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Volumn 15, Issue 2, 1999, Pages 48-64

Environmental antiandrogens: Low doses of the fungicide vinclozolin alter sexual differentiation of the male rat

Author keywords

abnormal sexual differentiation; dose response; hypospadias; risk assessment; vinclozolin

Indexed keywords

ANDROGEN RECEPTOR; ANTIANDROGEN; FUNGICIDE; TESTOSTERONE; VINCLOZOLIN;

EID: 0343962125     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1177/074823379901500106     Document Type: Article
Times cited : (282)

References (63)
  • 1
    • 85131987183 scopus 로고
    • Phytoestrogens
    • (P. R. Cheeke, ed.). CRC Press, Boca Raton, FL
    • Adams, N. R. (1989). “Phytoestrogens.” In: Toxicants of Plant Origin, Volume IV: Phenolics (P. R. Cheeke, ed.). CRC Press, Boca Raton, FL. pp. 23–51.
    • (1989) Toxicants of Plant Origin, Volume IV: Phenolics , pp. 23-51
    • Adams, N.R.1
  • 2
    • 0024319684 scopus 로고
    • Development of the external genitalia in fetuses of the southern minke whale, Balaenoptera acutorostrata
    • Amasaki, H., Ishikawa, H., and Daigo, M. (1989). “Development of the external genitalia in fetuses of the southern minke whale, Balaenoptera acutorostrata.” Acta Anat. (Basel) 165:142-148.
    • (1989) Acta Anat. (Basel) , vol.165 , pp. 142-148
    • Amasaki, H.1    Ishikawa, H.2    Daigo, M.3
  • 3
    • 84996154350 scopus 로고
    • Testicular and adrenal response in adult male Long-Evans rats after antiandrogen vinclozolin exposure
    • Anderson, S. A., Fail, P. A., Pearce, S. W., Tyl, R. W., and Gray, L. E., Jr. (1995). “Testicular and adrenal response in adult male Long-Evans rats after antiandrogen vinclozolin exposure.” Toxicologist 15:293-293.
    • (1995) Toxicologist , vol.15 , pp. 293
    • Anderson, S.A.1    Fail, P.A.2    Pearce, S.W.3    Tyl, R.W.4    Gray, L.E.5
  • 4
    • 0002438871 scopus 로고    scopus 로고
    • Endocrine disruptors in wildlife: a weight of evidence perspective
    • (R. Kendall, R. Dickerson, J. Giesy, W. Suk, eds.). SETAC Press, Pensacola, FL
    • Ankley, G. T. and Giesy, J. P. (1998). “Endocrine disruptors in wildlife: a weight of evidence perspective.” In: Principles and Processes for Evaluating Endocrine Disruption in Wildlife (R. Kendall, R. Dickerson, J. Giesy, W. Suk, eds.). SETAC Press, Pensacola, FL. pp. 349–367.
    • (1998) Principles and Processes for Evaluating Endocrine Disruption in Wildlife , pp. 349-367
    • Ankley, G.T.1    Giesy, J.P.2
  • 5
    • 0016912305 scopus 로고
    • The bioaccumulation aspects of DDT in the environment
    • (F. A. Gunther, ed.). Springer-Verlag, New York, NY
    • Bevenue, A. (1976). “The bioaccumulation aspects of DDT in the environment.” In: Residue Reviews (F. A. Gunther, ed.). Springer-Verlag, New York, NY. pp. 37–112.
    • (1976) Residue Reviews , pp. 37-112
    • Bevenue, A.1
  • 6
    • 0001386750 scopus 로고
    • Miroestrol: an oestrogen from the plant Pueraria mirifica
    • Cain, J. C. (1960). “Miroestrol: an oestrogen from the plant Pueraria mirifica.” Nature 188:774-774.
    • (1960) Nature , vol.188 , pp. 774
    • Cain, J.C.1
  • 7
    • 0023224442 scopus 로고
    • Anogenital ratio: measure of fetal virilization in premature and full-term newborn infants
    • Callegari, C., Evertt, S., Ross, M., and Brasel, J. (1987). “Anogenital ratio: measure of fetal virilization in premature and full-term newborn infants.” J. Pediatr. 111(2): 240-243.
