-
1
-
-
0033744235
-
Atmospheric oxygen accelerates the induction of a post-mitotic phenotype in human dermal fibroblasts: The key protective role of glutathione
-
Alaluf, S., Muir-Howie, H., Hu, H.L., Evans, A. Green, M.R. (2000). Atmospheric oxygen accelerates the induction of a post-mitotic phenotype in human dermal fibroblasts: the key protective role of glutathione. Differentiation 66, 147 155.
-
(2000)
Differentiation
, vol.66
, pp. 147-155
-
-
Alaluf, S.1
Muir-Howie, H.2
Hu, H.L.3
Evans, A.4
Green, M.R.5
-
2
-
-
0032960519
-
Role of interleukin-8 in tumor growth and metastasis of human melanoma
-
Bar-Eli, M. (1999). Role of interleukin-8 in tumor growth and metastasis of human melanoma. Pathobiology 67, 12 18.
-
(1999)
Pathobiology
, vol.67
, pp. 12-18
-
-
Bar-Eli, M.1
-
3
-
-
28844508928
-
The hypoxic microenvironment of the skin contributes to Akt mediated melanocyte transformation
-
Bedogni, B., Welford, S.M., Cassarino, D.S., Nickoloff, B.J., Giaccia, A.J. Powell, M.B. (2005). The hypoxic microenvironment of the skin contributes to Akt mediated melanocyte transformation. Cancer Cell 8, 443 454.
-
(2005)
Cancer Cell
, vol.8
, pp. 443-454
-
-
Bedogni, B.1
Welford, S.M.2
Cassarino, D.S.3
Nickoloff, B.J.4
Giaccia, A.J.5
Powell, M.B.6
-
4
-
-
55849139852
-
Notch1 is an effector of Akt and hypoxia in melanoma development
-
Bedogni, B., Warneke, J.A., Nickoloff, B.J., Giaccia, A.J. Powell, M.B. (2008). Notch1 is an effector of Akt and hypoxia in melanoma development. J. Clin. Invest. 118, 3660 3670.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 3660-3670
-
-
Bedogni, B.1
Warneke, J.A.2
Nickoloff, B.J.3
Giaccia, A.J.4
Powell, M.B.5
-
5
-
-
23244461708
-
Oncogene-induced senescence as an initial barrier in lymphoma development
-
Braig, M., Lee, S., Loddenkemper, C., Rudolph, C., Peters, A.H., Schlegelberger, B., Stein, H., Dorken, B., Jenuwein, T. Schmitt, C.A. (2005). Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 436, 660 665.
-
(2005)
Nature
, vol.436
, pp. 660-665
-
-
Braig, M.1
Lee, S.2
Loddenkemper, C.3
Rudolph, C.4
Peters, A.H.5
Schlegelberger, B.6
Stein, H.7
Dorken, B.8
Jenuwein, T.9
Schmitt, C.A.10
-
6
-
-
34547951896
-
Mechanism of UV-related carcinogenesis and its contribution to nevi/melanoma
-
Brozyna, A., Zbytek, B., Granese, J., Carlson, A.J., Ross, J. Slominski, A. (2007). Mechanism of UV-related carcinogenesis and its contribution to nevi/melanoma. Expert Rev. Dermatol. 2, 451 469.
-
(2007)
Expert Rev. Dermatol.
, vol.2
, pp. 451-469
-
-
Brozyna, A.1
Zbytek, B.2
Granese, J.3
Carlson, A.J.4
Ross, J.5
Slominski, A.6
-
7
-
-
22244467409
-
Hypoxia-inducible factor 1[alpha] is a new target of microphthalmia- associated transcription factor (MITF) in melanoma cells
-
Busca, R., Berra, E., Gaggioli, C. et al. (2005). Hypoxia-inducible factor 1[alpha] is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells. J. Cell Biol. 170, 49 59.
-
(2005)
J. Cell Biol.
, vol.170
, pp. 49-59
-
-
Busca, R.1
Berra, E.2
Gaggioli, C.3
-
8
-
-
39749099312
-
HIF gene expression in cancer therapy
-
Chan, D.A., Krieg, A.J., Turcotte, S. Giaccia, A.J. (2007). HIF gene expression in cancer therapy. Methods Enzymol. 435, 323 345.
-
(2007)
Methods Enzymol.
