메뉴 건너뛰기




Volumn 37, Issue 1, 2009, Pages 100-113

Cumulative effects of in utero administration of mixtures of "antiandrogens" on male rat reproductive development

Author keywords

Endocrine disrupters; Male reproduction; Reproductive system

Indexed keywords

LINURON; PHTHALIC ACID BENZYL BUTYL ESTER; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PHTHALIC ACID DIBUTYL ESTER; PROCHLORAZ; PROCYMIDONE; VINCLOZOLIN; ANDROGEN RECEPTOR; ANTIANDROGEN; BICYCLO COMPOUND; FUNGICIDE; OXAZOLE DERIVATIVE; PHTHALIC ACID DERIVATIVE;

EID: 62749155762     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623308329478     Document Type: Review
Times cited : (95)

References (83)
  • 1
    • 0033635575 scopus 로고    scopus 로고
    • Predictability of the toxicity of multiple chemical mixtures to Vibrio fischeri: Mixtures composed of similarly acting chemicals
    • Altenburger, R, T Backhaus, W Boedeker, M Faust, M Scholze, and LH Grimme (2000). Predictability of the toxicity of multiple chemical mixtures to Vibrio fischeri: Mixtures composed of similarly acting chemicals. Environ Toxicol Chem, 19, 2341-2347.
    • (2000) Environ Toxicol Chem , vol.19 , pp. 2341-2347
    • Altenburger, R.1    Backhaus, T.2    Boedeker, W.3    Faust, M.4    Scholze, M.5    Grimme, L.H.6
  • 2
    • 12344271909 scopus 로고    scopus 로고
    • Algal toxicity of nitrobenzenes: Combined effect analysis as a pharmacological probe for similar modes of interaction
    • Altenburger, R, H Schmitt, and G Schuurmann (2005). Algal toxicity of nitrobenzenes: Combined effect analysis as a pharmacological probe for similar modes of interaction. Environ Toxicol Chem, 24, 324-333.
    • (2005) Environ Toxicol Chem , vol.24 , pp. 324-333
    • Altenburger, R.1    Schmitt, H.2    Schuurmann, G.3
  • 4
    • 1642396354 scopus 로고    scopus 로고
    • Testosterone-stimulated weanlings as an alternative to castrated male rats in the Hershberger anti-androgen assay
    • Ashby, J, PA Lefevre, H Tinwell, J Odum, and W Owens (2004). Testosterone-stimulated weanlings as an alternative to castrated male rats in the Hershberger anti-androgen assay. Regul Toxicol Pharmacol, 39, 229-238.
    • (2004) Regul Toxicol Pharmacol , vol.39 , pp. 229-238
    • Ashby, J.1    Lefevre, P.A.2    Tinwell, H.3    Odum, J.4    Owens, W.5
  • 5
    • 0033636825 scopus 로고    scopus 로고
    • Predictability of the toxicity of a multiple mixture of dissimilarly acting chemicals to Vibrio fischeri
    • Backhaus, T, R Altenburger, W Boedeker, M Faust, M Scholze, and LH Grimme (2000). Predictability of the toxicity of a multiple mixture of dissimilarly acting chemicals to Vibrio fischeri. Environ Toxicol Chem, 19, 2348-2356.
    • (2000) Environ Toxicol Chem , vol.19 , pp. 2348-2356
    • Backhaus, T.1    Altenburger, R.2    Boedeker, W.3    Faust, M.4    Scholze, M.5    Grimme, L.H.6
  • 6
    • 84946384873 scopus 로고
    • The toxicity of poisons applied jointly
    • Bliss, CI (1939). The toxicity of poisons applied jointly. Ann Appl Biol, 26, 585-615.
    • (1939) Ann Appl Biol , vol.26 , pp. 585-615
    • Bliss, C.I.1
  • 7
    • 34347263811 scopus 로고    scopus 로고
    • Prochloraz inhibits testosterone production at dosages below those that affect androgen-dependent organ weights or the onset of puberty in the male Sprague Dawley rat
    • Blystone, CR, J Furr, CS Lambright, KL Howdeshell, BC Ryan, VS Wilson, GA Leblanc, and LE Gray, Jr (2007). Prochloraz inhibits testosterone production at dosages below those that affect androgen-dependent organ weights or the onset of puberty in the male Sprague Dawley rat. Toxicol Sci, 97, 65-74.
