The effects of aminorex and related compounds on brain monoamines and metabolites in CBA mice

Journal of Pharmacy and Pharmacology

Volumn 49, Issue 1, 1997, Pages 89-96

  Zheng, Yiwen ^a   Russell, Bruce ^a   Schmierer, David ^a   Laverty, Richard ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; AMINOREX; AMPHETAMINE DERIVATIVE; ANOREXIGENIC AGENT; BRAIN MONOAMINE; DOPAMINE; FENFLURAMINE; NEUROTRANSMITTER; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DOPAMINE BRAIN LEVEL; DOPAMINE RELEASE; DOPAMINERGIC SYSTEM; DRUG EFFECT; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MONOAMINE METABOLISM; MOUSE; NEUROTOXICITY; NONHUMAN; SEROTONIN BRAIN LEVEL; SEROTONIN RELEASE; SEROTONINERGIC SYSTEM; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION;

EID: 0031023380     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1997.tb06758.x     Document Type: Article

References (43)

1. Axt, K. J., Commins, D. L., Vosmer, G., Seiden, L. S. (1990) α-Methyl-p-tyrosine pretreatment partially prevents methamphetamine-induced endogenous neurotoxin formation. Brain Res. 515: 269-276
2. Blundell, J. (1991) Pharmacological approaches to appetite suppression. Trends Pharmacol. Sci. 12: 147-157
3. Clineschmidt, B. V., Totaro, J. A., Mcguffin, J. C., Pflueger, A. B. (1976) Fenfluramine: long-term reduction in brain serotonin (5-hydroxytryptamine). Eur. J. Pharmacol. 35: 211-214
4. Davis, F. T., Brewster, M. E. (1988) A fatality involving U4Euh, a cyclic derivative of phenylpropanolamine. J. Forensic Sci. 33: 549-553
5. Drug Control Section, Office of Diversion Control, Drug Enforcement Admin., USA (1988) Scheduling recommendation for 4-methylaminorea, September 1988
6. Fuller, R. W., Snoddy, H. D., Hemrick, S. K. (1978) Effects of fenfluramine and norfenfluramine on brain serotonin metabolism in rats. Proc. Soc. Exp. Biol. Med. 157: 202-205
7. Gurtner, H.P., Gertsch, M., Salzmann, C., Scheerer, M., Slucki, P., Wyss, F. (1968) Hëufen sich die Primër vasculëren formen des chronischen cor pulmonale? Schweiz. Med. Wochen. 98: 1579 and 1695
8. Hanson, G. R., Bunker, C. F., Johnson, M., Bush, L., Gibb, J. W. (1992) Response of monoaminergic and neuropeptide systems to 4-methylaminorex: a new stimulant of abuse. Eur. J. Pharmacol. 218: 287-293
9. Johnson, M. P., Nichols, D. E. (1989) Neurotoxic effects of the alpha-ethyl homologue of MDMA following subacute administration. Pharmacol. Biochem. Behav. 33: 105-108
10. Johnson, M. P., Nichols, D. E. (1990) Comparative serotonin neurotoxicity of the stereoisomers of fenfluramine and norfenfluramine. Pharmacol. Biochem. Behav. 36: 105-109
11. 3H]dopamine release from superfused rat brain slices. Eur. J. Pharmacol. 132: 269-276
12. 3H]Monoamine releaseing and uptake inhibition properties of 3,4-methylenedioxymethamphetamine and p-chloroamphetamine analogues. Eur. J. Pharmacol. 200: 9-16
13. Lim, H. K., Foltz, R. L. (1988) In vivo and vitro metabolism of 3,4-(methylenedioxy)methamphetamine in the rat: identification of metabolites using an ion trap detector. Chem. Res. Toxicol. 1: 370-378
14. Lim, H. K., Foltz, R. L. (1991a) In vivo formation of aromatic hydroxylated metabolites of 3,4-(methylenedioxy)methamphetamine in the rat: identification by ion trap ms/ms and ms/ms/ms techniques. Biol. Mass. Spectrom. 20: 667-686
15. Lim, H. K., Foltz, R. L. (1991b) Ion trap mass spectrometric evidence for the metabolism of 3,4-(methylenedioxy)methamphetamine to the potent neurotoxins 2,4,5-trihydroxymethamphetamine and 2,4,5-trihydroxyamphetamine. Chem. Res. Toxicol. 4: 626-632
16. Logan, B. J., Laverty, R., Sanderson, W. D., Yee, Y. B. (1988) Differences between rats and mice in MDMA (methylenedioxymethylamphetamine) neurotoxicity. Eur. J. Pharmacol. 152: 227-234
17. Mennini, T., Garattini, S., Caccia, S. (1985) Anorectic effect of fenfluramine isomers and metabolites: relationship between brain levels and in vitro potencies on serotonergic mechanisms. Psychopharmacology 85: 111-114
18. Neff, N. H., Tozer, T. N. (1968) In vivo measurement of brain serotonin turnover. Adv. Pharmacol. 6A: 97-109
19. Nichols, D. E., Oberlender, R., Burris, K., Hoffman, A. J., Johnson, M. P. (1989) Studies of dioxole ring substituted 3,4-methylenedioxyamphetamine (MDA) analogues. Pharmacol. Biochem. Behav. 34: 571-576