, vol.435
, pp. 323-345
-
-
Chan, D.A.1
Krieg, A.J.2
Turcotte, S.3
Giaccia, A.J.4
-
9
-
-
0037352170
-
Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: A target for cancer chemotherapy
-
Chang, F., Lee, J.T., Navolanic, P.M., Steelman, L.S., Shelton, J.G., Blalock, W.L., Franklin, R.A. McCubrey, J.A. (2003). Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Leukemia 17, 590 603.
-
(2003)
Leukemia
, vol.17
, pp. 590-603
-
-
Chang, F.1
Lee, J.T.2
Navolanic, P.M.3
Steelman, L.S.4
Shelton, J.G.5
Blalock, W.L.6
Franklin, R.A.7
McCubrey, J.A.8
-
10
-
-
43649109034
-
Prognostic biomarkers in uveal melanoma: Evidence for a stem cell-like phenotype associated with metastasis
-
Chang, S.H., Worley, L.A., Onken, M.D. Harbour, J.W. (2008). Prognostic biomarkers in uveal melanoma: evidence for a stem cell-like phenotype associated with metastasis. Melanoma Res. 18, 191 200.
-
(2008)
Melanoma Res.
, vol.18
, pp. 191-200
-
-
Chang, S.H.1
Worley, L.A.2
Onken, M.D.3
Harbour, J.W.4
-
11
-
-
44849096481
-
Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development
-
Cheung, M., Sharma, A., Madhunapantula, S.V. Robertson, G.P. (2008). Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development. Cancer Res. 68, 3429 3439.
-
(2008)
Cancer Res.
, vol.68
, pp. 3429-3439
-
-
Cheung, M.1
Sharma, A.2
Madhunapantula, S.V.3
Robertson, G.P.4
-
12
-
-
21344440000
-
Reactive oxygen species as mediators of cellular senescence
-
Colavitti, R. Finkel, T. (2005). Reactive oxygen species as mediators of cellular senescence. IUBMB Life 57, 277 281.
-
(2005)
IUBMB Life
, vol.57
, pp. 277-281
-
-
Colavitti, R.1
Finkel, T.2
-
13
-
-
0034698170
-
Inhibition of the phosphoinositide 3-kinase pathway induces a senescence-like arrest mediated by p27Kip1
-
Collado, M., Medema, R.H., Garcia-Cao, I., Dubuisson, M.L., Barradas, M., Glassford, J., Rivas, C., Burgering, B.M., Serrano, M. Lam, E.W. (2000). Inhibition of the phosphoinositide 3-kinase pathway induces a senescence-like arrest mediated by p27Kip1. J. Biol. Chem. 275, 21960 21968.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 21960-21968
-
-
Collado, M.1
Medema, R.H.2
Garcia-Cao, I.3
Dubuisson, M.L.4
Barradas, M.5
Glassford, J.6
Rivas, C.7
Burgering, B.M.8
Serrano, M.9
Lam, E.W.10
-
14
-
-
3142670517
-
Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis
-
Distler, O., Distler, J.H., Scheid, A. et al. (2004). Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis. Circ. Res. 95, 109 116.
-
(2004)
Circ. Res.
, vol.95
, pp. 109-116
-
-
Distler, O.1
Distler, J.H.2
Scheid, A.3
-
15
-
-
50849103301
-
Notch signaling regulates tumor angiogenesis by diverse mechanisms
-
Dufraine, J., Funahashi, Y. Kitajewski, J. (2008). Notch signaling regulates tumor angiogenesis by diverse mechanisms. Oncogene 27, 5132 5137.
-
(2008)
Oncogene
, vol.27
, pp. 5132-5137
-
-
Dufraine, J.1
Funahashi, Y.2
Kitajewski, J.3
-
16
-
-
2542561169
-
Akt stimulates aerobic glycolysis in cancer cells
-
Elstrom, R.L., Bauer, D.E., Buzzai, M. et al. (2004). Akt stimulates aerobic glycolysis in cancer cells. Cancer Res. 64, 3892 3899.
-
(2004)
Cancer Res.
, vol.64
, pp. 3892-3899
-
-
Elstrom, R.L.1
Bauer, D.E.2
Buzzai, M.3
-
17
-
-
33646365644
-
Lysyl oxidase is essential for hypoxia-induced metastasis
-
Erler, J.T., Bennewith, K.L., Nicolau, M., Dornhofer, N., Kong, C., Le, Q.T., Chi, J.T., Jeffrey, S.S. Giaccia, A.J. (2006). Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 440, 1222 1226.
