메뉴 건너뛰기




Volumn 21, Issue 9, 2008, Pages 481-488

Cdc7 as a potential new target for cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

CELL DIVISION CYCLE 7 KINASE; CYCLIN DEPENDENT KINASE 2; CYCLINE DEPENDENT KINASE 1; GLYCOGEN SYNTHASE KINASE 3BETA; MINICHROMOSOME MAINTENANCE PROTEIN; PHA 767491; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 61849163877     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2008.21.9.1290818     Document Type: Article
Times cited : (20)

References (73)
  • 1
    • 0015223149 scopus 로고
    • Genetic control of the cell division cycle in yeast. II. Genes controlling DNA replication and its initiation
    • Hartwell, L.H. Genetic control of the cell division cycle in yeast. II. Genes controlling DNA replication and its initiation. J Mol Biol 1971, 59(1): 183-94.
    • (1971) J Mol Biol , vol.59 , Issue.1 , pp. 183-194
    • Hartwell, L.H.1
  • 2
    • 0020429773 scopus 로고
    • A further two mutants defective in initiation of the S phase in the yeast Saccharomyces cerevisiae
    • Johnston, L.H. and Thomas, A.P. A further two mutants defective in initiation of the S phase in the yeast Saccharomyces cerevisiae. Mol Gen Genet 1982, 186(3): 445-8.
    • (1982) Mol Gen Genet , vol.186 , Issue.3 , pp. 445-448
    • Johnston, L.H.1    Thomas, A.P.2
  • 3
    • 0033947670 scopus 로고    scopus 로고
    • Cdc7p-Dbf4p becomes famous in the cell cycle
    • Sclafani, R.A. Cdc7p-Dbf4p becomes famous in the cell cycle. J Cell Sci 2000, 113(Pt. 12): 2111-7.
    • (2000) J Cell Sci , vol.113 , Issue.PART. 12 , pp. 2111-2117
    • Sclafani, R.A.1
  • 4
    • 0028979307 scopus 로고
    • hsk1+, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae CDC7, is required for chromosomal replication
    • Masai, H., Miyake, T. and Arai, K. hsk1+, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae CDC7, is required for chromosomal replication. EMBO J 1995, 14(13): 3094-104.
    • (1995) EMBO J , vol.14 , Issue.13 , pp. 3094-3104
    • Masai, H.1    Miyake, T.2    Arai, K.3
  • 6
    • 0036154983 scopus 로고    scopus 로고
    • Cdc7 kinase complex: A key regulator in the initiation of DNA replication
    • Masai, H. and Arai, K. Cdc7 kinase complex: A key regulator in the initiation of DNA replication. J Cell Physiol 2002, 190(3): 287-96.
    • (2002) J Cell Physiol , vol.190 , Issue.3 , pp. 287-296
    • Masai, H.1    Arai, K.2
  • 7
    • 0033472743 scopus 로고    scopus 로고
    • CDC7 kinase complex as a molecular switch for DNA replication
    • Masai, H., Sato, N., Takeda, T. and Arai, K. CDC7 kinase complex as a molecular switch for DNA replication. Front Biosci 1999, 4: D834-40.
    • (1999) Front Biosci , vol.4
    • Masai, H.1    Sato, N.2    Takeda, T.3    Arai, K.4
  • 8
    • 0015851413 scopus 로고
    • Role of protein synthesis in the replication of yeast DNA
    • Hereford, L.M. and Hartwell, L.H. Role of protein synthesis in the replication of yeast DNA. Nat New Biol 1973, 244(135): 129-31.
    • (1973) Nat New Biol , vol.244 , Issue.135 , pp. 129-131
    • Hereford, L.M.1    Hartwell, L.H.2
  • 9
    • 0022602028 scopus 로고
    • Molecular characterization of cell cycle gene CDC7 from Saccharomyces cerevisiae
    • Patterson, M., Sclafani, R.A., Fangman, W.L. and Rosamond, J. Molecular characterization of cell cycle gene CDC7 from Saccharomyces cerevisiae. Mol Cell Biol 1986, 6(5): 1590-8.
    • (1986) Mol Cell Biol , vol.6 , Issue.5 , pp. 1590-1598
    • Patterson, M.1    Sclafani, R.A.2    Fangman, W.L.3    Rosamond, J.4
  • 10
    • 0032519615 scopus 로고    scopus 로고
    • The Cdc7 protein kinase is required for origin firing during S phase
    • Bousset, K. and Diffley, J.F. The Cdc7 protein kinase is required for origin firing during S phase. Genes Dev 1998, 12(4): 480-90.