    • (2007) Toxicol Sci , vol.97 , pp. 65-74
    • Blystone, C.R.1    Furr, J.2    Lambright, C.S.3    Howdeshell, K.L.4    Ryan, B.C.5    Wilson, V.S.6    Leblanc, G.A.7    Gray Jr, L.E.8
  • 9
    • 39749187628 scopus 로고    scopus 로고
    • Exposure of the U.S. population to bisphenol A and 4-tertiary- octylphenol: 2003-2004
    • Calafat, AM, X Ye, LY Wong, JA Reidy, and LL Needham (2008). Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004. Environ Health Perspect, 116, 39-44.
    • (2008) Environ Health Perspect , vol.116 , pp. 39-44
    • Calafat, A.M.1    Ye, X.2    Wong, L.Y.3    Reidy, J.A.4    Needham, L.L.5
  • 11
    • 10044273892 scopus 로고    scopus 로고
    • A comparison of in vitro and in vivo EDSTAC test battery results for detecting antiandrogenic activity
    • Charles, GD, HL Kan, MR Schisler, B Bhaskar Gollapudi, and M Sue Marty (2005). A comparison of in vitro and in vivo EDSTAC test battery results for detecting antiandrogenic activity. Toxicol Appl Pharmacol, 202, 108-120.
    • (2005) Toxicol Appl Pharmacol , vol.202 , pp. 108-120
    • Charles, G.D.1    Kan, H.L.2    Schisler, M.R.3    Bhaskar Gollapudi, B.4    Sue Marty, M.5
  • 12
    • 40349113152 scopus 로고    scopus 로고
    • Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat
    • Christiansen, S, M Scholze, M Axelstad, J Boberg, A Kortenkamp, and U Hass (2008). Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat. Int J Androl, 31, 241-248.
    • (2008) Int J Androl , vol.31 , pp. 241-248
    • Christiansen, S.1    Scholze, M.2    Axelstad, M.3    Boberg, J.4    Kortenkamp, A.5    Hass, U.6
  • 15
    • 0032791061 scopus 로고    scopus 로고
    • Exposures of children to organophosphate pesticides and their potential adverse health effects
    • Eskenazi, B, A Bradman, and R Castorina (1999). Exposures of children to organophosphate pesticides and their potential adverse health effects. Environ Health Perspect, 107 (Suppl 3). 409-419.
    • (1999) Environ Health Perspect , vol.107 , Issue.SUPPL 3 , pp. 409-419
    • Eskenazi, B.1    Bradman, A.2    Castorina, R.3
  • 16
    • 0035025368 scopus 로고    scopus 로고
    • Effects of phthalate esters on the developing reproductive tract of male rats
    • DOI 10.1093/humupd/7.3.231
    • Foster, PM, E Mylchreest, KW Gaido, and M Sar (2001). Effects of phthalate esters on the developing reproductive tract of male rats. Hum Reprod Update, 7, 231-235. (Pubitemid 32440285)
    • (2001) Human Reproduction Update , vol.7 , Issue.3 , pp. 231-235
    • Foster, P.M.D.1    Mylchreest, E.2    Gaido, K.W.3    Sar, M.4
  • 17
    • 6844249435 scopus 로고    scopus 로고
    • Effects of pesticides and toxic substances on behavioral and morphological reproductive development: Endocrine versus nonendocrine mechanisms
    • Gray, LE, Jr, and J Ostby (1998). Effects of pesticides and toxic substances on behavioral and morphological reproductive development: endocrine versus nonendocrine mechanisms. Toxicol Ind Health, 14, 159-184.
    • (1998) Toxicol Ind Health , vol.14 , pp. 159-184
    • Jr G.Le1    Ostby, J.2
  • 18
    • 0034523473 scopus 로고    scopus 로고
    • Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat
    • Gray, LE, Jr, J Ostby, J Furr, M Price, DN Veeramachaneni, and L Parks (2000). Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicol Sci, 58, 350-365.
    • (2000) Toxicol Sci , vol.58 , pp. 350-365
    • Jr G.Le1    Ostby, J.2    Furr, J.3    Price, M.4    Veeramachaneni, D.N.5    Parks, L.6
  • 19
    • 0343962125 scopus 로고    scopus 로고
    • Environmental antiandrogens: Low doses of the fungicide vinclozolin alter sexual differentiation of the male rat
    • Gray, LE, Jr, J Ostby, E Monosson, and WR Kelce (1999). Environmental antiandrogens: low doses of the fungicide vinclozolin alter sexual differentiation of the male rat. Toxicol Ind Health, 15, 48-64.
