Identification and functional characterization of ASK/Dbf4, a novel cell survival gene in cutaneous melanoma with prognostic relevance

Carcinogenesis

Volumn 28, Issue 12, 2007, Pages 2501-2510

  Nambiar, Sandeep ^a   Mirmohammadsadegh, Alireza ^a   Hassan, Mohamed ^a   Mota, Rodrigo ^a   Marini, Alessandra ^a   Alaoui, Amine ^a   Tannapfel, Andrea ^b   Hegemann, Johannes H ^a   Hengge, Ulrich R ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACTIVATOR OF S PHASE KINASE; BROXURIDINE; CATHEPSIN B; CELL ADHESION MOLECULE; CXCL1 CHEMOKINE; CYCLIN A1; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 7; DIHYDROFOLATE REDUCTASE; INTERLEUKIN 18; KERATIN; LIPOCORTIN 5; MELANOMA ANTIGEN; MINICHROMOSOME MAINTENANCE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; NUCLEAR MATRIX PROTEIN; OLIGONUCLEOTIDE; OSTEOPONTIN; PHYCOERYTHRIN; PROTEIN KINASE; PROTEOCHONDROITIN SULFATE; RNA; SCATTER FACTOR RECEPTOR; SMALL INTERFERING RNA; STAT3 PROTEIN; TRANSCRIPTION FACTOR ELK 1; UNCLASSIFIED DRUG; VIMENTIN;

ARTICLE; CANCER CELL CULTURE; CANCER INVASION; CANCER RELAPSE; CELL ASSAY; CELL NUCLEUS; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DYSPLASTIC NEVUS; ENZYME SUBUNIT; EPIGENETICS; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC ANALYSIS; GENETIC SCREENING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MALIGNANT TRANSFORMATION; MELANOCYTE; MELANOMA; MELANOMA CELL; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; SKIN METASTASIS; TUMOR GROWTH; UPREGULATION; WESTERN BLOTTING;

CELL CYCLE PROTEINS; CELL NUCLEUS; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MELANOCYTES; MELANOMA; NEVUS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; SKIN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 36949016275     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgm197     Document Type: Article

References (23)

1. Albino,A.P. et al. (1997) Molecular biology of cutaneous malignant melanoma. In DeVita,V.T.Jr., Hellman,S. and Rosenberg,S.A. (eds) Cancer: Principles and Practice of Oncology. Lippincott-Raven, New York, pp. 1935-1946.
2. Ries,L.A.G.,Eisner,M.P. and Kosary,C.L. (eds) (2001) SEER Cancer Statistics Review, 1973-1998. National Cancer Institute, Bethesda, MD, USA.
3. Bittner,M. et al. (2000) Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature, 406 536-540.
4. Tschentscher,F. et al. (2003) Tumor classification based on gene expression profiling shows that uveal melanomas with and without monosomy 3 represent two distinct entities. Cancer Res., 3, 2578-2584.
5. Hoek,K. et al. (2004) Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas. Cancer Res., 64, 5270-5282.
6. Haqq,C. et al. (2005) The gene expression signatures of melanoma progression. Proc. Natl Acad. Sci. USA, 102, 6092-6097.
7. Saeed,A.I. et al. (2003) TM4: A free, open-source system for microarray data management and analysis. Biotechniques, 34, 374-378.
8. Mirmohammadsadegh,A. et al. (2006) STAT5 phosphorylation in malignant melanoma is important for survival and is mediated through SRC and JAK1 kinases. J. Invest. Dermatol., 126, 2272-2280.
9. Tusher,V.G. et al. (2001) Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl Acad. Sci. USA 98, 5116-5121.
10. Zhou,Y. et al. (2005) Osteopontin expression correlates with melanoma invasion. J. Invest. Dermatol., 124, 1044-1052.
11. Katagata,Y. et al. (1997) Keratin expression and its significance in five cultured melanoma cell lines derived from primary, recurrent and metastasized melanomas. FEBS Lett., 407, 25-31.
12. Sclafani,R.A. (2000) Cdc7p-Dbf4p becomes famous in the cell cycle. J. Cell Sci., 113, 2111-2117.
13. Kim,J.M. et al. (2002) Inactivation of Cdc7 kinase in mouse ES cells results in S-phase arrest and p53-dependent cell death. EMBO J. 21, 2168-2179.
14. Jackson,A.L. et al. (1993) Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein. Mol. Cell. Biol. 13, 2899-2908.
15. Yoon,H.J. et al. (1993) Regulation of Saccharomyces cerevisiae CDC7 function during the cell cycle. Mol. Biol. Cell., 4, 195-208.
16. Cheng,L. et al. (1999) Cell cycle regulation of DNA replication initiator factor Dbf4p. Mol. Cell. Biol., 19, 4270-4278.
17. Jiang,W. et al. (1999) Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication. EMBO J., 18, 5703-5713.
18. Oshiro,G. et al. (1999) Cell cycle control of Cdc7p kinase activity through regulation of Dbf4p stability. Mol. Cell. Biol., 19, 4888-4896.
19. Geisen,C. et al. (2002) The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein. J. Biol. Chem., 277, 39909-39918.
20. Geng,Y. et al. (2003) Cyclin E ablation in the mouse. Cell, 114, 431-443.
21. Bales,E. et al. (2005) The low molecular weight cyclin E isoforms augment angiogenesis and metastasis of human melanoma cells in vivo. Cancer Res., 65, 692-697.
22. Yoshizawa-Sugata,N. et al. (2005) second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases. J. Biol. Chem., 280, 13062-13070.
23. Tenca,P. et al. (2007) Cdc7 is an active kinase in human cancer cells undergoing replication stress. J. Biol. Chem., 282, 208-215.