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Volumn 12, Issue 4, 2007, Pages 384-402

Large-scale gene expression profiles, differentially represented in osteoarthritic synovium of the knee joint using cDNA microarray technology

Author keywords

Biomarker; Gene; Knee joint; Microarray; Osteoarthritis; Synovium

Indexed keywords

BIOLOGICAL MARKER; COMPLEMENTARY DNA;

EID: 34250785130     PISSN: 1354750X     EISSN: 13665804     Source Type: Journal    
DOI: 10.1080/13547500601162482     Document Type: Article
Times cited : (20)

References (56)
  • 1
    • 0035677833 scopus 로고    scopus 로고
    • Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology
    • Aigner, T., Zien, A., Gehrsitz, A., Gebhard, PM and McKenna, L. (2001) Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology. Arthritis & Rheumatism, 44, pp. 2777-2789.
    • (2001) Arthritis & Rheumatism , vol.44 , pp. 2777-2789
    • Aigner, T.1    Zien, A.2    Gehrsitz, A.3    Gebhard, P.M.4    McKenna, L.5
  • 3
    • 0022465236 scopus 로고
    • Development of criteria for the classification and reporting of osteoarthritis
    • Altman, R., Asch, E., Bloch, D., Bole, G., Borenstein, D., Brandt, K., Christy, W., Cooke, TD, Greenwald, R. and Hochberg, M. (1986) Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis & Rheumatism, 29, pp. 1039-1049.
    • (1986) Arthritis & Rheumatism , vol.29 , pp. 1039-1049
    • Altman, R.1    Asch, E.2    Bloch, D.3    Bole, G.4    Borenstein, D.5    Brandt, K.6    Christy, W.7    Cooke, T.D.8    Greenwald, R.9    Hochberg, M.10
  • 4
    • 0031833414 scopus 로고    scopus 로고
    • The role of nitric oxide in articular cartilage breakdown in osteoarthritis
    • Amin, AR and Abramson, SB (1998) The role of nitric oxide in articular cartilage breakdown in osteoarthritis. Current Opinions in Rheumatology, 10, pp. 263-268.
    • (1998) Current Opinions in Rheumatology , vol.10 , pp. 263-268
    • Amin, A.R.1    Abramson, S.B.2
  • 6
    • 0034041424 scopus 로고    scopus 로고
    • Comparison of the degradation of type II collagen and proteoglycan in nasal and articular cartilages induced by interleukin-1 and the selective inhibition of type II collagen cleavage by collagenase
    • Billinghurst, RC, Ionescu, M., Reiner, A., Dahlberg, L., Chen, J., van Wart, H. and Poole, AR (2000) Comparison of the degradation of type II collagen and proteoglycan in nasal and articular cartilages induced by interleukin-1 and the selective inhibition of type II collagen cleavage by collagenase. Arthritis & Rheumatism, 43, pp. 664-672.
    • (2000) Arthritis & Rheumatism , vol.43 , pp. 664-672
    • Billinghurst, R.C.1    Ionescu, M.2    Reiner, A.3    Dahlberg, L.4    Chen, J.5    van Wart, H.6    Poole, A.R.7
  • 10
    • 0033497836 scopus 로고    scopus 로고
    • Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: The Johnston County Osteoarthritis Project
    • Clark, AG, Jordan, JM, Vilim, V., Renner, JB, Dragomir, AD, Luta, G. and Kraus, VB (1999) Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: The Johnston County Osteoarthritis Project. Arthritis & Rheumatism, 42, pp. 2356-2364.
    • (1999) Arthritis & Rheumatism , vol.42 , pp. 2356-2364
    • Clark, A.G.1    Jordan, J.M.2    Vilim, V.3    Renner, J.B.4    Dragomir, A.D.5    Luta, G.6    Kraus, V.B.7
  • 11
    • 0038548270 scopus 로고    scopus 로고
    • Comparison of the catabolic effects of fibronectin fragments in human knee and ankle cartilages
    • Dang, Y., Cole, AA and Homandberg, GA (2003) Comparison of the catabolic effects of fibronectin fragments in human knee and ankle cartilages. Osteoarthritis & Cartilage, 11, pp. 538-547.
