). Hypoxia on the pulmonary circulation. Circ. Res., 38, 221-231.
10. FRID, M.G., MOISEEVA, E.P. & STENMARK, K.R. (1994). Multiple phenotypically distinct smooth muscle cell populations exist in the adult and developing bovine pulmonary arterial media in vivo. Circ. Res., 75, 669-681.
11. 1D receptor genes. Trends Pharmacol. Sci., 13, 152-159.
12. 1D receptor subtypes. Trends Pharmacol. Sci., 17, 103-105.
13. HEATH, D., EDWARDS, C., WINSON, M. & SMITH, P. (1973). Effects on the right ventricle, pulmonary vasculature, and carotid bodies of the rat of exposure to, and recovery from, simulated high altitude. Thorax, 28, 24-28.
14. 1D receptor in rat and human brain. J. Neurochem., 50, 1624-1631.
15. HERVÉ, P., DROUET, L., DOSQUET, C., LAUNAY, J.M., RAIN, B., SIMONNEAU, G., CAEN, J. & DUROUX, P. (1990). Primary pulmonary hypertension in a patient with a familial platelet storage pool disease-role of serotonin. Am. J. Med., 89, 17-20.
16. HERVÉ, P., LAUNAY, J.M., SCROBOHACI, M-L., BRENOT, F., SIMONNEAU, G., PETITPRETZ, P., POUBEAU, P., CERRINA, J., DUROUX, P. & DROUET, L. (1995). Increased plasma serotonin in primary pulmonary hypertension. Am. J. Med., 99, 249-254.
17. HOYER, D, CLARKE, D.E., FOZARD, J.R., HARTIG, P.R., MARTIN, G.R., MYLECHARANE, E.J., SAXENA, P.R. & HUMPHREY, P.P.A. (1994). VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamin (serotonin). Pharmacol. Rev., 46, 157-203.
18. 1-like receptor on dog saphenous vein. Br. J. Pharmacol., 94, 1123-1132.
19. HUNTER, C., BARER, G.R., SHAW, J.W. & CLEGG, E.J. (1974). Growth of the heart and lungs in hypoxic rodents: a model of human hypoxic disease, Clin. Sci. Mol. Med., 46, 375-391.
20. ISAACSON, T.C., HAMPL, V., WEIR, E.K., NELSON, O.P. & ARCHER, S.L. (1994). Increased endothelium-derived NO in hypertensive pulmonary circulation of chronically hypoxic rats. J. Appl. Physiol., 76, 933-940.
21. JOHNSON, D.E. & GEORGIEFF, M.K. (1989). Pulmonary neuroendocrine cells. Their secretory products and their potential roles in health and chronic lung disease in infancy. Am. Rev. Respir. Dis., 140, 1807-1812.
22. KANAI, Y., HORI, S., TANAKA, T., YASUOKA, M., WATANABE, K., AIKAWA, N. & HOSADA, Y. (1993). Role of 5-hydroxytryptamine in the progression of monocrotaline induced pulmonary hypertension in rats. Cardiovasc. Res., 27, 1619-1623.
23. 1-receptor mediated vasoconstriction in bovine isolated pulmonary arteries: Influence of vascular endothelium and tone. Pulmonary Pharmacol., 7, 65-72.
24. 1-like receptor-mediated vasoconstriction in human pulmonary artery. Br. J. Pharmacol., details at press.
25. B receptor-mediated vasoconstriction in rat pulmonary arteries and arterioles. J. Cardiovasc. Pharmacol., 23, 838-845.
26. MACLEAN, M.R., MCCULLOCH, K.M. & BAIRD, M. (1995). Effects of pulmonary hypertension on vasoconstrictor responses to endothelin-1 and sarafotoxin S6c and on inherent tone in rat pulmonary arteries. J. Cardiovasc. Pharmacol., 26, 822-830.
27. MCCULLOCH, K.M., BAIRD, M & MACLEAN, M.R. (1994). Heterogeneity and distribution of endothelin receptors involved in vasoconstrictor responses to endothelin-1 in human pulmonary arteries. Br. J. Pharmacol., 113, 161P.
28. MCCULLOCH, K.M., BAIRD, M. & MACLEAN, M.R. (1995). Endothelium-dependent relaxation, nitric oxide and vascular tone in control and chronic hypoxic rat pulmonary arteries. Br. J. Pharmacol., 116, 190P.
