The role of vitamin D in cancer prevention

American Journal of Public Health

Volumn 96, Issue 2, 2006, Pages 252-261

  Garland, Cedric F ^a,b   Garland, Frank C ^a,b   Gorham, Edward D ^a,b   Lipkin, Martin ^c   Newmark, Harold ^d   Mohr, Sharif B ^b   Holick, Michael F ^e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NAVAL MEDICAL CENTER SAN DIEGO   (United States)

^c STRANG CANCER PREVENTION CENTER   (United States)

^d RUTGERS UNIVERSITY   (United States)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VITAMIN D; VITAMIN D RECEPTOR;

BONE DEMINERALIZATION; BREAST CARCINOMA; CANCER INCIDENCE; CANCER PREVENTION; CANCER RISK; COLON CARCINOMA; COST BENEFIT ANALYSIS; DISEASE ASSOCIATION; DRUG OVERDOSE; GENOTYPE; HUMAN; HYPERCALCEMIA; HYPERCALCIURIA; KIDNEY CALCIFICATION; KIDNEY FAILURE; MORTALITY; OVARY CANCER; PROSTATE CARCINOMA; REVIEW; RISK REDUCTION; SKIN PIGMENTATION; UNITED STATES; VITAMIN D DEFICIENCY; VITAMIN INTAKE; VITAMIN SUPPLEMENTATION;

BREAST NEOPLASMS; COLORECTAL NEOPLASMS; CONTINENTAL POPULATION GROUPS; FEMALE; HUMANS; MALE; NEOPLASMS; PROSTATIC NEOPLASMS; UNITED STATES; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 31544459853     PISSN: 00900036     EISSN: None     Source Type: Journal    
DOI: 10.2105/AJPH.2004.045260     Document Type: Review

References (226)

1. Utiger R. The need for more vitamin D. N Engl J Med. 1998;338(12): 828-829.
2. Holick MF. Too little vitamin D in premenopausal women: why should we care? Am J Clin Nutr. 2002;76(1):3-4.
3. Compston J. Vitamin D deficiency: time for action. Evidence supports routine supplementation for elderly people and others at risk. BMJ. 1998;317(7171): 1466-1467.
4. Wharton B. Low plasma vitamin D in Asian toddlers in Britain. BMJ. 1999; 318(7175):2-3.
5. Garabedian M, Ben-Mehkbi H. Rickets and vitamin D deficiency. In: Holick M, ed. Vitamin D: Molecular Biology, Physiology, and Clinical Applications. Totowa, NJ: Humana; 1999: 273-286.
6. Holick M. Vitamin D and bone health. J Nutr. 1996;126(4 suppl): 1159S-1164S.
7. McCollum E, Simmonds N, Becker J, Shipley P. Studies on experimental rickets, XXI: an experimental demonstration of the existence of a vitamin which promotes calcium deposition. J Biol Chem. 1922;53:293-312.
8. Schwartz GG, Wang MH, Zang M, Singh RK, Siegal GP. 1 alpha,25- Dihydroxyvitamin D (calcitriol) inhibits the invasiveness of human prostate cancer cells. Cancer Epidemiol Biomarkers Prev. 1997;6(9):727-732.
9. Lipkin M, Newmark HL. Vitamin D, calcium and prevention of breast cancer: a review. J Am Coll Nutr. 1999;18 (5 suppl):392S-397S.
10. Guyton KZ, Kensler TW, Posner GH. Cancer chemoprevention using natural vitamin D and synthetic analogs. Annu Rev Pharmacol Toxicol 2001;41: 421-442.
11. Hansen CM, Binderup L, Hamberg KJ, Carlberg C. Vitamin D and cancer: effects of 1,25(OH)2D3 and its analogs on growth control and tumorigenesis. Front Biosci. 2001;6:D820-D848.
12. Garland C, Garland F. Do sunlight and vitamin D reduce the likelihood of colon cancer? Int J Epidemiol. 1980;9: 227-231.
13. Gorham E, Garland C, Garland F. Acid haze air pollution and breast and colon cancer in 20 Canadian cities. Can J Public Health. 1989;80:96-100.
14. Garland F, Garland C, Gorham E, Young J Jr. Geographic variation in breast cancer mortality in the United States: a hypothesis involving exposure to solar radiation. Prev Med. 1990;19: 614-622.
15. Lefkowitz ES, Garland CF. Sunlight, vitamin D, and ovarian cancer mortality rates in US women. Int J Epidemiol. 1994;23(6):1133-1136.
16. Schwartz GG, Hulka BS. Is vitamin D deficiency a risk factor for prostate cancer? (Hypothesis). Anticancer Res. 1990;10(5A):1307-1311.
17. Grant WB. An estimate of premature cancer mortality in the US because of inadequate doses of solar ultraviolet-B radiation. Cancer. 2002;94(6): 1867-1875.
18. Holick M. The use and interpretation of assays for vitamin D and its metabolites. Nutr. 1990;120: 1464-1469.
19. Nesby-O'Dell S, Scanlon KS, Cogswell ME, et al. Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994. Am J Clin Nutr. 2002; 76(1):187-192.
20. Looker AC, Dawson-Hughes B, Calvo MS, Gunter EW, Sahyoun NR. Serum 25-hydroxyvitamin D status of adolescents and adults in two seasonal subpopulations from NHANES III. Bone. 2002;30(5):771-777.
21. Awamey E, Hollis B, Bell N. Low serum 25-hydroxyvitamin D in blacks results from decreased production rate and not increased metabolic clearance rate [abstract]. J Bone Miner Res. 1996; 11:S165.
22. Mitra D, Bell N. Racial, geographic, genetic and body habitus effects on vitamin D metabolism. In: Feldman D, Glorieux FH, Pike JW, eds. Vitamin D. San Diego, Calif: Academic Press; 1997: 521-532.
23. Aloia JF, Mikhail M, Pagan CD, Arunachalam A, Yeh JK, Flaster E. Biochemical and hormonal variables in black and white women matched for age and weight. J Lab Clin Med. 1998; 132(5):383-389.