-
(2006)
Nature
, vol.440
, pp. 1222-1226
-
-
Erler, J.T.1
Bennewith, K.L.2
Nicolau, M.3
Dornhofer, N.4
Kong, C.5
Le, Q.T.6
Chi, J.T.7
Jeffrey, S.S.8
Giaccia, A.J.9
-
18
-
-
57849100048
-
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche
-
Erler, J.T., Bennewith, K.L., Cox, T.R., Lang, G., Bird, D., Koong, A., Le, Q.T. Giaccia, A.J. (2009). Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell 15, 35 44.
-
(2009)
Cancer Cell
, vol.15
, pp. 35-44
-
-
Erler, J.T.1
Bennewith, K.L.2
Cox, T.R.3
Lang, G.4
Bird, D.5
Koong, A.6
Le, Q.T.7
Giaccia, A.J.8
-
19
-
-
0014117481
-
The systemic oxygen supply to the surface of human skin
-
Evans, N.T. Naylor, P.F. (1967). The systemic oxygen supply to the surface of human skin. Respir. Physiol. 3, 21 37.
-
(1967)
Respir. Physiol.
, vol.3
, pp. 21-37
-
-
Evans, N.T.1
Naylor, P.F.2
-
20
-
-
33751089299
-
Oxygen levels in normal and previously irradiated human skin as assessed by EF5 binding
-
Evans, S.M., Schrlau, A.E., Chalian, A.A., Zhang, P. Koch, C.J. (2006). Oxygen levels in normal and previously irradiated human skin as assessed by EF5 binding. J. Invest. Dermatol. 126, 2596 2606.
-
(2006)
J. Invest. Dermatol.
, vol.126
, pp. 2596-2606
-
-
Evans, S.M.1
Schrlau, A.E.2
Chalian, A.A.3
Zhang, P.4
Koch, C.J.5
-
21
-
-
21844478747
-
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
-
Garraway, L.A., Widlund, H.R., Rubin, M.A. et al. (2005). Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature 436, 117 122.
-
(2005)
Nature
, vol.436
, pp. 117-122
-
-
Garraway, L.A.1
Widlund, H.R.2
Rubin, M.A.3
-
22
-
-
0142120661
-
Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin
-
Giatromanolaki, A., Sivridis, E., Kouskoukis, C., Gatter, K.C., Harris, A.L. Koukourakis, M.I. (2003). Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin. Melanoma Res. 13, 493 501.
-
(2003)
Melanoma Res.
, vol.13
, pp. 493-501
-
-
Giatromanolaki, A.1
Sivridis, E.2
Kouskoukis, C.3
Gatter, K.C.4
Harris, A.L.5
Koukourakis, M.I.6
-
23
-
-
16844371813
-
Immortalization of primary human prostate epithelial cells by c-Myc
-
Gil, J., Kerai, P., Lleonart, M., Bernard, D., Cigudosa, J.C., Peters, G., Carnero, A. Beach, D. (2005). Immortalization of primary human prostate epithelial cells by c-Myc. Cancer Res. 65, 2179 2185.
-
(2005)
Cancer Res.
, vol.65
, pp. 2179-2185
-
-
Gil, J.1
Kerai, P.2
Lleonart, M.3
Bernard, D.4
Cigudosa, J.C.5
Peters, G.6
Carnero, A.7
Beach, D.8
-
24
-
-
0030025773
-
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
-
Graeber, T.G., Osmanian, C., Jacks, T., Housman, D.E., Koch, C.J., Lowe, S.W. Giaccia, A.J. (1996). Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379, 88 91.
-
(1996)
Nature
, vol.379
, pp. 88-91
-
-
Graeber, T.G.1
Osmanian, C.2
Jacks, T.3
Housman, D.E.4
Koch, C.J.5
Lowe, S.W.6
Giaccia, A.J.7
-
25
-
-
27644561755
-
Hypoxia requires notch signaling to maintain the undifferentiated cell state
-
Gustafsson, M.V., Zheng, X., Pereira, T., Gradin, K., Jin, S., Lundkvist, J., Ruas, J.L., Poellinger, L., Lendahl, U. Bondesson, M. (2005). Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev. Cell 9, 617 628.