    • (1999) Toxicol Ind Health , vol.15 , pp. 48-64
    • Jr G.Le1    Ostby, J.2    Monosson, E.3    Kelce, W.R.4
  • 20
    • 0027937899 scopus 로고
    • Developmental effects of an environmental antiandrogen: The fungicide vinclozolin alters sex differentiation of the male rat
    • Gray, LE, Jr, JS Ostby, and WR Kelce (1994). Developmental effects of an environmental antiandrogen: the fungicide vinclozolin alters sex differentiation of the male rat. Toxicol Appl Pharmacol, 129, 46-52.
    • (1994) Toxicol Appl Pharmacol , vol.129 , pp. 46-52
    • Jr G.Le1    Ostby, J.S.2    Kelce, W.R.3
  • 24
    • 0343090362 scopus 로고    scopus 로고
    • Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p -DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat
    • Gray, LE, C Wolf, C Lambright, P Mann, M Price, RL Cooper, and J Ostby (1999). Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p -DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat. Toxicol Ind Health, 15, 94-118.
    • (1999) Toxicol Ind Health , vol.15 , pp. 94-118
    • Gray, L.E.1    Wolf, C.2    Lambright, C.3    Mann, P.4    Price, M.5    Cooper, R.L.6    Ostby, J.7
  • 25
    • 34249039261 scopus 로고    scopus 로고
    • Polychlorinated biphenyls, DDT, polybrominated diphenyl ethers, and organic pesticides in United Kingdom harbor seals (Phoca vitulina)-mixed exposures and thyroid homeostasis
    • Hall, AJ, and GO Thomas (2007). Polychlorinated biphenyls, DDT, polybrominated diphenyl ethers, and organic pesticides in United Kingdom harbor seals (Phoca vitulina)-mixed exposures and thyroid homeostasis. Environmental toxicology and chemistry/SETAC, 26, 851-861.
    • (2007) Environmental Toxicology and Chemistry/SETAC , vol.26 , pp. 851-861
    • Hall, A.J.1    Thomas, G.O.2
  • 27
    • 18844385994 scopus 로고    scopus 로고
    • Environmental monitoring and ecological risk assessment for pesticide contamination and effects in Lake Pamvotis, northwestern Greece
    • Hela, DG, DA Lambropoulou, IK Konstantinou, and TA Albanis (2005). Environmental monitoring and ecological risk assessment for pesticide contamination and effects in Lake Pamvotis, northwestern Greece. Environmental toxicology and chemistry/SETAC, 24, 1548-1556.
    • (2005) Environmental Toxicology and Chemistry/SETAC , vol.24 , pp. 1548-1556
    • Hela, D.G.1    Lambropoulou, D.A.2    Konstantinou, I.K.3    Albanis, T.A.4
  • 28
    • 0033779813 scopus 로고    scopus 로고
    • Pre-and postnatal oral toxicity of vinclozolin in Wistar and Long-Evans rats
    • Hellwig, J, B van Ravenzwaay, M Mayer, and C Gembardt (2000). Pre-and postnatal oral toxicity of vinclozolin in Wistar and Long-Evans rats. Regul Toxicol Pharmacol, 32, 42-50.
    • (2000) Regul Toxicol Pharmacol , vol.32 , pp. 42-50
    • Hellwig, J.1    Van Ravenzwaay, B.2    Mayer, M.3    Gembardt, C.4
  • 29
    • 0020332739 scopus 로고
    • Joint toxicity of mixtures of 8 and 24 chemicals to the guppy (Poecilia reticulata)
    • Hermens, J, and P Leeuwangh (1982). Joint toxicity of mixtures of 8 and 24 chemicals to the guppy (Poecilia reticulata). Ecotoxicol Environ Saf, 6, 302-310.
    • (1982) Ecotoxicol Environ Saf , vol.6 , pp. 302-310
    • Hermens, J.1    Leeuwangh, P.2
  • 31
    • 9744248326 scopus 로고    scopus 로고
    • A mixture of the "antiandrogens" linuron and butyl benzyl phthalate alters sexual differentiation of the male rat in a cumulative fashion
    • Hotchkiss, AK, LG Parks-Saldutti, JS Ostby, C Lambright, J Furr, JG Vandenbergh, and LE Gray (2004). A mixture of the "antiandrogens" linuron and butyl benzyl phthalate alters sexual differentiation of the male rat in a cumulative fashion. Biol Reprod, 71, 1852-1861.
