Metabolic effects of aldose reductase inhibition during low-flow ischemia and reperfusion

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 275, Issue 1 44-1, 1998, Pages

  Ramasamy, Ravichandran ^a   Trueblood, Nathan ^b   Schaefer, Saul ^b,c  

^a Columbia University ^*  (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Diabetes; Nuclear magnetic resonance; Zopolrestat

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; CREATINE PHOSPHATE; LACTIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SORBITOL; ZOPOLRESTAT;

ANIMAL TISSUE; ARTICLE; CELL PH; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME INHIBITION; GLYCOLYSIS; HEART MUSCLE ISCHEMIA; HEART MUSCLE OXYGEN CONSUMPTION; HEART MUSCLE REPERFUSION; HEART PROTECTION; ISOLATED HEART; MALE; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RAT;

EID: 33750867930     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1998.275.1.h195     Document Type: Article

References (43)

1. Apstein, C. S., F. N. Gravino, and C. C. Haudenschild. Determinants of a protective effect of glucose and insulin on the ischemic myocardium. Circ. Res. 52: 515-526, 1983.
2. Bergmeyer, H. U., J. Bergmeyer, and M. Grabl. Carbohydrates. In: Methods of Enzymatic Analysis. Verlag Chemie, Deerfield Beach, FL: 1995, p. 570-587.
3. 13C NMR study of glucose oxidation in the intact functioning rat heart after diabetes induced cardiomyopathy. J. Mol. Cell. Cardiol. 25: 1203-1213, 1993
4. 87Rb NMR spectroscopic study. Magn. Reson. Med. 34: 673-685, 1995.
5. Dennis, S. C., W. Gevers, and L. H. Opie. Protons in ischemia: where do they come from, where do they go to? J. Mol. Cell. Cardiol. 23: 1077-1086, 1991.
6. Garlick, P. B., G. K. Radda, and P. J. Seeley. Studies of acidosis in the ischaemic heart by phosphorus nuclear magnetic resonance. Biochem. J. 184: 547-554, 1979.
7. Garvey, W. T., M. Hardin, M. Juhaszova, and J. H. Dominguez. Effects of diabetes on myocardial glucose transport system in rats: implications for diabetic cardiomyopathy. Am. J. Physiol. 264 (Heart Circ. Physiol. 33): H837-H844, 1993.
8. + exchange. Am. J. Physiol. 265 (Heart Circ. Physiol. 34): H289-H298, 1993.
9. Higuchi, M., K. Miyagi, J. Nakasone, and M. Sakanashi. Role of high glycogen in underperfused diabetic rat hearts with added norepinephrine. J. Cardiovasc. Pharmacol. 26: 899-907, 1995.
10. Jenkins, R. L., H. G. McDaniel, S. Digerness, S. W. Parrish, and R. L. Ong. Adenine nucleotide metabolism in hearts of diabetic rats. Comparison to diaphragm, liver and kidney. Diabetes 37: 629-636, 1988.
11. Khandoudi, N., M. Bernard, P. Cozzone, and D. Feuvray. Mechanisms of intracellular pH regulation during postischemic reperfusion of diabetic rat hearts. Diabetes 44: 196-202, 1995.
12. + in normal galactose-fed and diabetic rat lens. Biochim. Biophys. Acta 841: 247-253, 1985.
13. Liedtke, A. J. Alterations of carbohydrate and lipid metabolism in the acutely ischemic heart. Prog. Cardiovasc. Dis. 23: 321-336, 1981.
14. Liedtke, A. J., H. C. Hughes, and J. R. Neely. Metabolic responses to varying restrictions of coronary blood flow in swine. Am. J. Physiol. 228: 655-662, 1975.
15. Malone, J. Red cell sorbitol, an indicator of diabetic control. Diabetes 29: 861-864, 1980.
16. Masuda, T., G. P. Dobson, and R. L. Veech. The Gibbs-Donnan near equilibrium system of the heart. J. Biol. Chem. 265: 20321-20334, 1990.
17. Mylari, B. L., E. R. Larson, T. A. Beyer, W. J. Zembrowski, C. E. Aldinger, M. F. Dee, T. W. Siegel, and D. H. Singleton. Novel, potent aldose reductase inhibitors: 3,4-dihydroxo-4-oxo-3-[[(trifluoromethyl)-2-benzothiazolyl]methyl]-1- phthalazineacetic acid (zopolrestat) and congeners. J. Med. Chem. 34: 108-122, 1991.
18. Opie, L. H., K. Bruyneel, and P. Owen. Effects of glucose, insulin and potassium infusion on tissue metabolic changes within the first hour of myocardial infarction in the baboon. Circulation 52: 49-57, 1975.
19. Opie, L. H., and P. Owen. Effect of glucose-insulin-potassium infusions on arteriovenous differences of glucose and free fatty acids and on tissue metabolic changes in dogs with developing myocardial infarction. Am. J. Cardiol. 38: 310-321, 1976.