-
(2005)
Dev. Cell
, vol.9
, pp. 617-628
-
-
Gustafsson, M.V.1
Zheng, X.2
Pereira, T.3
Gradin, K.4
Jin, S.5
Lundkvist, J.6
Ruas, J.L.7
Poellinger, L.8
Lendahl, U.9
Bondesson, M.10
-
27
-
-
36749001007
-
Oxygen sensing and the DNA-damage response
-
Hammond, E.M., Kaufmann, M.R. Giaccia, A.J. (2007). Oxygen sensing and the DNA-damage response. Curr. Opin. Cell Biol. 19, 680 684.
-
(2007)
Curr. Opin. Cell Biol.
, vol.19
, pp. 680-684
-
-
Hammond, E.M.1
Kaufmann, M.R.2
Giaccia, A.J.3
-
28
-
-
33745138232
-
Regulation of angiogenesis by hypoxia-inducible factor 1
-
Hirota, K. Semenza, G.L. (2006). Regulation of angiogenesis by hypoxia-inducible factor 1. Crit. Rev. Oncol. Hematol. 59, 15 26.
-
(2006)
Crit. Rev. Oncol. Hematol.
, vol.59
, pp. 15-26
-
-
Hirota, K.1
Semenza, G.L.2
-
29
-
-
0025726352
-
Effects of oxygen tension on the growth and pigmentation of normal human melanocytes
-
Horikoshi, T., Balin, A.K. Carter, D.M. (1991). Effects of oxygen tension on the growth and pigmentation of normal human melanocytes. J. Invest. Dermatol. 96, 841 844.
-
(1991)
J. Invest. Dermatol.
, vol.96
, pp. 841-844
-
-
Horikoshi, T.1
Balin, A.K.2
Carter, D.M.3
-
30
-
-
0035917313
-
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing
-
Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J.M., Lane, W.S. Kaelin, W.G. Jr. (2001). HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292, 464 468.
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin Jr., W.G.10
-
32
-
-
0041835985
-
Cutaneous photobiology. the melanocyte vs. the sun: Who will win the final round?
-
Kadekaro, A.L., Kavanagh, R.J., Wakamatsu, K., Ito, S., Pipitone, M.A. Abdel-Malek, Z.A. (2003). Cutaneous photobiology. The melanocyte vs. the sun: who will win the final round? Pigment Cell Res. 16, 434 447.
-
(2003)
Pigment Cell Res.
, vol.16
, pp. 434-447
-
-
Kadekaro, A.L.1
Kavanagh, R.J.2
Wakamatsu, K.3
Ito, S.4
Pipitone, M.A.5
Abdel-Malek, Z.A.6
-
33
-
-
12844256351
-
Insulin-like growth factor-binding protein-1 (IGFBP-1) mediates hypoxia-induced embryonic growth and developmental retardation
-
Kajimura, S., Aida, K. Duan, C. (2005). Insulin-like growth factor-binding protein-1 (IGFBP-1) mediates hypoxia-induced embryonic growth and developmental retardation. Proc. Natl Acad. Sci. USA 102, 1240 1245.
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 1240-1245
-
-
Kajimura, S.1
Aida, K.2
Duan, C.3
-
34
-
-
0037418002
-
Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model
-
Kannan, K., Sharpless, N.E., Xu, J., O'Hagan, R.C., Bosenberg, M. Chin, L. (2003). Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model. Proc. Natl Acad. Sci. USA 100, 1221 1225.
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 1221-1225
-
-
Kannan, K.1
Sharpless, N.E.2
Xu, J.3
O'Hagan, R.C.4
Bosenberg, M.5
Chin, L.6
-
35
-
-
0037816586
-
Nuclear factor-kappaB mediates angiogenesis and metastasis of human bladder cancer through the regulation of interleukin-8
-
Karashima, T., Sweeney, P., Kamat, A., Huang, S., Kim, S.J., Bar-Eli, M., McConkey, D.J. Dinney, C.P. (2003). Nuclear factor-kappaB mediates angiogenesis and metastasis of human bladder cancer through the regulation of interleukin-8. Clin. Cancer Res. 9, 2786 2797.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 2786-2797
-
-
Karashima, T.1
Sweeney, P.2
Kamat, A.3
Huang, S.4
Kim, S.J.5
Bar-Eli, M.6
McConkey, D.J.7
Dinney, C.P.8
-
36
-
-
48149100937
-
IGFBPs contribute to survival of pancreatic cancer cells under severely hypoxic conditions
-
Koga, T., Endo, H., Miyamoto, Y., Mukai, M., Akira, S. Inoue, M. (2008). IGFBPs contribute to survival of pancreatic cancer cells under severely hypoxic conditions. Cancer Lett. 268, 82 88.