    • (2004) Biol Reprod , vol.71 , pp. 1852-1861
    • Hotchkiss, A.K.1    Parks-Saldutti, L.G.2    Ostby, J.S.3    Lambright, C.4    Furr, J.5    Vandenbergh, J.G.6    Gray, L.E.7
  • 32
    • 34547896247 scopus 로고    scopus 로고
    • Cumulative effects of dibutyl phthalate and diethylhexyl phthalate on male rat reproductive tract development: Altered fetal steroid hormones and genes
    • Howdeshell, KL, J Furr, CR Lambright, CV Rider, VS Wilson, and LE Gray, Jr (2007). Cumulative effects of dibutyl phthalate and diethylhexyl phthalate on male rat reproductive tract development: altered fetal steroid hormones and genes. Toxicol Sci, 99, 190-202.
    • (2007) Toxicol Sci , vol.99 , pp. 190-202
    • Howdeshell, K.L.1    Furr, J.2    Lambright, C.R.3    Rider, C.V.4    Wilson, V.S.5    Gray Jr, L.E.6
  • 33
    • 49249119674 scopus 로고    scopus 로고
    • A mixture of five phthalate esters inhibits fetal testicular testosterone production in the sprague-dawley rat in a cumulative, dose-additive manner
    • Howdeshell, KL, VS Wilson, J Furr, CR Lambright, CV Rider, CR Blystone, AK Hotchkiss, and LE Gray, Jr (2008). A mixture of five phthalate esters inhibits fetal testicular testosterone production in the sprague-dawley rat in a cumulative, dose-additive manner. Toxicol Sci, 105, 153-165.
    • (2008) Toxicol Sci , vol.105 , pp. 153-165
    • Howdeshell, K.L.1    Wilson, V.S.2    Furr, J.3    Lambright, C.R.4    Rider, C.V.5    Blystone, C.R.6    Hotchkiss, A.K.7    Gray Jr, L.E.8
  • 34
    • 28844434848 scopus 로고    scopus 로고
    • Brominated flame retardants and organochlorine pollutants in aquatic and terrestrial predatory birds of Belgium: Levels, patterns, tissue distribution and condition factors
    • Jaspers, VL, A Covaci, S Voorspoels, T Dauwe, M Eens, and P Schepens (2006). Brominated flame retardants and organochlorine pollutants in aquatic and terrestrial predatory birds of Belgium: levels, patterns, tissue distribution and condition factors. Environ Pollut, 139, 340-352.
    • (2006) Environ Pollut , vol.139 , pp. 340-352
    • Jaspers, V.L.1    Covaci, A.2    Voorspoels, S.3    Dauwe, T.4    Eens, M.5    Schepens, P.6
  • 36
    • 39049177296 scopus 로고    scopus 로고
    • Introduction: The ecological relevance of chemically induced endocrine disruption in wildlife
    • Jobling, S, and CR Tyler (2006). Introduction: The ecological relevance of chemically induced endocrine disruption in wildlife. Environ Health Perspect, 114 (Suppl 1). 7-8.
    • (2006) Environ Health Perspect , vol.114 , Issue.SUPPL 1 , pp. 7-8
    • Jobling, S.1    Tyler, C.R.2
  • 39
    • 0028228821 scopus 로고
    • Environmental hormone disruptors: Evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites
    • Kelce, WR, E Monosson, MP Gamcsik, SC Laws, and LE Gray (1994). Environmental hormone disruptors: Evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites. Toxicol Appl Pharmacol, 126, 276-285.
    • (1994) Toxicol Appl Pharmacol , vol.126 , pp. 276-285
    • Kelce, W.R.1    Monosson, E.2    Gamcsik, M.P.3    Laws, S.C.4    Gray, L.E.5
  • 41
    • 0030981923 scopus 로고    scopus 로고
    • Environmental antiandrogens: Developmental effects, molecular mechanisms, and clinical implications
    • Kelce, WR, and EM Wilson (1997). Environmental antiandrogens: Developmental effects, molecular mechanisms, and clinical implications. J Molec Med, 75, 198-207.
    • (1997) J Molec Med , vol.75 , pp. 198-207
    • Kelce, W.R.1    Wilson, E.M.2
  • 42
    • 0842328573 scopus 로고    scopus 로고
    • Evaluation of the rodent Hershberger assay using three reference endocrine disrupters (androgen and antiandrogens)
    • Kennel, PF, CT Pallen, and RG Bars (2004). Evaluation of the rodent Hershberger assay using three reference endocrine disrupters (androgen and antiandrogens). Reprod Toxicol, 18, 63-73.