    • (2003) Osteoarthritis & Cartilage , vol.11 , pp. 538-547
    • Dang, Y.1    Cole, A.A.2    Homandberg, G.A.3
  • 15
    • 0036228716 scopus 로고    scopus 로고
    • DNA microarrays: Boundless technology or bound by technology? Guidelines for studies using microarray technology
    • Firestein, GS and Pisetsky, DS (2002) DNA microarrays: Boundless technology or bound by technology? Guidelines for studies using microarray technology. Arthritis & Rheumatism, 46, pp. 859-861.
    • (2002) Arthritis & Rheumatism , vol.46 , pp. 859-861
    • Firestein, G.S.1    Pisetsky, D.S.2
  • 16
    • 0141427820 scopus 로고    scopus 로고
    • Urinary type II collagen C-telopeptide levels are increased in patients with rapidly destructive hip osteoarthritis
    • Garnero, P., Conrozier, T., Christgau, S., Mathieu, P., Delmas, PD and Vignon, E. (2003) Urinary type II collagen C-telopeptide levels are increased in patients with rapidly destructive hip osteoarthritis. Annals of Rheumatic Diseases, 62, pp. 939-943.
    • (2003) Annals of Rheumatic Diseases , vol.62 , pp. 939-943
    • Garnero, P.1    Conrozier, T.2    Christgau, S.3    Mathieu, P.4    Delmas, P.D.5    Vignon, E.6
  • 18
    • 0028264798 scopus 로고
    • Differential expression of the small inducible cytokines GRO alpha and GRO beta by synovial fibroblasts in chronic arthritis: Possible role in growth regulation
    • Hogan, M., Sherry, B., Ritchlin, C., Fabre, M., Winchester, R., Cerami, A. and Bucala, R. (1994) Differential expression of the small inducible cytokines GRO alpha and GRO beta by synovial fibroblasts in chronic arthritis: Possible role in growth regulation. Cytokine, 6, pp. 61-69.
    • (1994) Cytokine , vol.6 , pp. 61-69
    • Hogan, M.1    Sherry, B.2    Ritchlin, C.3    Fabre, M.4    Winchester, R.5    Cerami, A.6    Bucala, R.7
  • 19
    • 0028987190 scopus 로고
    • Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin
    • Huhtala, P., Humphries, MJ, McCarthy, JB, Tremble, PM, Werb, Z. and Damsky, CH (1995) Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin. Journal of Cell Biology, 129, pp. 867-879.
    • (1995) Journal of Cell Biology , vol.129 , pp. 867-879
    • Huhtala, P.1    Humphries, M.J.2    McCarthy, J.B.3    Tremble, P.M.4    Werb, Z.5    Damsky, C.H.6
  • 20
    • 0029924794 scopus 로고    scopus 로고
    • Serum YKL-40 levels in healthy children and adults
    • Johansen, JS, Hvolris, J., Hansen, M., Backer, V., Lorenzen, I. and Price, PA (1996) Serum YKL-40 levels in healthy children and adults. Comparison with serum and synovial fluid levels of YKL-40 in patients with osteoarthritis or trauma of the knee joint. British Journal of Rheumatology, 35, pp. 553-559.
    • (1996) British Journal of Rheumatology , vol.35 , pp. 553-559
    • Johansen, J.S.1    Hvolris, J.2    Hansen, M.3    Backer, V.4    Lorenzen, I.5    Price, P.A.6
  • 23
    • 0034782261 scopus 로고    scopus 로고
    • Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries
    • Kumar, S., Connor, JR, Dodds, RA, Halsey, W., Van Horn, M., Mao, J., Sathe, G., Mui, P., Agarwal, P. and Badger, AM (2001) Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries. Osteoarthritis & Cartilage, 9, pp. 641-653.
