Cdc7 is an active kinase in human cancer cells undergoing replication stress

Journal of Biological Chemistry

Volumn 282, Issue 1, 2007, Pages 208-215

  Tenca, Pierluigi ^a   Brotherton, Deborah ^a,b   Montagnoli, Alessia ^a   Rainoldi, Sonia ^a   Albanese, Clara ^a   Santocanale, Corrado ^a  

^a Nerviano Medical Sciences Oncology ^*  (Italy)

^b Chroma Therapeutics   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL VIABILITY; EUKARYOTIC ORGANISMS; REPLICATION STRESS; RIBONUCLEOTIDE REDUCTASE INHIBITORS;

CELL DEATH; DNA; IMMUNOLOGY; NUCLEOTIDES; PHOSPHORYLATION; RNA; TUMORS;

ENZYME ACTIVITY;

CDC7 KINASE; ETOPOSIDE; GYRASE INHIBITOR; HYDROXYUREA; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 12A10; PROTEIN; PROTEIN DBT4; PROTEIN DRF1; PROTEIN KINASE; PROTEIN MCM4; REAGENT; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CDC7 PROTEIN, HUMAN; CELL CYCLE PROTEIN; DNA; MCM2 PROTEIN, HUMAN; NUCLEAR PROTEIN; PROTEIN SERINE THREONINE KINASE; RIBONUCLEOTIDE REDUCTASE;

ARTICLE; CANCER CELL; CELL DEATH; CELL STRESS; CELL VIABILITY; CHROMATIN; COMPLEX FORMATION; CONTROLLED STUDY; DNA REPLICATION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; MOLECULAR STABILITY; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; APOPTOSIS; CELL SURVIVAL; CHEMISTRY; DRUG ANTAGONISM; HELA CELL; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN BINDING; RNA INTERFERENCE;

EUKARYOTA;

APOPTOSIS; CELL CYCLE PROTEINS; CELL SURVIVAL; CHROMATIN; DNA; ETOPOSIDE; HELA CELLS; HUMANS; HYDROXYUREA; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; RIBONUCLEOTIDE REDUCTASES; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 33846956472     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M604457200     Document Type: Article

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