20. Nichols, D. E., Brewster, W. K., Johnson, M. P., Oberlender, R., Riggs, R. M. (1990) Nonneurotoxic tetralin and indan analogues of 3,4-(methlenedioxy)amphetamine(MDA). J. Med. Chem. 33: 703-710
21. Paris, J. M., Cunningham, K. A. (1991) Lack of serotonin neurotoxicity after intraraphe microinjection of (+ )-3,4-methylenedioxymethamphetamine (MDMA). Brain Res. Bull. 28: 115-119
22. Ram, F. S. F., Laverty, R. (1993) Differences in anorectic potency of fenfluramine, methylenedioxymethamphetamine (MDMA) and aminorex in rats and mice. Proc. Univ. Otago Med. Sch. 71: 29
23. Ricaurte, G., Bryan, G., Strauss, L., Seiden, L., Schuster, C. (1985) Hallucinogenic amphetamine selectively destroys brain serotonin nerve terminals. Science 229: 986-988
24. Ricaurte, G. A., Forno, L. S., Wilson, M. A., DeLanney, L. E., Irwin, I., Molliver, M. E., Langston, J. W. (1988) (±) 3,4-Methylenedioxymethamphetamine selectively damages central serotonergic neurons in nonhuman primates. J. Am. Med. Assoc. 260: 51-55
25. Ricaurte, G. A., DeLanney, L. E., Irwin, I. Witkin, J. M., Katz, J. L., Langston, J. W. (1989) Evaluation of the neurotoxic potential of N,N-dimethylamphetamine: an illicit analog of methamphetamine. Brain Res. 490: 301-306
26. Roszkowski, A. P., Kelley, N. M. (1963) A rapid method for assessing drug inhibition of feeding behavior. J. Pharmacol. Exp. Ther. 140: 367-374
27. Rowland, N. E., Carlton, J. (1986) Neurobiology of an anorectic drug: fenfluramine. Prog. Neurobiol. 27: 13-62
28. Schmidt, C. J. (1987) Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. J. Pharmacol. Exp. Ther. 240: 1-7
29. Schmidt, C. J., Kehne, J. H. (1990) Neurotoxicity of MDMA: neurochemical effects. Ann. NY Acad. Sci. 600: 665-680
30. Schmidt, C. J., Taylor, V. L. (1987) Depression of rat brain tryptophan hydroxylase following the acute administration of methylenedioxymethamphetamine. Biochem. Pharmacol. 36: 4095-4102
31. Schmidt, C. J., Wu, L., Lovenberg, W. (1986) Methylenedioxymethamphetamine: a potentially neurotoxic amphetamine analogue. Eur. J. Pharmacol. 124: 175-178
32. Schmidt, C. J., Levin, J. A., Lovenberg, W. (1987) In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain. Biochem. Pharmacol. 36: 747-755
33. Schwartz, D., Hemandez, L., Hoebel, B. G. (1989) Fenfluramine administered systemically or locally increases extracellular serotonin in the lateral hypothalamus as measured by microdialysis. Brain Res. 482: 261-270
34. Shulgin, A. T., Sargent, T., Naranjo, C. (1969) Structure-activity relationships of one-ring psychotomimetics. Nature 221: 537-541
35. 3H]monoamines into synaptosomes from different regions of rat brain. Biochem. Pharmacol. 36: 2297-2303
36. Steranka, L. R., Sanders-Bush, E. (1979) Long-term effects of fenfluramine on central serotonergic mechanisms. Neuropharmacology 18: 895-903
37. Stone, D. M., Merchant, K. M., Hanson, G. R., Gibb, J. W. (1987) Immediate and long-term effects of 3,4-methylenedioxymethamphetamine on serotonin pathways in brain of rat. Neuropharmacology 26: 1677-1683
38. Stone, D. M., Johnson, M., Hanson, G. R., Gibb, J. W. (1988) Role of endogenous dopamine in the central serotonergic deficits induced by 3,4-methylenedioxymethamphetamine. J. Pharmacol. Exp. Ther. 247: 79-87
39. Tozer, T. N., Neff, N. H., Brodie, B. B. (1966) Application of steady state kinetics to the synthesis rate and turnover time of serotonin in the brain of normal and reserpine-treated rats. J. Pharmacol. Exp. Ther. 153: 177-182
40. Wagner, G. C., Ricaurte, G. A., Seiden, L. S., Schuster, C. R., Miller, R. J., Westley, J. (1980) Long-lasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine. Brain Res. 181: 151-160
41. Yelnosky, J., Katz, R. (1963) Sympathomimetic actions of cis-2-amino-4-methyl-5-phenyl-2-oxazoline. J. Pharmacol. Exp. Ther. 141: 180-184
42. Young, R. (1992) Aminorex produces stimulus effects similar to amphetamine and unlike those of fenfiuramine. Pharmacol. Biochem. Behav. 42: 175-178
43. Zheng, Y., Laverty, R. (1993) Neurotoxic effects of MDMA in different strains of mice. Proc. Univ. Otago Med. Sch. 71: 5-6