    • (2004) Reprod Toxicol , vol.18 , pp. 63-73
    • Kennel, P.F.1    Pallen, C.T.2    Bars, R.G.3
  • 43
    • 0037085574 scopus 로고    scopus 로고
    • Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams, 1999-2000: A national reconnaissance
    • Kolpin, DW, ET Furlong, MT Meyer, EM Thurman, SD Zaugg, LB Barber, and HT Buxton (2002). Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams, 1999-2000: A national reconnaissance. Environ Sci Technol, 36, 1202-1211.
    • (2002) Environ Sci Technol , vol.36 , pp. 1202-1211
    • Kolpin, D.W.1    Furlong, E.T.2    Meyer, M.T.3    Thurman, E.M.4    Zaugg, S.D.5    Barber, L.B.6    Buxton, H.T.7
  • 44
    • 0033931562 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of action of linuron: An antiandrogenic herbicide that produces reproductive malformations in male rats
    • Lambright, C, J Ostby, K Bobseine, V Wilson, AK Hotchkiss, PC Mann, and LE Gray (2000). Cellular and molecular mechanisms of action of linuron: An antiandrogenic herbicide that produces reproductive malformations in male rats. Toxicol Sci, 56, 389-399.
    • (2000) Toxicol Sci , vol.56 , pp. 389-399
    • Lambright, C.1    Ostby, J.2    Bobseine, K.3    Wilson, V.4    Hotchkiss, A.K.5    Mann, P.C.6    Gray, L.E.7
  • 47
    • 0036147796 scopus 로고    scopus 로고
    • Male rats exposed to linuron in utero exhibit permanent changes in anogenital distance, nipple retention, and epididymal malformations that result in subsequent testicular atrophy
    • McIntyre, BS, NJ Barlow, and PM Foster (2002). Male rats exposed to linuron in utero exhibit permanent changes in anogenital distance, nipple retention, and epididymal malformations that result in subsequent testicular atrophy. Toxicol Sci, 65, 62-70.
    • (2002) Toxicol Sci , vol.65 , pp. 62-70
    • McIntyre, B.S.1    Barlow, N.J.2    Foster, P.M.3
  • 49
    • 0034283411 scopus 로고    scopus 로고
    • Effects of in utero exposure to linuron on androgen-dependent reproductive development in the male Crl:CD(SD)BR rat
    • McIntyre, BS, NJ Barlow, DG Wallace, SC Maness, KW Gaido, and PM Foster (2000). Effects of in utero exposure to linuron on androgen-dependent reproductive development in the male Crl:CD(SD)BR rat. Toxicol Appl Pharmacol, 167, 87-99.
    • (2000) Toxicol Appl Pharmacol , vol.167 , pp. 87-99
    • McIntyre, B.S.1    Barlow, N.J.2    Wallace, D.G.3    Maness, S.C.4    Gaido, K.W.5    Foster, P.M.6
  • 51
    • 0033360298 scopus 로고    scopus 로고
    • Peripubertal exposure to the antiandrogenic fungicide, vinclozolin, delays puberty, inhibits the development of androgen-dependent tissues, and alters androgen receptor function in the male rat
    • Monosson, E, WR Kelce, C Lambright, J Ostby, and LE Gray, Jr (1999). Peripubertal exposure to the antiandrogenic fungicide, vinclozolin, delays puberty, inhibits the development of androgen-dependent tissues, and alters androgen receptor function in the male rat. Toxicol Ind Health, 15, 65-79.
    • (1999) Toxicol Ind Health , vol.15 , pp. 65-79
    • Monosson, E.1    Kelce, W.R.2    Lambright, C.3    Ostby, J.4    Gray Jr, L.E.5
  • 52
    • 0034667194 scopus 로고    scopus 로고
    • DBP exerts its antiandrogenic activity by indirectly interfering with androgen signaling pathways
    • Mylchreest, E, and PM Foster (2000). DBP exerts its antiandrogenic activity by indirectly interfering with androgen signaling pathways. Toxicol Appl Pharmacol, 168, 174-175.
