Epidermal Growth Factor Receptor Activation Protects Gastric Epithelial Cells From Helicobacter pylori-Induced Apoptosis

Gastroenterology

Volumn 136, Issue 4, 2009, Pages

  Yan, Fang ^a   Cao, Hanwei ^a   Chaturvedi, Rupesh ^a,b   Krishna, Uma ^a   Hobbs, Stuart S ^a   Dempsey, Peter J ^c   Peek Jr , Richard M ^a   Cover, Timothy L ^a,b   Washington, M Kay ^a   Wilson, Keith T ^a,b   Polk, D Brent ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; DISINTEGRIN; EPIDERMAL GROWTH FACTOR RECEPTOR; MATRIX METALLOPROTEINASE 17; NEUTRALIZING ANTIBODY; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EPITHELIUM CELL; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STOMACH EPITHELIUM; TRANSGENIC MOUSE; WILD TYPE;

EID: 62949152938     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2008.12.059     Document Type: Article

References (59)

1. Peek Jr. R.M., and Blaser M.J. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer 2 (2002) 28-37
2. Peek Jr. R.M., and Crabtree J.E. Helicobacter infection and gastric neoplasia. J Pathol 208 (2006) 233-248
3. Crabtree J.E., Court M., Aboshkiwa M.A., et al. Gastric mucosal cytokine and epithelial cell responses to Helicobacter pylori infection in Mongolian gerbils. J Pathol 202 (2004) 197-207
4. + Helicobacter pylori strains. Cancer Res 61 (2001) 1406-1411
5. Ernst P.B., Crowe S.E., and Reyes V.E. How does Helicobacter pylori cause mucosal damage?. The inflammatory response. Gastroenterology 113 (1997) S35-S42
6. Gupta R.A., Polk D.B., Krishna U., et al. Activation of peroxisome proliferator-activated receptor γ suppresses nuclear factor κB-mediated apoptosis induced by Helicobacter pylori in gastric epithelial cells. J Biol Chem 276 (2001) 31059-31066
7. Cover T.L., Krishna U.S., Israel D.A., et al. Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin. Cancer Res 63 (2003) 951-957
8. Kawahara T., Teshima S., Kuwano Y., et al. Helicobacter pylori lipopolysaccharide induces apoptosis of cultured guinea pig gastric mucosal cells. Am J Physiol Gastrointest Liver Physiol 281 (2001) G726-G734
9. Rudi J., Kuck D., Strand S., et al. Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis. J Clin Invest 102 (1998) 1506-1514
10. Shibata J., Goto H., Arisawa T., et al. Regulation of tumour necrosis factor (TNF) induced apoptosis by soluble TNF receptors in Helicobacter pylori infection. Gut 45 (1999) 24-31
11. Xu H., Chaturvedi R., Cheng Y., et al. Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis. Cancer Res 64 (2004) 8521-8525
12. Shirin H., Sordillo E.M., Kolevska T.K., et al. Chronic Helicobacter pylori infection induces an apoptosis-resistant phenotype associated with decreased expression of p27(kip1). Infect Immun 68 (2000) 5321-5328
13. Mimuro H., Suzuki T., Nagai S., et al. Helicobacter pylori dampens gut epithelial self-renewal by inhibiting apoptosis, a bacterial strategy to enhance colonization of the stomach. Cell Host Microbe 2 (2007) 250-263
14. + strains and dissociation of gastric epithelial cell proliferation from apoptosis. J Natl Cancer Inst 89 (1997) 863-868
15. Peek Jr. R.M., Wirth H.P., Moss S.F., et al. Helicobacter pylori alters gastric epithelial cell cycle events and gastrin secretion in Mongolian gerbils. Gastroenterology 118 (2000) 48-59
16. Keates S., Keates A.C., Katchar K., et al. Helicobacter pylori induces up-regulation of the epidermal growth factor receptor in AGS gastric epithelial cells. J Infect Dis 196 (2007) 95-103