-
(2008)
Cancer Lett.
, vol.268
, pp. 82-88
-
-
Koga, T.1
Endo, H.2
Miyamoto, Y.3
Mukai, M.4
Akira, S.5
Inoue, M.6
-
37
-
-
11244347171
-
Glycolytic enzymes can modulate cellular life span
-
Kondoh, H., Lleonart, M.E., Gil, J., Wang, J., Degan, P., Peters, G., Martinez, D., Carnero, A. Beach, D. (2005). Glycolytic enzymes can modulate cellular life span. Cancer Res. 65, 177 185.
-
(2005)
Cancer Res.
, vol.65
, pp. 177-185
-
-
Kondoh, H.1
Lleonart, M.E.2
Gil, J.3
Wang, J.4
Degan, P.5
Peters, G.6
Martinez, D.7
Carnero, A.8
Beach, D.9
-
38
-
-
0037374289
-
Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1
-
Krishnamachary, B., Berg-Dixon, S., Kelly, B. et al. (2003). Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer Res. 63, 1138 1143.
-
(2003)
Cancer Res.
, vol.63
, pp. 1138-1143
-
-
Krishnamachary, B.1
Berg-Dixon, S.2
Kelly, B.3
-
39
-
-
34248193424
-
Mutant V600E BRAF increases hypoxia inducible factor-1alpha expression in melanoma
-
Kumar, S.M., Yu, H., Edwards, R., Chen, L., Kazianis, S., Brafford, P., Acs, G., Herlyn, M. Xu, X. (2007). Mutant V600E BRAF increases hypoxia inducible factor-1alpha expression in melanoma. Cancer Res. 67, 3177 3184.
-
(2007)
Cancer Res.
, vol.67
, pp. 3177-3184
-
-
Kumar, S.M.1
Yu, H.2
Edwards, R.3
Chen, L.4
Kazianis, S.5
Brafford, P.6
Acs, G.7
Herlyn, M.8
Xu, X.9
-
40
-
-
0030694237
-
Intratumoral oxygen tension in metastatic melanoma
-
Lartigau, E., Randrianarivelo, H., Avril, M.F., Margulis, A., Spatz, A., Eschwege, F. Guichard, M. (1997). Intratumoral oxygen tension in metastatic melanoma. Melanoma Res. 7, 400 406.
-
(1997)
Melanoma Res.
, vol.7
, pp. 400-406
-
-
Lartigau, E.1
Randrianarivelo, H.2
Avril, M.F.3
Margulis, A.4
Spatz, A.5
Eschwege, F.6
Guichard, M.7
-
41
-
-
0033583242
-
Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species
-
Lee, A.C., Fenster, B.E., Ito, H., Takeda, K., Bae, N.S., Hirai, T., Yu, Z.X., Ferrans, V.J., Howard, B.H. Finkel, T. (1999). Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J. Biol. Chem. 274, 7936 7940.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 7936-7940
-
-
Lee, A.C.1
Fenster, B.E.2
Ito, H.3
Takeda, K.4
Bae, N.S.5
Hirai, T.6
Yu, Z.X.7
Ferrans, V.J.8
Howard, B.H.9
Finkel, T.10
-
42
-
-
33646257783
-
Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/phosphatidylinositol 3-kinase-Akt pathways and up-regulating Ncadherin expression
-
Liu, Z.J., Xiao, M., Balint, K., Smalley, K.S., Brafford, P., Qiu, R., Pinnix, C.C., Li, X. Herlyn, M. (2006). Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/phosphatidylinositol 3-kinase-Akt pathways and up-regulating Ncadherin expression. Cancer Res. 66, 4182 4190.
-
(2006)
Cancer Res.
, vol.66
, pp. 4182-4190
-
-
Liu, Z.J.1
Xiao, M.2
Balint, K.3
Smalley, K.S.4
Brafford, P.5
Qiu, R.6
Pinnix, C.C.7
Li, X.8
Herlyn, M.9
-
43
-
-
34247477207
-
Hypoxia inducible factor-2alpha in cancer
-
Lofstedt, T., Fredlund, E., Holmquist-Mengelbier, L., Pietras, A., Ovenberger, M., Poellinger, L. Pahlman, S. (2007). Hypoxia inducible factor-2alpha in cancer. Cell Cycle 6, 919 926.
