SR147778 [5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-N-(1- piperidinyl)-1H-pyrazole-3-carboxamide], a new potent and selective antagonist of the CB1 cannabinoid receptor: Biochemical and pharmacological characterization

Journal of Pharmacology and Experimental Therapeutics

Volumn 310, Issue 3, 2004, Pages 905-914

  Rinaldi Carmona, Murielle ^a   Barth, Francis ^a   Congy, Christian ^a   Martinez, Serge ^a   Oustric, Didier ^a   Pério, Alain ^a   Poncelet, Martine ^a   Maruani, Jeanne ^a   Arnone, Michèle ^a   Finance, Olivier ^a   Soubrié, Philippe ^a   Le Fur, Gérard ^a  

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; 5 (4 BROMOPHENYL) 1 (2,4 DICHLOROPHENYL) 4 ETHYL N (1 PIPERIDINYL) 1H PYRAZOLE 3 CARBOXAMIDE; 5 (4 BROMOPHENYL) 1 (2,4 DICHLOROPHENYL) 4 ETHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; CANNABINOID 1 RECEPTOR ANTAGONIST; CANNABINOID 2 RECEPTOR; CANNABINOID DERIVATIVE; RIMONABANT; UNCLASSIFIED DRUG;

ALCOHOL CONSUMPTION; ANALGESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING COMPETITION; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRINKING BEHAVIOR; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; ENZYME ACTIVITY; FEEDING BEHAVIOR; HYPOTHERMIA; INTESTINE TRANSIT TIME; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; MALE; MICE; PIPERIDINES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTOR, CANNABINOID, CB1; SPECIES SPECIFICITY;

EID: 4243066291     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.067884     Document Type: Article

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