Serotonin and cocaine-sensitive inactivation of human serotonin transporters by methanethiosulfonates targeted to transmembrane domain I

Journal of Biological Chemistry

Volumn 278, Issue 39, 2003, Pages 37052-37063

  Henry, L Keith ^b   Adkins, Erika M ^b   Han, Qiao ^b   Blakely, Randy D ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; MUTAGENESIS; SENSITIVITY ANALYSIS; TRANSPORT PROPERTIES;

CONFORMATIONAL CHANGES;

BIOCHEMISTRY;

[2 (TRIMETHYLAMMONIUM)ETHYL]METHANETHIOSULFONATE BROMIDE; AMINOETHYLMETHANETHIOSULFONATE; ASPARTIC ACID; COCAINE; COCAINE DERIVATIVE; CYSTEINE; GLYCINE; ISOLEUCINE; MESYLIC ACID DERIVATIVE; METHANETHIOSULFONATE DERIVATIVE; MUTANT PROTEIN; REAGENT; SEROTONIN; SEROTONIN TRANSPORTER; SODIUM (2 SULFONATOETHYL)METHANETHIOSULFONATE; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AQUEOUS SOLUTION; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOPLASM; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; LOW TEMPERATURE; MEMBRANE TRANSPORT; MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN TARGETING; ROOM TEMPERATURE; SEROTONIN UPTAKE; TRANSMEMBRANE DOMAIN I;

COCAINE; HELA CELLS; HUMANS; IMMUNOBLOTTING; MESYLATES; RECEPTORS, SEROTONIN; SEROTONIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0141844649     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M305514200     Document Type: Article

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