    • (1987) J. Pediatr. , vol.111 , Issue.2 , pp. 240-243
    • Callegari, C.1    Evertt, S.2    Ross, M.3    Brasel, J.4
  • 8
    • 0026657024 scopus 로고
    • Evidence for decreasing quality of semen during past 50 years
    • Carlsen, E., Giwercman, A., Keiding, N., and Skakkebaek, N. E. (1992). “Evidence for decreasing quality of semen during past 50 years.” Brit. Med. J. 305:609-613.
    • (1992) Brit. Med. J. , vol.305 , pp. 609-613
    • Carlsen, E.1    Giwercman, A.2    Keiding, N.3    Skakkebaek, N.E.4
  • 11
    • 0027524416 scopus 로고
    • Investigation of a mechanism for Leydig cell tumorigenesis by linuron in rats
    • Cook, J. C., Mullin, L. S., Frame, S. R., and Biegel, L. B. (1993). “Investigation of a mechanism for Leydig cell tumorigenesis by linuron in rats.” Toxicol. Appl. Pharmacol. 119:195-204.
    • (1993) Toxicol. Appl. Pharmacol. , vol.119 , pp. 195-204
    • Cook, J.C.1    Mullin, L.S.2    Frame, S.R.3    Biegel, L.B.4
  • 12
    • 0343052130 scopus 로고
    • Pesticide tolerance for vinclozolin
    • Corporate Author (1987). “Pesticide tolerance for vinclozolin.” Federal Register 52(160): 17954-17955.
    • (1987) Federal Register , vol.52 , Issue.160 , pp. 17954-17955
  • 13
    • 0014601399 scopus 로고
    • Chlorinated hydrocarbon insecticides in organs of stillborn and blood of newborn babies
    • Curley, A., Copeland, F., and Kimbrough, R. D. (1969). “Chlorinated hydrocarbon insecticides in organs of stillborn and blood of newborn babies.” Arch. Environ. Health 19:628-632.
    • (1969) Arch. Environ. Health , vol.19 , pp. 628-632
    • Curley, A.1    Copeland, F.2    Kimbrough, R.D.3
  • 14
    • 0013832241 scopus 로고
    • Chlorinated insecticides in the body fat of people in India
    • Dale, W. E., Copeland, M. F., and Hayes, W. J., Jr. (1965). “Chlorinated insecticides in the body fat of people in India.” Bull. Wildl. Health Org. 33:471-477.
    • (1965) Bull. Wildl. Health Org. , vol.33 , pp. 471-477
    • Dale, W.E.1    Copeland, M.F.2    Hayes, W.J.3
  • 17
    • 0031201344 scopus 로고    scopus 로고
    • Conception failure in swine: importance of the sex ratio of females birth litter and tests of other factors
    • Drickamer, L. C., Arthur, R. D., and Rosenthal, T. L. (1997). “Conception failure in swine: importance of the sex ratio of females birth litter and tests of other factors.” J. Anim. Sci. 75:2192-2196.
    • (1997) J. Anim. Sci. , vol.75 , pp. 2192-2196
    • Drickamer, L.C.1    Arthur, R.D.2    Rosenthal, T.L.3
  • 18
    • 0027284557 scopus 로고
    • Teratogenic evaluation of di-n-butyl phthalate in rats
    • Ema, M., Amano, H., Itami, T., and Kawasaki, H. (1993). “Teratogenic evaluation of di-n-butyl phthalate in rats.” Toxicol. Lett. 69:197-203.
    • (1993) Toxicol. Lett. , vol.69 , pp. 197-203
    • Ema, M.1    Amano, H.2    Itami, T.3    Kawasaki, H.4
  • 19
    • 0028174620 scopus 로고
    • Characterization of the developmental toxicity of di-n-butyl phthalate in rats
    • Ema, M., Amano, H., and Ogawa, Y. (1994). “Characterization of the developmental toxicity of di-n-butyl phthalate in rats.” Toxicology 86:163-174.