-
(2007)
Cell Cycle
, vol.6
, pp. 919-926
-
-
Lofstedt, T.1
Fredlund, E.2
Holmquist-Mengelbier, L.3
Pietras, A.4
Ovenberger, M.5
Poellinger, L.6
Pahlman, S.7
-
44
-
-
41149170819
-
Understanding signaling cascades in melanoma
-
Lopez-Bergami, P., Fitchman, B. Ronai, Z. (2008). Understanding signaling cascades in melanoma. Photochem. Photobiol. 84, 289 306.
-
(2008)
Photochem. Photobiol.
, vol.84
, pp. 289-306
-
-
Lopez-Bergami, P.1
Fitchman, B.2
Ronai, Z.3
-
45
-
-
23244447037
-
BRAFE600-associated senescence-like cell cycle arrest of human naevi
-
Michaloglou, C., Vredeveld, L.C., Soengas, M.S., Denoyelle, C., Kuilman, T., van der Horst, C.M., Majoor, D.M., Shay, J.W., Mooi, W.J. Peeper, D.S. (2005). BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436, 720 724.
-
(2005)
Nature
, vol.436
, pp. 720-724
-
-
Michaloglou, C.1
Vredeveld, L.C.2
Soengas, M.S.3
Denoyelle, C.4
Kuilman, T.5
Van Der Horst, C.M.6
Majoor, D.M.7
Shay, J.W.8
Mooi, W.J.9
Peeper, D.S.10
-
46
-
-
0035032219
-
Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation
-
Minamino, T., Mitsialis, S.A. Kourembanas, S. (2001). Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation. Mol. Cell. Biol. 21, 3336 3342.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 3336-3342
-
-
Minamino, T.1
Mitsialis, S.A.2
Kourembanas, S.3
-
47
-
-
2942731503
-
Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia
-
Nakayama, K., Frew, I.J., Hagensen, M. et al. (2004). Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia. Cell 117, 941 952.
-
(2004)
Cell
, vol.117
, pp. 941-952
-
-
Nakayama, K.1
Frew, I.J.2
Hagensen, M.3
-
48
-
-
24744454582
-
Senescence comes of age
-
Narita, M. Lowe, S.W. (2005). Senescence comes of age. Nat. Med. 11, 920 922.
-
(2005)
Nat. Med.
, vol.11
, pp. 920-922
-
-
Narita, M.1
Lowe, S.W.2
-
49
-
-
0017619294
-
Extension of the lifespan of cultured normal human diploid cells by vitamin E: A reevaluation
-
Packer, L. Smith, J.R. (1977). Extension of the lifespan of cultured normal human diploid cells by vitamin E: a reevaluation. Proc. Natl Acad. Sci. USA 74, 1640 1641.
-
(1977)
Proc. Natl Acad. Sci. USA
, vol.74
, pp. 1640-1641
-
-
Packer, L.1
Smith, J.R.2
-
50
-
-
0042195820
-
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
-
Parrinello, S., Samper, E., Krtolica, A., Goldstein, J., Melov, S. Campisi, J. (2003). Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat. Cell Biol. 5, 741 747.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 741-747
-
-
Parrinello, S.1
Samper, E.2
Krtolica, A.3
Goldstein, J.4
Melov, S.5
Campisi, J.6
-
51
-
-
55949104211
-
The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways
-
Qi, J., Nakayama, K., Gaitonde, S., Goydos, J.S., Krajewski, S., Eroshkin, A., Bar-Sagi, D., Bowtell, D. Ronai, Z. (2008). The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways. Proc. Natl Acad. Sci. USA 105, 16713 16718.
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 16713-16718
-
-
Qi, J.1
Nakayama, K.2
Gaitonde, S.3
Goydos, J.S.4
Krajewski, S.5
Eroshkin, A.6
Bar-Sagi, D.7
Bowtell, D.8
Ronai, Z.9
-
52
-
-
17844384528
-
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
-
Rangarajan, A., Talora, C., Okuyama, R. et al. (2001). Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J. 20, 3427 3436.
-
(2001)
EMBO J.
, vol.20
, pp. 3427-3436
-
-
Rangarajan, A.1
Talora, C.2
Okuyama, R.3
-
53
-
-
38048999665
-
Two faces of p53: Aging and tumor suppression
-
Rodier, F., Campisi, J. Bhaumik, D. (2007). Two faces of p53: aging and tumor suppression. Nucleic Acids Res. 35, 7475 7484.
-
(2007)
Nucleic Acids Res.
