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Volumn 31, Issue 2, 2008, Pages 241-248

Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat

Author keywords

Androgen receptor antagonist; Flutamide; Hypospadias; Procymidone; Rat; Vinclozolin

Indexed keywords

FLUTAMIDE; PROCYMIDONE; VINCLOZOLIN;

EID: 40349113152     PISSN: 01056263     EISSN: 13652605     Source Type: Journal    
DOI: 10.1111/j.1365-2605.2008.00866.x     Document Type: Conference Paper
Times cited : (126)

References (32)
  • 3
    • 0043092172 scopus 로고    scopus 로고
    • Effects of in utero exposure to finasteride on androgen‐dependent reproductive development in the male rat
    • Bowman, C. J., Barlow, N. J., Turner, K. J., Wallace, D. G. & Foster, P. M. D. (2003) Effects of in utero exposure to finasteride on androgen‐dependent reproductive development in the male rat. Toxicol Sci 74, 393–406.
    • (2003) Toxicol Sci , vol.74 , pp. 393-406
    • Bowman, C.J.1    Barlow, N.J.2    Turner, K.J.3    Wallace, D.G.4    Foster, P.M.D.5
  • 6
    • 33645220588 scopus 로고    scopus 로고
    • Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters
    • Foster, P. M. D. (2006) Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters. International Journal of Andrology 29, 140–147.
    • (2006) International Journal of Andrology , vol.29 , pp. 140-147
    • Foster, P.M.D.1
  • 7
    • 0036185791 scopus 로고    scopus 로고
    • Endocrine active agents: implications of adverse and non‐adverse changes
    • Foster, P. M. & McIntyre, B. S. (2002) Endocrine active agents: implications of adverse and non‐adverse changes. Toxicologic Pathology 30, 59–65.
    • (2002) Toxicologic Pathology , vol.30 , pp. 59-65
    • Foster, P.M.1    McIntyre, B.S.2
  • 8
    • 0027937899 scopus 로고
    • Developmental effects of an environmental antiandrogen: the fungicide vinclozolin alters sex differentiation of the male rat
    • Gray, L., Ostby, J. S. & Kelce, W. R. (1994) Developmental effects of an environmental antiandrogen: the fungicide vinclozolin alters sex differentiation of the male rat. Toxicology and Applied Pharmacology 129, 46–52.
    • (1994) Toxicology and Applied Pharmacology , vol.129 , pp. 46-52
    • Gray, L.1    Ostby, J.S.2    Kelce, W.R.3
  • 12
    • 0028958647 scopus 로고
    • The abnormal development of male sex organs in the rat using a pure antiandrogen and a 5 alpha‐reductase inhibitor during gestation
    • Hib, J. & Ponzio, R. (1995) The abnormal development of male sex organs in the rat using a pure antiandrogen and a 5 alpha‐reductase inhibitor during gestation. Acta Physiologica, Pharmacologica Et Therapeutica Latinoamericana 45, 27–33.
    • (1995) Acta Physiologica, Pharmacologica Et Therapeutica Latinoamericana , vol.45 , pp. 27-33
    • Hib, J.1    Ponzio, R.2
  • 13
    • 9744248326 scopus 로고    scopus 로고
    • A mixture of the “antiandrogens” linuron and butyl benzyl phthalate alters sexual differentiation of the male rat in a cumulative fashion
    • Hotchkiss, A. K., Parks‐Saldutti, L. G., Ostby, J. S., Lambright, C., Furr, J., Vandenbergh, J. G. & Gray, L. E., Jr. (2004) A mixture of the “antiandrogens” linuron and butyl benzyl phthalate alters sexual differentiation of the male rat in a cumulative fashion. Biology of Reproduction 71, 1852–1861.
    • (2004) Biology of Reproduction , vol.71 , pp. 1852-1861
    • Hotchkiss, A.K.1    Parks‐Saldutti, L.G.2    Ostby, J.S.3    Lambright, C.4    Furr, J.5    Vandenbergh, J.G.6    Gray, L.E.7
  • 14
    • 34547896247 scopus 로고    scopus 로고
    • Cumulative effects of dibutyl phthalate and diethylhexyl phthalate on male rat reproductive tract development: altered fetal steroid hormones and genes
    • Howdeshell, K. L., Furr, J., Lambright, C. R., Rider, C. V., Wilson, V. S. & Gray, L. E., Jr. (2007) Cumulative effects of dibutyl phthalate and diethylhexyl phthalate on male rat reproductive tract development: altered fetal steroid hormones and genes. Toxicological Sciences 99, 190–202.