17. Dickson J.H., Grabowska A., El-Zaatari M., et al. A Helicobacter pylori can induce heparin-binding epidermal growth factor expression via gastrin and its receptor. Cancer Res 66 (2006) 7524-7531
18. + Helicobacter pylori induce transactivation of the epidermal growth factor receptor in AGS gastric epithelial cells. J Biol Chem 276 (2001) 48127-48134
19. Citri A., and Yarden Y. EGF-ERBB signalling: towards the systems level. Nat Rev Mol Cell Biol 7 (2006) 505-516
20. O'Dwyer P.J., and Benson III A.B. Epidermal growth factor receptor-targeted therapy in colorectal cancer. Semin Oncol 29 (2002) 10-17
21. Mendelsohn J., and Baselga J. Status of epidermal growth factor receptor antagonists in the biology and treatment of Cancer. J Clin Oncol 21 (2003) 2787-2799
22. Franco A.T., Israel D.A., Washington M.K., et al. Activation of β-catenin by carcinogenic Helicobacter pylori. Proc Natl Acad Sci U S A 102 (2005) 10646-10651
23. Whitehead R.H., VanEeden P.E., Noble M.D., et al. Establishment of conditionally immortalized epithelial cell lines from both colon and small intestine of adult H-2Kb-tsA58 transgenic mice. Proc Natl Acad Sci U S A 90 (1993) 587-591
24. Garton K.J., Gough P.J., Philalay J., et al. Stimulated shedding of vascular cell adhesion molecule 1 (VCAM-1) is mediated by tumor necrosis factor-α-converting enzyme (ADAM 17). J Biol Chem 278 (2003) 37459-37464
25. Garton K.J., Gough P.J., Blobel C.P., et al. Tumor necrosis factor-α-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1). J Biol Chem 276 (2001) 37993-38001
26. Sanderson M.P., Erickson S.N., Gough P.J., et al. ADAM10 mediates ectodomain shedding of the betacellulin precursor activated by p-aminophenylmercuric acetate and extracellular calcium influx. J Biol Chem 280 (2005) 1826-1837
27. Yamaoka T., Yan F., Cao H., et al. Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis. Proc Natl Acad Sci U S A 105 (2008) 11772-11777
28. Luetteke N.C., Phillips H.K., Qiu T.H., et al. The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase. Genes Dev 8 (1994) 399-413
29. Fox J.G., Wang T.C., Rogers A.B., et al. Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia. Gastroenterology 124 (2003) 1879-1890
30. Polk D.B. Ontogenic regulation of PLCγ1 activity and expression in the rat small intestine. Gastroenterology 107 (1994) 109-116
31. Yan F., Cao H., Cover T.L., et al. Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth. Gastroenterology 132 (2007) 562-575
32. Yan F., John S.K., Wilson G., et al. Kinase suppressor of Ras protects intestinal epithelium from cytokine-mediated apoptosis during inflammation. J Clin Invest 114 (2004) 1272-1280
33. Chaturvedi R., Cheng Y., Asim M., et al. Induction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarization. J Biol Chem 279 (2004) 40161-40173
34. Rodrigues G.A., Falasca M., Zhang Z., et al. A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling. Mol Cell Biol 20 (2000) 1448-1459
35. Fischer O.M., Hart S., Gschwind A., et al. EGFR signal transactivation in cancer cells. Biochem Soc Trans 31 (2003) 1203-1208
36. Sunnarborg S.W., Hinkle C.L., Stevenson M., et al. Tumor necrosis factor-α converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability. J Biol Chem 277 (2002) 12838-12845
37. Lee D.C., Sunnarborg S.W., Hinkle C.L., et al. TACE/ADAM17 processing of EGFR ligands indicates a role as a physiological convertase. Ann N Y Acad Sci 995 (2003) 22-38
38. Hinkle C.L., Sunnarborg S.W., Loiselle D., et al. Selective roles for tumor necrosis factor α-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency. J Biol Chem 279 (2004) 24179-24188 Epub April 5, 2004
