Protection of ischemic hearts by high glucose is mediated, in part, by GLUT-4

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 281, Issue 1 50-1, 2001, Pages

  Ramasamy, Ravichandran ^a   Hwang, Yuying C ^a   Whang, John ^a   Bergmann, Steven R ^a  

^a The New York Presbyterian Hospital   (United States)

Author keywords

Insulin sensitive glucose transporters; Metabolism

Indexed keywords

ALBUMIN; CYTOCHALASIN B; GLUCOSE; GLUCOSE TRANSPORTER; PALMITIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GLYCOLYSIS; HEART MUSCLE ISCHEMIA; HEART PERFUSION; HEART PROTECTION; HEMODYNAMICS; INFUSION; METABOLISM; NONHUMAN; PRIORITY JOURNAL; RAT; SARCOLEMMA;

EID: 0034803990     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2001.281.1.h290     Document Type: Article

References (30)

1. Determinants of a protective effect of glucose and insulin on the ischemic myocardium
2. Metabolic and therapeutic lessons from genetic manipulation of GLUT4
3. Glucose-insulin-potassium therapy for treatment of acute myocardial infarction: An overview of randomized placebo-controlled trials
4. Glucose transport and glucose transporter GLUT4 are regulated by product(s) of intermediary metabolism in cardiomyocytes
5. Role of fructose 2,6-bisphosphate in the control of glycolysis in mammalian tissues
6. Ischemic preconditioning stimulates anaerobic glycolysis in the isolated rabbit heart
7. Substrate selection in the isolated working rat heart: Effects of reperfusion, afterload and concentration
8. Glucose and glycogen utilization in myocardial ischemia. Changes in metabolism and consequences for the myocyte
9. i elevation and ATP depletion
10. Methods
11. Alterations of carbohydrate and lipid metabolism in the acutely ischemic heart
12. Quantitative methods for measuring the insulin-regulatable glucose transporter (GLUT-4)
13. Relationship between carbohydrate and lipid metabolism and the energy balance of heart muscle
14. Effects of wortmannin on insulin- and ischemia-induced stimulation of GLUT4 translocation and FDG uptake in perfused hearts
15. Effects of glucose, insulin and potassium infusion on tissue metabolic changes within the first hour of myocardial infarction in the baboon
16. Effect of glucose-insulin-potassium infusions on arteriovenous differences of glucose and free fatty acids and on tissue metabolic changes in dogs with developing myocardial infarction
17. Glucose flux rate regulates onset of ischemic contracture in globally underperfused rat hearts
18. Aldose reductase inhibition protects diabetic and nondiabetic rat hearts from ischemic injury
19. Metabolic effects of aldose reductase inhibition during low-flow ischemia and reperfusion
20. Fructose-2,6-bisphosphate, a potent stimulator of phosphofructokinase, is increased by high exogenous glucose perfusion
21. Effects of glycogen depletion on ischemic injury in the isolated rat heart: Insights into preconditioning
22. Requirement of glycolytic substrate for metabolic recovery during moderate low flow ischemia
23. Translocation of the glucose transporter GLUT4 in cardiac myocytes of the rat
24. Effects of glucose-insulin-potassium on myocardial substrate availability and utilization in stable coronary artery disease
25. Regulation of myocardial carbohydrate metabolism under normal and ischemic conditions. Potential for pharmacological interventions
26. Ischemia induces translocation of the insulin-responsive glucose transporter GLUT-4 to the plasma membrane of cardiac myocytes
27. Rate of glycolysis during ischemia determine extent of ischemic injury and functional recovery after reperfusion
28. The relative importance of myocardial energy metabolism compared with ischemic contracture in the determination of ischemic injury in isolated rabbit hearts
29. Low-flow ischemia leads to translocation of canine heart GLUT-4 and GLUT-1 transporters to the sarcolemma in vivo
30. Effects of insulin on glucose transport and glucose transporters in rat heart