24. Kyriakidou-Himonas M, Aloia JF, Yeh JK. Vitamin D supplementation in postmenopausal black women. J Clin Endocrinol Metab. 1999;84(11): 3988-3990.
25. Agarwal KS, Mughal MZ, Upadhyay P, Berry JL, Mawer EB, Puliyel JM. The impact of atmospheric pollution on vitamin D status of infants and toddlers in Delhi, India. Arch Dis Child. 2002; 87(2):111-113.
26. Guillemant J, Le HT, Maria A, Allemandou A, Peres G, Guillemant S. Wintertime vitamin D deficiency in male adolescents: effect on parathyroid function and response to vitamin D3 supplements. Osteoporos Int. 2001; 12(10):875-879.
27. Juttmann J, Visser T, Buurman C. Seasonal fluctuations in serum concentrations of vitamin D metabolites in normal subjects. Br Med J. 1981;282: 1349-1352.
28. Nakamura K, Nashimoto M, Matsuyama S, Yamamoto M. Low serum concentrations of 25-hydroxyvitamin D in young adult Japanese women: a cross sectional study. Nutrition. 2001; 17(11-12):921-925.
29. Carnevale V, Modoni S, Pileri M, et al. Longitudinal evaluation of vitamin D status in healthy subjects from southern Italy: seasonal and gender differences. Osteoporos Int. 2001;12(12): 1026-1030.
30. Vieth R, Cole DE, Hawker GA, Trang HM, Rubin LA. Wintertime vitamin D insufficiency is common in young Canadian women, and their vitamin D intake does not prevent it. Eur J Clin Nutr. 2001;55(12):1091-1097.
31. Rucker D, Allan JA, Fick GH, Hanley DA. Vitamin D insufficiency in a population of healthy western Canadians. CMAJ. 2002;166(12):1517-1524.
32. Kudlacek S, Schneider B, Peterlik M, et al. Assessment of vitamin D and calcium status in healthy adult Austrians. Eur J Clin Invest. 2003;33(4):323-331.
33. Rosen CJ, Morrison A, Zhou H, et al. Elderly women in northern New England exhibit seasonal changes in bone mineral density and calciotropic hormones. Bone Miner. 1994;25(2): 83-92.
34. Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr. 2000;72(3):690-693.
35. Dawodu A, Agarwal M, Hossain M, Kochiyil J, Zayed R. Hypovitaminosis D and vitamin D deficiency in exclusively breast-feeding infants and their mothers in summer: a justification for vitamin D supplementation of breast-feeding infants. J Pediatr. 2003;142(2):169-173.
36. Arya V, Bhambri R, Godbole MM, Mithal A. Vitamin D status and its relationship with bone mineral density in healthy Asian Indians. Osteoporos Int. 2004;15(1):56-61.
37. Frederick J, Lubin D. The budget of biologically active ultraviolet radiation in the earth-atmosphere system. J Geophys Res. 1988;93:3825-3832.
38. Lubin D, Jensen E, Gies P. Global surface ultraviolet radiation climatology from TOMS and ERBE data. J Geophys Res. 1998;103(D20):26061-26091.
39. Ainsleigh HG. Beneficial effects of sun exposure on cancer mortality. Prev Med. 1993;22(1):132-140.
40. Webb AR, Kline L, Holick MF. Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab. 1988;67(2):373-378.
41. Garland C, Garland F, Gorham E. Could sunscreens increase melanoma risk? Am J Public Health. 1992;82: 614-615.
42. Garland C, Garland F, Gorham E. Lack of efficacy of common sunscreens in melanoma prevention. In: Grob J, Stern R, MacKie R, Weinstock M, eds. Epidemiology, Causes and Prevention of Skin Disease. Oxford, England: Blackwell Science; 1997:151-159.
43. Manson J, Rexrode K, Garland F, Garland C, Weinstock M. The case of a comprehensive national campaign to prevent melanoma and associated mortality. Epidemiology. 2000;11: 728-734.
44. Johnson EY, Lookingbill DF. Sunscreen use and sun exposure. Trends in a white population. Arch Dermatol. 1984;120(6):727-731.
45. Matsuoka LY, Ide L, Wortsman J, MacLaughlin JA, Holick MF. Sunscreens suppress cutaneous vitamin D3 synthesis. J Clin Endocrinol Metab. 1987;64(6): 1165-1168.
46. Matsuoka LY, Wortsman J, Hollis BW. Use of topical sunscreen for the evaluation of regional synthesis of vitamin D3. J Am Acad Dermatol. 1990; 22(5 Pt 1):772-775.
47. Matsuoka L, Wortsman J, Holick M. Chronic sunscreen use decreases the concentration of 25-hydroxyvitamin D: a preliminary study. Arch Dermatol. 1988;124:1802-1804.
48. Haddad JG Jr, Rojanasathit S. Acute administration of 25-hydroxycholecalciferol in man. J Clin Endocrinol Metab. 1976;42(2):284-290.
49. Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly. Endocrinol Rev Monogr. 2000; 22:477-501.
50. Garland C, Comstock G, Garland F, Helsing K, Shaw E, Gorham E. Serum 25-hydroxyvitamin D and colon cancer: eight-year prospective study. Lancet. 1989;2:1176-1178.
51. Tangrea J, Helzlsouer K, Pietinen P, et al. Serum levels of vitamin D metabolites and the subsequent risk of colon and rectal cancer in Finnish men. Cancer Causes Control. 1997;8(4): 615-625.
52. Feskanich D, Ma J, Fuchs CS, et al. Plasma vitamin D metabolites and risk of colorectal cancer in women. Cancer Epidemiol Biomarkers Prev. 2004;13(9): 1502-1508.
53. Holick MF, Shao Q, Liu WW, Chen TC. The vitamin D content of fortified milk and infant formula. N Engl J Med. 1992;326(18):1178-1181.
54. Jacobus CH, Holick MF, Shao Q, et al. Hypervitaminosis D associated with drinking milk. N Engl J Med. 1992; 326(18):1173-1177.
55. Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr. 1999; 69:842-856.
56. Garland C, Shekelle RB, Barrett-Connor E, Criqui MH, Rossof AH, Paul O. Dietary vitamin D and calcium and risk of colorectal cancer: a 19-year prospective study in men. Lancet. 1985; 1(8424):307-309.
57. Garland C, Garland F, Gorham E. Sunlight, sulfur dioxide and breast and colon cancer in Italy. Abstract presented at: Annual Meeting of the American Association for the Advancement of Science; February 15-20, 1990; New Orleans, La.
58. Ferraroni M, La Vecchia C, D'Avanzo B, Negri E, Franceschi S, Decarli A. Selected micronutrient intake and the risk of colorectal cancer. Br J Cancer. 1994; 70(6):1150-1155.
59. Braun MM, Helzlsouer KJ, Hollis BW, Comstock GW. Colon cancer and serum vitamin D metabolite levels 10-17 years prior to diagnosis. Am J Epidemiol. 1995;142(6):608-611.
60. Martinez ME, Giovannucci EL, Colditz GA, et al. Calcium, vitamin D, and the occurrence of colorectal cancer among women. J Natl Cancer Inst. 1996; 88(19):1375-1382.
61. Pritchard RS, Baron JA, Gerhardsson de Verdier M. Dietary calcium, vitamin D, and the risk of colorectal cancer in Stockholm, Sweden. Cancer Epidemiol Biomarkers Prev. 1996;5(11): 897-900.
62. Kearney J, Giovannucci E, Rimm EB, et al. Calcium, vitamin D, and dairy foods and the occurrence of colon cancer in men. Am J Epidemiol. 1996; 143(9):907-917.
63. La Vecchia C, Braga C, Negri E, et al. Intake of selected micronutrients and risk of colorectal cancer. Int J Cancer. 1997;73:525-530.
64. Freedman D, Dosemeci M, McGlynn K. Sunlight and mortality from breast, ovarian, colon, prostate, and nonmelanoma skin cancer: a composite death certificate based case-control study. Occup Environ Med. 2002;59: 257-262.
65. McCullough ML, Robertson AS, Rodriguez C, et al. Calcium, vitamin D, dairy products, and risk of colorectal cancer in the Cancer Prevention Study II Nutrition Cohort (United States). Cancer Causes Control. 2003;14(1): 1-12.
66. Mizoue T. Ecological studies of solar radiation and cancer mortality in Japan. Health Phys. 2004;87(5): 532-538.
67. Platz EA, Hankinson SE, Hollis BW, et al. Plasma 1,25-dihydroxy- and 25-hydroxyvitamin D and adenomatous polyps of the distal colorectum. Cancer Epidemiol Biomarkers Prev. 2000;9(10): 1059-1065.
68. Peters U, McGlynn KA, Chatterjee N, et al. Vitamin D, calcium, and vitamin D receptor polymorphism in colorectal adenomas. Cancer Epidemiol Biomarkers Prev. 2001;10(12):1267-1274.
69. Grau MV, Baron JA, Sandler RS, et al. Vitamin D, calcium supplementation, and colorectal adenomas: results of a randomized trial. J Natl Cancer Inst. 2003;95(23):1765-1771.
70. Lieberman D, Prindiville S, Weiss D, Willett W. Risk factors for advanced colonic neoplasia and hyperplastic polyps in asymptomatic individuals. JAMA. 2003;290(22):2959-2967.
71. Bostick RM, Potter JD, Sellers TA, McKenzie DR, Kushi LH, Folsom AR. Relation of calcium, vitamin D, and dairy food intake to incidence of colon cancer among older women. The Iowa Women's Health Study. Am J Epidemiol. 1993;137(12):1302-1317.
72. Zheng W, Anderson KE, Kushi LH, et al. A prospective cohort study of intake of calcium, vitamin D, and other micronutrients in relation to incidence of rectal cancer among postmenopausal women. Cancer Epidemiol Biomarkers Prev. 1998;7(3):221-225.
73. Marcus PM, Newcomb PA. The association of calcium and vitamin D, and colon and rectal cancer in Wisconsin women. Int J Epidemiol. 1998;27(5): 788-793.
74. Pritchard RS, Baron JA, Gerhardsson de Verdier M. Dietary calcium, vitamin D and the risk of colorectal cancer. Int J Cancer. 1997;73:525-530.
75. Grant WB. Ecologic studies of solar UV-B radiation and cancer mortality rates. Recent Results Cancer Res. 2003;164:371-377.
76. Peters RK, Pike MC, Garabrant D, Mack TM. Diet and colon cancer in Los Angeles County, California. Cancer Causes Control. 1992;3(5):457-473.
77. Kampman E, Giovannucci E, van 't Veer P, et al. Calcium, vitamin D, dairy foods, and the occurrence of colorectal adenomas among men and women in two prospective studies. Am J Epidemiol. 1994;139(1):16-29.
78. Jarvinen R, Knekt P, Hakulinen T, Aromaa A. Prospective study on milk products, calcium and cancers of the colon and rectum. Eur J Clin Nutr. 2001;55:1000-1007.
79. Terry P, Baron JA, Bergkvist L, Holmberg L, Wolk A. Dietary calcium and vitamin D intake and risk of colorectal cancer: a prospective cohort study in women. Nutr Cancer. 2002;43(1): 39-46.
80. Robsahm TE, Tretli S, Dahlback A, Moan J. Vitamin D3 from sunlight may improve the prognosis of breast-, colon- and prostate cancer (Norway). Cancer Causes Control. 2004;15(2):149-158.
81. Gorham ED, Garland FC, Garland CF. Sunlight and breast cancer incidence in the USSR. Int J Epidemiol. 1990;19(4):820-824.
82. Janowsky EC, Lester GE, Weinberg CR, et al. Association between low levels of 1,25-dihydroxyvitamin D and breast cancer risk. Public Health Nutr. 1999;2(3):283-291.