, vol.35
, pp. 7475-7484
-
-
Rodier, F.1
Campisi, J.2
Bhaumik, D.3
-
54
-
-
57749105319
-
Hypoxia-inducible factor 1alpha mediates anoikis resistance via suppression of alpha5 integrin
-
Rohwer, N., Welzel, M., Daskalow, K., Pfander, D., Wiedenmann, B., Detjen, K. Cramer, T. (2008). Hypoxia-inducible factor 1alpha mediates anoikis resistance via suppression of alpha5 integrin. Cancer Res. 68, 10113 10120.
-
(2008)
Cancer Res.
, vol.68
, pp. 10113-10120
-
-
Rohwer, N.1
Welzel, M.2
Daskalow, K.3
Pfander, D.4
Wiedenmann, B.5
Detjen, K.6
Cramer, T.7
-
55
-
-
0034902568
-
Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): Implication for cell cycle disruption in transformation by Notch(ic)
-
Ronchini, C. Capobianco, A.J. (2001). Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic). Mol. Cell. Biol. 21, 5925 5934.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 5925-5934
-
-
Ronchini, C.1
Capobianco, A.J.2
-
56
-
-
59649083306
-
Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells
-
Rosati, E., Sabatini, R., Rampino, G., Tabilio, A., Di Ianni, M., Fettucciari, K., Bartoli, A., Coaccioli, S., Screpanti, I. Marconi, P. (2008). Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells. Blood 113, 856 865.
-
(2008)
Blood
, vol.113
, pp. 856-865
-
-
Rosati, E.1
Sabatini, R.2
Rampino, G.3
Tabilio, A.4
Di Ianni, M.5
Fettucciari, K.6
Bartoli, A.7
Coaccioli, S.8
Screpanti, I.9
Marconi, P.10
-
57
-
-
22344435698
-
Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27 Kip1 degradation
-
Sarmento, L.M., Huang, H., Limon, A., Gordon, W., Fernandes, J., Tavares, M.J., Miele, L., Cardoso, A.A., Classon, M. Carlesso, N. (2005). Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27 Kip1 degradation. J. Exp. Med. 202, 157 168.
-
(2005)
J. Exp. Med.
, vol.202
, pp. 157-168
-
-
Sarmento, L.M.1
Huang, H.2
Limon, A.3
Gordon, W.4
Fernandes, J.5
Tavares, M.J.6
Miele, L.7
Cardoso, A.A.8
Classon, M.9
Carlesso, N.10
-
58
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza, G.L. (2003). Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 3, 721 732.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
59
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
Serrano, M., Lin, A.W., McCurrach, M.E., Beach, D. Lowe, S.W. (1997). Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593 602.
-
(1997)
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
60
-
-
33750619348
-
Glucose metabolism and cancer
-
Shaw, R.J. (2006). Glucose metabolism and cancer. Curr. Opin. Cell Biol. 18, 598 608.
-
(2006)
Curr. Opin. Cell Biol.
, vol.18
, pp. 598-608
-
-
Shaw, R.J.1
-
61
-
-
0019993528
-
Skin sensitization by misonidazole: A demonstration of uniform mild hypoxia
-
Stewart, F.A., Denekamp, J. Randhawa, V.S. (1982). Skin sensitization by misonidazole: a demonstration of uniform mild hypoxia. Br. J. Cancer 45, 869 877.
-
(1982)
Br. J. Cancer
, vol.45
, pp. 869-877
-
-
Stewart, F.A.1
Denekamp, J.2
Randhawa, V.S.3
-
62
-
-
0034307725
-
Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen
-
Studer, L., Csete, M., Lee, S.H., Kabbani, N., Walikonis, J., Wold, B. McKay, R. (2000). Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen. J. Neurosci. 20, 7377 7383.
-
(2000)
J. Neurosci.
, vol.20
, pp. 7377-7383
-
-
Studer, L.1
Csete, M.2
Lee, S.H.3
Kabbani, N.4
Walikonis, J.5
Wold, B.6
McKay, R.7
-
63
-
-
0032544113
-
Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: A possible model for IGFBP-1 expression in fetal hypoxia
-
Tazuke, S.I., Mazure, N.M., Sugawara, J., Carland, G., Faessen, G.H., Suen, L.F., Irwin, J.C., Powell, D.R., Giaccia, A.J. Giudice, L.C. (1998). Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: a possible model for IGFBP-1 expression in fetal hypoxia. Proc. Natl Acad. Sci. USA 95, 10188 10193.
