The fungicide procymidone alters sexual differentiation in the male rat by acting as an androgen-receptor antagonist in vivo and in vitro

Toxicology and Industrial Health

Volumn 15, Issue 2, 1999, Pages 80-93

  Ostby, Joseph ^a   Kelce, William R ^a   Lambright, Christy ^a   Wolf, Cynthia J ^a   Mann, Peter ^b   Gray, L Earl ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b EXPERIMENTAL PATHOLOGY LABORATORIES INC   (United States)

Author keywords

antiandrogen; binding; developmental reproductive toxicity; endocrine disruption; procymidone; sexual differentiation; transcriptional activation

Indexed keywords

ANDROGEN RECEPTOR; ANTIANDROGEN; PROCYMIDONE;

ANIMAL CELL; ANIMAL EXPERIMENT; CHEMICAL STRUCTURE; CONFERENCE PAPER; CONTROLLED STUDY; ENDOCRINE DISEASE; GENE EXPRESSION SYSTEM; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; RAT; RECEPTOR BINDING; REPRODUCTIVE TOXICITY; SEX DIFFERENTIATION; TRANSCRIPTION INITIATION;

ANIMALS; BICYCLO COMPOUNDS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FUNGICIDES, INDUSTRIAL; GENE EXPRESSION REGULATION; GENITALIA, MALE; MALE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, LONG-EVANS; RECEPTORS, ANDROGEN;

ANIMALIA; GLANS; MAMMALIA; MOUSE MAMMARY TUMOR VIRUS;

EID: 0033363929     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1177/074823379901500108     Document Type: Article

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