    • (2000) Toxicol Appl Pharmacol , vol.168 , pp. 174-175
    • Mylchreest, E.1    Foster, P.M.2
  • 53
    • 0033010382 scopus 로고    scopus 로고
    • Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide
    • Mylchreest, E, M Sar, RC Cattley, and PM Foster (1999). Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide. Toxicol Appl Pharmacol, 156, 81-95.
    • (1999) Toxicol Appl Pharmacol , vol.156 , pp. 81-95
    • Mylchreest, E.1    Sar, M.2    Cattley, R.C.3    Foster, P.M.4
  • 54
    • 0037292159 scopus 로고    scopus 로고
    • The combined effects of vinclozolin and procymidone do not deviate from expected additivity in vitro and in vivo
    • Nellemann, C, M Dalgaard, HR Lam, and AM Vinggaard (2003). The combined effects of vinclozolin and procymidone do not deviate from expected additivity in vitro and in vivo. Toxicol Sci, 71, 251-262.
    • (2003) Toxicol Sci , vol.71 , pp. 251-262
    • Nellemann, C.1    Dalgaard, M.2    Lam, H.R.3    Vinggaard, A.M.4
  • 55
    • 18844429502 scopus 로고    scopus 로고
    • Late gestational exposure to the fungicide prochloraz delays the onset of parturition and causes reproductive malformations in male but not female rat offspring
    • Noriega, NC, J Ostby, C Lambright, VS Wilson, and LE Gray (2005). Late gestational exposure to the fungicide prochloraz delays the onset of parturition and causes reproductive malformations in male but not female rat offspring. Biol Reprod, 72, 1324-1335.
    • (2005) Biol Reprod , vol.72 , pp. 1324-1335
    • Noriega, N.C.1    Ostby, J.2    Lambright, C.3    Wilson, V.S.4    Gray, L.E.5
  • 56
    • 0036740127 scopus 로고    scopus 로고
    • Evaluation of a 15-day screening assay using intact male rats for identifying antiandrogens
    • O'Connor, JC, SR Frame, and GS Ladics (2002). Evaluation of a 15-day screening assay using intact male rats for identifying antiandrogens. Toxicol Sci, 69, 92-108.
    • (2002) Toxicol Sci , vol.69 , pp. 92-108
    • O'Connor, J.C.1    Frame, S.R.2    Ladics, G.S.3
  • 57
    • 0033363929 scopus 로고    scopus 로고
    • The fungicide procymidone alters sexual differentiation in the male rat by acting as an androgen-receptor antagonist in vivo and in vitro
    • Ostby, J, WR Kelce, C Lambright, CJ Wolf, P Mann, and LE Gray (1999). The fungicide procymidone alters sexual differentiation in the male rat by acting as an androgen-receptor antagonist in vivo and in vitro. Toxicol Ind Health, 15, 80-93.
    • (1999) Toxicol Ind Health , vol.15 , pp. 80-93
    • Ostby, J.1    Kelce, W.R.2    Lambright, C.3    Wolf, C.J.4    Mann, P.5    Gray, L.E.6
  • 58
    • 34249028612 scopus 로고    scopus 로고
    • The OECD program to validate the rat Hershberger bioassay to screen compounds for in vivo androgen and antiandrogen responses: Phase 2 dose-response studies
    • Owens, W, LE Gray, E Zeiger, M Walker, K Yamasaki, J Ashby, and E Jacob (2007). The OECD program to validate the rat Hershberger bioassay to screen compounds for in vivo androgen and antiandrogen responses: phase 2 dose-response studies. Environ Health Perspect, 115, 671-678.
    • (2007) Environ Health Perspect , vol.115 , pp. 671-678
    • Owens, W.1    Gray, L.E.2    Zeiger, E.3    Walker, M.4    Yamasaki, K.5    Ashby, J.6    Jacob, E.7
  • 59
    • 0034521058 scopus 로고    scopus 로고
    • The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat
    • Parks, LG, JS Ostby, CR Lambright, BD Abbott, GR Klinefelter, NJ Barlow, and LE Gray (2000). The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat. Toxicol Sci, 58, 339-349.
    • (2000) Toxicol Sci , vol.58 , pp. 339-349
    • Parks, L.G.1    Ostby, J.S.2    Lambright, C.R.3    Abbott, B.D.4    Klinefelter, G.R.5    Barlow, N.J.6    Gray, L.E.7
  • 60
    • 40349110847 scopus 로고    scopus 로고
    • A mixture of seven antiandrogens induces reproductive malformations in rats
    • Rider, CV, J Furr, VS Wilson, and LE Gray (2008). A mixture of seven antiandrogens induces reproductive malformations in rats. Int J Androl, 31, 249-262.