    • (1998) Genes Dev , vol.12 , Issue.4 , pp. 480-490
    • Bousset, K.1    Diffley, J.F.2
  • 11
    • 0032520181 scopus 로고    scopus 로고
    • Cdc7 is required throughout the yeast S phase to activate replication origins
    • Donaldson, A.D., Fangman, W.L. and Brewer, B.J. Cdc7 is required throughout the yeast S phase to activate replication origins. Genes Dev 1998, 12(4): 491-501.
    • (1998) Genes Dev , vol.12 , Issue.4 , pp. 491-501
    • Donaldson, A.D.1    Fangman, W.L.2    Brewer, B.J.3
  • 12
    • 0027978640 scopus 로고
    • Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo
    • Dowell, S.J., Romanowski, P. and Diffley, J.F. Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo. Science 1994, 265(5176): 1243-6.
    • (1994) Science , vol.265 , Issue.5176 , pp. 1243-1246
    • Dowell, S.J.1    Romanowski, P.2    Diffley, J.F.3
  • 13
    • 0032814213 scopus 로고    scopus 로고
    • A fission yeast gene, him1(+)/dfp1(+), encoding a regulatory subunit for Hsk1 kinase, plays essential roles in S-phase initiation as well as in S-phase checkpoint control and recovery from DNA damage
    • Takeda, T., Ogino, K., Matsui, E. et al. A fission yeast gene, him1(+)/dfp1(+), encoding a regulatory subunit for Hsk1 kinase, plays essential roles in S-phase initiation as well as in S-phase checkpoint control and recovery from DNA damage. Mol Cell Biol 1999, 19(8): 5535-47.
    • (1999) Mol Cell Biol , vol.19 , Issue.8 , pp. 5535-5547
    • Takeda, T.1    Ogino, K.2    Matsui, E.3
  • 14
    • 0034765174 scopus 로고    scopus 로고
    • Regulation of initiation of S phase, replication checkpoint signaling, and maintenance of mitotic chromosome structures during S phase by Hsk1 kinase in the fission yeast
    • Takeda, T., Ogino, K., Tatebayashi, K., Ikeda, H., Arai, K. and Masai, H. Regulation of initiation of S phase, replication checkpoint signaling, and maintenance of mitotic chromosome structures during S phase by Hsk1 kinase in the fission yeast. Mol Biol Cell 2001, 12(5): 1257-74.
    • (2001) Mol Biol Cell , vol.12 , Issue.5 , pp. 1257-1274
    • Takeda, T.1    Ogino, K.2    Tatebayashi, K.3    Ikeda, H.4    Arai, K.5    Masai, H.6
  • 15
    • 0033587674 scopus 로고    scopus 로고
    • Cell cycle regulation of Dfp1, an activator of the Hsk1 protein kinase
    • Brown, G.W. and Kelly, T.J. Cell cycle regulation of Dfp1, an activator of the Hsk1 protein kinase. Proc Natl Acad Sci U S A 1999, 96(15): 8443-8.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.15 , pp. 8443-8448
    • Brown, G.W.1    Kelly, T.J.2
  • 17
    • 44449112225 scopus 로고    scopus 로고
    • Cdc 7 kinase mediates Claspin phosphorylation in DNA replication checkpoint
    • Kim, J.M., Kakusho, N., Yamada, M., Kanoh, Y, Takemoto, N. and Masai, H. Cdc 7 kinase mediates Claspin phosphorylation in DNA replication checkpoint. Oncogene 2007, 27(24): 3475-82.
    • (2007) Oncogene , vol.27 , Issue.24 , pp. 3475-3482
    • Kim, J.M.1    Kakusho, N.2    Yamada, M.3    Kanoh, Y.4    Takemoto, N.5    Masai, H.6
  • 18
    • 0034666016 scopus 로고    scopus 로고
    • Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a critical threonine residue of Cdc7 by Cdks
    • Masai, H., Matsui, E., You, Z., Ishimi, Y, Tamai, K. and Arai, K. Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a critical threonine residue of Cdc7 by Cdks. J Biol Chem 2000, 275(37): 29042-52.
    • (2000) J Biol Chem , vol.275 , Issue.37 , pp. 29042-29052
    • Masai, H.1    Matsui, E.2    You, Z.3    Ishimi, Y.4    Tamai, K.5    Arai, K.6
  • 19
    • 33845976373 scopus 로고    scopus 로고
    • Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin
    • Masai, H., Taniyama, C., Ogino, K. et al. Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin. J Biol Chem 2006, 281(51): 39249-61.
    • (2006) J Biol Chem , vol.281 , Issue.51 , pp. 39249-39261
    • Masai, H.1    Taniyama, C.2    Ogino, K.3
  • 20
    • 33744508705 scopus 로고    scopus 로고
    • Identification of Mcm2 phosphorylation sites by S-phase-regulating kinases
    • Montagnoli, A., Valsasina, B., Brotherton, D. et al. Identification of Mcm2 phosphorylation sites by S-phase-regulating kinases. J Biol Chem 2006, 281(15): 10281-90.
