Aldose reductase mediates myocardial ischemia-reperfusion injury in part by opening mitochondrial permeability transition pore

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 296, Issue 2, 2009, Pages

  Ananthakrishnan, Radha ^a   Kaneko, Michiyo ^a   Hwang, Yuying C ^a   Quadri, Nosirudeen ^a   Gomez, Teodoro ^a   Li, Qing ^a   Caspersen, Casper ^a   Ramasamy, Ravichandran ^a  

^a Columbia University ^*  (United States)

Author keywords

Mitochondria; Mitochondrial permeability transition pore; Polyol pathway

Indexed keywords

ALDEHYDE REDUCTASE; ANTIOXIDANT; CALCIUM ION; CYCLOSPORIN A; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; RESVERATROL; CALCIUM; CARRIER PROTEIN; CYCLOSPORIN; DEOXYGLUCOSE; GLUTATHIONE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; STILBENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRESS; CONTROLLED STUDY; ENZYME INHIBITION; HEART; HEART MUSCLE ISCHEMIA; HEART PROTECTION; MEASUREMENT; MITOCHONDRIAL PERMEABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT STRAIN; REPERFUSION INJURY; TRANSGENIC MOUSE; WILD TYPE; ANIMAL; C57BL MOUSE; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; HEART MITOCHONDRION; HEART MUSCLE; HUMAN; METABOLISM; MITOCHONDRION SWELLING; PATHOLOGY;

ALDEHYDE REDUCTASE; ANIMALS; ANTIOXIDANTS; CALCIUM; CYCLOSPORINE; DEOXYGLUCOSE; DISEASE MODELS, ANIMAL; GLUTATHIONE; HUMANS; HYDROGEN PEROXIDE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIA, HEART; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL SWELLING; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; REACTIVE OXYGEN SPECIES; STILBENES;

EID: 61949182565     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01012.2008     Document Type: Article

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