29. MEYRICK, B. & REID, L. (1978). The effect of continued hypoxia on rat pulmonary arterial circulation: an ultrastructural study. Lab. Invest., 38, 188-200.
30. OKA, M., HASUNUMA, K., WEBB, S.A., STELZNER, T.J., RODMAN, D.M. & MCMURTRY, I.F. (1993). EDRF suppresses an unidentified vasoconstrictor mechanism in hypertensive rat lungs. Am. J. Physiol., 264, L587-L597.
31. 1-like receptors in rabbit isolated basilar arteries. Eur. J. Pharmacol., 174, 189-196.
32. 1D binding sites. Eur. J. Pharmacol., 163, 133-136.
33. PITTMAN, R.N. & DULING, B.R. (1973). Oxygen sensitivity of vascular smooth muscle. Microvasc. Res., 6, 202-211.
34. RENEMAN, R.S. & VAN DER STARRE, P.J. (1990). Serotonin and acute cardiovascular disorders. Cardiovasc. Drug Ther., 4 (suppl. 1), 19-25.
35. SASAKI, S-I., KOBAYASHI, N., DAMBARA, T., KIRA, S. & SAKAI, T. (1995). Structural organisation of pulmonary arteries in the rat lung. Anat. Embryol., 191, 477-489.
36. SAXENA, P.R. & VILLALON, C.M. (1990). Cardiovascular effects of serotonin agonists and antagonists. J. Cardiovasc. Pharmacol., 15 (suppl. 7), S17-S34.
37. SHAUL, P.W., WELLS, L.B. & HORNING, K.M. (1993). Acute and prolonged hypoxia attenuate endothelial nitric oxide production in rat pulmonary arteries by different mechanisms. J Cardiovasc. Pharmacol., 22, 819-827.
38. STAUB, N.C. (1985). Site of hypoxic pulmonary vasoconstriction. Chest, 88, 240s-245s.
39. 1D binding sites in porcine brain can be differentiated by GR43175. Br. J. Pharmacol., 97, 410P.
40. SUMNER, M.J. & HUMPHREY, P.P.A. (1990). Sumatriptan (GR43175) inhibits cyclic-AMP accumulation in dog isolated saphenous vein. Br. J. Pharmacol., 99, 219-220.
41. SWEENEY, G., MCCULLOGH, K., JOHNSTON, E., BAIRD, M., MORECROFT, I., DOCCHERT, C., POOLEY, M. & MACLEAN, M.R. (1996). The role of cyclic nucleotides in pulmonary hypertension. Am. J. Resp. Crit. Care Med., 153, A189.
42. SWEENEY, G., TEMPLETON, A., CLAYTON, R.A., BAIRD, M., SHERIDAN, J.S., JOHNSTON, E.D. & MACLEAN, M.R. (1995). Contractile responses to sumatriptan in isolated bovine pulmonary artery rings: relationship with tone and cyclic nucleotide levels. J. Cardiovasc. Pharmacol., 26, 751-760.
43. TEMPLETON, A.G.B., CLAYTON, R.A., MCINTYRE, P.D., HILLIS, W.S., PEACOCK, A. & MACLEAN, M.R. (1993). Sensitivity of human, bovine and rabbit pulmonary arteries to sumatriptan: comparison with 5-HT, Br. J. Pharmacol., 110, 113P.
44. TEMPLETON, A.G.B., CLAYTON, R.A., & MACLEAN, M.R. (1994). Contractile responses of human pulmonary artery to 5-HT and sumatriptan. Thorax, 49, 425P.
45. 1B receptor. EMBO J., 10, 4017-4023.
46. WANSTALL, J.C. & O'DONNELL, S.R. (1990). Endothelin and 5-hydroxytryptamine on rat pulmonary artery in pulmonary hypertension. Eur. J. Pharmacol., 176, 159-168.
47. WANSTALL, J.C., O'DONNELL, S.R. & KAY, C.S. (1991). Increased relaxation by felodipine on pulmonary artery from rats with monocrotaline-induced pulmonary hypertension does not reflect functional impairment of the endothelium. Pulmonary Pharmacol., 4, 60-66.
48. XUE, C., RENGASAMY, A., LE CRAS, T.D., KOBERNA, P.A., DAILEY, G.C. & JOHNS, R.A. (1994). Distribution of NOS in normoxic vs. hypoxic rat lung: upregulation of NOS by chronic hypoxia. Am. J. Physiol., 267, L667-L678.