    • (1994) Toxicology , vol.86 , pp. 163-174
    • Ema, M.1    Amano, H.2    Ogawa, Y.3
  • 20
    • 0004042383 scopus 로고    scopus 로고
    • EXTOXNET: A Pesticide Information Project of the Cooperative Extension Offices of Cornell University, Michigan State University, Oregon State University, and University of California at Davis
    • Extension Toxicology Network (EXTOXNET) (1996). Pesticide Information Profiles: Vinclozolin. EXTOXNET: A Pesticide Information Project of the Cooperative Extension Offices of Cornell University, Michigan State University, Oregon State University, and University of California at Davis (http://ace.orst.edu/cgi-mfs/01/pips/vinclozo.htm.).
    • (1996) Pesticide Information Profiles: Vinclozolin
  • 21
    • 0013573788 scopus 로고
    • Endocrine and reproductive toxicity of vinclozolin in male Long-Evans hooded rats
    • Fail, P., Pearce, S. W., Anderson, S. A., Tyl, R. W., and Gray, L. E., Jr. (1995). “Endocrine and reproductive toxicity of vinclozolin in male Long-Evans hooded rats.” Toxicologist 15:293-293.
    • (1995) Toxicologist , vol.15 , pp. 293
    • Fail, P.1    Pearce, S.W.2    Anderson, S.A.3    Tyl, R.W.4    Gray, L.E.5
  • 22
    • 0002077142 scopus 로고    scopus 로고
    • Xenobiotic modulation of endocrine function in fishes
    • (R. Kendall, R. Dickerson, J. Giesy, W. Suk, eds.). SETAC Press, Pensacola, FL
    • Giesy, J. P. and Snyder, E. M. (1998). “Xenobiotic modulation of endocrine function in fishes.” In: Principles and Processes for Evaluating Endocrine Disruption in Wildlife (R. Kendall, R. Dickerson, J. Giesy, and W. Suk, eds.). SETAC Press, Pensacola, FL. pp. 155–237.
    • (1998) Principles and Processes for Evaluating Endocrine Disruption in Wildlife , pp. 155-237
    • Giesy, J.P.1    Snyder, E.M.2
  • 23
    • 0027013380 scopus 로고
    • Chemical-induced alterations of sexual differentiation: a review of effects in humans and rodents
    • (T. Colborn, C. Clement, eds.). Princeton Scientific Publishing, Princeton, NJ
    • Gray, L. E., Jr. (1992). “Chemical-induced alterations of sexual differentiation: a review of effects in humans and rodents.” In: Chemically-Induced Alterations in Sexual and Functional Development: The Wildlife/Human Connection (T. Colborn and C. Clement, eds.). Princeton Scientific Publishing, Princeton, NJ. pp. 203–230.
    • (1992) Chemically-Induced Alterations in Sexual and Functional Development: The Wildlife/Human Connection , pp. 203-230
    • Gray, L.E.1
  • 24
    • 9444265876 scopus 로고    scopus 로고
    • Latent effects of pesticides and toxic substances on sexual differentiation
    • Gray, L. E., Jr. and Kelce, W. R. (1996). “Latent effects of pesticides and toxic substances on sexual differentiation.” Toxicol. Ind. Health 12:515-531.
    • (1996) Toxicol. Ind. Health , vol.12 , pp. 515-531
    • Gray, L.E.1    Kelce, W.R.2
  • 25
    • 0024561277 scopus 로고
    • A dose-response analysis of methoxychlor-induced alterations of reproductive development and function in the rat
    • Gray, L. E., Jr., Ostby, J., Ferrell, J., Sigmon, R., Cooper, R., Goldman, J., Slott, V., and Laskey, J. (1989). “A dose-response analysis of methoxychlor-induced alterations of reproductive development and function in the rat.” Fundam. Appl. Toxicol. 12:92-108.
    • (1989) Fundam. Appl. Toxicol. , vol.12 , pp. 92-108
    • Gray, L.E.1    Ostby, J.2    Ferrell, J.3    Sigmon, R.4    Cooper, R.5    Goldman, J.6    Slott, V.7    Laskey, J.8
  • 26
    • 0027937899 scopus 로고
    • Developmental effects of an environmental antiandrogen: the fungicide vinclozolin alters sex differentiation of the male rats
    • Gray, L. E., Ostby, J., and Kelce, W. R. (1994). “Developmental effects of an environmental antiandrogen: the fungicide vinclozolin alters sex differentiation of the male rats.” Toxicol. Appl. Pharmacol. 129:46-52.
    • (1994) Toxicol. Appl. Pharmacol. , vol.129 , pp. 46-52
    • Gray, L.E.1    Ostby, J.2    Kelce, W.R.3
  • 27
    • 0001462135 scopus 로고    scopus 로고
    • Dibutyl phthalate induces antiandrogenic but not estrogenic in vivo effects in LE hooded rats
    • Gray, L. E., Ostby, J. S., Mylchreest, E., Foster, P. M. D., and Kelce, W. R. (1998). “Dibutyl phthalate induces antiandrogenic but not estrogenic in vivo effects in LE hooded rats.” Toxicologist 42:176-176.
    • (1998) Toxicologist , vol.42 , pp. 176
    • Gray, L.E.1    Ostby, J.S.2    Mylchreest, E.3    Foster, P.M.D.4    Kelce, W.R.5
  • 28
    • 84996204324 scopus 로고    scopus 로고
    • Administration of the potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p′-DDE and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat
    • (herein)
    • Gray, L. E., Jr., Wolf, C., Lambright, C., Mann, P., Price, M., Cooper, R., and Ostby, J. “Administration of the potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p′-DDE and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat.” Toxicol. Ind. Health (herein).
    • Toxicol. Ind. Health
    • Gray, L.E.1    Wolf, C.2    Lambright, C.3    Mann, P.4    Price, M.5    Cooper, R.6    Ostby, J.7
  • 29
    • 0017508275 scopus 로고
    • Sexing mouse pups
    • Greenham, L. W. and Greenham, V. (1977). “Sexing mouse pups.” Lab. Anim. 11:181-184.
    • (1977) Lab. Anim. , vol.11 , pp. 181-184
    • Greenham, L.W.1    Greenham, V.2
  • 30
    • 0028129515 scopus 로고
    • Developmental abnormalities of the gonad and abnormal sex hormone concentrations in juvenile alligators from contaminated and control lakes in Florida
    • Guillette, L. J., Gross, T. S., Masson, G. R., Matter, J. M., Percival, H. F., and Woodward, A. R. (1994). “Developmental abnormalities of the gonad and abnormal sex hormone concentrations in juvenile alligators from contaminated and control lakes in Florida.” Environ. Health Perspect. 102:680-688.
    • (1994) Environ. Health Perspect. , vol.102 , pp. 680-688
    • Guillette, L.J.1    Gross, T.S.2    Masson, G.R.3    Matter, J.M.4    Percival, H.F.5    Woodward, A.R.6
  • 35
    • 0027745502 scopus 로고
    • Developmental changes in paramesonephric and mesonephric ducts and anogenital distance in fetal Mongolian gerbils during sexual differentiation
    • Inomata, T., Ito, Y., Suzuki, K., Ninomiya, H., Takizawa, T., Yamamoto, M., Arishima, K., Eguchi, Y., Saito, H., and Mochizuki, K. (1993). “Developmental changes in paramesonephric and mesonephric ducts and anogenital distance in fetal Mongolian gerbils during sexual differentiation.” J. Vet. Med. Sci. 55:959-962.
    • (1993) J. Vet. Med. Sci. , vol.55 , pp. 959-962
    • Inomata, T.1    Ito, Y.2    Suzuki, K.3    Ninomiya, H.4    Takizawa, T.5    Yamamoto, M.6    Arishima, K.7    Eguchi, Y.8    Saito, H.9    Mochizuki, K.10
  • 36
    • 0028228821 scopus 로고
    • Environmental hormone disruptors: evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites
    • Kelce, W. R., Monosson, E., Gamcsik, M. P., Laws, S. C., and Gray, L. E., Jr. (1994). “Environmental hormone disruptors: evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites.” Toxicol. Appl. Pharmacol. 126:275-285.