20. Opie, L. H., M. J. Tansey, and B. M. Kennelly. The heart in diabetes mellitus. Part I. Biochemical basis for myocardial dysfunction. S. Afr. Med. J. 56: 207-211, 1979.
21. Osborn, B. A., J. T. Daar, R. A. Laddaga, F. D. Romano, and D. J. Paulson. Exercise training increases sarcolemmal GLUT-4 protein and mRNA content in diabetic heart. J. Appl. Physiol. 82: 828-834, 1997.
22. Owen, P., S. Dennis, and L. H. Opie. Glucose flux rate regulates onset of ischemic contracture in globally underperfused rat hearts. Circ. Res. 66: 344-354, 1990.
23. Ramasamy, R., H. Liu, S. Anderson, J. Lundmark, and S. Schaefer. Ischemic preconditioning stimulates sodium and proton transport in the isolated rat heart. J. Clin. Invest. 96: 1464-1472, 1995.
24. Ramasamy, R., P. J. Oates, and S. Schaefer. Aldose reductase inhibition protects diabetic and nondiabetic rat hearts from ischemic injury. Diabetes 46: 292-300, 1997.
25. Rovetto, M. J., W. F. Lamberton, and J. R. Neely. Mechanisms of glycolytic inhibition in ischemic rat hearts. Circ. Res. 37: 742-751, 1975.
26. Schaefer, S., L. J. Carr, E. Prussel, and R. Ramasamy. Effects of glycogen depletion on ischemic injury in the isolated rat heart: insights into preconditioning. Am. J. Physiol. 268 (Heart Circ. Physiol. 37): H935-H944, 1995.
27. Schaefer, S., E. Prussel, and L. J. Carr. Requirement of glycolytic substrate for metabolic recovery during moderate low flow ischemia. J. Mol. Cell. Cardiol. 27: 2167-2176, 1995.
28. Schaefer, S., and R. Ramasamy. Transient inhibition of the Na-H exchanger limits acidosis and ischemic injury during global ischemia. Cardiovasc. Res. 34: 329-336, 1997.
29. Schaefer, S., and R. Ramasamy. Glycogen utilization and ischemic injury in the isolated rat heart. Cardiovasc. Res. 35: 90-98, 1997.
30. Stanley, A. W., R. E. Moraski, R. O. Russell, W. J. Rogers, J. A. Mantle, R. A. Kreisberg, H. G. McDaniel, and C. E. Rackley. Effects of glucose-insulin-potassium on myocardial substrate availability and utilization in stable coronary artery disease. Am. J. Cardiol. 36: 929-937, 1975.
31. Stanley, W. C., J. R. Hall, K. R. Smith, G. D. Cartee, T. A. Hacker, and J. A. Wisneski. Myocardial glucose transporters and glycolytic metabolism during ischemia in hyperglycemic diabetic swine. Metabolism 43: 61-69, 1994.
32. Stanley, W. C., G. D. Lopaschuk, J. L. Hall, and J. G. McCormack. Regulation of myocardial carbohydrate metabolism under normal and ischemic conditions. Potential for pharmacological interventions. Cardiovasc. Res. 33: 243-257, 1997.
33. +)-ATPase in the slowing of nerve conduction in the streptozotocin diabetic rat. J. Clin. Invest. 94: 853-859, 1994.
34. Surges, R., and P. J. Oates. Aldose reductase inhibitors: recent developments. Prog. Drug Res. 40: 99-161, 1993.
35. 2+ overload and depressed recovery of ventricular function of reperfused ischemic rat hearts. Circ. Res. 65: 1045-1056, 1989.
36. 2+ overload and impairs function in anoxic rat heart. J. Mol. Cell. Cardiol. 22: 57-72, 1990.
37. Trueblood, N., and R. Ramasamy. Aldose reductase inhibition improves altered glucose metabolism of isolated diabetic rat hearts. Am. J. Physiol. 275 (Heart Circ. Physiol. 44): H75-H83, 1998.
38. i recovery after global ischemia in the perfused heart. Circ. Res. 72: 993-1003, 1993.
39. Vanoverschelde, J.-L. J., M. F. Janier, J. E. Bakke, D. R. Marshall, and S. R. Bergmann. Rate of glycolysis during ischemia determines extent of ischemic injury and functional recovery after reperfusion. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H1785-H1794, 1994.
40. Vanoverschelde, J.-L. J., M. F. Janier, and S. R. Bergmann. The relative importance of myocardial energy metabolism compared with ischemic contracture in the determination of ischemic injury in isolated rabbit hearts. Circ. Res. 74: 817-828, 1994.
41. + loss and cardiac function in ischemic and reperfused mammalian ventricle. Circ. Res. 71: 1324-1333, 1992.
42. Weiss, J., and B. Hiltbrand. Functional compartmentation of glycolytic versus oxidative metabolism in isolated rabbit heart. J. Clin. Invest. 75: 436-447, 1985.
43. Williamson, J. R., K. Chang, M. Frangos, K. S. Hasan, Y. Ido, T. Kawamura, J. R. Nyengaard, M. Van den Enden, C. Kilo, and R. G. Tilton. Hyperglycemic pseudohypoxia and diabetic complications. Diabetes 42: 801-813, 1993.