    • (2007) Toxicological Sciences , vol.99 , pp. 190-202
    • Howdeshell, K.L.1    Furr, J.2    Lambright, C.R.3    Rider, C.V.4    Wilson, V.S.5    Gray, L.E.6
  • 15
    • 0028228821 scopus 로고
    • Environmental hormone disruptors: evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites
    • Kelce, W. R., Monosson, E., Gamcsik, M. P., Laws, S. C. & Gray, L. E. (1994) Environmental hormone disruptors: evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites. Toxicology and Applied Pharmacology 126, 276–285.
    • (1994) Toxicology and Applied Pharmacology , vol.126 , pp. 276-285
    • Kelce, W.R.1    Monosson, E.2    Gamcsik, M.P.3    Laws, S.C.4    Gray, L.E.5
  • 16
    • 0031019418 scopus 로고    scopus 로고
    • Vinclozolin and p,p’‐DDE alter androgen‐dependent gene expression: in vivo confirmation of an androgen receptor‐mediated mechanism
    • Kelce, W. R., Lambright, C. R., Gray, L. E. & Roberts, K. P. (1997) Vinclozolin and p,p’‐DDE alter androgen‐dependent gene expression: in vivo confirmation of an androgen receptor‐mediated mechanism. Toxicology and Applied Pharmacology 142, 192–200.
    • (1997) Toxicology and Applied Pharmacology , vol.142 , pp. 192-200
    • Kelce, W.R.1    Lambright, C.R.2    Gray, L.E.3    Roberts, K.P.4
  • 17
    • 32044470078 scopus 로고    scopus 로고
    • Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age
    • Main, K., Mortensen, G. K., Kaleva, M. M., Boisen, K. A., Damgaard, I. N., Chellakooty, M. et al. (2006) Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age. Environmental Health Perspectives 114, 270–276.
    • (2006) Environmental Health Perspectives , vol.114 , pp. 270-276
    • Main, K.1    Mortensen, G.K.2    Kaleva, M.M.3    Boisen, K.A.4    Damgaard, I.N.5    Chellakooty, M.6
  • 18
    • 0003663926 scopus 로고
    • Generalized linear models
    • McCullagh, P. & Nelder, J. A. (1989) Generalized linear models, 2nd edn. Chapman and Hall, London.
    • (1989)
    • McCullagh, P.1    Nelder, J.A.2
  • 19
    • 0034894623 scopus 로고    scopus 로고
    • Androgen‐mediated development in male rat offspring exposed to flutamide in utero: permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen‐dependent tissues
    • McIntyre, B. S., Barlow, N. J. & Foster, P. M. D. (2001) Androgen‐mediated development in male rat offspring exposed to flutamide in utero: permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen‐dependent tissues. Toxicological Sciences 62, 236–249.
    • (2001) Toxicological Sciences , vol.62 , pp. 236-249
    • McIntyre, B.S.1    Barlow, N.J.2    Foster, P.M.D.3
  • 20
    • 0036147796 scopus 로고    scopus 로고
    • Male rats exposed to linuron in utero exhibit permanent changes in anogenital distance, nipple retention, and epididymal malformations that result in subsequent testicular atrophy
    • McIntyre, B. S., Barlow, N. J. & Foster, P. M. (2002) Male rats exposed to linuron in utero exhibit permanent changes in anogenital distance, nipple retention, and epididymal malformations that result in subsequent testicular atrophy. Toxicological Science 65, 62–70.
    • (2002) Toxicological Science , vol.65 , pp. 62-70
    • McIntyre, B.S.1    Barlow, N.J.2    Foster, P.M.3
  • 23
    • 0037292159 scopus 로고    scopus 로고
    • The combined effects of vinclozolin and procymidone do not deviate from expected additivity in vitro and in vivo
    • Nellemann, C., Dalgaard, M., Lam, H. R. & Vinggaard, A. M. (2003) The combined effects of vinclozolin and procymidone do not deviate from expected additivity in vitro and in vivo. Toxicological Sciences 71, 251–262.
    • (2003) Toxicological Sciences , vol.71 , pp. 251-262
    • Nellemann, C.1    Dalgaard, M.2    Lam, H.R.3    Vinggaard, A.M.4
  • 24
    • 0033363929 scopus 로고    scopus 로고
    • The fungicide procymidone alters sexual differentiation in the male rat by acting as an androgen‐receptor antagonist in vivo and in vitro