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 10188-10193
-
-
Tazuke, S.I.1
Mazure, N.M.2
Sugawara, J.3
Carland, G.4
Faessen, G.H.5
Suen, L.F.6
Irwin, J.C.7
Powell, D.R.8
Giaccia, A.J.9
Giudice, L.C.10
-
64
-
-
34547121206
-
Hypoxia in cancer: Significance and impact on clinical outcome
-
Vaupel, P. Mayer, A. (2007). Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev. 26, 225 239.
-
(2007)
Cancer Metastasis Rev.
, vol.26
, pp. 225-239
-
-
Vaupel, P.1
Mayer, A.2
-
65
-
-
0024408986
-
Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
-
Vaupel, P., Kallinowski, F. Okunieff, P. (1989). Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res. 49, 6449 6465.
-
(1989)
Cancer Res.
, vol.49
, pp. 6449-6465
-
-
Vaupel, P.1
Kallinowski, F.2
Okunieff, P.3
-
66
-
-
33750066023
-
Involvement of HIF-1 in invasion of Mum2B uveal melanoma cells
-
Victor, N., Ivy, A., Jiang, B.H. Agani, F.H. (2006). Involvement of HIF-1 in invasion of Mum2B uveal melanoma cells. Clin. Exp. Metastasis 23, 87 96.
-
(2006)
Clin. Exp. Metastasis
, vol.23
, pp. 87-96
-
-
Victor, N.1
Ivy, A.2
Jiang, B.H.3
Agani, F.H.4
-
67
-
-
38849168162
-
Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7
-
Wajapeyee, N., Serra, R.W., Zhu, X., Mahalingam, M. Green, M.R. (2008). Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell 132, 363 374.
-
(2008)
Cell
, vol.132
, pp. 363-374
-
-
Wajapeyee, N.1
Serra, R.W.2
Zhu, X.3
Mahalingam, M.4
Green, M.R.5
-
68
-
-
2642610318
-
Myc activates telomerase
-
Wang, J., Xie, L.Y., Allan, S., Beach, D. Hannon, G.J. (1998). Myc activates telomerase. Genes Dev. 12, 1769 1774.
-
(1998)
Genes Dev.
, vol.12
, pp. 1769-1774
-
-
Wang, J.1
Xie, L.Y.2
Allan, S.3
Beach, D.4
Hannon, G.J.5
-
69
-
-
33645473185
-
Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells
-
Wang, Z., Zhang, Y., Li, Y., Banerjee, S., Liao, J. Sarkar, F.H. (2006). Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells. Mol. Cancer Ther. 5, 483 493.
-
(2006)
Mol. Cancer Ther.
, vol.5
, pp. 483-493
-
-
Wang, Z.1
Zhang, Y.2
Li, Y.3
Banerjee, S.4
Liao, J.5
Sarkar, F.H.6
-
70
-
-
33845710642
-
HIF1alpha delays premature senescence through the activation of MIF
-
Welford, S.M., Bedogni, B., Gradin, K., Poellinger, L., Broome Powell, M. Giaccia, A.J. (2006). HIF1alpha delays premature senescence through the activation of MIF. Genes Dev. 20, 3366 3371.
-
(2006)
Genes Dev.
, vol.20
, pp. 3366-3371
-
-
Welford, S.M.1
Bedogni, B.2
Gradin, K.3
Poellinger, L.4
Broome Powell, M.5
Giaccia, A.J.6
-
71
-
-
47749131186
-
TWIST activation by hypoxia inducible factor-1 (HIF-1): Implications in metastasis and development
-
Yang, M.H. Wu, K.J. (2008). TWIST activation by hypoxia inducible factor-1 (HIF-1): implications in metastasis and development. Cell Cycle 7, 2090 2096.
-
(2008)
Cell Cycle
, vol.7
, pp. 2090-2096
-
-
Yang, M.H.1
Wu, K.J.2
-
72
-
-
0035859692
-
HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation
-
Yu, F., White, S.B., Zhao, Q. Lee, F.S. (2001). HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc. Natl Acad. Sci. USA 98, 9630 9635.
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 9630-9635
-
-
Yu, F.1
White, S.B.2
Zhao, Q.3
Lee, F.S.4
-
73
-
-
42149117769
-
Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways
-
Zheng, X., Linke, S., Dias, J.M. et al. (2008). Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. Proc. Natl Acad. Sci. USA 105, 3368 3373.
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 3368-3373
-
-
Zheng, X.1
Linke, S.2
Dias, J.M.3
|