    • (2001) Osteoarthritis & Cartilage , vol.9 , pp. 641-653
    • Kumar, S.1    Connor, J.R.2    Dodds, R.A.3    Halsey, W.4    Van Horn, M.5    Mao, J.6    Sathe, G.7    Mui, P.8    Agarwal, P.9    Badger, A.M.10
  • 25
    • 0027450277 scopus 로고
    • Metalloproteinases, tissue inhibitor, and proteoglycan fragments in knee synovial fluid in human osteoarthritis
    • Lohmander, LS, Hoerrner, LA and Lark, MW (1993) Metalloproteinases, tissue inhibitor, and proteoglycan fragments in knee synovial fluid in human osteoarthritis. Arthritis & Rheumatism, 36, pp. 181-189.
    • (1993) Arthritis & Rheumatism , vol.36 , pp. 181-189
    • Lohmander, L.S.1    Hoerrner, L.A.2    Lark, M.W.3
  • 26
    • 0033862120 scopus 로고    scopus 로고
    • Influence of polymorphism in the manganese superoxide dismutase locus on disease outcome in rheumatoid arthritis: Evidence for interaction with glutathione S-transferase genes
    • Mattey, DL, Hassell, AB, Dawes, PT, Jones, PW, Yengi, L., Alldersea, J., Strange, RC and Fryer, AA (2000) Influence of polymorphism in the manganese superoxide dismutase locus on disease outcome in rheumatoid arthritis: Evidence for interaction with glutathione S-transferase genes. Arthritis & Rheumatism, 43, pp. 859-864.
    • (2000) Arthritis & Rheumatism , vol.43 , pp. 859-864
    • Mattey, D.L.1    Hassell, A.B.2    Dawes, P.T.3    Jones, P.W.4    Yengi, L.5    Alldersea, J.6    Strange, R.C.7    Fryer, A.A.8
  • 27
    • 0026064363 scopus 로고
    • Radiographic criteria for classification of osteoarthritis
    • Menkes, CJ (1991) Radiographic criteria for classification of osteoarthritis. Journal of Rheumatology Supplement, 27, pp. 13-15.
    • (1991) Journal of Rheumatology Supplement , vol.27 , pp. 13-15
    • Menkes, C.J.1
  • 28
    • 0032727901 scopus 로고    scopus 로고
    • Measurement of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in patients with knee osteoarthritis: Comparison with generalised osteoarthritis
    • Naito, K., Takahashi, M., Kushida, K., Suzuki, M., Ohishi, T., Miura, M., Inoue, T. and Nagano, A. (1999) Measurement of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in patients with knee osteoarthritis: Comparison with generalised osteoarthritis. Rheumatology, 38, pp. 510-515.
    • (1999) Rheumatology , vol.38 , pp. 510-515
    • Naito, K.1    Takahashi, M.2    Kushida, K.3    Suzuki, M.4    Ohishi, T.5    Miura, M.6    Inoue, T.7    Nagano, A.8
  • 30
    • 0036164195 scopus 로고    scopus 로고
    • Identification of differentially expressed genes in rheumatoid arthritis by a combination of complementary DNA array and RNA arbitrarily primed Polymerase chain reaction
    • Neaumann, E., Kullmann, F., Judex, M., Justen, HP, Wessinghage, D., Gay, S., Scholmerich, J. and Muller-Ladner, U. (2002) Identification of differentially expressed genes in rheumatoid arthritis by a combination of complementary DNA array and RNA arbitrarily primed Polymerase chain reaction. Arthritis & Rheumatism, 46, pp. 52-63.