    • Ostby, J., Kelce, W. R., Lambright, C., Wolf, C. J., Mann, P. & Gray, L. E. Jr. (1999) The fungicide procymidone alters sexual differentiation in the male rat by acting as an androgen‐receptor antagonist in vivo and in vitro. Toxicology and Industrial Health 15, 80–93.
    • (1999) Toxicology and Industrial Health , vol.15 , pp. 80-93
    • Ostby, J.1    Kelce, W.R.2    Lambright, C.3    Wolf, C.J.4    Mann, P.5    Gray, L.E.6
  • 25
    • 0036737088 scopus 로고    scopus 로고
    • Combining xenoestrogens at levels below individual no‐observed effect concentrations dramatically enhances steroid hormone action
    • Rajapakse, N., Silva, E. & Kortenkamp, A. (2002) Combining xenoestrogens at levels below individual no‐observed effect concentrations dramatically enhances steroid hormone action. Environmental Health Perspectives 110, 917–921.
    • (2002) Environmental Health Perspectives , vol.110 , pp. 917-921
    • Rajapakse, N.1    Silva, E.2    Kortenkamp, A.3
  • 26
    • 0037166044 scopus 로고    scopus 로고
    • Comparison of antiandrogenic activities of vinclozolin and ‐camphorquinone in androgen receptor gene transcription assay in vitro and mouse in utero exposure assay in vivo
    • Shimamura, M., Kodaira, K., Kenichi, H., Ishimoto, Y., Tamura, H. & Iguchi, T. (2002) Comparison of antiandrogenic activities of vinclozolin and ‐camphorquinone in androgen receptor gene transcription assay in vitro and mouse in utero exposure assay in vivo. Toxicology 174, 97–107.
    • (2002) Toxicology , vol.174 , pp. 97-107
    • Shimamura, M.1    Kodaira, K.2    Kenichi, H.3    Ishimoto, Y.4    Tamura, H.5    Iguchi, T.6
  • 27
    • 0037090577 scopus 로고    scopus 로고
    • Something from “nothing”– eight weak estrogenic chemicals combined at concentrations below NOECs produce significant mixture effects
    • Silva, E., Rajapakse, N. & Kortenkamp, A. (2002) Something from “nothing”–eight weak estrogenic chemicals combined at concentrations below NOECs produce significant mixture effects. Environmental Science and Technology 36, 1751–1756.
    • (2002) Environmental Science and Technology , vol.36 , pp. 1751-1756
    • Silva, E.1    Rajapakse, N.2    Kortenkamp, A.3
  • 28
    • 0022639044 scopus 로고
    • Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues
    • Simard, J., Luthy, I., Guay, J., Belanger, A. & Labrie, F. (1986) Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues. Molecular and Cellular Endocrinology 44, 261–270.
    • (1986) Molecular and Cellular Endocrinology , vol.44 , pp. 261-270
    • Simard, J.1    Luthy, I.2    Guay, J.3    Belanger, A.4    Labrie, F.5
  • 30
    • 4344686391 scopus 로고    scopus 로고
    • Sensitivity of the immature rat uterotrophic assay to mixtures of estrogens
    • Tinwell, H. & Ashby, J. (2004) Sensitivity of the immature rat uterotrophic assay to mixtures of estrogens. Environmental Health Perspectives 112, 575–582.
    • (2004) Environmental Health Perspectives , vol.112 , pp. 575-582
    • Tinwell, H.1    Ashby, J.2
  • 31
    • 0035011479 scopus 로고    scopus 로고
    • Trends in the incidence of cryptorchidism and hypospadias, and methodological limitations of registry‐based data
    • Toppari, J., Kaleva, M. & Virtanen, H. E. (2001) Trends in the incidence of cryptorchidism and hypospadias, and methodological limitations of registry‐based data. Human Reproduction Update 7, 282–286.
    • (2001) Human Reproduction Update , vol.7 , pp. 282-286
    • Toppari, J.1    Kaleva, M.2    Virtanen, H.E.3
  • 32
    • 0003747369 scopus 로고    scopus 로고
    • Linear and Nonlinear Models for the Analysis of Repeated Measurements
    • Vonesh, E. & Chinchilli, V. M. (1996) Linear and Nonlinear Models for the Analysis of Repeated Measurements. Marcel Dekker, New York.
    • (1996)
    • Vonesh, E.1    Chinchilli, V.M.2


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