    • (2006) J Biol Chem , vol.281 , Issue.15 , pp. 10281-10290
    • Montagnoli, A.1    Valsasina, B.2    Brotherton, D.3
  • 21
    • 33746849859 scopus 로고    scopus 로고
    • CDC7 kinase phosphorylates serine residues adjacent to acidic amino acids in the minichromosome maintenance 2 protein
    • Cho, W.H., Lee, Y.J., Kong, S.I., Hurwitz, J. and Lee, J.K. CDC7 kinase phosphorylates serine residues adjacent to acidic amino acids in the minichromosome maintenance 2 protein. Proc Natl Acad Sci U S A 2006, 103(31): 11521-6.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.31 , pp. 11521-11526
    • Cho, W.H.1    Lee, Y.J.2    Kong, S.I.3    Hurwitz, J.4    Lee, J.K.5
  • 22
    • 38949196402 scopus 로고    scopus 로고
    • Cdc28-clb5 (CDK-S) and Cdc7-Dbf4 (DDK) c2 collaborate to initiate meiotic recombination in yeast
    • Wan, L., Niu, H., Futcher, B., Zhang, C., Shokat, K.M., Boulton, S.J. and Hollingsworth, N.M. Cdc28-clb5 (CDK-S) and Cdc7-Dbf4 (DDK) c2 collaborate to initiate meiotic recombination in yeast. Genes Dev 2008, 22(3): 386-97.
    • (2008) Genes Dev , vol.22 , Issue.3 , pp. 386-397
    • Wan, L.1    Niu, H.2    Futcher, B.3    Zhang, C.4    Shokat, K.M.5    Boulton, S.J.6    Hollingsworth, N.M.7
  • 23
    • 38949184968 scopus 로고    scopus 로고
    • Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination
    • Sasanuma, H., Hirota, K., Fukuda, T. et al. Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination. Genes Dev 2008, 22(3): 398-410.
    • (2008) Genes Dev , vol.22 , Issue.3 , pp. 398-410
    • Sasanuma, H.1    Hirota, K.2    Fukuda, T.3
  • 24
    • 33749075373 scopus 로고    scopus 로고
    • Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression
    • Sheu, Y.J. and Stillman, B. Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression. Mol Cell 2006, 24(1): 101-13.
    • (2006) Mol Cell , vol.24 , Issue.1 , pp. 101-113
    • Sheu, Y.J.1    Stillman, B.2
  • 25
    • 0000879111 scopus 로고    scopus 로고
    • Growth regulation of the expression of mouse cDNA and gene encoding a serine/ threonine kinase related to Saccharomyces cerevisiae CDC7 essential for G1/S transition. Structure, chromosomal localization, and expression of mouse gene for S. cerevisiae Cdc7-related kinase
    • Kim, J.M., Sato, N., Yamada, M., Arai, K. and Masai, H. Growth regulation of the expression of mouse cDNA and gene encoding a serine/ threonine kinase related to Saccharomyces cerevisiae CDC7 essential for G1/S transition. Structure, chromosomal localization, and expression of mouse gene for S. cerevisiae Cdc7-related kinase. J Biol Chem 1998, 273(36): 23248-57.
    • (1998) J Biol Chem , vol.273 , Issue.36 , pp. 23248-23257
    • Kim, J.M.1    Sato, N.2    Yamada, M.3    Arai, K.4    Masai, H.5
  • 26
    • 35649026263 scopus 로고    scopus 로고
    • Identification and characterization of human cdc7 nuclear retention and export sequences in the context of chromatin binding
    • Kim, B.J., Kim, S.Y. and Lee, H. Identification and characterization of human cdc7 nuclear retention and export sequences in the context of chromatin binding. J Biol Chem 2007, 282(41): 30029-38.
    • (2007) J Biol Chem , vol.282 , Issue.41 , pp. 30029-30038
    • Kim, B.J.1    Kim, S.Y.2    Lee, H.3
  • 27
    • 0024545513 scopus 로고
    • The yeast gene, DBF4, essential for entry into S phase is cell cycle regulated
    • Chapman, J.W. and Johnston, L.H. The yeast gene, DBF4, essential for entry into S phase is cell cycle regulated. Exp Cell Res 1989,180(2): 419-28.
    • (1989) Exp Cell Res , vol.180 , Issue.2 , pp. 419-428
    • Chapman, J.W.1    Johnston, L.H.2
  • 28
    • 0027192941 scopus 로고
    • Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein
    • Jackson, A.L., Pahl, P.M., Harrison, K., Rosamond, J. and Sclafani, R.A. Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein. Mol Cell Biol 1993, 13(5): 2899-908.