83. Grant WB. An ecologic study of dietary and solar ultraviolet-B links to breast carcinoma mortality rates. Cancer. 2002;94(1):272-281.
84. Shin MH, Holmes MD, Hankinson SE, Wu K, Colditz GA, Willett WC. Intake of dairy products, calcium, and vitamin D and risk of breast cancer. J Natl Cancer Inst. 2002;94(17):1301-1311.
85. John E, Schwartz G, Dreon D, Koo J. Vitamin D and breast cancer risk: the NHANES I epidemiologic follow-up study, 1971-1975 to 1992. Cancer Epidemiol Biomarkers Prev. 1999;8: 399-406.
86. Hiatt R, Krieger N, Lobaugh B, Drezner M, Vogelman J, Orentreich N. Prediagnostic serum vitamin D and breast cancer. J Natl Cancer Inst. 1998; 90(6):461-463.
87. Manchette CL, Schwartz GG. Geographic patterns of prostate cancer mortality. Evidence for a protective effect of ultraviolet radiation. Cancer. 1992; 70(12):2861-2869.
88. Corder EH, Guess HA, Hulka BS, et al. Vitamin D and prostate cancer: a prediagnostic study with stored sera. Cancer Epidemiol Biomarkers Prev. 1993;2(5):467-472.
89. Schwartz GG. Geographic trends in prostate cancer mortality: an application of spatial smoothers and the need for adjustment. Ann Epidemiol. 1997; 7(6):430.
90. Ahonen MH, Tenkanen L, Teppo L, Hakama M, Tuohimaa P. Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels (Finland). Cancer Causes Control. 2000;11(9): 847-852.
91. Tuohimaa P, Lyakhovich A, Aksenov N, et al. Vitamin D and prostate cancer. J Steroid Biochem Mol Biol. 2001;76(1-5):125-134.
92. Luscombe CJ, Fryer AA, French ME, et al. Exposure to ultraviolet radiation: association with susceptibility and age at presentation with prostate cancer. Lancet. 2001;358(9282):641-642.
93. Grant WB. A multicountry ecologic study of risk and risk reduction factors for prostate cancer mortality. Eur Urol. 2004;45(3):271-279.
94. Grant WB. Geographic variation of prostate cancer mortality rates in the United States: implications for prostate cancer risk related to vitamin D. Int J Cancer. 2004;111(3):470-471.
95. John EM, Dreon DM, Koo J, Schwartz GG. Residential sunlight exposure is associated with a decreased risk of prostate cancer. J Steroid Biochem Mol Biol. 2004;89-90(1-5):549-552.
96. Nomura AM, Stemmermann GN, Lee J, et al. Serum vitamin D metabolite levels and the subsequent development of prostate cancer (Hawaii, United States). Cancer Causes Control. 1998;9: 425-432.
97. Braun MM, Helzlsouer KJ, Hollis BW, Comstock GW. Prostate cancer and prediagnostic levels of serum vitamin D metabolites (Maryland, United States). Cancer Causes Control. 1995;6(3): 235-239.
98. Gann P, Ma J, Hennekens C, et al. Circulating vitamin D metabolites in relation to subsequent development of prostate cancer. Cancer Epidemiol Biomarkers Prev. 1996;5(2):121-126.
99. Andersson SO, Wolk A, Bergstrom R, et al. Energy, nutrient intake and prostate cancer risk: a population-based case-control study in Sweden. Int J Cancer. 1996;68(6):716-722.
100. Giovannucci E, Rimm EB, Wolk A, et al. Calcium and fructose intake in relation to risk of prostate cancer. Cancer Res. 1998;58(3):442-447.
101. Chan JM, Giovannucci E, Andersson SO, Yuen J, Adami HO, Wolk A. Dairy products, calcium, phosphorous, vitamin D, and risk of prostate cancer (Sweden). Cancer Causes Control. 1998;9(6): 559-566.
102. Chan JM, Pietinen P, Virtanen M, et al. Diet and prostate cancer risk in a cohort of smokers, with a specific focus on calcium and phosphorus (Finland). Cancer Causes Control. 2000;11(9): 859-867.
103. Platz EA, Leitzmann MF, Hollis BW, Willett WC, Giovannucci E. Plasma 1,25-dihydroxy- and 25-hydroxyvitamin D and subsequent risk of prostate cancer. Cancer Causes Control. 2004;15(3): 255-265.
104. Kristal AR, Cohen JH, Qu P, Stanford JL. Associations of energy, fat, calcium, and vitamin D with prostate cancer risk. Cancer Epidemiol Biomarkers Prev. 2002;11(8):719-725.
105. Rodriguez C, McCullough ML, Mondul AM, et al. Calcium, dairy products, and risk of prostate cancer in a prospective cohort of United States men. Cancer Epidemiol Biomarkers Prev. 2003;12(7):597-603.
106. Tuohimaa P, Tenkanen L, Ahonen M, et al. Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries. Int J Cancer. 2004; 108(1):104-108.
107. Salazar-Martinez E, Lazcano-Ponce EC, Gonzalez Lira-Lira G, Escudero-De los Rios P, Hernandez-Avila M. Nutritional determinants of epithelial ovarian cancer risk: a case-control study in Mexico. Oncology. 2002;63(2):151-157.
108. Luscombe CJ, French ME, Liu S, et al. Prostate cancer risk: associations with ultraviolet radiation, tyrosinase and melanocortin-1 receptor genotypes. Br J Cancer. 2001;85(10):1504-1509.
109. Luscombe CJ, French ME, Liu S, et al. Outcome in prostate cancer associations with skin type and polymorphism in pigmentation-related genes. Carcinogenesis. 2001;22(9):1343-1347.
110. Nomura A, Stemmermann G, Lee J, et al. Serum vitamin D metabolite levels and the subsequent development of prostate cancer. Cancer Causes Control. 1998;9:425-432.
111. Egaas E, Lambertsen G. Naturally occurring vitamin D3 in fish products analysed by HPLC, using vitamin D2 as an international standard. Int J Vitam Nutr Res. 1979;49(1):35-42.