    • (2008) Int J Androl , vol.31 , pp. 249-262
    • Rider, C.V.1    Furr, J.2    Wilson, V.S.3    Gray, L.E.4
  • 61
    • 24944462035 scopus 로고    scopus 로고
    • An integrated addition and interaction model for assessing toxicity of chemical mixtures
    • Rider, CV, and GA Leblanc (2005). An integrated addition and interaction model for assessing toxicity of chemical mixtures. Toxicol Sci, 87, 520-528.
    • (2005) Toxicol Sci , vol.87 , pp. 520-528
    • Rider, C.V.1    Leblanc, G.A.2
  • 62
    • 15944428546 scopus 로고    scopus 로고
    • Gene expression analysis in the ventral prostate of rats exposed to vinclozolin or procymidone
    • Rosen, MB, VS Wilson, JE Schmid, and LE Gray (2005). Gene expression analysis in the ventral prostate of rats exposed to vinclozolin or procymidone. Reprod Toxicol, 19, 367-379.
    • (2005) Reprod Toxicol , vol.19 , pp. 367-379
    • Rosen, M.B.1    Wilson, V.S.2    Schmid, J.E.3    Gray, L.E.4
  • 63
    • 0024997614 scopus 로고
    • Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: Environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs)
    • Safe, S (1990). Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: Environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). Crit Rev Toxicol, 21, 51-88.
    • (1990) Crit Rev Toxicol , vol.21 , pp. 51-88
    • Safe, S.1
  • 64
    • 34247868851 scopus 로고    scopus 로고
    • OECD validation of the rodent Hershberger assay using three reference chemicals; 17alpha-methyl-testosterone, procymidone, and p,p'-DDE
    • Shin, JH, HJ Moon, IH Kang, TS Kim, SJ Lee, JY Ahn, H Bae, EB Jeung, and SY Han (2007). OECD validation of the rodent Hershberger assay using three reference chemicals; 17alpha-methyl-testosterone, procymidone, and p,p'-DDE. Arch Toxicol, 81, 309-318.
    • (2007) Arch Toxicol , vol.81 , pp. 309-318
    • Shin, J.H.1    Moon, H.J.2    Kang, I.H.3    Kim, T.S.4    Lee, S.J.5    Ahn, J.Y.6    Bae, H.7    Jeung, E.B.8    Han, S.Y.9
  • 65
    • 1542686315 scopus 로고    scopus 로고
    • Urinary levels of seven phthalate metabolites in the US population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000 (vol 112, pg 331, 2004)
    • Silva, E, DB Barr, JA Reidy, NA Malek, CC Hodge, SP Caudill, JW Brock, LL Needham, and AM Calafat (2004). Urinary levels of seven phthalate metabolites in the US population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000 (vol 112, pg 331, 2004). Environ Health Perspect, 112, 331-338.
    • (2004) Environ Health Perspect , vol.112 , pp. 331-338
    • Silva, E.1    Barr, D.B.2    Reidy, J.A.3    Malek, N.A.4    Hodge, C.C.5    Caudill, S.P.6    Brock, J.W.7    Needham, L.L.8    Calafat, A.M.9
  • 66
    • 0037090577 scopus 로고    scopus 로고
    • Something from "nothing"-Eight weak estrogenic chemicals combined at concentrations below NOECs produce significant mixture effects
    • Silva, E, N Rajapakse, and A Kortenkamp (2002). Something from "nothing"-Eight weak estrogenic chemicals combined at concentrations below NOECs produce significant mixture effects. Environ Sci Technol, 36, 1751-1756.
    • (2002) Environ Sci Technol , vol.36 , pp. 1751-1756
    • Silva, E.1    Rajapakse, N.2    Kortenkamp, A.3
  • 68
    • 0036558057 scopus 로고    scopus 로고
    • VOCs, pesticides, nitrate, and their mixtures in groundwater used for drinking water in the United States
    • Squillace, PJ, JC Scott, MJ Moran, BT Nolan, and DW Kolpin (2002). VOCs, pesticides, nitrate, and their mixtures in groundwater used for drinking water in the United States. Environ Sci Technol, 36, 1923-1930.