    • (1993) Mol Cell Biol , vol.13 , Issue.5 , pp. 2899-2908
    • Jackson, A.L.1    Pahl, P.M.2    Harrison, K.3    Rosamond, J.4    Sclafani, R.A.5
  • 29
    • 0034683026 scopus 로고    scopus 로고
    • Dbf4 motifs: Conserved motifs in activation subunits for Cdc7 kinases essential for S-phase
    • Masai, H. and Arai, K. Dbf4 motifs: Conserved motifs in activation subunits for Cdc7 kinases essential for S-phase. Biochem Biophys Res Commun 2000, 275(1): 228-32.
    • (2000) Biochem Biophys Res Commun , vol.275 , Issue.1 , pp. 228-232
    • Masai, H.1    Arai, K.2
  • 30
    • 0035903117 scopus 로고    scopus 로고
    • Bipartite binding of a kinase activator activates Cdc7-related kinase essential for S phase
    • Ogino, K., Takeda, T., Matsui, E., Iiyama, H., Taniyama, C., Arai, K. and Masai H. Bipartite binding of a kinase activator activates Cdc7-related kinase essential for S phase. J Biol Chem 2001, 276(33): 31376-87.
    • (2001) J Biol Chem , vol.276 , Issue.33 , pp. 31376-31387
    • Ogino, K.1    Takeda, T.2    Matsui, E.3    Iiyama, H.4    Taniyama, C.5    Arai, K.6    Masai, H.7
  • 31
    • 0033026068 scopus 로고    scopus 로고
    • A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells
    • Kumagai, H., Sato, N., Yamada, M. et al. A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells. Mol Cell Biol 1999, 19(7): 5083-95.
    • (1999) Mol Cell Biol , vol.19 , Issue.7 , pp. 5083-5095
    • Kumagai, H.1    Sato, N.2    Yamada, M.3
  • 32
    • 0036277242 scopus 로고    scopus 로고
    • A conserved domain of Schizosac-charomyces pombe dfp1(+) is uniquely required for chromosome stability following alkylation damage during S phase
    • Fung, A.D., On, J., Bueler, S. and Brown G.W. A conserved domain of Schizosac-charomyces pombe dfp1(+) is uniquely required for chromosome stability following alkylation damage during S phase. Mol Cell Biol 2002, 22(13): 4477-90.
    • (2002) Mol Cell Biol , vol.22 , Issue.13 , pp. 4477-4490
    • Fung, A.D.1    On, J.2    Bueler, S.3    Brown, G.W.4
  • 33
    • 0038027050 scopus 로고    scopus 로고
    • Cell cycle regulation of chromatin binding and nuclear localization of human Cdc7-ASK kinase complex
    • Sato, N., Sato, M., Nakayama, M., Saitoh, R., Arai, K. and Masai, H. Cell cycle regulation of chromatin binding and nuclear localization of human Cdc7-ASK kinase complex. Genes Cells 2003, 8(5): 451-63.
    • (2003) Genes Cells , vol.8 , Issue.5 , pp. 451-463
    • Sato, N.1    Sato, M.2    Nakayama, M.3    Saitoh, R.4    Arai, K.5    Masai, H.6
  • 34
    • 20944441115 scopus 로고    scopus 로고
    • Functional analyses of mouse ASK, an activation subunit for Cdc7 kinase, using conditional ASK knockout ES cells
    • Yamashita, N., Kim, J.M., Koiwai, O., Arai, K. and Masai, H. Functional analyses of mouse ASK, an activation subunit for Cdc7 kinase, using conditional ASK knockout ES cells. Genes Cells 2005, 10(6): 551-63.
    • (2005) Genes Cells , vol.10 , Issue.6 , pp. 551-563
    • Yamashita, N.1    Kim, J.M.2    Koiwai, O.3    Arai, K.4    Masai, H.5
  • 35
    • 0032881250 scopus 로고    scopus 로고
    • MCM proteins in DNA replication
    • Tye, B.K. MCM proteins in DNA replication. Annu Rev Biochem 1999, 68: 649-86.
    • (1999) Annu Rev Biochem , vol.68 , pp. 649-686
    • Tye, B.K.1
  • 36
    • 0030877320 scopus 로고    scopus 로고
    • Sato, N., Arai, K. and Masai, H. Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: In vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7. EMBO J 1997,16(14): 4340051.
    • Sato, N., Arai, K. and Masai, H. Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: In vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7. EMBO J 1997,16(14): 4340051.
  • 37
    • 0031435940 scopus 로고    scopus 로고
    • Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis
    • Lei, M., Kawasaki, Y, Young, M.R., Kihara, M., Sugino, A. and Tye, B.K. Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis. Genes Dev 1997, 11(24): 3365-74.
    • (1997) Genes Dev , vol.11 , Issue.24 , pp. 3365-3374
    • Lei, M.1    Kawasaki, Y.2    Young, M.R.3    Kihara, M.4    Sugino, A.5    Tye, B.K.6
  • 38
    • 33749496131 scopus 로고    scopus 로고
    • Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells
    • Tsuji, T., Ficarro, S.B. and Jiang, W. Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells. Mol Biol Cell 2006, 17(10): 4459-72.