39. Downward J. PI 3-kinase, Akt and cell survival. Semin Cell Dev Biol 15 (2004) 177-182
40. Citri A., Skaria K.B., and Yarden Y. The deaf and the dumb: the biology of ErbB-2 and ErbB-3. Exp Cell Res 284 (2003) 54-65
41. Carpenter G. ErbB-4: mechanism of action and biology. Exp Cell Res 284 (2003) 66-77
42. Engelman J.A., Janne P.A., Mermel C., et al. ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines. Proc Natl Acad Sci U S A 102 (2005) 3788-3793
43. Wallasch C., Crabtree J.E., Bevec D., et al. Helicobacter pylori-stimulated EGF receptor transactivation requires metalloprotease cleavage of HB-EGF. Biochem Biophys Res Commun 295 (2002) 695-701
44. Peschon J.J., Slack J.L., Reddy P., et al. An essential role for ectodomain shedding in mammalian development. Science 282 (1998) 1281-1284
45. Romano M., Ricci V., Di Popolo A., et al. Helicobacter pylori up-regulates expression of epidermal growth factor-related peptides, but inhibits their proliferative effect in MKN 28 gastric mucosal cells. J Clin Invest 101 (1998) 1604-1613
46. Lindholm C., Quiding-Jarbrink M., Lonroth H., et al. Local cytokine response in Helicobacter pylori-infected subjects. Infect Immun 66 (1998) 5964-5971
47. Brynskov J., Foegh P., Pedersen G., et al. Tumour necrosis factor α converting enzyme (TACE) activity in the colonic mucosa of patients with inflammatory bowel disease. Gut 51 (2002) 37-43
48. Colon A.L., Menchen L.A., Hurtado O., et al. Implication of TNF-α convertase (TACE/ADAM17) in inducible nitric oxide synthase expression and inflammation in an experimental model of colitis. Cytokine 16 (2001) 220-226
49. Black R.A. Tumor necrosis factor-α converting enzyme. Int J Biochem Cell Biol 34 (2002) 1-5
50. Rio C., Buxbaum J.D., Peschon J.J., et al. Tumor necrosis factor-α-converting enzyme is required for cleavage of ErbB4/HER4. J Biol Chem 275 (2000) 10379-10387
51. van Deventer S.J.H. A place for TACE. Gut 51 (2002) 5-6
52. Nagy T.A., Frey M.R., Yan Y., et al. Helicobacter pylori regulates cellular migration and apoptosis by activation of phosphatidylinositol 3-kinase signaling. J Infect Dis 199 (2009) 641-651
53. Choi I.J., Kim J.S., Kim J.M., et al. Effect of inhibition of extracellular signal-regulated kinase 1 and 2 pathway on apoptosis and bcl-2 expression in Helicobacter pylori-infected AGS cells. Infect Immun 71 (2003) 830-837
54. Fu S., Ramanujam K.S., Wong A., et al. Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis. Gastroenterology 116 (1999) 1319-1329
55. Romano M., Ricci V., Memoli A., et al. Helicobacter pylori up-regulates cyclooxygenase-2 mRNA expression and prostaglandin E2 synthesis in MKN 28 gastric mucosal cells in vitro. J Biol Chem 273 (1998) 28560-28563
56. Kim T.I., Lee Y.C., Lee K.H., et al. Effects of nonsteroidal anti-inflammatory drugs on Helicobacter pylori-infected gastric mucosae of mice: apoptosis, cell proliferation, and inflammatory activity. Infect Immun 69 (2001) 5056-5063
57. Wilson K.T., and Crabtree J.E. Immunology of Helicobacter pylori: insights into the failure of the immune response and perspectives on vaccine studies. Gastroenterology 133 (2007) 288-308
58. Sasaki T., Nakamura T., Rebhun R.B., et al. Modification of the primary tumor microenvironment by transforming growth factor α-epidermal growth factor receptor signaling promotes metastasis in an orthotopic colon cancer model. Am J Pathol 173 (2008) 205-216
59. Oguma K., Oshima H., Aoki M., et al. Activated macrophages promote Wnt signalling through tumour necrosis factor-α in gastric tumour cells. EMBO J 27 (2008) 1671-1681