    • (2002) Environ Sci Technol , vol.36 , pp. 1923-1930
    • Squillace, P.J.1    Scott, J.C.2    Moran, M.J.3    Nolan, B.T.4    Kolpin, D.W.5
  • 69
    • 23044442687 scopus 로고    scopus 로고
    • In vivo and in vitro anti-androgenic effects of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture
    • Stoker, TE, RL Cooper, CS Lambright, VS Wilson, J Furr, and LE Gray (2005). In vivo and in vitro anti-androgenic effects of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture. Toxicol Appl Pharmacol, 207, 78-88.
    • (2005) Toxicol Appl Pharmacol , vol.207 , pp. 78-88
    • Stoker, T.E.1    Cooper, R.L.2    Lambright, C.S.3    Wilson, V.S.4    Furr, J.5    Gray, L.E.6
  • 71
    • 1942467869 scopus 로고    scopus 로고
    • Feasibility study of cumulative risk assessment methods for drinking water disinfection by-product mixtures
    • Teuschler, LK, GE Rice, CR Wilkes, JC Lipscomb, and FW Power (2004). Feasibility study of cumulative risk assessment methods for drinking water disinfection by-product mixtures. J Toxicol Environ Health A, 67, 755-777.
    • (2004) J Toxicol Environ Health A , vol.67 , pp. 755-777
    • Teuschler, L.K.1    Rice, G.E.2    Wilkes, C.R.3    Lipscomb, J.C.4    Power, F.W.5
  • 72
    • 0038494012 scopus 로고    scopus 로고
    • Altered gene expression during rat Wolffian duct development in response to in utero exposure to the antiandrogen linuron
    • Turner, KJ, BS McIntyre, SL Phillips, NJ Barlow, CJ Bowman, and PM Foster (2003). Altered gene expression during rat Wolffian duct development in response to in utero exposure to the antiandrogen linuron. Toxicol Sci, 74, 114-128.
    • (2003) Toxicol Sci , vol.74 , pp. 114-128
    • Turner, K.J.1    McIntyre, B.S.2    Phillips, S.L.3    Barlow, N.J.4    Bowman, C.J.5    Foster, P.M.6
  • 75
    • 0344507322 scopus 로고    scopus 로고
    • Rapid and sensitive reporter gene assays for detection of antiandrogenic and estrogenic effects of environmental chemicals
    • Vinggaard, AM, EC Joergensen, and JC Larsen (1999). Rapid and sensitive reporter gene assays for detection of antiandrogenic and estrogenic effects of environmental chemicals. Toxicol Appl Pharmacol, 155, 150-160.
    • (1999) Toxicol Appl Pharmacol , vol.155 , pp. 150-160
    • Vinggaard, A.M.1    Joergensen, E.C.2    Larsen, J.C.3
  • 76
    • 40349089612 scopus 로고    scopus 로고
    • Diverse mechanisms of anti-androgen action: Impact on male rat reproductive tract development
    • Wilson, VS, CR Blystone, AK Hotchkiss, CV Rider, and LE Gray, Jr (2008). Diverse mechanisms of anti-androgen action: impact on male rat reproductive tract development. Int J Androl, 31, 178-187.
    • (2008) Int J Androl , vol.31 , pp. 178-187
    • Wilson, V.S.1    Blystone, C.R.2    Hotchkiss, A.K.3    Rider, C.V.4    Gray Jr, L.E.5
  • 77
    • 0346366559 scopus 로고    scopus 로고
    • Phthalate ester-induced gubernacular lesions are associated with reduced ins13 gene expression in the fetal rat testis
    • Wilson, VS, C Lambright, J Furr, J Ostby, C Wood, G Held, and LE Gray (2004). Phthalate ester-induced gubernacular lesions are associated with reduced ins13 gene expression in the fetal rat testis. Toxicol Lett, 146, 207-215.
    • (2004) Toxicol Lett , vol.146 , pp. 207-215
    • Wilson, V.S.1    Lambright, C.2    Furr, J.3    Ostby, J.4    Wood, C.5    Held, G.6    Gray, L.E.7
  • 78
    • 0034068757 scopus 로고    scopus 로고
    • Characterization of the period of sensitivity of fetal male sexual development to vinclozolin
    • Wolf, CJ, GA LeBlanc, JS Ostby, and LE Gray, Jr (2000). Characterization of the period of sensitivity of fetal male sexual development to vinclozolin. Toxicol Sci, 55, 152-161.
    • (2000) Toxicol Sci , vol.55 , pp. 152-161
    • Wolf, C.J.1    Leblanc, G.A.2    Ostby, J.S.3    Gray Jr, L.E.4
  • 83


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.