112. US Dept of Agriculture. USDA National Nutrient Database for Standard Reference, Release 17. Available at: http://www.nal.usda.gov/fnic/foodcomp/Data/ SR17/wtrank/wt_rank.html. Accessed July 10, 2005.
113. Caygill CP, Hill MJ. Fish, n-3 fatty acids and human colorectal and breast cancer mortality. Eur J Cancer Prev. 1995;4(4):329-332.
114. Caygill CP, Charlett A, Hill MJ. Fat, fish, fish oil and cancer. Br J Cancer. 1996;74(1):159-164.
115. Kaizer L, Boyd NF, Kriukov V, Tritchler D. Fish consumption and breast cancer risk: an ecological study. Nutr Cancer. 1989;12(1):61-68.
116. Augustsson K, Michaud DS, Rimm EB, et al. A prospective study of intake of fish and marine fatty acids and prostate cancer. Cancer Epidemiol Biomarkers Prev. 2003;12(1):64-67.
117. Terry P, Lichtenstein P, Feychting M, Ahlbom A, Wolk A. Fatty fish consumption and risk of prostate cancer. Lancet. 2001;357(9270):1764-1766.
118. Slattery ML, Schumacher MC, Smith KR, West DW, Abd-Elghany N. Physical activity, diet and risk of colon cancer in Utah. Am J Epidemiol. 1988; 128(5):989-999.
119. Colbert LH, Hartman TJ, Malila N, et al. Physical activity in relation to cancer of the colon and rectum in a cohort of male smokers. Cancer Epidemiol Biomarkers Prev. 2001;10(3):265-268.
120. Fredriksson M, Bengtsson NO, Hardell L, Axelson O. Colon cancer, physical activity, and occupational exposures. A case-control study. Cancer. 1989;63(9):1838-1842.
121. Gorham E, Garland C, Garland F. Physical activity and colon cancer risk. Int J Epidemiol. 1989;18:728-729.
122. Yeh JK, Aloia JF. Effect of physical activity on calciotropic hormones and calcium balance in rats. Am J Physiol. 1990;258(2 Pt 1):E263-E268.
123. Chesney RW, Rosen JF, Hamstra AJ, Smith C, Mahaffey K, DeLuca HF. Absence of seasonal variation in serum concentrations of 1,25-dihydroxyvitamin D despite a rise in 25-hydroxyvitamin D in summer. J Clin Endocrinol Metab. 1981;53(1):139-142.
124. Overgaard K, Nilas L, Johansen JS, Christiansen C. Lack of seasonal variation in bone mass and biochemical estimates of bone turnover. Bone. 1988; 9(5):285-288.
125. Bouillon RA, Auwerx JH, Lissens WD, Pelemans WK. Vitamin D status in the elderly: seasonal substrate deficiency causes 1,25-dihydroxycholecalciferol deficiency. Am J Clin Nutr. 1987; 45(4):755-763.
126. Kristal-Boneh E, Froom P, Harari G, Ribak J. Seasonal changes in calcitropic hormones in Israeli men. Eur J Epidemiol. 1999;15(3):237-244.
127. 3 in cities around the world. In: Holick M, Kligman A, eds. Biologic Effects of Light. New York, NY: Walter de Gruyter; 1992:48-52.
128. Punnonen R, Gillespy M, Hahl M, et al. Serum 25-OHD, vitamin A and vitamin E concentrations in healthy Finnish and Floridian women. Int J Vitam Nutr Res. 1988;58:37-39.
129. Oliveri MB, Ladizesky M, Somoza J, Martinez L, Mautalen C. Winter serum levels of 25-hydroxy-vitamin D in Ushuaia and Buenos Aires. Medicina (B Aires). 1990;50(4):310-314.
130. McKenna MJ. Differences in vitamin D status between countries in young adults and the elderly. Am J Med. 1992;93(1):69-77.
131. Sturgeon SR, Schairer C, Gail M, McAdams M, Brinton LA, Hoover RN. Geographic variation in mortality from breast cancer among white women in the United States. J Natl Cancer Inst. 1995;87(24):1846-1853.
132. Prehn AW, West DW. Evaluating local differences in breast cancer incidence rates: a census-based methodology (United States). Cancer Causes Control. 1998;9(5):511-517.
133. Adams J, Clemens T, Parrish J, Holick M. Vitamin D synthesis and metabolism after ultraviolet irradiation of normal and vitamin-D-deficient subjects. N Engl J Med. 1982;306:722-725.
134. Holick M. Photosynthesis of vitamin D in the skin: effect of environment and life-style variables. Fed Proc. 1987; 46:1876-1882.
135. Webb A, Pilbeam C, Hanofin N, Holick M. An evaluation of the relative contributions of exposure to sunlight and of diet to the circulating concentrations of 25-hydroxyvitamin D in an elderly nursing home population in Boston. Am J Clin Nutr. 1990;51: 1075-1081.
136. Wecksler WR, Mason RS, Norman AW. Specific cytosol receptors for 1,25-dihydroxyvitamin D3 in human intestine. J Clin Endocrinol Metab. 1979; 48(4):715-717.
137. Delvin EE, Lopez V, Levy E, Menard D. Developmental expression of calcitriol receptors, 9-kilodalton calcium-binding protein, and calcidiol 24-hydroxylase in human intestine. Pediatr Res. 1996;40(5):664-670.
138. Huerta S, Irwin RW, Heber D, et al. 1alpha,25-(OH)(2)-D(3) and its synthetic analogue decrease tumor load in the Apc(min) mouse. Cancer Res. 2002; 62(3):741-746.
139. Eisman JA, Martin TJ, MacIntyre I, Moseley JM. 1,25-dihydroxyvitamin-D- receptor in breast cancer cells. Lancet. 1979;2(8156-8157):1335-1336.
140. Colston K, Berger U, Wilson P, et al. Mammary gland 1,25-dihydroxyvitamin D3 receptor content during pregnancy and lactation. Mol Cell Endocrinol. 1988;60:15-22.
