Single 23S rRNA mutations at the ribosomal peptidyl transferase centre confer resistance to valnemulin and other antibiotics in Mycobacterium smegmatis by perturbation of the drug binding pocket

Molecular Microbiology

Volumn 71, Issue 5, 2009, Pages 1218-1227

  Long, Katherine S ^a   Poehlsgaard, Jacob ^b   Hansen, Lykke H ^b   Hobbie, Sven N ^c   Böttger, Erik C ^c   Vester, Birte ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; PEPTIDYLTRANSFERASE; PLEUROMUTILIN; RIBOSOME RNA; RNA 23S; TIAMULIN; UNCLASSIFIED DRUG; VALNEMULIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL MUTATION; DRUG BINDING SITE; MYCOBACTERIUM SMEGMATIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OPERON; PRIORITY JOURNAL; RIBOSOME;

ANTI-BACTERIAL AGENTS; BINDING SITES; DITERPENES; DRUG RESISTANCE, BACTERIAL; MICROBIAL SENSITIVITY TESTS; MUTATION; MYCOBACTERIUM SMEGMATIS; PEPTIDYL TRANSFERASES; RNA, BACTERIAL; RNA, RIBOSOMAL, 23S; RRNA OPERON;

BACTERIA (MICROORGANISMS); BRACHYSPIRA; ESCHERICHIA COLI; MYCOBACTERIUM SMEGMATIS;

EID: 60649086618     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2009.06596.x     Document Type: Article

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