    • (2006) Mol Biol Cell , vol.17 , Issue.10 , pp. 4459-4472
    • Tsuji, T.1    Ficarro, S.B.2    Jiang, W.3
  • 39
    • 0036566328 scopus 로고    scopus 로고
    • Inactivation of Cdc7 kinase in mouse ES cells results in S-phase arrest and p53-dependent cell death
    • Kim, J.M., Nakao, K., Nakamura, K., Saito, I., Katsuki, M., Arai, K. and Masai, H. Inactivation of Cdc7 kinase in mouse ES cells results in S-phase arrest and p53-dependent cell death. EMBO J 2002, 21(9): 2168-79.
    • (2002) EMBO J , vol.21 , Issue.9 , pp. 2168-2179
    • Kim, J.M.1    Nakao, K.2    Nakamura, K.3    Saito, I.4    Katsuki, M.5    Arai, K.6    Masai, H.7
  • 40
    • 4944256913 scopus 로고    scopus 로고
    • Cdc7 inhibition reveals a p53-dependent replication checkpoint that is defective in cancer cells
    • Montagnoli, A., Tenca, P., Sola, F., Carpani, D., Brotherton, D., Albanese, C. and Santocanale, C. Cdc7 inhibition reveals a p53-dependent replication checkpoint that is defective in cancer cells. Cancer Res 2004, 64(19): 7110-6.
    • (2004) Cancer Res , vol.64 , Issue.19 , pp. 7110-7116
    • Montagnoli, A.1    Tenca, P.2    Sola, F.3    Carpani, D.4    Brotherton, D.5    Albanese, C.6    Santocanale, C.7
  • 41
    • 30044438705 scopus 로고    scopus 로고
    • Hsk1-Dfp1/Him1, the Cdc7-Dbf4 kinase in Schizosaccharomyces pombe, associates with Swil, a component of the replication fork protection complex
    • Matsumoto, S., Ogino, K., Noguchi, E., Russell, P. and Masai, H. Hsk1-Dfp1/Him1, the Cdc7-Dbf4 kinase in Schizosaccharomyces pombe, associates with Swil, a component of the replication fork protection complex. J Biol Chem 2005, 280(52): 42536-42.
    • (2005) J Biol Chem , vol.280 , Issue.52 , pp. 42536-42542
    • Matsumoto, S.1    Ogino, K.2    Noguchi, E.3    Russell, P.4    Masai, H.5
  • 42
    • 15044358104 scopus 로고    scopus 로고
    • Schizosaccharomyces pombe Swil, Swi3, and Hsk1 are components of a novel S-phase response pathway to alkylation damage
    • Sommariva, E., Pellny, T.K., Karahan, N., Kumar, S., Huberman, J.A. and Dalgaard, J.Z. Schizosaccharomyces pombe Swil, Swi3, and Hsk1 are components of a novel S-phase response pathway to alkylation damage. Mol Cell Biol 2005, 25(7): 2770-84.
    • (2005) Mol Cell Biol , vol.25 , Issue.7 , pp. 2770-2784
    • Sommariva, E.1    Pellny, T.K.2    Karahan, N.3    Kumar, S.4    Huberman, J.A.5    Dalgaard, J.Z.6
  • 43
    • 1642421759 scopus 로고    scopus 로고
    • BCR/ABL translocates to the nucleus and disrupts an ATR-dependent intra-S phase checkpoint
    • Dierov, J., Dierova, R. and Carroll, M BCR/ABL translocates to the nucleus and disrupts an ATR-dependent intra-S phase checkpoint. Cancer Cell 2004, 5(3): 275-85.
    • (2004) Cancer Cell , vol.5 , Issue.3 , pp. 275-285
    • Dierov, J.1    Dierova, R.2    Carroll, M.3
  • 44
    • 0033215306 scopus 로고    scopus 로고
    • Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway
    • Weinreich, M. and Stillman, B. Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway. EMBO J 1999, 18(19): 5334-46.
    • (1999) EMBO J , vol.18 , Issue.19 , pp. 5334-5346
    • Weinreich, M.1    Stillman, B.2
  • 45
    • 41949133033 scopus 로고    scopus 로고
    • The role of the Saccharomyces cerevisiae Cdc7-Dbf4 complex in the replication checkpoint
    • Ogi, H., Wang, C.Z., Nakai, W., Kawasaki, Y. and Masumoto, H. The role of the Saccharomyces cerevisiae Cdc7-Dbf4 complex in the replication checkpoint. Gene 2008, 414(1-2): 32-40.