141. Miller GJ, Stapleton GE, Hedlund TE, Moffat KA. Vitamin D receptor expression, 24-hydroxylase activity, and inhibition of growth by 1alpha,25-dihydroxyvitamin D3 in seven human prostatic carcinoma cell lines. Clin Cancer Res. 1995;1(9):997-1003.
142. Holick M. Noncalcemic actions of 1,25-dihydroxyvitamin D3 and clinical applications. Bone. 1995;17(2 suppl): 107S-111S.
143. Tangpricha V, Pearce EN, Chen TC, Holick MF. Vitamin D insufficiency among free-living healthy young adults. Am J Med. 2002;112(8):659-662.
144. Schwartz GG, Whitlatch LW, Chen TC, Lokeshwar BL, Holick MF. Human prostate cells synthesize 1,25-dihydroxyvitamin D3 from 25-hydroxyvitamin D3. Cancer Epidemiol Biomarkers Prev. 1998;7(5):391-395.
145. Welsh J. Vitamin D and breast cancer: insights from animal models. Am J Clin Nutr. 2004;80(6 suppl): 1721S-1724S.
146. Zehnder D, Bland R, Williams MC, et al. Extrarenal expression of 25-hydroxyvitamin d(3)-1alpha-hydroxylase. J Clin Endocrinol Metab. 2001;86(2): 888-894.
147. Matsuoka LY, Wortsman J, Chen TC, Holick MF. Compensation for the interracial variance in the cutaneous synthesis of vitamin D. J Lab Clin Med. 1995; 126(5):452-457.
148. Harris S, Dawson-Hughes B. Seasonal changes in plasma 25-hydroxyvitamin D concentrations of young American black and white women. Am J Clin Nutr. 1998;67(6):1232-1236.
149. Harris SS, Soteriades E, Coolidge JA, Mudgal S, Dawson-Hughes B. Vitamin D insufficiency and hyperparathyroidism in a low income, multiracial, elderly population. J Clin Endocrinol Metab. 2000;85(11):4125-4130.
150. Bell NH, Morrison NA, Nguyen TV, Eisman J, Hollis BW. Apal polymorphisms of the vitamin D receptor predict bone density of the lumbar spine and not racial difference in bone density in young men. J Lab Clin Med. 2001;137(2):133-140.
151. Centers for Disease Control and Prevention. WONDER database. Available at: http//:wonder.cdc.gov. Accessed June 2004.
152. Cooper GS, Yuan Z, Rimm AA. Racial disparity in the incidence and case-fatality of colorectal cancer: analysis of 329 United States counties. Cancer Epidemiol Biomarkers Prev. 1997; 6(4):283-285.
153. Chen VW, Fenoglio-Preiser CM, Wu XC, et al. Aggressiveness of colon carcinoma in blacks and whites. National Cancer Institute Black/White Cancer Survival Study Group. Cancer Epidemiol Biomarkers Prev. 1997;6(12): 1087-1093.
154. Clegg LX, Li FP, Hankey BF, Chu K, Edwards BK. Cancer survival among US whites and minorities: a SEER (Surveillance, Epidemiology, and End Results) Program population-based study. Arch Intern Med. 2002;162(17):1985-1993.
155. McGuire V, Herrinton L, Whittemore AS. Race, epithelial ovarian cancer survival, and membership in a large health maintenance organization. Epidemiology. 2002;13(2):231-234.
156. National Cancer Institute. Surveillance, Epidemiology, and End Results Program (SEER) Web site (data for 1992-2001). Available at: http://seer.cancer. gov. Accessed August 12, 2005.
157. Henson DE, Chu KC, Levine PH. Histologic grade, stage, and survival in breast carcinoma: comparison of African American and Caucasian women. Cancer. 2003;98(5):908-917.
158. Schwartz KL, Crossley-May H, Vigneau FD, Brown K, Banerjee M. Race, socioeconomic status and stage at diagnosis for five common malignancies. Cancer Causes Control. 2003;14(8): 761-766.
159. Gargiulo P, Wingo P, Coates R, Thompson T. Recent trends in mortality rates for four major cancers by sex race and ethnicity-United States, 1990-1998. MMWK Morb Mortal Wkly Rep. 2002; 51(3):49-53.
160. Blackman D, Bennett E, Miller D. Trends in self-reported use of mammography (1989-1997) and Papanicolaou tests (1991-1997)-Behavioral Risk Factor Surveillance System. MMWR CDC Surveill Summ. 1999;48(6):1-22.
161. Zmuda JM, Cauley JA, Ferrell RE. Molecular epidemiology of vitamin D receptor gene variants. Epidemiol Rev. 2000;22(2):203-217.
162. Ma J, Stampfer MJ, Gann PH, et al. Vitamin D receptor polymorphisms, circulating vitamin D metabolites, and risk of prostate cancer in United States physicians. Cancer Epidemiol Biomarkers Prev. 1998;7(5):385-390.
163. Slatter ML, Yakumo K, Hoffman M, Neuhausen S. Variants of the VDR gene and risk of colon cancer (united States). Cancer Causes Control. 2001;12(4): 359-364.
164. Oh JY, Barrett-Connor E. Association between vitamin D receptor polymorphism and type 2 diabetes or metabolic syndrome in community-dwelling older adults: the Rancho Bernardo Study. Metabolism. 2002;51(3): 356-359.
165. Habuchi T, Suzuki T, Sasaki R, et al. Association of vitamin D receptor gene polymorphism with prostate cancer and benign prostatic hyperplasia in a Japanese population. Cancer Res. 2000;60(2):305-308.
166. Bretherton-Watt D, Given-Wilson R, Mansi JL, Thomas V, Carter N, Colston KW. Vitamin D receptor gene polymorphisms are associated with breast cancer risk in a UK Caucasian population. Br J Cancer. 2001;85(2):171-175.
167. Guy M, Lowe LC, Bretherton-Watt D, Mansi JL, Colston KW. Approaches to evaluating the association of vitamin D receptor gene polymorphisms with breast cancer risk. Recent Results Cancer Res. 2003;164:43-54.
168. Ingles SA, Garcia DG, Wang W, et al. Vitamin D receptor genotype and breast cancer in Latinas (United States). Cancer Causes Control. 2000;11(1): 25-30.
169. Ruggiero M, Pacini S, Aterini S, Fallai C, Ruggiero C, Pacini P. Vitamin D receptor gene polymorphism is associated with metastatic breast cancer. Oncol Res. 1998;10(1):43-46.
170. Hamasaki T, Inatomi H, Katoh T, Ikuyama T, Matsumoto T. Clinical and pathological significance of vitamin D receptor gene polymorphism for prostate cancer which is associated with a higher mortality in Japanese. Endocr J. 2001; 48(5):543-549.
171. Kibel AS, Isaacs SD, Isaacs WB, Bova GS. Vitamin D receptor polymorphisms and lethal prostate cancer. J Urol. 1998;160(4):1405-1409.
172. Blazer DG 3rd, Umbach DM, Bostick RM, Taylor JA. Vitamin D receptor polymorphisms and prostate cancer. Mol Carcinog. 2000;27(1):18-23.
173. Lundin AC, Soderkvist P, Eriksson B, Bergman-Jungestrom M, Wingren S. Association of breast cancer progression with a vitamin D receptor gene polymorphism. South-East Sweden Breast Cancer Group. Cancer Res. 1999;59(10): 2332-2334.
174. Rees GS, Symes EK, Nicholl CG, Legon S, Chapman RS. Lack of correlation of free deoxypyridinoline excretion with Taq1 restriction length polymorphisms in the vitamin D receptor gene in males. Clin Chim Acta. 1998;272(2): 149-157.
175. Lipkin M, Newmark H. Effect of added dietary calcium on colonic epithelial cell proliferation in subjects at high risk for familial colon cancer. N Engl J Med. 1985;313:1381-1384.
176. Brenner B, Russell N, Albrecht S, Davies R. The effect of dietary vitamin D3 on the intracellular calcium gradient in mammalian colonic crypts. Cancer Lett. 1998;12(7):43-53.
177. Lamprecht SA, Lipkin M. Migrating colonic crypt epithelial cells: primary targets for transformation. Carcinogenesis. 2002;23(11):1777-1780.
178. Benito E, Obrador A, Stiggelbout A, et al. A population-based case-control study of colorectal cancer in Majorca, I: dietary factors. Int J Cancer. 1990;45(1): 69-76.
179. Mawer E, Walls J, Howell A, Davies M, Ratcliffe W, Bundred N. Serum 1,25-dihydroxyvitamin D may be related inversely to disease activity in breast cancer patients with bone metastases. J Clin Endocrinol Metab. 1997;82:118-122.
180. Newmark HL. Vitamin D adequacy: a possible relationship to breast cancer. Adv Exp Med Biol. 1994;364: 109-114.
181. Carroll KK, Jacobson EA, Eckel LA, Newmark HL. Calcium and carcinogenesis of the mammary gland. Am J Clin Nutr. 1991;54(1 suppl): 206S-208S.
182. Iseki K, Tatsuta M, Uehara H, et al. Inhibition of angiogenesis as a mechanism for inhibition by 1 alpha-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 of colon carcinogenesis induced by azoxymethane in Wistar rats. Int J Cancer. 1999;81(5):730-733.
183. Majewski S, Skopinska M, Marczak M, Szmurlo A, Bollag W, Jablonska S. Vitamin D3 is a potent inhibitor of tumor cell-induced angiogenesis. J Investig Dermatol Symp Proc. 1996;1(1): 97-101.
184. Shokravi MT, Marcus DM, Alroy J, Egan K, Saornil MA, Albert DM. Vitamin D inhibits angiogenesis in transgenic murine retinoblastoma. Invest Ophthalmal Vis Sci. 1995;36(1):83-87.
185. Mantell DJ, Owens PE, Bundred NJ, Mawer EB, Canfield AE. 1 alpha,25-dihydroxyvitamin D(3) inhibits angiogenesis in vitro and in vivo. Circ Res. 2000;87(3):214-220.
186. Palmer HG, Gonzalez-Sancho JM, Espada J, et al. Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling. J Cell Biol. 2001;154(2):369-387.
187. Fujioka T, Suzuki Y, Okamoto T, Mastushita N, Hasegawa M, Omori S. Prevention of renal cell carcinoma by active vitamin D3. World J Surg. 2000; 24(10):1205-1210.
188. Lipkin M, Newmark H. Effect of added dietary calcium on colonic epithelial-cell proliferation in subjects at high risk for familial colonic cancer. N Engl J Med. 1985;313(22):1381-1384.
189. Holt P, Arber N, Halmos B, et al. Colonic epithelial cell proliferation decreases with increasing levels of serum 25-hydroxy vitamin D. Cancer Epidemiol Biomarkers Prev. 2002;11(1):113-119.
190. Campbell MJ, Reddy GS, Koeffler HP. Vitamin D3 analogs and their 24-oxo metabolites equally inhibit clonal proliferation of a variety of cancer cells but have differing molecular effects. J Cell Biochem. 1997;66(3):413-425.
191. Mathiasen IS, Sergeev IN, Bastholm L, Elling F, Norman AW, Jaattela M. Calcium and calpain as key mediators of apoptosis-like death induced by vitamin D compounds in breast cancer cells. J Biol Chem. 2002;277(34):30738-30745.
192. National Academy of Sciences, Institute of Medicine, Food and Nutrition Board. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press; 1997.
193. Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr. 2003; 77(1):204-210.
194. Malabanan A, Veronikis IE, Holick MF. Redefining vitamin D insufficiency. Lancet. 1998;351(9105):805-806.
195. Ebeling P, Sandgren M, Lane A, DeLuca H, Riggs B. Evidence of an age-related decrease in intestinal responsiveness to vitamin D: relationship between serum 1,25-dihydroxyvitamin D3 and intestinal vitamin D receptor concentrations in normal women. J Clin Endocrinol Metab. 1992;75:176-182.
