Tumor necrosis factor-α converting enzyme

International Journal of Biochemistry and Cell Biology

Volumn 34, Issue 1, 2002, Pages 1-5

  Black, Roy A ^a  

^a AMGEN INC   (United States)

Author keywords

Metalloprotease disintegrin; Shedding; TACE; Tumor necrosis factor

Indexed keywords

DISINTEGRIN; ENZYME INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR; ISOENZYME; MEMBRANE ENZYME; MEMBRANE PROTEIN; MESSENGER RNA; METALLOPROTEINASE; METZINCIN; PEPTIDEHYDROXAMIC ACID; PROTEIN P55; PROTEIN P75; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

CELL ACTIVATION; DOWN REGULATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME MECHANISM; ENZYME SUBSTRATE; ENZYME SYNTHESIS; INFLAMMATORY DISEASE; MOLECULAR RECOGNITION; NONHUMAN; PROTEIN DOMAIN; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0036133646     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-2725(01)00097-8     Document Type: Short Survey

References (15)

1. A metalloproteinase disintegrin that releases tumour necrosis factor-α from cells
2. Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α
3. Metalloporotease-disintegrins: Modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding
4. The metzincins - Topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a superfamily of zinc-peptidases
5. Crystal structure of the catalytic domain of human tumor necrosis factor-α-converting enzyme
6. Intracellular maturation and localization of the tumour necrosis factor alpha convertase (TACE)
7. Stimulation-induced down-regulation of tumor necrosis factor-α converting enzyme
8. An essential role for ectodomain shedding in mammalian development
9. Evidence that tumor necrosis factor-α converting enzyme is involved in regulated α-secretase cleavage of the Alzheimer amyloid protein precursor
10. Functional analysis of the domain structure of tumor necrosis factor-α converting enzyme
11. Constitutive and regulated α-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease
12. Membrane protein secretases
13. Ectodomain shedding of TGF-α and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades
14. TNF-α converting enzyme (TACE) is inhibited by TIMP-3
15. Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor