The OECD program to validate the rat Hershberger bioassay to screen compounds for in vivo androgen and antiandrogen responses: Phase 2 dose-response studies

Environmental Health Perspectives

Volumn 115, Issue 5, 2007, Pages 671-678

  Owens, J William ^a   Gray Jr , L Earl ^b   Zeiger, Errol ^c   Walker, Michael ^d   Yamasaki, Kanji ^e   Ashby, John ^f   Jacob, Elard ^g  

^a PROCTER AND GAMBLE COMPANY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c Errol Zeiger Consulting   (United States)

^d HEALTH CANADA   (Canada)

^e CHEMICALS EVALUATION AND RESEARCH INSTITUTE   (Japan)

^f JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

^g BASF SE   (Germany)

Author keywords

Androgen; Antiandrogen; Bulbocavernosus; Cowper's glands; DDE; Endocrine disruption; Finasteride; Glans penis; Hershberger; Levator ani; Linuron; Methyl testosterone; Procymidone; Seminal vesicles; Trenbolone; Validation; Ventral prostate; Vinclozolin

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; ANDROGEN; ANTIANDROGEN; ENDOCRINE DISRUPTOR; FINASTERIDE; FLUTAMIDE; LINURON; METHYLTESTOSTERONE; PROCYMIDONE; TRENBOLONE; VINCLOZOLIN;

ANIMAL EXPERIMENT; ANIMAL HUSBANDRY; ANIMAL TISSUE; ARTICLE; BIOASSAY; BULBOURETHRAL GLAND; CONTROLLED STUDY; DOSE RESPONSE; HERSHBERGER BIOASSAY; HORMONE RESPONSE; IN VIVO STUDY; LEVATOR ANI MUSCLE; MALE; NONHUMAN; PENIS GLANS; PRIORITY JOURNAL; PROSTATE VENTRAL LOBE; RAT; RAT STRAIN; REPRODUCIBILITY; SCREENING TEST; SEMINAL VESICLE; SENSITIVITY ANALYSIS; VALIDATION PROCESS; WEIGHT CHANGE;

ANDROGEN ANTAGONISTS; ANDROGENS; ANIMALS; BIOLOGICAL ASSAY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCRINE DISRUPTORS; EUROPE; GENITALIA; ORGAN SIZE; RATS; REPRODUCIBILITY OF RESULTS; VALIDATION STUDIES AS TOPIC;

GLANS; RATTUS; RODENTIA;

EID: 34249028612     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.9666     Document Type: Article

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