Accelerated loss of islet β cells in sucrose-fed Goto-Kakizaki rats, a genetic model of non-insulin-dependent diabetes mellitus

American Journal of Pathology

Volumn 153, Issue 2, 1998, Pages 537-545

  Koyama, Motoi ^a   Wada, Ryu Ichi ^a   Sakuraba, Hiroyasu ^a   Mizukami, Hiroki ^a   Yagihashi, Soroku ^a  

^a HIROSAKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; BROXURIDINE; DNA; GLUCOSE; PROTEIN BCL 2; SUCROSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DENSITY; CELL LOSS; CELL PROLIFERATION; CELL VOLUME; CONTROLLED STUDY; CYSTIC FIBROSIS; DNA DAMAGE; FEEDING; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0031857392     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65596-4     Document Type: Article

References (35)

1. Weir GC, Leahy JL: Pathogenesis of non-insulin-dependent (type II) diabetes mellitus. Joslin's Diabetes Mellitus, ed 13. Edited by CR Kahn, GC Weir. Philadelphia, Lea & Febiger, 1994, pp 240-263
2. Cooppan R: General approach to the treatment of diabetes. Joslin's Diabetes Mellitus, ed 13. Edited by CR Kahn, GC Weir. Philadelphia, Lea & Febiger, 1994, pp 397-403
3. Clark A, Wells CA, Buley ID, Cruickshank JK, Vanhegan RI, Matthews DR, Cooper GJS, Holman RR, Turner RC: Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes. Diabetes Res 1988, 9:151-159
4. Saito K, Yaginuma N, Takahashi T: Differential volumetry of A, B and D cells in the pancreatic islets of diabetic and nondiabetic subjects. Tohoku J Exp Med 1979, 129:273-283
5. Rahier J, Goebbels RM, Henquin JC: Cellular composition of the human diabetes pancreas. Diabetologia 1983, 24:366-371
6. Stefan Y, Orci L, Malaisse-Lagae F, Perrelet A, Patel Y, Unger RH: Quantitation of endocrine cell content in the pancreas of nondiabetic and diabetic humans. Diabetes 1982, 31:694-699
7. John LL: Natural history of β-cell dysfunction in NIDDM. Diabetes Care 1990, 13:992-1010
8. Goto Y, Suzuki K, Sasaki M, Ono T, Abe S: GK rat as a model of nonobese, noninsulin-dependent diabetes: selective breeding over 35 generations. Frontiers in Diabetes Research: Lessons from Animal Diabetes II. Edited by E Shafrir, AE Renold. London, John Libbey, 1988, pp 301-303
9. Portha B, Serradas P, Bailbe D, Suzuki K, Goto Y, Giroix M-H: β-cell insensitivity to glucose in the GK rat, a spontaneous nonobese model for type II diabetes. Diabetes 1991, 40:486-491
10. Ostenson C-G, Khan A, Abdel-Halim SM, Guenifi A, Suzuki K, Goto Y, Efendic S: Abnormal insulin secretion and glucose metabolism in pancreatic islets from the spontaneously diabetic GK rat. Diabetologia 1993, 36:3-8
11. Ostenson C-G, Abdel-Halim SM, Andersson A, Efendic S: Studies on the pathogenesis of NIDDM in the GK (Goto-Kakizaki) rat. Lessons from Animal Diabetes. VI. Edited by E Shafrir. Boston, Birkhäuser, 1996, pp 299-315
12. Guenifi A, Abdel-Halim SM, Hoog A, Falkmer S, Ostenson C-G: Preserved β-cell density in the endocrine pancreas of young, spontaneously diabetic Goto-Kakizaki (GK) rats. Pancreas 1995, 10:148-153
13. Movassat J, Saulnier C, Portha B: β-cell mass depletion precedes the onset of hyperglycaemia in the GK rat, a genetic model of non-insulin dependent diabetes mellitus. Diabetes Metab 1995, 21:365-370
14. Movassat J, Saulnier C, Serradas P, Portha B: Impaired development of pancreatic β-cell mass is a primary event during the progression to diabetes in the GK rat. Diabetologia 1997, 40:916-925
15. Koyama M, Wada R, Sakuraba Y, Odaka H, Ikeda H, Yagihashi S: Long-term effects of voglibose on pancreatic islets in GK rats: morphometric analysis. Diabetes Frontier 1997, 8:375-376 (Abstract in Japanese)