    • (2008) Gene , vol.414 , Issue.1-2 , pp. 32-40
    • Ogi, H.1    Wang, C.Z.2    Nakai, W.3    Kawasaki, Y.4    Masumoto, H.5
  • 46
    • 0033781393 scopus 로고    scopus 로고
    • Schizosaccharomyces pombe Hsk1p is a potential cds1p target required for genome integrity
    • Snaith, H.A., Brown, G.W. and Forsburg, S.L. Schizosaccharomyces pombe Hsk1p is a potential cds1p target required for genome integrity. Mol Cell Biol 2000, 20(21): 7922-32.
    • (2000) Mol Cell Biol , vol.20 , Issue.21 , pp. 7922-7932
    • Snaith, H.A.1    Brown, G.W.2    Forsburg, S.L.3
  • 48
    • 25844447786 scopus 로고    scopus 로고
    • Cdc7-Drf1 is a developmentally regulated protein kinase required for the initiation of vertebrate DNA replication
    • Takahashi, T.S. and Walter, J.C. Cdc7-Drf1 is a developmentally regulated protein kinase required for the initiation of vertebrate DNA replication. Genes Dev 2005, 19(19): 2295-300.
    • (2005) Genes Dev , vol.19 , Issue.19 , pp. 2295-2300
    • Takahashi, T.S.1    Walter, J.C.2
  • 49
    • 0142039875 scopus 로고    scopus 로고
    • Xenopus Drf1, a regulator of Cdc7, displays checkpoint-dependent accumulation on chromatin during an S-phase arrest
    • Yanow, S.K., Gold, D.A., Yoo, H.Y. and Dunphy, W.G. Xenopus Drf1, a regulator of Cdc7, displays checkpoint-dependent accumulation on chromatin during an S-phase arrest. J Biol Chem 2003, 278(42): 41083-92.
    • (2003) J Biol Chem , vol.278 , Issue.42 , pp. 41083-41092
    • Yanow, S.K.1    Gold, D.A.2    Yoo, H.Y.3    Dunphy, W.G.4
  • 50
    • 0037179866 scopus 로고    scopus 로고
    • Cell type-specific responses of human cells to inhibition of replication licensing
    • Shreeram, S., Sparks, A., Lane, D.P. and Blow, J.J. Cell type-specific responses of human cells to inhibition of replication licensing. Oncogene 2002, 21(43): 6624-32.
    • (2002) Oncogene , vol.21 , Issue.43 , pp. 6624-6632
    • Shreeram, S.1    Sparks, A.2    Lane, D.P.3    Blow, J.J.4
  • 51
    • 16844364661 scopus 로고    scopus 로고
    • A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases
    • Yoshizawa-Sugata, N., Ishii, A., Taniyama, C., Matsui, E., Arai, K. and Masai, H. A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases. J Biol Chem 2005, 280(13): 13062-70.
    • (2005) J Biol Chem , vol.280 , Issue.13 , pp. 13062-13070
    • Yoshizawa-Sugata, N.1    Ishii, A.2    Taniyama, C.3    Matsui, E.4    Arai, K.5    Masai, H.6
  • 52
    • 54449087508 scopus 로고    scopus 로고
    • ATR-dependent activation of p38 AMP kinase is responsible for apoptotic cell death in cells depleted of Cdc7
    • Im, J.S. and Lee, J.K. ATR-dependent activation of p38 AMP kinase is responsible for apoptotic cell death in cells depleted of Cdc7. J Biol Chem 2008, 283(37): 25171-7.
    • (2008) J Biol Chem , vol.283 , Issue.37 , pp. 25171-25177
    • Im, J.S.1    Lee, J.K.2
  • 53
    • 0032574671 scopus 로고    scopus 로고
    • A human homolog of the yeast CDC7 gene is overexpressed in some tumors and transformed cell lines
    • Hess, G.F., Drong, R.F., Weiland, K.L., Slightom, J.L., Sclafani, R.A. and Hollingsworth, R.E. A human homolog of the yeast CDC7 gene is overexpressed in some tumors and transformed cell lines. Gene 1998, 211(1): 133-40.
    • (1998) Gene , vol.211 , Issue.1 , pp. 133-140
    • Hess, G.F.1    Drong, R.F.2    Weiland, K.L.3    Slightom, J.L.4    Sclafani, R.A.5    Hollingsworth, R.E.6
  • 54
    • 37049030384 scopus 로고    scopus 로고
    • Defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expression
    • Kaufmann, W.K., Nevis, K.R., Qu, P. et al. Defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expression. J Invest Dermatol 2008, 128(1): 175-87.
    • (2008) J Invest Dermatol , vol.128 , Issue.1 , pp. 175-187
    • Kaufmann, W.K.1    Nevis, K.R.2    Qu, P.3
  • 55
    • 36949016275 scopus 로고    scopus 로고
    • Identification and functional characterization of ASK/Dbf4, a novel cell survival gene in cutaneous melanoma with prognostic relevance
    • Nambiar, S., Mirmohammadsadegh, A., Hassan, M. et al. Identification and functional characterization of ASK/Dbf4, a novel cell survival gene in cutaneous melanoma with prognostic relevance. Carcinogenesis 2007, 28(12): 2501-10.
