The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 43, 2008, Pages 16713-16718

  Qi, Jianfei ^a   Nakayama, Koh ^a,e   Gaitonde, Supriya ^a   Goydos, James S ^b   Krajewski, Stan ^a   Eroshkin, Alexey ^a   Bar Sagi, Dafna ^c   Bowtell, David ^d   Ronai, Ze'ev ^a  

^a BURNHAM INSTITUTE   (United States)

^b RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d PETER MACCALLUM CANCER CENTRE   (Australia)

^e TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

HIF; Hypoxia; Prolyl hydroxylase; Siah; Sprouty

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MUTANT PROTEIN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLYL HYDROXYLASE 3; RAS PROTEIN; RING FINGER PROTEIN; SPROUTY PROTEIN; SPROUTY PROTEIN 2; UBIQUITIN LIGASE SIAH2; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STABILITY; ENZYME SUBSTRATE; EXPERIMENTAL MODEL; EXPERIMENTAL MOUSE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG METASTASIS; MELANOMA; MELANOMA CELL; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TUMOR GROWTH; WESTERN BLOTTING;

ANIMALS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MELANOMA, EXPERIMENTAL; MEMBRANE PROTEINS; MICE; NEOPLASM METASTASIS; PROCOLLAGEN-PROLINE DIOXYGENASE; RAS PROTEINS; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASES;

EID: 55949104211     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0804063105     Document Type: Article

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