16. Zhu M, Noma Y, Mizuno A, Sano T, Shima K: Poor capacity for proliferation of pancreatic β-cell in Otsuka-Long-Evans-Tokushima fatty rat: a model of spontaneous NIDDM. Diabetes 1996, 45:941-946
17. Klöppel G, Drenck CR, Oberholzer M, Heitz PU: Morphometric evidence for a striking B-cell reduction at the clinical onset of type 1 diabetes. Virchows Arch A 1984, 403:441-452
18. Blume N, Skouv J, Larsson L-I, Holst JJ, Madsen OD: Potent inhibitory effects of transplantable rat glucagonomas and insulinomas on the respective endogenous islet cells are associated with pancreatic apoptosis. J Clin Invest 1995, 96:2227-2235
19. Hattori Y, Nishigori C, Tanaka T, Uchida K, Nikaido O, Osawa T, Hiai H, Imamura S, Toyokuni S: 8-Hydroxy-2′-deoxyguanosine is increased in epidermal cells of hairless mice after chronic ultraviolet B exposure. J Invest Dermatol 1997, 107:733-737
20. Leahy JL, Bonner-Weir S, Weir GC: Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy. J Clin Invest 1988, 81:1407-1414
21. Ling Z, Kiekens R, Mahler T, Schuit FC, Pipeleers-Marichal M, Sener A, Klöppel G, Malaisse WJ, Pipeleers DG: Effects of chronically elevated glucose levels on the functional properties of rat pancreatic β-cells. Diabetes 1996, 45:1774-1782
22. Malaisse WJ, Marynissen G, Sener A: Possible role of glycogen accumulation in B-cell glucotoxicity. Metabolism 1992, 41:814-819
23. Korsgren O, Jansson L, Sandler S, Andersson A: Hyperglycemia-induced B cell toxicity. J Clin Invest 1990, 86:2161-2168
24. Tajiri Y, Möller C, Grill V: Long term effects of aminoguanidine on insulin release and biosynthesis, evidence that the formation of advanced glycosylation end products inhibits B cell function. Endocrinology 1997, 138:273-280
25. Kaneto H, Fujii J, Myint T, Miyazawa N, Islam KN, Kawasaki Y, Suzuki K, Nakamura M, Tatsumi H, Yamasaki Y, Taniguchi N: Reducing sugars trigger oxidative modification and apoptosis in pancreatic β-cells by provoking oxidative stress through the glycation reaction. Biochem J 1996, 320:855-863
26. Berthelier C, Kergoat M, Portha B: Lack of deterioration of insulin action with aging in the GK rat: a contrasted adaptation as compared with nondiabetic rats. Metabolism 1997, 46:890-896
27. Picarel-Blanchot F, Berthelier C, Bailbe D, Portha B: Impaired insulin secretion and excessive hepatic glucose production are both early events in the diabetic GK rat. Am J Physiol 1996, 271:E755-E762
28. Yoshida K, Hirokawa J, Tagami S, Kawakami Y, Urata Y, Kondo T: Weakened cellular scavenging activity against oxidative stress in diabetes mellitus: regulation of glutathione synthesis and efflux. Diabetologia 1995, 38:201-210
29. Oltvai ZN, Milliman CL, Korsmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell 1993, 74:609-619
30. Hockenbery DM, Zutter M, Hickey W, Nahm M, Korsmeyer SJ: Bcl2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA 1991, 88:6961-6965
31. Iwahashi H, Hanafusa T, Eguchi Y, Nakajima H, Miyagawa J, Itoh N, Tomita K, Namba M, Kuwajima M, Noguchi T, Tsujimoto Y, Matsuzawa Y: Cytokine-induced apoptotic cell death in a mouse pancreatic β-cell line: inhibition by Bcl-2. Diabetologia 1996, 39:530-536
32. Kroemer G: The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat Med 1997, 3:614-620
33. Yin X-M, Oltvai ZN, Korsmeyer SJ: BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature 1994, 369:321-323
34. Galli J, Li L-S, Glaser A, Ostenson C-G, Jiao H, Fakhrai-Rad H, Jacob HS, Lander ES, Luthman H: Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nat Genet 1996, 12:31-37
35. Gauguier D, Froguel P, Parent V, Bernard C, Bihoreau M-T, Portha B, James MR, Penicaud L, Lathrop M, Ktorza A: Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat. Nat Genet 1996, 12:38-43