    • (1994) Toxicol. Appl. Pharmacol. , vol.126 , pp. 275-285
    • Kelce, W.R.1    Monosson, E.2    Gamcsik, M.P.3    Laws, S.C.4    Gray, L.E.5
  • 37
    • 0029047149 scopus 로고
    • The persistent DDT metabolite p,p′ DDE is a potent androgen receptor antagonist
    • Kelce, W. R., Stone, C. R., Laws, S. C., Gray, L. E., Kemppainen, J. A., and Wilson, E. M. (1995). “The persistent DDT metabolite p,p′ DDE is a potent androgen receptor antagonist.” Nature 375:581-585.
    • (1995) Nature , vol.375 , pp. 581-585
    • Kelce, W.R.1    Stone, C.R.2    Laws, S.C.3    Gray, L.E.4    Kemppainen, J.A.5    Wilson, E.M.6
  • 38
    • 0031019418 scopus 로고    scopus 로고
    • Vinclozolin and p,p′-DDE alter androgen-dependent gene expression: in vivo confirmation of an androgen receptor mediated mechanism
    • Kelce, W. R., Stone, C. R., Gray, L. E., Jr., and Roberts, K. (1997). “Vinclozolin and p,p′-DDE alter androgen-dependent gene expression: in vivo confirmation of an androgen receptor mediated mechanism.” Toxicol. Appl. Pharmacol. 142:192-200.
    • (1997) Toxicol. Appl. Pharmacol. , vol.142 , pp. 192-200
    • Kelce, W.R.1    Stone, C.R.2    Gray, L.E.3    Roberts, K.4
  • 39
    • 0018163755 scopus 로고
    • Teratogenicity studies on linuron, malathion and methoxychlor in rats
    • Khera, K. S., Whalen, C., and Trivett, G. (1978). “Teratogenicity studies on linuron, malathion and methoxychlor in rats.” Toxicol. Appl. Pharmacol. 45:435-444.
    • (1978) Toxicol. Appl. Pharmacol. , vol.45 , pp. 435-444
    • Khera, K.S.1    Whalen, C.2    Trivett, G.3
  • 40
    • 0031458685 scopus 로고    scopus 로고
    • A computationally-based hazard identification algorithm that incorporates ligand flexibility: 1. Identification of potential androgen receptor ligands
    • Mekengan, O., Ivanov, J., Karabunarliev, S., Bradbury, S., Ankley, G., and Karcher, W. (1997). “A computationally-based hazard identification algorithm that incorporates ligand flexibility: 1. Identification of potential androgen receptor ligands.” Environ. Sci. Technol. 31:3702-3711.
    • (1997) Environ. Sci. Technol. , vol.31 , pp. 3702-3711
    • Mekengan, O.1    Ivanov, J.2    Karabunarliev, S.3    Bradbury, S.4    Ankley, G.5    Karcher, W.6
  • 41
    • 0023689753 scopus 로고
    • A chemical classification of nonsteroidal antagonists of sex-steroid hormone action
    • Miquel, J. and Gilbert, J. (1988). “A chemical classification of nonsteroidal antagonists of sex-steroid hormone action.” J. Steroid Biochem. 4B:525-544.
    • (1988) J. Steroid Biochem. , vol.4B , pp. 525-544
    • Miquel, J.1    Gilbert, J.2
  • 42
    • 0001004106 scopus 로고    scopus 로고
    • Reproductive and developmental effects of contaminants in fish populations: establishing cause and effect
    • (R. Rolland, M. Gilbertson, R. E. Peterson, eds.). SETAC Press, Pensacola, FL
    • Monosson, E. (1997). “Reproductive and developmental effects of contaminants in fish populations: establishing cause and effect.” In: Chemically Induced Alterations in Functional Development and Reproduction in Fishes (R. Rolland, M. Gilbertson, R. E. Peterson, eds.). SETAC Press, Pensacola, FL. pp. 177–194.
    • (1997) Chemically Induced Alterations in Functional Development and Reproduction in Fishes , pp. 177-194
    • Monosson, E.1
  • 43
    • 0031860360 scopus 로고    scopus 로고
    • Male reproductive tract malformations in rats following gestational and lactational exposure to DBP: an antiandrogenic mechanism
    • Mylchreest, E., Cattley, R., and Foster, P. M. D. (1998). “Male reproductive tract malformations in rats following gestational and lactational exposure to DBP: an antiandrogenic mechanism.” Toxicol. Sci. 43:47-60.
    • (1998) Toxicol. Sci. , vol.43 , pp. 47-60
    • Mylchreest, E.1    Cattley, R.2    Foster, P.M.D.3
  • 44
    • 84996174581 scopus 로고    scopus 로고
    • The fungicide procymidone alters sexual differentiation in the male rat by acting as an androgen-receptor antagonist in vivo and in vitro
    • (herein)
    • Ostby, J., Kelce, W. R., Lambright, C., Wolf, C. J., Mann, P., and Gray, L. E., Jr. “The fungicide procymidone alters sexual differentiation in the male rat by acting as an androgen-receptor antagonist in vivo and in vitro.” Toxicol. Ind. Health (herein).
    • Toxicol. Ind. Health
    • Ostby, J.1    Kelce, W.R.2    Lambright, C.3    Wolf, C.J.4    Mann, P.5    Gray, L.E.6
  • 45
    • 0014442677 scopus 로고
    • Effect of DDT on reproduction in the rat
    • Ottoboni, A. (1969). “Effect of DDT on reproduction in the rat.” Toxicol. Appl. Pharmacol. 14:74-81.
    • (1969) Toxicol. Appl. Pharmacol. , vol.14 , pp. 74-81
    • Ottoboni, A.1
  • 46
    • 0027352827 scopus 로고
    • Mosaic 35, X/36XY karotype and intersex in a red panda (Ailurus fulgens fulgens)
    • Reddacliff, G. L., Halnan, C. R., and Martin, I. C. (1993). “Mosaic 35, X/36XY karotype and intersex in a red panda (Ailurus fulgens fulgens).” J. Wildl. Dis. 29:169-173.
    • (1993) J. Wildl. Dis. , vol.29 , pp. 169-173
    • Reddacliff, G.L.1    Halnan, C.R.2    Martin, I.C.3
  • 47
    • 0001861226 scopus 로고
    • Hormones and hormonal antagonists
    • (J. L. Schardein, ed.). Marcel Dekker, New York, NY
    • Schardein, J. L. (1993). “Hormones and hormonal antagonists.” In: Chemically Induced Birth Defects (J. L. Schardein, ed.). Marcel Dekker, New York, NY. pp. 271–339.
    • (1993) Chemically Induced Birth Defects , pp. 271-339
    • Schardein, J.L.1
  • 48
    • 0027232797 scopus 로고
    • Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?
    • Sharpe, R. M. and Skakkebaek, N. M. (1993). “Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?” Lancet 341:1392-1395.
    • (1993) Lancet , vol.341 , pp. 1392-1395
    • Sharpe, R.M.1    Skakkebaek, N.M.2
  • 49
    • 0021985348 scopus 로고
    • The toxicology of mycotoxins
    • Ueno, Y. (1985). “The toxicology of mycotoxins.” Crit. Rev. Toxicol. 14:99-132.
    • (1985) Crit. Rev. Toxicol. , vol.14 , pp. 99-132
    • Ueno, Y.1
  • 50
    • 0343052128 scopus 로고
    • MRID No. 00062645 (HED Doc No. 000244), Washington, DC.
    • US Environmental Protection Agency (EPA) (1977). 3-Generation Reproduction Rat Study. MRID No. 00062645 (HED Doc No. 000244), Washington, DC.
    • (1977) 3-Generation Reproduction Rat Study
  • 53
    • 0343923797 scopus 로고
    • Last IRIS Update as of 6/13/98 for Health Assessment Information on Vinclozolin. Washington, DC
    • US Environmental Protection Agency (EPA) (1992). Integrated Risk Management System. Last IRIS Update as of 6/13/98 for Health Assessment Information on Vinclozolin. Washington, DC (http://www.epa.gov/ngispgm3/iris/irisdat/0126.DAT).
    • (1992) Integrated Risk Management System
  • 55
    • 0002947541 scopus 로고    scopus 로고
    • A comparison of bleached kraft mill effluent, 17 estradiol, and sitosterol effects on reproduction in fish
    • (R. Kendall, R. Dickerson, J. Giesy, and W. Suk, eds.). SETAC Press, Pensacola, FL
    • Van Der Kraak, G., Munkittrick, K. R., McMaster, M. E., and MacLatchy, D. (1998). “A comparison of bleached kraft mill effluent, 17 estradiol, and sitosterol effects on reproduction in fish.” In: Principles and Processes for Evaluating Endocrine Disruption in Wildlife (R. Kendall, R. Dickerson, J. Giesy, and W. Suk, eds.). SETAC Press, Pensacola, FL. pp. 249–265.
    • (1998) Principles and Processes for Evaluating Endocrine Disruption in Wildlife , pp. 249-265
    • Van Der Kraak, G.1    Munkittrick, K.R.2    McMaster, M.E.3    MacLatchy, D.4
  • 57
    • 0028818581 scopus 로고
    • The anogenital distance index, a predictor of the intrauterine position effects on reproduction in female house mice
    • Vandenbergh, J. G. and Huggett, C. L. (1995). “The anogenital distance index, a predictor of the intrauterine position effects on reproduction in female house mice.” Lab. Anim. Sci. 45:567-573.
    • (1995) Lab. Anim. Sci. , vol.45 , pp. 567-573
    • Vandenbergh, J.G.1    Huggett, C.L.2
  • 58
    • 0017222258 scopus 로고
    • Chronology of the development of the genital tract of the calf fetus
    • Viger, B., Prepin, J., and Jost, A. (1976). “Chronology of the development of the genital tract of the calf fetus.” Arch. Anat. Microsc. Morphol. Exp. 1976:77-101.
    • (1976) Arch. Anat. Microsc. Morphol. Exp. , vol.1976 , pp. 77-101
    • Viger, B.1    Prepin, J.2    Jost, A.3
  • 59
    • 0029874114 scopus 로고    scopus 로고
    • Three dimensional quantitative structure activity relationships for androgen receptor ligands
    • Waller, C., Juma, B., Gray, L. E., Jr., and Kelce, W. R. (1996). “Three dimensional quantitative structure activity relationships for androgen receptor ligands.” Toxicol. Appl. Pharmacol. 137:219-227.
    • (1996) Toxicol. Appl. Pharmacol. , vol.137 , pp. 219-227
    • Waller, C.1    Juma, B.2    Gray, L.E.3    Kelce, W.R.4
  • 61
    • 0017918452 scopus 로고
    • Sexual differentiation
    • Wilson, J. D. (1978). “Sexual differentiation.” Annu. Rev. Physiol. 40:279-306.
    • (1978) Annu. Rev. Physiol. , vol.40 , pp. 279-306
    • Wilson, J.D.1
  • 62
    • 0030953834 scopus 로고    scopus 로고
    • Reproductive toxicity of di-n-butyl phthalate in a continuous breeding protocol in Sprague-Dawley rats
    • Wine, R., Ling-Hong, L., Barnes, L., Gulati, D., and Chapin, R. (1997). “Reproductive toxicity of di-n-butyl phthalate in a continuous breeding protocol in Sprague-Dawley rats.” Environ. Health Perspect. 105:102-107.
    • (1997) Environ. Health Perspect. , vol.105 , pp. 102-107
    • Wine, R.1    Ling-Hong, L.2    Barnes, L.3    Gulati, D.4    Chapin, R.5


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