196. Stamp TC, Haddad JG, Twigg CA. Comparison of oral 25- hydroxycholecalciferol, vitamin D, and ultraviolet light as determinants of circulating 25-hydroxyvitamin D. Lancet. 1977; 1(8026):1341-1343.
197. Vieth R. Why the optimal requirement for Vitamin D3 is probably much higher than what is officially recommended for adults. J Steroid Biochem Mol Biol. 2004;20:575-579.
198. Vieth R, Chan PC, MacFarlane GD. Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level. Am J Clin Nutr. 2001;73(2): 288-294.
199. Lowe L, Hansen CM, Senaratne S, Colston KW. Mechanisms implicated in the growth regulatory effects of vitamin D compounds in breast cancer cells. Recent Results Cancer Res. 2003; 164:99-110.
200. Matsuoka LY, Wortsman J, Haddad JG, Hollis BW. In vivo threshold for cutaneous synthesis of vitamin D3. J Lab Clin Med. 1989;114(3):301-305.
201. Bowman K. A global climatology of total ozone from the Nimbus-7 total ozone mapping spectrometer. In: Zerefos CS, Ghazi A, eds. Atmospheric Ozone: Proceedings of a Quadrennial Symposium Held in Halkidiki, Greece, 3-7 September 1984. Boston, Mass: Kluwer Academic Publishers; 1985:363-367.
202. Waggoner A, Vanderpool A, Charlson R, et al. Sulfate light scattering as an index of the role of sulfur in tropospheric optics. Nature. 1976;261: 120-122.
203. Garland C, Garland F, Gorham E. Epidemiology of cancer risk and vitamin D. In: Holick M, ed. Vitamin D: Molecular Biology, Physiology, and Clinical Applications. Totowa, NJ: Humana; 1999:375-409.
204. Webb A, DeCosta B, Holick M. Sunlight regulates the cutaneous production of vitamin D3 by causing its photodegradation. J Clin Endocrinol Metab. 1989;68:882-887.
205. Fitzpatrick TB. The validity and practicality of sun-reactive skin types I through VI. Arch Dermatol. 1988; 124(6):869-871.
206. Chen T. Photobiology of vitamin D. In: Holick M, ed. Vitamin D: Molecular Biology, Physiology, and Clinical Applications. Totowa, NJ: Humana; 1999: 17-37.
207. Chapuy MC, Preziosi P, Maamer M, et al. Prevalence of vitamin D insufficiency in an adult normal population. Osteoporos Int. 1997;7(5):439-443.
208. Dawson-Hughes B, Harris S, Krall E, Dallal G. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. New Engl J Med. 1997;337: 670-676.
209. Holick MF. Vitamin D requirements for humans of all ages: new increased requirements for women and men 50 years and older. Osteoporos Int. 1998;8(8):S24-S29.
210. Davies M, Adams PH. The continuing risk of vitamin-D intoxication. Lancet. 1978;2(8090):621-623.
211. Curhan GC, Willett WC, Rimm EB, Stampfer MJ. A prospective study of dietary calcium and other nutrients and the risk of symptomatic kidney stones. N Engl J Med. 1993;328(12):833-838.
212. Muray S, Parisi E, Cardus A, Craver L, Fernandez E. Influence of vitamin D receptor gene polymorphisms and 25-hydroxyvitamin D on blood pressure in apparently healthy subjects. J Hypertens. 2003;21(11):2069-2075.
213. Sowers MF, Wallace RB, Hollis BW, Lemke JH. Relationship between 1,25-dihydroxyvitamin D and blood pressure in a geographically defined population. Am J Clin Nutr. 1988;48(4): 1053-1056.
214. Lind L, Hanni A, Lithell H, Hvarfner A, Sorensen OH, Ljunghall S. Vitamin D is related to blood pressure and other cardiovascular risk factors in middle-aged men. Am J Hypertens. 1995; 8(9):894-901.
215. Sowers MR, Wallace RB, Lemke JH. The association of intakes of vitamin D and calcium with blood pressure among women. Am J Clin Nutr. 1985; 42(1):135-142.
216. Scragg R, Jackson R, Holdaway I, Lim T, Beaglehole R. Myocardial infarction is inversely associated with plasma 25-hydroxyvitamin D3 levels: a community-based study. Int J Epidemiol. 1990;19(3):559-563.
217. Bostick RM, Kushi LH, Wu Y, Meyer KA, Sellers TA, Folsom AR. Relation of calcium, vitamin D, and dairy food intake to ischemic heart disease mortality among postmenopausal women. Am J Epidemiol. 1999;149(2): 151-161.
218. Zittermann A, Schleithoff SS, Tenderich G, Berthold HK, Korfer R, Stehle P. Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure? J Am Coll Cardiol 2003;41(1):105-112.
219. Vik T, Try K, Thelle D, Førde O. Tromsø Heart Study: vitamin D metabolism and myocardial infarction. Br Med J. 1979;21:176.
220. Rajasree S, Rajpal K, Karma CC, et al. Serum 25-hydroxyvitamin D3 levels are elevated in South Indian patients with ischemic heart disease. Eur J Epidemiol. 2001;17(6):567-571.
221. Hypponen E, Laara E, Reunanen A, Jarvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet. 2001; 358(9292):1500-1503.
222. Stene LC, Joner G. Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: a large, population-based, case-control study. Am J Clin Nutr. 2003;78(6):1128-1134.
223. Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr. 2004;79(5): 820-825.
224. Borissova AM, Tankova T, Kirilov G, Dakovska L, Kovacheva R. The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients. Int J Clin Pract. 2003; 57(4):258-261.
225. Trang HM, Cole DE, Rubin LA, Pierratos A, Siu S, Vieth R. Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2. Am J Clin Nutr. 1998; 68(4);854-858.
226. Lilliu H, Pamphile R, Chapuy MC, Schulten J, Allot M, Meunier PJ. Calcium-vitamin D3 supplementation is cost-effective in hip fractures prevention. Maturitas. 2003;44(4):299-305.