    • (2002) Arthritis & Rheumatism , vol.46 , pp. 52-63
    • Neaumann, E.1    Kullmann, F.2    Judex, M.3    Justen, H.P.4    Wessinghage, D.5    Gay, S.6    Scholmerich, J.7    Muller-Ladner, U.8
  • 33
    • 2342610548 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor up-regulates the expression of interleukin-8 messenger RNA in synovial fibroblasts of rheumatoid arthritis patients: Common transcriptional regulatory mechanism between interleukin-8 and interleukin-1beta
    • Onodera, S., Nishihira, J., Koyama, Y., Majima, T., Aoki, Y., Ichiyama, H., Ishibashi, T. and Minami, A. (2004) Macrophage migration inhibitory factor up-regulates the expression of interleukin-8 messenger RNA in synovial fibroblasts of rheumatoid arthritis patients: Common transcriptional regulatory mechanism between interleukin-8 and interleukin-1beta. Arthritis & Rheumatism, 50, pp. 1437-1447.
    • (2004) Arthritis & Rheumatism , vol.50 , pp. 1437-1447
    • Onodera, S.1    Nishihira, J.2    Koyama, Y.3    Majima, T.4    Aoki, Y.5    Ichiyama, H.6    Ishibashi, T.7    Minami, A.8
  • 34
    • 0142029009 scopus 로고    scopus 로고
    • Global gene expression profiles in fibroblasts from synovial, skin and lymphoid tissue reveals distinct cytokine and chemokine expression patterns
    • Parsonage, G., Falciani, F., Burman, A., Filer, A., Ross, E., Bofill, M., Martin, S., Salmon, M. and Buckley, CD (2003) Global gene expression profiles in fibroblasts from synovial, skin and lymphoid tissue reveals distinct cytokine and chemokine expression patterns. Thrombosis & Haemostasis, 90, pp. 688-697.
    • (2003) Thrombosis & Haemostasis , vol.90 , pp. 688-697
    • Parsonage, G.1    Falciani, F.2    Burman, A.3    Filer, A.4    Ross, E.5    Bofill, M.6    Martin, S.7    Salmon, M.8    Buckley, C.D.9
  • 36
    • 0036855694 scopus 로고    scopus 로고
    • Is osteoarthritis a 'fibronectin-integrin imbalance disorder?'
    • Peters, JH, Loredo, GA and Benton, HP (2002) Is osteoarthritis a 'fibronectin-integrin imbalance disorder?'. Osteoarthritis & Cartilage, 10, pp. 831-835.
    • (2002) Osteoarthritis & Cartilage , vol.10 , pp. 831-835
    • Peters, J.H.1    Loredo, G.A.2    Benton, H.P.3
  • 38
    • 1942532229 scopus 로고    scopus 로고
    • Technical validation of cDNA based microarray as screening technique to identify candidate genes in synovial tissue biopsy specimens from patients with spondyloarthropathy
    • Rihl, M., Baeten, D., Seta, N., De Keyser, F., Veys, EM, Kuipers, JG, Zeidler, H. and Yu, DT (2004) Technical validation of cDNA based microarray as screening technique to identify candidate genes in synovial tissue biopsy specimens from patients with spondyloarthropathy. Arthritis & Rheumatism Dis, 63, pp. 498-507.
    • (2004) Arthritis & Rheumatism Dis , vol.63 , pp. 498-507
    • Rihl, M.1    Baeten, D.2    Seta, N.3    De Keyser, F.4    Veys, E.M.5    Kuipers, J.G.6    Zeidler, H.7    Yu, D.T.8
  • 40
    • 0029085898 scopus 로고
    • Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA
    • Sadouk, MB, Pelletier, JP, Tardif, G., Kiansa, K., Cloutier, JM and Martel-Pelletier, J. (1995) Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA. The increased level of the IL-1 receptor in osteoarthritic cells is related to an increased level of the type I receptor. Laboratory Investigations, 73, pp. 347-355.
