Effects of in utero linuron exposure on rat Wolffian duct development

Reproductive Toxicology

Volumn 16, Issue 2, 2002, Pages 131-139

  McIntyre, Barry S ^a   Barlow, Norman J ^a   Sar, Madhabananda ^a   Wallace, Duncan G ^a   Foster, Paul M D ^a  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

Author keywords

Antiandrogen; Epididymal development; In utero exposure; Linuron; Testosterone levels; Wolffian duct

Indexed keywords

HERBICIDE; LINURON; PARAFFIN; TESTOSTERONE;

ANIMAL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL DIVISION; CONTROLLED STUDY; DRUG EFFECT; EMBRYONIC STRUCTURES; EPIDIDYMIS; FEEDING; FEMALE; FETUS; GESTATIONAL AGE; HISTOPATHOLOGY; IMMUNOREACTIVITY; MALE; METABOLISM; NONHUMAN; ORGAN WEIGHT; ORGANOGENESIS; PATHOLOGY; PERINATAL DEVELOPMENT; PHENOTYPE; PREGNANCY; PRENATAL EXPOSURE; RAT; RECEPTOR INTRINSIC ACTIVITY; REPRODUCTIVE TOXICITY; TESTIS; TESTIS INJURY; TESTOSTERONE BLOOD LEVEL; VAS DEFERENS; GROWTH, DEVELOPMENT AND AGING; ORGAN SIZE;

WOLFFIA; ZEA MAYS;

ANIMALS; BODY WEIGHT; CELL DIVISION; EPIDIDYMIS; FEMALE; FETUS; HERBICIDES; LINURON; MALE; ORGAN SIZE; PARAFFIN EMBEDDING; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; TESTIS; TESTOSTERONE; WOLFFIAN DUCT;

EID: 0036011121     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0890-6238(02)00010-2     Document Type: Article

References (35)

1. Androgen metabolism in the prostate of the finasteride-treated, adult rat: A possible explanation for the differential action of testosterone and 5 α-dihydrotestosterone during development of the male urogenital tract
2. Testosterone and dihydrotestosterone in sexual ducts and genital tubercle of rabbit fetuses during sexual organogenesis: Effects of fetal decapitation
3. The androgen receptor of the urogenital tract of the fetal rat is regulated by androgen
4. Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p.p′-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat
5. Comparison of the effects of the 5 α-reductase inhibitor finasteride and the antiandrogen flutamide on prostate and genital differentiation: Dose-response studies
6. Antiandrogens as environmental endocrine disruptors
7. Cellular and molecular mechanisms of action of linuron: An antiandrogenic herbicide that produces reproductive malformations in male rats
8. Effects of in utero exposure to linuron on androgen dependent reproductive development in the male Crl:CD(SD)BR rat
9. Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide
10. The fungicide procymidone alters sexual differentiation in the male rat by acting as an androgen-receptor antagonist in vivo and in vitro
11. The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat
12. Investigation of a mechanism for Leydig cell tumorigenesis by linuron in rats
13. Male rats exposed to linuron in utero exhibit permanent changes in anogenital distance, nipple retention, and epididymal malformations that results in subsequent testicular atrophy
14. Developmental effects of an environmental antiandrogen: The fungicide vinclozolin alters sex differentiation of the male rat
15. Androgen -mediated development in male rat offspring exposed to flutamide in utero: Permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues
16. Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to Di(n-butyl) phthalate during late gestation
17. Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat
18. Efferent ducts, epididymis and vas deferens: Structure, functions and their regulation
19. Differentiation of the rat epididymis after withdrawal of androgen
20. Development of cell types and of regional differences in the postnatal rat epididymis
21. Imprinting by neonatal sex steroids on the structure and function of the mature mouse prostate
22. Neonatal estrogen exposure induces lobe-specific alterations in adult rat prostate androgen receptor expression
23. Neonatal imprinting predetermines the sexually dimorphic, estrogen- dependent expression of galanin in luteinizing hormone-releasing hormone neurons
24. Imprinting by the neonatal testis: A mechanism for sexual dimorphism of rat liver xanthine oxidase
25. Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: An index of cell proliferation with evidence of deregulated expression in some neoplasms
26. Quantitative study of the cell populations of the seminiferous tubules in immature rats
27. Proliferation of Sertoli cells in fetal and postnatal rats: A quantitative autoradiographic study
28. Latent effects of pesticides and toxic substances on sexual differentiation of rodents
29. The dissociation of testosterone- and 5 α-di-hydrotestosterone- receptor complexes formed within cultured human hurnan genital skin fibroblasts
30. Androgen receptors are similar in fetal and adult rabbits
31. Binding properties of androgen receptors. Evidence for identical receptors in rat testis, epididymis, and prostate