Aldose reductase-deficient mice are protected from delayed motor nerve conduction velocity, increased c-Jun NH2-terminal kinase activation, depletion of reduced glutathione, increased superoxide accumulation, and DNA damage

Diabetes

Volumn 55, Issue 7, 2006, Pages 1946-1953

  Ho, Eric C M ^a   Lam, Karen S L ^a   Yuk, Shan Chen ^a   Yip, Johnny C W ^a   Arvindakshan, Meena ^a   Yamagishi, Shin Ichiro ^b   Yagihashi, Soroku ^b   Oates, Peter J ^c   Ellery, Craig A ^c   Chung, Stephen S M ^a   Chung, Sookja K ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b HIROSAKI UNIVERSITY   (Japan)

^c PFIZER INC   (United States)

Author keywords

AR, aldose reductase; ARI, AR inhibitor; DHE, dihydroethidium; ERK, extracellular signal regulated kinase 1; JNK, c Jun NH2 terminal kinase; MAPK, mitogen activated protein kinase; MNCV, motor nerve conduction velocity; PAR, poly(ADP ribose)

Indexed keywords

ALDEHYDE REDUCTASE; GLUTATHIONE; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE; FRUCTOSE; GLUCOSE; INOSITOL; POLY(ADENOSINE DIPHOSPHATE RIBOSE); SORBITOL;

ANIMAL MODEL; ARTICLE; DIABETES MELLITUS; DNA DAMAGE; ENZYME ACTIVATION; ENZYME DEFICIENCY; GLUCOSE METABOLISM; MOTOR NERVE CONDUCTION; MOUSE; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SCIATIC NERVE; ANIMAL; EXPERIMENTAL DIABETES MELLITUS; GENETICS; METABOLISM; MOTONEURON; MOUSE MUTANT; NERVE CONDUCTION; PATHOPHYSIOLOGY; PHYSIOLOGY; REFERENCE VALUE; REPORTER GENE; SURAL NERVE;

ALDEHYDE REDUCTASE; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DNA DAMAGE; ENZYME ACTIVATION; FRUCTOSE; GENES, REPORTER; GLUCOSE; GLUTATHIONE; INOSITOL; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MICE, KNOCKOUT; MOTOR NEURONS; NEURAL CONDUCTION; POLY ADENOSINE DIPHOSPHATE RIBOSE; REFERENCE VALUES; SORBITOL; SUPEROXIDES; SURAL NERVE;

EID: 33747069158     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db05-1497     Document Type: Article

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