    • (1995) Laboratory Investigations , vol.73 , pp. 347-355
    • Sadouk, M.B.1    Pelletier, J.P.2    Tardif, G.3    Kiansa, K.4    Cloutier, J.M.5    Martel-Pelletier, J.6
  • 41
    • 0026710173 scopus 로고
    • Synovial fluid analysis of two groups of proteoglycan epitopes distinguishes early and late cartilage lesions
    • Saxne, T. and Heinegard, D. (1992) Synovial fluid analysis of two groups of proteoglycan epitopes distinguishes early and late cartilage lesions. Arthritis & Rheumatism, 35, pp. 385-390.
    • (1992) Arthritis & Rheumatism , vol.35 , pp. 385-390
    • Saxne, T.1    Heinegard, D.2
  • 42
    • 0028797761 scopus 로고
    • Increased release of bone sialoprotein into synovial fluid reflects tissue destruction in rheumatoid arthritis
    • Saxne, T., Zunino, L. and Heinegard, D. (1995) Increased release of bone sialoprotein into synovial fluid reflects tissue destruction in rheumatoid arthritis. Arthritis & Rheumatism, 38, pp. 82-90.
    • (1995) Arthritis & Rheumatism , vol.38 , pp. 82-90
    • Saxne, T.1    Zunino, L.2    Heinegard, D.3
  • 44
    • 0346220031 scopus 로고    scopus 로고
    • Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor beta/bone morphogenetic protein inhibitors during experimental osteoarthritis
    • Scharstuhl, A., Vitters, EL, van der Kraan, PM and Berg, WB van den (2003) Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor beta/bone morphogenetic protein inhibitors during experimental osteoarthritis. Arthritis & Rheumatism, 48, pp. 3442-3451.
    • (2003) Arthritis & Rheumatism , vol.48 , pp. 3442-3451
    • Scharstuhl, A.1    Vitters, E.L.2    van der Kraan, P.M.3    van den Berg, W.B.4
  • 45
    • 0031856464 scopus 로고    scopus 로고
    • Use of differential subtraction method to identify genes that characterize the phenotype of cultured rheumatoid arthritis synoviocytes
    • Seki, T., Selby, J., Haupl, T. and Winchester, R. (1998) Use of differential subtraction method to identify genes that characterize the phenotype of cultured rheumatoid arthritis synoviocytes. Arthritis & Rheumatism, 41, pp. 1356-1364.
    • (1998) Arthritis & Rheumatism , vol.41 , pp. 1356-1364
    • Seki, T.1    Selby, J.2    Haupl, T.3    Winchester, R.4
  • 46
    • 4043134601 scopus 로고    scopus 로고
    • Suggestion of nonlinear or phasic progression of knee osteoarthritis based on measurements of serum cartilage oligomeric matrix protein levels over five years
    • Sharif, M., Kirwan, JR, Elson, CJ, Granell, R. and Clarke, S. (2004) Suggestion of nonlinear or phasic progression of knee osteoarthritis based on measurements of serum cartilage oligomeric matrix protein levels over five years. Arthritis & Rheumatism, 50, pp. 2479-2488.
    • (2004) Arthritis & Rheumatism , vol.50 , pp. 2479-2488
    • Sharif, M.1    Kirwan, J.R.2    Elson, C.J.3    Granell, R.4    Clarke, S.5
  • 47
    • 0031047265 scopus 로고    scopus 로고
    • Synovial membrane inflammation and cytokine production in patients with early osteoarthritis
    • Smith, MD, Triantafillou, S., Parker, A., Youssef, PP and Coleman, M. (1997) Synovial membrane inflammation and cytokine production in patients with early osteoarthritis. Journal of Rheumatology, 24, pp. 365-371.
