The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat

Toxicological Sciences

Volumn 58, Issue 2, 2000, Pages 339-349

  Parks, Louise G ^a   Ostby, Joe S ^a   Lambright, Christy R ^a   Abbott, Barbara D ^a   Klinefelter, Gary R ^a   Barlow, Norman J ^b   Gray Jr , L Earl ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b Endocrine Reproductive and Developmental Toxicology Program ^*  (United States)

Author keywords

Antiandrogen; DEHP; Endocrine disrupters; Phthalate; Sexual differentiation; Testis; Testosterone

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; ANDROGEN RECEPTOR; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PLASTICIZER; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL HYPERPLASIA; CONTROLLED STUDY; EXPOSURE; FEMALE; FETUS; GENDER; GENITAL MALFORMATION; HISTOPATHOLOGY; IN VITRO STUDY; LEYDIG CELL; MALE; MULTINUCLEAR CELL; NEWBORN; NONHUMAN; PERINATAL PERIOD; PRENATAL EXPOSURE; PROGENY; RAT; RECEPTOR AFFINITY; SEX DIFFERENTIATION; TESTIS WEIGHT; TESTOSTERONE SYNTHESIS;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; BODY WEIGHT; DIETHYLHEXYL PHTHALATE; FEMALE; GENITALIA, MALE; LEYDIG CELLS; MALE; PLASTICIZERS; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; SEX DIFFERENTIATION; TESTIS; TESTOSTERONE;

ANIMALIA;

EID: 0034521058     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/58.2.339     Document Type: Article

References (49)

1. Oral toxicity of bis(2-ethylhexyl) phthalate during pregnancy and suckling in the Long-Evans rat
2. Serum levels of follicle stimulating hormone, luteinizing hormone, prolactin, testosterone, 5α-dihydrotestosterone, 5α-androstane-3α, 17β-diol, 5α-androstane-3β, 17β-diol, and 17β-estradiol from male beagles with spontaneous or ind
3. The wildlife/human connection: Modernizing risk decisions
4. Developmental effects of endocrine-disrupting chemicals in wildlife and humans
5. Testicular toxicity and reduced Sertoli cell numbers in neonatal rats by di(2-ethylhexyl) phthalate and the recovery of fertility as adults
6. Vasoactive intestinal peptide is an important endocrine regulatory factor of fetal rat testicular steroidogenesis
7. Gonadotropin-independent regulation of steroidogenesis in the fetal rat testis
8. Testicular androgen and estrogen secretion and benign prostatic hyperplasia in the beagle
9. Risk assessment
10. Antiandrogenic effects of phthalate esters on male reproductive development in the rat
11. Dioxin-like and non-dioxin-like toxic effects of polychlorinated biphenyls (PCBs): Implications for risk assessment
12. Endocrine screening methods workshop report: Detection of estrogenic and androgenic hormonal and antihormonal activity for chemicals that act via receptor or steroidogenic enzyme mechanisms
13. Perinatal exposure to the phthalate DEHP, BBP, and DINP, but not DEP, DMP, or DOP, alter sexual differentiation of the male rat
14. Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p′-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) duri
15. Short-term toxicity study of di-(2-ethylhexyl) phthalate in rats
16. Species differences in the testicular toxicity of phthalate esters
17. Differentiation of Leydig cell precursors in vitro: A role for androgen
18. The estrogenic activity of phthalate esters in vitro
19. Developmental effects of dibutyl phthalate in frogs and rabbits
20. A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic
21. Subchronic toxicity of Di(2-ethylhexyl)phthalate in common marmosets: Lack of hepatic peroxisome proliferation, testicular atrophy, or pancreatic acinar cell hyperplasia
22. Studies on the effects of orally administered Di-(2-ethylhexyl) phthalate in the ferret
23. Effects of relatively low levels of mono-(2-ethylhexyl) phthalate on cocultured Sertoli cells and gonocytes from neonatal rats
24. Male reproductive tract malformations in rats following gestational and lactational exposure to Di(n-butyl) phthalate: An antiandrogenic mechanism?
25. Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide
26. Nonadditive development toxicity in mixtures of trichloroethylene, Di(2-ethylhexyl) phthalate, and heptachlor in a 5 × 5 × 5 design
27. Testicular atrophy induced by phthalic acid esters: Effects on testosterone and zinc concentrations
28. The fungicide procymidone alters sexual differentiation in the male rat by acting as an androgen-receptor antagonist in vivo and in vitro
29. Differential effects of single and repeated administrations of gonadotropins on luteinizing hormone receptors and testosterone synthesis in two populations of Leydig cells
30. Subchronic oral toxicity of di-n-octyl phthalate and di(2-ethylhexyl) phthalate in the rat food
31. Effects of prenatal testosterone on sexual behavior, reproductive morphology, and LH secretion in the female rat
32. Comparative pharmacokinetics and subacute toxicity of di(2-ethylhexyl) phthalate (DEHP) in rats and marmosets: Extrapolation of effects in rodents to man
33. Simultaneous determination of testosterone, 5α-androstan-17β-ol- 3-one, 5α-androstane-3α, 17β-diol and 5α-androstane- 3β, 17β-diol in plasma of adult male rabbits by radioimmunoassay (1)
34. Experimental evidence for Sertoli-germ cell and Sertoli-Leydig cell interactions
35. Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production
36. Biological effects of di-(2-ethylhexyl) phthalate and other phthalic acid esters
37. Sexual differentiation and environmental endocrine disrupters
38. Developmental toxicity evaluation of dietary di(2-ethylhexyl)phthalate in Fischer 344 rats and CD-1 mice
39. Receptor- and nonreceptor-mediated organ-specific toxicity of di(2-ethylhexyl)phthalate (DEHP) in peroxisome proliferator-activated receptor alpha-null mice
40. Plasma testosterone and progesterone titers of pregnant rats, their male and female fetuses, and neonatal offspring
41. Diethylhexyl phthalate
42. Adhesion and signaling proteins associated with inhibited spermiation
43. Androgen receptor antagonist versus agonist activities of the fungicide vinclozolin relative to hydroxyflutamide
44. Examination of the in vitro and in vivo estrogenic activities of eight commercial phthalate esters