Dynamin-related protein 1 mediates high glucose induced pancreatic beta cell apoptosis

International Journal of Biochemistry and Cell Biology

Volumn 41, Issue 4, 2009, Pages 879-890

  Men, Xiuli ^a   Wang, Haiyan ^b   Li, Mi ^c   Cai, Hanqing ^a   Xu, Shiqin ^a   Zhang, Wenjian ^a   Xu, Yaping ^a   Ye, Liya ^a   Yang, Wenying ^a   Wollheim, Claes B ^b   Lou, Jinning ^a  

^a CHINA JAPAN FRIENDSHIP HOSPITAL   (China)

^b UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^c SUN YAT SEN UNIVERSITY   (China)

Author keywords

Apoptosis; Beta cell dysfunction; Dynamin related protein 1; Glucotoxicity; Mitochondrial fission

Indexed keywords

CASPASE 3; CYTOCHROME C; DYNAMIN RELATED PROTEIN 1; GUANINE NUCLEOTIDE BINDING PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL LINE; CONTROLLED STUDY; ENZYME ACTIVATION; HYPERGLYCEMIA; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MUTANT; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; WILD TYPE;

ANIMALS; APOPTOSIS; CASPASE 3; CELL LINE; CYTOCHROMES C; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; GLUCOSE; GTP PHOSPHOHYDROLASES; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INSULIN-SECRETING CELLS; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIAL PROTEINS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 59649130026     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2008.08.031     Document Type: Article

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