    • (2007) Carcinogenesis , vol.28 , Issue.12 , pp. 2501-2510
    • Nambiar, S.1    Mirmohammadsadegh, A.2    Hassan, M.3
  • 56
    • 33645474441 scopus 로고    scopus 로고
    • Gene expression in poorly differentiated papillary thyroid carcinomas
    • Fluge, O., Bruland, O., Akslen, L.A., Lillehaug, J.R. and Varhaug, J.E. Gene expression in poorly differentiated papillary thyroid carcinomas. Thyroid 2006, 16(2): 161-75.
    • (2006) Thyroid , vol.16 , Issue.2 , pp. 161-175
    • Fluge, O.1    Bruland, O.2    Akslen, L.A.3    Lillehaug, J.R.4    Varhaug, J.E.5
  • 57
    • 32944464047 scopus 로고    scopus 로고
    • Gene expression differences associated with human papillomavirus status in head and neck squamous cell carcinoma
    • Slebos, R.J., Yi, Y, Ely, K. et al. Gene expression differences associated with human papillomavirus status in head and neck squamous cell carcinoma. Clin Cancer Res 2006, 12(3 Pt. 1): 701-9.
    • (2006) Clin Cancer Res , vol.12 , Issue.3 PART. 1 , pp. 701-709
    • Slebos, R.J.1    Yi, Y.2    Ely, K.3
  • 58
    • 33645026707 scopus 로고    scopus 로고
    • Genomic analysis defines a cancer-specific gene expression signaturefor human squamous cell carcinoma and distinguishes malignant hyperproliferation from benign hyperplasia
    • Haider, A.S., Peters, S.B., Kaporis, H. et al. Genomic analysis defines a cancer-specific gene expression signaturefor human squamous cell carcinoma and distinguishes malignant hyperproliferation from benign hyperplasia. J Invest Dermatol 2006, 126(4): 869-81.
    • (2006) J Invest Dermatol , vol.126 , Issue.4 , pp. 869-881
    • Haider, A.S.1    Peters, S.B.2    Kaporis, H.3
  • 59
    • 13444270648 scopus 로고    scopus 로고
    • Control of DNA replication and its potential clinical exploitation
    • Gonzalez, M.A., Tachibana, K.E., Laskey, R.A. and Coleman, N. Control of DNA replication and its potential clinical exploitation. Nat Rev Cancer 2005, 5(2): 135-41.
    • (2005) Nat Rev Cancer , vol.5 , Issue.2 , pp. 135-141
    • Gonzalez, M.A.1    Tachibana, K.E.2    Laskey, R.A.3    Coleman, N.4
  • 60
    • 4444276755 scopus 로고    scopus 로고
    • ORC-associated replication factors as biomarkers for cancer
    • Semple, J.W. and Duncker, B.P. ORC-associated replication factors as biomarkers for cancer. Biotechnol Adv 2004, 22(8): 621-31.
    • (2004) Biotechnol Adv , vol.22 , Issue.8 , pp. 621-631
    • Semple, J.W.1    Duncker, B.P.2
  • 61
    • 34247481285 scopus 로고    scopus 로고
    • Targeting check point kinase 1 in cancer therapeutics
    • Tse, A.N., Carvajal, R. and Schwartz, G.K. Targeting check point kinase 1 in cancer therapeutics. Clin Cancer Res 2007, 13(7): 1955-60.
    • (2007) Clin Cancer Res , vol.13 , Issue.7 , pp. 1955-1960
    • Tse, A.N.1    Carvajal, R.2    Schwartz, G.K.3
  • 62
    • 34247259822 scopus 로고    scopus 로고
    • Antitumor activity of MLN8054, an orally active small-molecule inhibitor Of Aurora A kinase
    • Manfredi, M.G., Ecsedy, J.A., Meetze, K.A. et al. Antitumor activity of MLN8054, an orally active small-molecule inhibitor Of Aurora A kinase. Proc Natl Acad Sci U S A 2007, 104(10): 4106-11.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.10 , pp. 4106-4111
    • Manfredi, M.G.1    Ecsedy, J.A.2    Meetze, K.A.3
  • 63
    • 33645316142 scopus 로고    scopus 로고
    • Targeting polo-like kinase 1 for cancer therapy
    • Strebhardt, K. and Ullrich, A. Targeting polo-like kinase 1 for cancer therapy. Nat Rev Cancer 2006, 6(4): 321-30.