    • (1997) Journal of Rheumatology , vol.24 , pp. 365-371
    • Smith, M.D.1    Triantafillou, S.2    Parker, A.3    Youssef, P.P.4    Coleman, M.5
  • 48
    • 0030966943 scopus 로고    scopus 로고
    • Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease
    • Spector, TD, Hart, DJ, Nandra, D., Doyle, DV, Mackillop, N., Gallimore, JR and Pepys, MB (1997) Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease. Arthritis & Rheumatism, 40, pp. 723-727.
    • (1997) Arthritis & Rheumatism , vol.40 , pp. 723-727
    • Spector, T.D.1    Hart, D.J.2    Nandra, D.3    Doyle, D.V.4    Mackillop, N.5    Gallimore, J.R.6    Pepys, M.B.7
  • 49
    • 4043100538 scopus 로고    scopus 로고
    • Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts
    • Tardif, G., Hum, D., Pelletier, JP, Boileau, C., Ranger, P. and Martel-Pelletier, J. (2004) Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts. Arthritis & Rheumatism, 50, pp. 2521-2530.
    • (2004) Arthritis & Rheumatism , vol.50 , pp. 2521-2530
    • Tardif, G.1    Hum, D.2    Pelletier, J.P.3    Boileau, C.4    Ranger, P.5    Martel-Pelletier, J.6
  • 51
    • 0033986279 scopus 로고    scopus 로고
    • Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-beta injections
    • van Beuningen, HM, Glansbeek, HL, van der Kraan, PM and Berg, WB van den (2000) Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-beta injections. Osteoarthritis & Cartilage, 8, pp. 25-33.
    • (2000) Osteoarthritis & Cartilage , vol.8 , pp. 25-33
    • van Beuningen, H.M.1    Glansbeek, H.L.2    van der Kraan, P.M.3    van den Berg, W.B.4
  • 52
    • 0038151908 scopus 로고    scopus 로고
    • Discovery of distinctive gene expression profiles in rheumatoid synovium using cDNA microarray technology: Evidence for the existence of multiple pathways of tissue destruction and repair
    • Kraan, TC van der Pouw, van Gaalen, FA, Huizinga, W., Pieterman, E., Breedveld, FC and Verweij, CL (2003) Discovery of distinctive gene expression profiles in rheumatoid synovium using cDNA microarray technology: Evidence for the existence of multiple pathways of tissue destruction and repair. Genes Immunology, 4, pp. 187-196.
    • (2003) Genes Immunology , vol.4 , pp. 187-196
    • Kraan, T.C.1    van der Pouw van Gaalen, F.A.2    Huizinga, W.3    Pieterman, E.4    Breedveld, F.C.5    Verweij, C.L.6
  • 55
    • 0034777333 scopus 로고    scopus 로고
    • Serum cartilage oligomeric matrix protein reflects the presence of clinically diagnosed synovitis in patients with knee osteoarthritis
    • Vilim, V., Vytasek, R., Olejarova, M., Machacek, S., Gatterova, J., Prochazka, B., Kraus, VB and Pavelka, K. (2001) Serum cartilage oligomeric matrix protein reflects the presence of clinically diagnosed synovitis in patients with knee osteoarthritis. Osteoarthritis & Cartilage, 9, pp. 612-618.
    • (2001) Osteoarthritis & Cartilage , vol.9 , pp. 612-618
    • Vilim, V.1    Vytasek, R.2    Olejarova, M.3    Machacek, S.4    Gatterova, J.5    Prochazka, B.6    Kraus, V.B.7    Pavelka, K.8
  • 56
    • 0036897909 scopus 로고    scopus 로고
    • Microarray analysis reveals the involvement of beta-2 microglobulin (B2M) in human osteoarthritis
    • Zhang, H., Liew, CC and Marshall, KW (2002) Microarray analysis reveals the involvement of beta-2 microglobulin (B2M) in human osteoarthritis. Osteoarthritis & Cartilage, 10, pp. 950-960.
    • (2002) Osteoarthritis & Cartilage , vol.10 , pp. 950-960
    • Zhang, H.1    Liew, C.C.2    Marshall, K.W.3


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