    • (2006) Nat Rev Cancer , vol.6 , Issue.4 , pp. 321-330
    • Strebhardt, K.1    Ullrich, A.2
  • 64
    • 34147167723 scopus 로고    scopus 로고
    • P276-00, a novel cyclin-dependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models
    • Joshi, K.S., Rathos, M.J., Mahajan, P. et al. P276-00, a novel cyclin-dependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models. Mol Cancer Ther 2007, 6(3): 926-34.
    • (2007) Mol Cancer Ther , vol.6 , Issue.3 , pp. 926-934
    • Joshi, K.S.1    Rathos, M.J.2    Mahajan, P.3
  • 65
    • 0037418273 scopus 로고    scopus 로고
    • The Cdc23 (Mcm10) protein is required for the phosphorylation of minichromosome maintenance complex by the Dfp1-Hsk1 kinase
    • Lee, J.K., Seo, Y.S. and Hurwitz, J. The Cdc23 (Mcm10) protein is required for the phosphorylation of minichromosome maintenance complex by the Dfp1-Hsk1 kinase. Proc Natl Acad Sci U S A 2003, 100(5): 2334-9.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.5 , pp. 2334-2339
    • Lee, J.K.1    Seo, Y.S.2    Hurwitz, J.3
  • 66
    • 50349085907 scopus 로고    scopus 로고
    • Identification of stimulators and inhibitors of CDC7 kinase in vitro
    • Kakusho, N., Taniyama, C. and Masai, H. Identification of stimulators and inhibitors of CDC7 kinase in vitro. J Biol Chem 2008, 283(28): 19211-8.
    • (2008) J Biol Chem , vol.283 , Issue.28 , pp. 19211-19218
    • Kakusho, N.1    Taniyama, C.2    Masai, H.3
  • 67
    • 0021125696 scopus 로고
    • Kinetics of activation of casein kinase II by polyamines and reversal of 2,3-bisphosphoglycerate inhibition
    • Hathaway, G.M. and Traugh, J.A. Kinetics of activation of casein kinase II by polyamines and reversal of 2,3-bisphosphoglycerate inhibition. J Biol Chem 1984, 259(11): 7011-5.
    • (1984) J Biol Chem , vol.259 , Issue.11 , pp. 7011-7015
    • Hathaway, G.M.1    Traugh, J.A.2
  • 68
    • 39149143359 scopus 로고    scopus 로고
    • Cdc7 kinase inhibitors: Pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships
    • Vanotti, E., Amici, R., Bargiotti, A. et al. Cdc7 kinase inhibitors: Pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships. J Med Chem 2008, 51(3): 487-501.
    • (2008) J Med Chem , vol.51 , Issue.3 , pp. 487-501
    • Vanotti, E.1    Amici, R.2    Bargiotti, A.3
  • 69
    • 43749097854 scopus 로고    scopus 로고
    • A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity
    • Montagnoli, A., Valsasina, B., Croci, V. et al. A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. Nat Chem Biol 2008, 4(6): 357-65.
    • (2008) Nat Chem Biol , vol.4 , Issue.6 , pp. 357-365
    • Montagnoli, A.1    Valsasina, B.2    Croci, V.3
  • 70
    • 17244366865 scopus 로고    scopus 로고
    • Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
    • Gorgoulis, V.G., Vassiliou, L.V, Karakaidos, P. et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 2005, 434(7035): 907-13.
    • (2005) Nature , vol.434 , Issue.7035 , pp. 907-913
    • Gorgoulis, V.G.1    Vassiliou, L.V.2    Karakaidos, P.3
  • 71
    • 17244367849 scopus 로고    scopus 로고
    • DNA damage response as a candidate anticancer barrier in early human tumorigenesis
    • Bartkova, J., Horejsi, Z., Koed, K. et al. DNA damage response as a candidate anticancer barrier in early human tumorigenesis. Nature 2005, 434(7035): 864-70.
    • (2005) Nature , vol.434 , Issue.7035 , pp. 864-870
    • Bartkova, J.1    Horejsi, Z.2    Koed, K.3
  • 72
    • 0242610832 scopus 로고    scopus 로고
    • Inhibiting the expression of DNA replication-initiation proteins induces apoptosis in human cancer cells
    • Feng, D., Tu, Z., Wu, W. and Liang, C. Inhibiting the expression of DNA replication-initiation proteins induces apoptosis in human cancer cells. Cancer Res 2003, 63(21): 7356-64.
    • (2003) Cancer Res , vol.63 , Issue.21 , pp. 7356-7364
    • Feng, D.1    Tu, Z.2    Wu, W.3    Liang, C.4
  • 73
    • 34047261441 scopus 로고    scopus 로고
    • Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint
    • Yoshizawa-Sugata, N. and Masai, H. Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint. J Biol Chem 2007, 282(4): 2729-40.
    • (2007) J Biol Chem , vol.282 , Issue.4 , pp. 2729-2740
    • Yoshizawa-Sugata, N.1    Masai, H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.